JP2013500976A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013500976A5 JP2013500976A5 JP2012523006A JP2012523006A JP2013500976A5 JP 2013500976 A5 JP2013500976 A5 JP 2013500976A5 JP 2012523006 A JP2012523006 A JP 2012523006A JP 2012523006 A JP2012523006 A JP 2012523006A JP 2013500976 A5 JP2013500976 A5 JP 2013500976A5
- Authority
- JP
- Japan
- Prior art keywords
- glucocerebrosidase
- antibody
- mixture
- labeled
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22919509P | 2009-07-28 | 2009-07-28 | |
| US61/229,195 | 2009-07-28 | ||
| US30304410P | 2010-02-10 | 2010-02-10 | |
| US61/303,044 | 2010-02-10 | ||
| US31751310P | 2010-03-25 | 2010-03-25 | |
| US61/317,513 | 2010-03-25 | ||
| US33337210P | 2010-05-11 | 2010-05-11 | |
| US61/333,372 | 2010-05-11 | ||
| US35933810P | 2010-06-28 | 2010-06-28 | |
| US61/359,338 | 2010-06-28 | ||
| PCT/US2010/043586 WO2011017177A1 (en) | 2009-07-28 | 2010-07-28 | Compositions and methods for treating gaucher disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015045704A Division JP6066503B2 (ja) | 2009-07-28 | 2015-03-09 | ゴーシェ病を治療するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500976A JP2013500976A (ja) | 2013-01-10 |
| JP2013500976A5 true JP2013500976A5 (https=) | 2013-09-12 |
| JP5815521B2 JP5815521B2 (ja) | 2015-11-17 |
Family
ID=43527246
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523006A Active JP5815521B2 (ja) | 2009-07-28 | 2010-07-28 | ゴーシェ病を治療するための組成物および方法 |
| JP2015045704A Active JP6066503B2 (ja) | 2009-07-28 | 2015-03-09 | ゴーシェ病を治療するための組成物および方法 |
| JP2016136753A Active JP6378257B2 (ja) | 2009-07-28 | 2016-07-11 | ゴーシェ病を治療するための組成物および方法 |
| JP2018000259A Pending JP2018077246A (ja) | 2009-07-28 | 2018-01-04 | ゴーシェ病を治療するための組成物および方法 |
| JP2019194895A Pending JP2020033367A (ja) | 2009-07-28 | 2019-10-28 | ゴーシェ病を治療するための組成物および方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015045704A Active JP6066503B2 (ja) | 2009-07-28 | 2015-03-09 | ゴーシェ病を治療するための組成物および方法 |
| JP2016136753A Active JP6378257B2 (ja) | 2009-07-28 | 2016-07-11 | ゴーシェ病を治療するための組成物および方法 |
| JP2018000259A Pending JP2018077246A (ja) | 2009-07-28 | 2018-01-04 | ゴーシェ病を治療するための組成物および方法 |
| JP2019194895A Pending JP2020033367A (ja) | 2009-07-28 | 2019-10-28 | ゴーシェ病を治療するための組成物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20110027254A1 (https=) |
| EP (2) | EP2459212B1 (https=) |
| JP (5) | JP5815521B2 (https=) |
| CN (3) | CN102686237B (https=) |
| AU (3) | AU2010281403B2 (https=) |
| CA (2) | CA2768999C (https=) |
| CO (1) | CO6660423A2 (https=) |
| ES (2) | ES2887552T3 (https=) |
| IL (3) | IL262668B2 (https=) |
| MX (3) | MX379016B (https=) |
| NZ (3) | NZ713967A (https=) |
| PL (1) | PL3354277T3 (https=) |
| RU (2) | RU2733466C2 (https=) |
| WO (1) | WO2011017177A1 (https=) |
| ZA (2) | ZA201200704B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
| HRP20120994T1 (hr) | 2006-02-07 | 2012-12-31 | Shire Human Genetic Therapies, Inc. | Stabilizirana smjesa glukocerebrozidaze |
| AU2009262670B2 (en) | 2008-06-26 | 2013-06-20 | Zevra Denmark A/S | Use of Hsp70 as a regulator of enzymatic activity |
| AU2010281403B2 (en) | 2009-07-28 | 2016-03-10 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Gaucher disease |
| WO2012012461A2 (en) * | 2010-07-19 | 2012-01-26 | Shire Human Genetic Therapies, Inc. | Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof |
| CA2817773A1 (en) | 2010-11-30 | 2012-06-07 | Orphazyme Aps | Methods for increasing intracellular activity of hsp70 |
| US9387236B2 (en) * | 2011-06-10 | 2016-07-12 | Prothera Inc. | Pharmaceutical compositions containing protease and methods for the treatment of lysosomal storage diseases |
| US8609820B2 (en) | 2011-10-28 | 2013-12-17 | Neotope Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| NZ629296A (en) | 2012-01-27 | 2016-06-24 | Prothena Biosciences Ltd | Humanized antibodies that recognize alpha-synuclein |
| WO2013130963A1 (en) * | 2012-03-02 | 2013-09-06 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating type iii gaucher disease |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| US10513555B2 (en) * | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| AU2015317447B2 (en) | 2014-09-15 | 2021-02-25 | Zevra Denmark A/S | Arimoclomol formulation |
| US20180296542A1 (en) * | 2015-09-22 | 2018-10-18 | Saint Louis University | Iminosugars for improving bone mineral density in bone disease |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| DK3782624T3 (da) | 2016-04-29 | 2025-12-15 | Zevra Denmark As | Arimoclomol til behandling af glucocerebrosidase-associerede lidelser |
| EP3264092A1 (en) * | 2016-07-01 | 2018-01-03 | Centogene AG | Use of lyso-gb1 as druggable target |
| CN111278439A (zh) * | 2017-10-26 | 2020-06-12 | 夏尔人类遗传性治疗公司 | 包含葡萄糖脑苷脂酶和异烟肼的调配物 |
| US20210113703A1 (en) * | 2018-05-27 | 2021-04-22 | Bioasis Technologies Inc. | Treatment of gaucher disease |
| JP7642561B2 (ja) * | 2019-04-25 | 2025-03-10 | 武田薬品工業株式会社 | イソファゴミン塩、その使用方法および製剤 |
| WO2021022045A1 (en) | 2019-07-31 | 2021-02-04 | Ecolab Usa Inc. | Personal protective equipment free delimer compositions |
| RU2759054C2 (ru) * | 2019-11-27 | 2021-11-09 | федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ гриппа им. А.А. Смородинцева" Минздрава России) | Рекомбинантный штамм вируса гриппа A/PR8-NS124-Luc и способ оценки поствакцинальных нейтрализующих антител с использованием биолюминесцентной детекции |
| EP4139442A4 (en) * | 2020-04-23 | 2024-06-19 | Wuxi Biologics Ireland Limited | A genetically modified cell line producing a recombinant glycoprotein having a mannose-terminated n-glycan |
| BR112022026396A2 (pt) * | 2020-06-24 | 2023-03-14 | Kempharm Denmark As | Arimoclomol para o tratamento da doença de gaucher |
| CA3188000A1 (en) * | 2020-07-13 | 2022-01-20 | Genentech, Inc. | Cell-based methods for predicting polypeptide immunogenicity |
| IL301549A (en) * | 2020-10-01 | 2023-05-01 | Sangamo Therapeutics Inc | Methods of detecting anti-aav antibodies |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5241093B2 (https=) | 1973-05-16 | 1977-10-17 | ||
| US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| US5272066A (en) * | 1986-03-07 | 1993-12-21 | Massachusetts Institute Of Technology | Synthetic method for enhancing glycoprotein stability |
| WO1989005850A1 (en) | 1987-12-23 | 1989-06-29 | The United States Of America, As Represented By Th | Cloned dna for synthesizing unique glucocerebrosidase |
| US5549892A (en) * | 1988-12-23 | 1996-08-27 | Genzyme Corporation | Enhanced in vivo uptake of glucocerebrosidase |
| US5236838A (en) * | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| JPH03503721A (ja) | 1988-12-23 | 1991-08-22 | ジェンザイム コーポレイション | 酵素的に活性な組換えグルコセレブロシダーゼ |
| WO1990007573A1 (en) | 1988-12-23 | 1990-07-12 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| US5401650A (en) | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| DE69213714T2 (de) | 1991-01-21 | 1997-01-23 | Genzyme Corp., Cambridge, Mass. | Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen |
| WO1993006217A1 (en) | 1991-09-19 | 1993-04-01 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5911983A (en) | 1992-06-26 | 1999-06-15 | University Of Pittsburgh | Gene therapy for Gaucher disease using retroviral vectors |
| DK0675727T3 (da) | 1992-12-10 | 2002-08-05 | Enzon Inc | Glycolipidenzympolymerkonjugater |
| WO1994014837A1 (en) | 1992-12-21 | 1994-07-07 | Enzon, Inc. | Purification of proteinaceous material |
| EP0675204B1 (en) | 1994-03-30 | 2001-05-30 | Takara Shuzo Co. Ltd. | Transglycosylating process for producing carbohydrates or glycoconjugates |
| JP3002113B2 (ja) | 1994-03-30 | 2000-01-24 | 寳酒造株式会社 | 糖質又は複合糖質の製造方法 |
| US5670132A (en) | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| DE69637875D1 (de) | 1995-09-14 | 2009-04-30 | Virginia Tech Intell Prop | Produktion von lysosomalen enzymen in pflanzlichen expressionssystemen |
| JP2002504083A (ja) | 1996-03-05 | 2002-02-05 | オーケスト インコーポレイテッド | ヒアルロン酸および増殖因子による骨の増殖を促進する方法 |
| US6177447B1 (en) | 1996-07-15 | 2001-01-23 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| JP4001925B2 (ja) | 1996-09-13 | 2007-10-31 | トランスカーヨティック セラピーズ インク. | α―ガラクトシダーゼA欠損症の治療 |
| IL155588A0 (en) | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| JPH10273500A (ja) | 1997-03-03 | 1998-10-13 | Noguchi Inst | 複合糖ペプチド及びその製造法 |
| JPH10306099A (ja) | 1997-03-04 | 1998-11-17 | Noguchi Inst | 新規複合糖ペプチドおよびその製法 |
| TW542721B (en) | 1997-08-06 | 2003-07-21 | Melaleuca Inc | Dietary supplements containing natural ingredients |
| US6340746B1 (en) | 1997-08-07 | 2002-01-22 | University Of Utah | Prodrugs and conjugates of thiol- and selenol- containing compounds and methods of use thereof |
| US5939279A (en) * | 1997-09-18 | 1999-08-17 | The Board Of Trustees Of The University Of Arkansas | Inhibition of bacterial binding by high-mannose oligosaccharides |
| WO1999032135A1 (en) | 1997-12-22 | 1999-07-01 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| GB9802249D0 (en) | 1998-02-03 | 1998-04-01 | Ciba Geigy Ag | Organic compounds |
| GB9807464D0 (en) | 1998-04-07 | 1998-06-10 | Pharming Bv | Purification of human acid µ-glucosidase |
| EP0976838A1 (en) | 1998-05-06 | 2000-02-02 | Rhone-Poulenc Nutrition Animale | Enzymes mixture |
| JPH11318441A (ja) | 1998-05-14 | 1999-11-24 | Nagase & Co Ltd | 超耐熱耐酸性アミロプルラナーゼ |
| KR19990086271A (ko) | 1998-05-27 | 1999-12-15 | 손경식 | 면역세포의 신규한 엔도뉴클레아제 및 이를 사용한 면역보조제 |
| EP1084240A1 (fr) | 1998-06-05 | 2001-03-21 | Aventis Pharma S.A. | Polypeptides possedant une activite de type beta-secretase |
| ES2558160T3 (es) | 1998-12-09 | 2016-02-02 | Phyton Holdings, Llc | Glicoproteínas que tienen glicosilación de tipo humano |
| GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| WO2000076480A2 (en) * | 1999-06-11 | 2000-12-21 | Eli Lilly And Company | Pharmaceutical materials and methods for their preparation and use |
| ATE234626T1 (de) | 1999-07-26 | 2003-04-15 | Searle & Co | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
| US6537785B1 (en) * | 1999-09-14 | 2003-03-25 | Genzyme Glycobiology Research Institute, Inc. | Methods of treating lysosomal storage diseases |
| US6770468B1 (en) * | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
| DE60031999T2 (de) | 1999-10-04 | 2007-06-06 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Stabilisierte flüssige polypeptid-haltige pharmazeutische zusammensetzungen |
| AU2352201A (en) | 1999-12-30 | 2001-07-16 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| WO2001097829A2 (en) * | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
| CN1156702C (zh) * | 2001-07-11 | 2004-07-07 | 上海晶泰生物技术有限公司 | 采用标记链霉亲和素-生物素技术的蛋白质芯片 |
| WO2003048357A1 (fr) | 2001-12-04 | 2003-06-12 | Mitsubishi Pharma Corporation | Procede d'activation de proteine |
| AU2003211990A1 (en) | 2002-02-14 | 2003-09-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution pharmaceuticals |
| US7429460B2 (en) * | 2003-01-15 | 2008-09-30 | Yeda Research And Development Co., Ltd. | Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases |
| US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
| PT2441467E (pt) | 2003-01-31 | 2015-10-12 | Sinai School Medicine | Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica |
| US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| MXPA06011824A (es) * | 2004-04-16 | 2006-12-15 | Genentech Inc | Ensayo para anticuerpos. |
| US20060008415A1 (en) | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
| EP1828224B1 (en) | 2004-12-22 | 2016-04-06 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| WO2007019232A2 (en) | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations |
| HRP20120994T1 (hr) | 2006-02-07 | 2012-12-31 | Shire Human Genetic Therapies, Inc. | Stabilizirana smjesa glukocerebrozidaze |
| US7713709B2 (en) * | 2006-03-17 | 2010-05-11 | Biomarin Pharmaceutical Inc. | Assay for detection of antibodies to lysosomal enzymes |
| EP2012788A4 (en) * | 2006-04-18 | 2010-05-26 | Ekr Therapeutics Inc | PREPARED USE-READY INTRAVENOUS BOLUSA COMPOSITIONS AND USE METHOD |
| PT1860101E (pt) | 2006-05-24 | 2011-07-12 | Amicus Therapeutics Inc | Sal de tartrato da isofagomina e métodos de uso |
| JP5303458B2 (ja) * | 2006-06-23 | 2013-10-02 | アミークス セラピューティックス インコーポレイテッド | β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 |
| DK2041270T3 (da) * | 2006-07-13 | 2014-01-27 | Wyeth Llc | Fremstilling af glycoproteiner |
| TWI489984B (zh) * | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| AU2010281403B2 (en) | 2009-07-28 | 2016-03-10 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Gaucher disease |
| EP2542674B1 (en) | 2010-03-02 | 2014-01-15 | Protalix Ltd. | Glucocerebrosidase multimers and uses thereof |
| WO2012012461A2 (en) | 2010-07-19 | 2012-01-26 | Shire Human Genetic Therapies, Inc. | Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof |
-
2010
- 2010-07-28 AU AU2010281403A patent/AU2010281403B2/en active Active
- 2010-07-28 ES ES18161509T patent/ES2887552T3/es active Active
- 2010-07-28 MX MX2017000266A patent/MX379016B/es unknown
- 2010-07-28 NZ NZ713967A patent/NZ713967A/en unknown
- 2010-07-28 EP EP10806936.0A patent/EP2459212B1/en active Active
- 2010-07-28 MX MX2012001268A patent/MX2012001268A/es active IP Right Grant
- 2010-07-28 JP JP2012523006A patent/JP5815521B2/ja active Active
- 2010-07-28 RU RU2015141669A patent/RU2733466C2/ru active
- 2010-07-28 WO PCT/US2010/043586 patent/WO2011017177A1/en not_active Ceased
- 2010-07-28 EP EP18161509.7A patent/EP3354277B1/en active Active
- 2010-07-28 ES ES10806936.0T patent/ES2668079T3/es active Active
- 2010-07-28 PL PL18161509T patent/PL3354277T3/pl unknown
- 2010-07-28 US US12/845,653 patent/US20110027254A1/en not_active Abandoned
- 2010-07-28 CN CN201080042877.7A patent/CN102686237B/zh active Active
- 2010-07-28 CN CN201811078247.XA patent/CN109172813B/zh active Active
- 2010-07-28 CA CA2768999A patent/CA2768999C/en active Active
- 2010-07-28 NZ NZ598156A patent/NZ598156A/en not_active Application Discontinuation
- 2010-07-28 RU RU2012107103/15A patent/RU2568831C2/ru active
- 2010-07-28 CN CN201510580649.XA patent/CN105126086B/zh active Active
- 2010-07-28 MX MX2015000528A patent/MX344786B/es unknown
- 2010-07-28 IL IL262668A patent/IL262668B2/en unknown
- 2010-07-28 CA CA3120503A patent/CA3120503A1/en not_active Abandoned
- 2010-07-28 NZ NZ623910A patent/NZ623910A/en active IP Right Revival
-
2012
- 2012-01-26 IL IL217774A patent/IL217774B/en active IP Right Grant
- 2012-01-27 ZA ZA2012/00704A patent/ZA201200704B/en unknown
- 2012-03-01 CO CO12036036A patent/CO6660423A2/es unknown
-
2014
- 2014-01-31 US US14/169,628 patent/US11571466B2/en active Active
-
2015
- 2015-03-09 JP JP2015045704A patent/JP6066503B2/ja active Active
- 2015-07-31 ZA ZA2015/05556A patent/ZA201505556B/en unknown
-
2016
- 2016-02-05 AU AU2016200739A patent/AU2016200739B2/en active Active
- 2016-07-11 JP JP2016136753A patent/JP6378257B2/ja active Active
-
2018
- 2018-01-04 JP JP2018000259A patent/JP2018077246A/ja active Pending
- 2018-05-11 AU AU2018203308A patent/AU2018203308B2/en active Active
- 2018-05-16 IL IL259413A patent/IL259413B/en active IP Right Grant
-
2019
- 2019-10-28 JP JP2019194895A patent/JP2020033367A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013500976A5 (https=) | ||
| CN109172813B (zh) | 用于治疗戈谢病的组合物和方法 | |
| Powell et al. | Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients | |
| Pouliquen et al. | Characterization of the relationship between dose and blood eosinophil response following subcutaneous administration of mepolizumab | |
| JP6475293B2 (ja) | Iii型ゴーシェ病を治療するための組成物および方法 | |
| JP2020530002A (ja) | Dlbcl患者サブグループのオビヌツズマブ治療 | |
| JP2022523328A (ja) | 治療に対する応答での患者における疾患の進行および退行をモニタリングするための組成物および方法 | |
| Singh et al. | Thymoma-associated exfoliative dermatitis with post-thymectomy myasthenia gravis in a cat | |
| Volkow et al. | Carbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study | |
| Agersø et al. | Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients | |
| JP2010519512A5 (https=) | ||
| WO2018107205A1 (en) | Radiolabelled material for targeted administration | |
| Hirai et al. | Imaging alloreactive T cells provides early warning of organ transplant rejection | |
| JP2019523759A5 (https=) | ||
| WO2020014175A1 (en) | Methods and compositions for analyzing immortalized megakaryocyte progenitor cell lines and platelet-like particles derived therefrom | |
| Mostafa et al. | Effect of candesartan and ramipril on liver fibrosis in patients with chronic hepatitis C viral infection: a randomized controlled prospective study | |
| Riviere et al. | Bioequivalence of a novel omalizumab solution for injection compared with the standard lyophilized powder formulation | |
| WO2020010189A1 (en) | Methods and compositions for analyzing platelets by mass cytometry | |
| Shaw et al. | Effect of PCC on thrombin generation among patients on factor Xa inhibitors with major bleeding or needing urgent surgery (GAUGE): design and rationale | |
| Keir et al. | Airway responsiveness in an allergic rabbit model | |
| BR112019023141A2 (pt) | métodos de tratamento seletivo da asma usando antagonistas de il-17 | |
| Fragni | Identification of novel readouts to assess anti-fibrotic efficacy of new compounds in a bleomycin-induced pulmonary fibrosis mouse model | |
| US20260116977A1 (en) | Methods of treating melanoma using an anti-ctla4 antibody | |
| WINDYGA et al. | Disclosure of Interest: None declared. | |
| Patel et al. | Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M2-receptor dysfunction |