JP2010519512A5 - - Google Patents
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- Publication number
- JP2010519512A5 JP2010519512A5 JP2009549628A JP2009549628A JP2010519512A5 JP 2010519512 A5 JP2010519512 A5 JP 2010519512A5 JP 2009549628 A JP2009549628 A JP 2009549628A JP 2009549628 A JP2009549628 A JP 2009549628A JP 2010519512 A5 JP2010519512 A5 JP 2010519512A5
- Authority
- JP
- Japan
- Prior art keywords
- thyroid
- patient
- antibody
- antibodies
- depletes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 16
- 108010036012 Iodide peroxidase Proteins 0.000 claims 14
- 102000014267 Thyroid peroxidases Human genes 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 102000013135 CD52 Antigen Human genes 0.000 claims 10
- 108010065524 CD52 Antigen Proteins 0.000 claims 10
- 210000004698 lymphocyte Anatomy 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 230000001404 mediated effect Effects 0.000 claims 6
- 210000001685 thyroid gland Anatomy 0.000 claims 6
- 208000024799 Thyroid disease Diseases 0.000 claims 5
- 229960000548 alemtuzumab Drugs 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 201000006417 multiple sclerosis Diseases 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000003228 microsomal effect Effects 0.000 claims 3
- 210000001589 microsome Anatomy 0.000 claims 3
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 206010033661 Pancytopenia Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 208000024389 cytopenia Diseases 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- 230000035931 haemagglutination Effects 0.000 claims 1
- 208000003532 hypothyroidism Diseases 0.000 claims 1
- 230000002989 hypothyroidism Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000691 measurement method Methods 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90173207P | 2007-02-16 | 2007-02-16 | |
| US60/901,732 | 2007-02-16 | ||
| PCT/US2008/002047 WO2008103292A1 (en) | 2007-02-16 | 2008-02-15 | Method of identifying risk for thyroid disorder |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014110361A Division JP6058585B2 (ja) | 2007-02-16 | 2014-05-28 | 甲状腺障害リスクの同定方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519512A JP2010519512A (ja) | 2010-06-03 |
| JP2010519512A5 true JP2010519512A5 (https=) | 2011-03-17 |
| JP5662684B2 JP5662684B2 (ja) | 2015-02-04 |
Family
ID=39434244
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549628A Active JP5662684B2 (ja) | 2007-02-16 | 2008-02-15 | 甲状腺障害リスクの同定方法 |
| JP2014110361A Active JP6058585B2 (ja) | 2007-02-16 | 2014-05-28 | 甲状腺障害リスクの同定方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014110361A Active JP6058585B2 (ja) | 2007-02-16 | 2014-05-28 | 甲状腺障害リスクの同定方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20100136587A1 (https=) |
| EP (2) | EP2538217A1 (https=) |
| JP (2) | JP5662684B2 (https=) |
| CN (2) | CN101657721B (https=) |
| AU (1) | AU2008219097B2 (https=) |
| BR (1) | BRPI0807601B8 (https=) |
| CA (1) | CA2678199A1 (https=) |
| CY (1) | CY1118663T1 (https=) |
| DK (1) | DK2130044T3 (https=) |
| ES (1) | ES2612558T3 (https=) |
| HR (1) | HRP20170121T1 (https=) |
| HU (1) | HUE031421T2 (https=) |
| IL (2) | IL200314A (https=) |
| LT (1) | LT2130044T (https=) |
| MX (1) | MX2009008642A (https=) |
| PL (1) | PL2130044T3 (https=) |
| PT (1) | PT2130044T (https=) |
| RS (1) | RS55636B1 (https=) |
| RU (1) | RU2013120485A (https=) |
| SI (1) | SI2130044T1 (https=) |
| WO (1) | WO2008103292A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| FR2934129B1 (fr) * | 2008-07-24 | 2014-05-02 | Oreal | Procede de traitement cosmetique. |
| EP2335066B1 (en) * | 2008-09-19 | 2016-12-28 | University of Utah Research Foundation | Methods for prediction of multiple sclerosis disease and therapy response |
| CN106257288A (zh) * | 2016-08-15 | 2016-12-28 | 余洋 | 一种血清TPOAb IgG4水平检测方法 |
| CN112312921A (zh) | 2018-07-02 | 2021-02-02 | 美国西门子医学诊断股份有限公司 | 新型甲状腺过氧化物酶自身抗体免疫测定 |
| KR102469743B1 (ko) | 2020-06-10 | 2022-11-22 | 주식회사 타이로스코프 | 약물 복용에 따른 갑상선 기능 모니터링 방법, 이를 수행하는 모니터링 서버 및 사용자 단말 |
| EP4001919A1 (en) * | 2020-11-13 | 2022-05-25 | Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal | Predictive biomarkers of autoimmunity in patients treated with alemtuzumab |
| WO2024158259A1 (ko) * | 2023-01-27 | 2024-08-02 | 주식회사 타이로스코프 | 대상에 대한 갑상선기능이상증의 예측방법 및 시스템 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5846534A (en) | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| GB9125768D0 (en) * | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| GB2265713A (en) * | 1992-05-16 | 1993-10-06 | R S R Limited | Assay for autoantibodies against thyroglobulin or thyroid peroxidase |
| DE19710211C2 (de) * | 1997-03-12 | 1999-12-16 | Brahms Diagnostica Gmbh | Verfahren zur Bestimmung von Schilddrüsen-Autoantikörpern |
| GB9823397D0 (en) * | 1998-10-27 | 1998-12-23 | Rsr Ltd | Assays for thyroid autoantibodies |
| JP2008523785A (ja) * | 2004-10-12 | 2008-07-10 | カーランテック，インコーポレーテッド | 神経変性、自己免疫脱髄、および糖尿病のウイルス病原に対する動物モデル系 |
| US9498528B2 (en) | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
-
2008
- 2008-02-15 JP JP2009549628A patent/JP5662684B2/ja active Active
- 2008-02-15 EP EP12176625A patent/EP2538217A1/en not_active Withdrawn
- 2008-02-15 BR BRPI0807601A patent/BRPI0807601B8/pt active IP Right Grant
- 2008-02-15 LT LTEP08725657.4T patent/LT2130044T/lt unknown
- 2008-02-15 CN CN200880012149.4A patent/CN101657721B/zh active Active
- 2008-02-15 DK DK08725657.4T patent/DK2130044T3/en active
- 2008-02-15 PL PL08725657T patent/PL2130044T3/pl unknown
- 2008-02-15 PT PT87256574T patent/PT2130044T/pt unknown
- 2008-02-15 ES ES08725657.4T patent/ES2612558T3/es active Active
- 2008-02-15 MX MX2009008642A patent/MX2009008642A/es active IP Right Grant
- 2008-02-15 RS RS20170083A patent/RS55636B1/sr unknown
- 2008-02-15 EP EP08725657.4A patent/EP2130044B1/en active Active
- 2008-02-15 AU AU2008219097A patent/AU2008219097B2/en active Active
- 2008-02-15 WO PCT/US2008/002047 patent/WO2008103292A1/en not_active Ceased
- 2008-02-15 HU HUE08725657A patent/HUE031421T2/hu unknown
- 2008-02-15 HR HRP20170121TT patent/HRP20170121T1/hr unknown
- 2008-02-15 CN CN201810058824.2A patent/CN108303546B/zh active Active
- 2008-02-15 US US12/526,129 patent/US20100136587A1/en not_active Abandoned
- 2008-02-15 CA CA002678199A patent/CA2678199A1/en not_active Withdrawn
- 2008-02-15 SI SI200831753A patent/SI2130044T1/sl unknown
-
2009
- 2009-08-10 IL IL200314A patent/IL200314A/en active IP Right Grant
-
2012
- 2012-12-05 US US13/705,944 patent/US9664688B2/en active Active
-
2013
- 2013-05-06 RU RU2013120485/15A patent/RU2013120485A/ru not_active Application Discontinuation
-
2014
- 2014-05-28 JP JP2014110361A patent/JP6058585B2/ja active Active
-
2015
- 2015-11-02 IL IL242391A patent/IL242391A/en active IP Right Grant
-
2017
- 2017-01-26 CY CY20171100113T patent/CY1118663T1/el unknown
- 2017-05-10 US US15/591,547 patent/US10648986B2/en active Active
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