JP2013127477A5 - - Google Patents
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- JP2013127477A5 JP2013127477A5 JP2013029661A JP2013029661A JP2013127477A5 JP 2013127477 A5 JP2013127477 A5 JP 2013127477A5 JP 2013029661 A JP2013029661 A JP 2013029661A JP 2013029661 A JP2013029661 A JP 2013029661A JP 2013127477 A5 JP2013127477 A5 JP 2013127477A5
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- 108090000623 proteins and genes Proteins 0.000 claims 13
- -1 KIT Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 102100022307 DNA polymerase alpha catalytic subunit Human genes 0.000 claims 6
- 101000902558 Homo sapiens DNA polymerase alpha catalytic subunit Proteins 0.000 claims 6
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 claims 6
- 102000007537 Type II DNA Topoisomerases Human genes 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 5
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 5
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 5
- 102100034157 DNA mismatch repair protein Msh2 Human genes 0.000 claims 5
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 5
- 101001134036 Homo sapiens DNA mismatch repair protein Msh2 Proteins 0.000 claims 5
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 5
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 5
- 229910015837 MSH2 Inorganic materials 0.000 claims 5
- 102000013609 MutL Protein Homolog 1 Human genes 0.000 claims 5
- 108010026664 MutL Protein Homolog 1 Proteins 0.000 claims 5
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 5
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 5
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 102100025498 Proepiregulin Human genes 0.000 claims 4
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- 238000004458 analytical method Methods 0.000 claims 4
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- 230000009456 molecular mechanism Effects 0.000 claims 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 4
- 108010065524 CD52 Antigen Proteins 0.000 claims 3
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- 108010058546 Cyclin D1 Proteins 0.000 claims 3
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- 101100239628 Danio rerio myca gene Proteins 0.000 claims 2
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- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 2
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- 101000893054 Homo sapiens Follitropin subunit beta Proteins 0.000 claims 2
- 101000920748 Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPB Proteins 0.000 claims 2
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 claims 2
- 101001066429 Homo sapiens HIG1 domain family member 1A, mitochondrial Proteins 0.000 claims 2
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- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 2
- 101000764294 Homo sapiens Lymphotoxin-beta Proteins 0.000 claims 2
- 101000585693 Homo sapiens Mitochondrial 2-oxodicarboxylate carrier Proteins 0.000 claims 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
- 101000961071 Homo sapiens NF-kappa-B inhibitor alpha Proteins 0.000 claims 2
- 101000979338 Homo sapiens Nuclear factor NF-kappa-B p100 subunit Proteins 0.000 claims 2
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims 2
- 101001041245 Homo sapiens Ornithine decarboxylase Proteins 0.000 claims 2
- 101000741790 Homo sapiens Peroxisome proliferator-activated receptor gamma Proteins 0.000 claims 2
- 101000611888 Homo sapiens Platelet-derived growth factor C Proteins 0.000 claims 2
- 101001056707 Homo sapiens Proepiregulin Proteins 0.000 claims 2
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 claims 2
- 101000712530 Homo sapiens RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 claims 2
- 101000640876 Homo sapiens Retinoic acid receptor RXR-beta Proteins 0.000 claims 2
- 101001112293 Homo sapiens Retinoic acid receptor alpha Proteins 0.000 claims 2
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 2
- 101000844686 Homo sapiens Thioredoxin reductase 1, cytoplasmic Proteins 0.000 claims 2
- 101000945477 Homo sapiens Thymidine kinase, cytosolic Proteins 0.000 claims 2
- 101000809797 Homo sapiens Thymidylate synthase Proteins 0.000 claims 2
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 2
- 101000818543 Homo sapiens Tyrosine-protein kinase ZAP-70 Proteins 0.000 claims 2
- 101000742596 Homo sapiens Vascular endothelial growth factor C Proteins 0.000 claims 2
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 2
- 102100020791 Interleukin-13 receptor subunit alpha-1 Human genes 0.000 claims 2
- 108010091221 Lymphotoxin beta Receptor Proteins 0.000 claims 2
- 102100026894 Lymphotoxin-beta Human genes 0.000 claims 2
- 101150039798 MYC gene Proteins 0.000 claims 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
- 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 claims 2
- 102100023059 Nuclear factor NF-kappa-B p100 subunit Human genes 0.000 claims 2
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims 2
- 102100021079 Ornithine decarboxylase Human genes 0.000 claims 2
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 2
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims 2
- 102100028960 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Human genes 0.000 claims 2
- 102100032543 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Human genes 0.000 claims 2
- 108010064209 Phosphoribosylglycinamide formyltransferase Proteins 0.000 claims 2
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 2
- 102100040681 Platelet-derived growth factor C Human genes 0.000 claims 2
- 102100024028 Progonadoliberin-1 Human genes 0.000 claims 2
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims 2
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 2
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 2
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 claims 2
- 102100034253 Retinoic acid receptor RXR-beta Human genes 0.000 claims 2
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 2
- 102100029329 Somatostatin receptor type 1 Human genes 0.000 claims 2
- 101000874827 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) Dephospho-CoA kinase Proteins 0.000 claims 2
- 102100036407 Thioredoxin Human genes 0.000 claims 2
- 102100031208 Thioredoxin reductase 1, cytoplasmic Human genes 0.000 claims 2
- 102100034838 Thymidine kinase, cytosolic Human genes 0.000 claims 2
- 102100038618 Thymidylate synthase Human genes 0.000 claims 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 2
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims 2
- 102100021125 Tyrosine-protein kinase ZAP-70 Human genes 0.000 claims 2
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims 2
- 208000008383 Wilms tumor Diseases 0.000 claims 2
- 101100459258 Xenopus laevis myc-a gene Proteins 0.000 claims 2
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- 238000013388 immunohistochemistry analysis Methods 0.000 claims 2
- 201000008026 nephroblastoma Diseases 0.000 claims 2
- 108010060054 peroxisome-proliferator-activated receptor-gamma coactivator-1 Proteins 0.000 claims 2
- 102000003998 progesterone receptors Human genes 0.000 claims 2
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- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 claims 1
- 102000053723 Angiotensin-converting enzyme 2 Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101000852559 Homo sapiens Thioredoxin Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010061336 Pelvic neoplasm Diseases 0.000 claims 1
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- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 claims 1
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- 239000002773 nucleotide Substances 0.000 claims 1
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- 201000002528 pancreatic cancer Diseases 0.000 claims 1
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74764506P | 2006-05-18 | 2006-05-18 | |
| US60/747,645 | 2006-05-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511252A Division JP2009537154A (ja) | 2006-05-18 | 2007-05-18 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015153083A Division JP6129251B2 (ja) | 2006-05-18 | 2015-08-03 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013127477A JP2013127477A (ja) | 2013-06-27 |
| JP2013127477A5 true JP2013127477A5 (https=) | 2014-06-05 |
Family
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Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511252A Pending JP2009537154A (ja) | 2006-05-18 | 2007-05-18 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2013029661A Withdrawn JP2013127477A (ja) | 2006-05-18 | 2013-02-19 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2015153083A Active JP6129251B2 (ja) | 2006-05-18 | 2015-08-03 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2017078333A Active JP6568551B2 (ja) | 2006-05-18 | 2017-04-11 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2019142983A Pending JP2020005641A (ja) | 2006-05-18 | 2019-08-02 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2021212100A Pending JP2022050488A (ja) | 2006-05-18 | 2021-12-27 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2023118742A Pending JP2023139147A (ja) | 2006-05-18 | 2023-07-21 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2025172607A Pending JP2026016460A (ja) | 2006-05-18 | 2025-10-14 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511252A Pending JP2009537154A (ja) | 2006-05-18 | 2007-05-18 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015153083A Active JP6129251B2 (ja) | 2006-05-18 | 2015-08-03 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2017078333A Active JP6568551B2 (ja) | 2006-05-18 | 2017-04-11 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2019142983A Pending JP2020005641A (ja) | 2006-05-18 | 2019-08-02 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2021212100A Pending JP2022050488A (ja) | 2006-05-18 | 2021-12-27 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2023118742A Pending JP2023139147A (ja) | 2006-05-18 | 2023-07-21 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
| JP2025172607A Pending JP2026016460A (ja) | 2006-05-18 | 2025-10-14 | 疾患状態に対する個別化された医学的介入を決定するためのシステムおよび方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8700335B2 (https=) |
| EP (2) | EP3399450A1 (https=) |
| JP (8) | JP2009537154A (https=) |
| KR (1) | KR101356305B1 (https=) |
| CN (2) | CN103424541B (https=) |
| AU (1) | AU2007253740A1 (https=) |
| BR (1) | BRPI0711011A2 (https=) |
| CA (1) | CA2651995C (https=) |
| CO (1) | CO6141496A2 (https=) |
| IL (8) | IL282783B2 (https=) |
| MX (1) | MX2008014608A (https=) |
| RU (1) | RU2008146868A (https=) |
| WO (1) | WO2007137187A2 (https=) |
| ZA (1) | ZA200809783B (https=) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2364495T3 (es) | 2005-02-03 | 2011-09-05 | The General Hospital Corporation | Método para tratar cáncer resistente a gefitinib. |
| JP2009514870A (ja) | 2005-11-04 | 2009-04-09 | ワイス | ｍＴＯＲインヒビター、ハーセプチン、および／またはＨＫＩ−２７２の抗悪性腫瘍性組み合わせ |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| US12366585B2 (en) | 2006-05-18 | 2025-07-22 | Caris Mpi, Inc. | Molecular profiling of tumors |
| CN103424541B (zh) | 2006-05-18 | 2018-01-30 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
| CN101743329A (zh) * | 2007-05-11 | 2010-06-16 | 平移基因组学研究所 | 测定外部刺激对活细胞中生物通路影响的方法 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| US10365279B2 (en) | 2008-01-25 | 2019-07-30 | Berg Llc | Assay system for the assessment of oncogenicity, tumor progression, and treatment efficacy |
| CN102084366A (zh) | 2008-05-12 | 2011-06-01 | 皇家飞利浦电子股份有限公司 | 医学分析系统 |
| ES2692769T3 (es) | 2008-06-17 | 2018-12-05 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| CN105147713A (zh) | 2008-08-04 | 2015-12-16 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
| US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US20100069298A1 (en) * | 2008-09-16 | 2010-03-18 | Robert Penny | Methods for Detecting Overexpression of SPARC and Therapeutic and Diagnostic Methods Relating to Same |
| CN102232117A (zh) * | 2008-10-14 | 2011-11-02 | 卡里斯Mpi公司 | 描绘肿瘤类型生物标志模式和特征集的基因靶和基因表达的蛋白靶 |
| FR2937801B1 (fr) * | 2008-10-23 | 2010-12-03 | Souriau | Ensemble de connexion a verrouillage rapide et procede d'accouplement et de desaccouplement de l'ensemble |
| WO2011109440A1 (en) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| GB2463401B (en) | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
| IL313131A (en) * | 2009-02-11 | 2024-07-01 | Caris Mpi Inc | Molecular characterization of tumors |
| SG174382A1 (en) | 2009-04-06 | 2011-11-28 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
| WO2010118782A1 (en) * | 2009-04-17 | 2010-10-21 | Universite Libre De Bruxelles | Methods and tools for predicting the efficiency of anthracyclines in cancer |
| CN102034016B (zh) * | 2009-09-30 | 2016-08-31 | 帕斯维基因组学公司 | 基于基因组的药物管理系统 |
| CA2787048C (en) * | 2010-01-13 | 2021-06-22 | Wyeth Llc | A cut-point in pten protein expression that accurately identifies tumors and is predictive of drug response to a pan-erbb inhibitor |
| FI20105252A0 (fi) | 2010-03-12 | 2010-03-12 | Medisapiens Oy | Menetelmä, järjestely ja tietokoneohjelmatuote biologisen tai lääketieteellisen näytteen analysoimiseen |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| CN101984070B (zh) * | 2010-09-21 | 2013-04-24 | 广州益善生物技术有限公司 | 一种c-KIT基因突变检测液相芯片 |
| RU2565550C2 (ru) | 2010-09-24 | 2015-10-20 | Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити | Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров |
| WO2012093363A2 (en) * | 2011-01-07 | 2012-07-12 | Koninklijke Philips Electronics N.V. | Integrated access to and interation with multiplicity of clinica data analytic modules |
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