JP2012501452A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012501452A5 JP2012501452A5 JP2011525223A JP2011525223A JP2012501452A5 JP 2012501452 A5 JP2012501452 A5 JP 2012501452A5 JP 2011525223 A JP2011525223 A JP 2011525223A JP 2011525223 A JP2011525223 A JP 2011525223A JP 2012501452 A5 JP2012501452 A5 JP 2012501452A5
- Authority
- JP
- Japan
- Prior art keywords
- kit
- sample
- members
- panel
- evaluating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 41
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 230000002496 gastric effect Effects 0.000 claims 19
- 238000002626 targeted therapy Methods 0.000 claims 19
- 230000000875 corresponding effect Effects 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 239000003153 chemical reaction reagent Substances 0.000 claims 13
- 206010009900 Colitis ulcerative Diseases 0.000 claims 12
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 238000000034 method Methods 0.000 claims 8
- 239000003550 marker Substances 0.000 claims 7
- 238000001574 biopsy Methods 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 229960000598 infliximab Drugs 0.000 claims 5
- 210000001072 colon Anatomy 0.000 claims 4
- 238000012360 testing method Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000004976 peripheral blood cell Anatomy 0.000 claims 3
- 239000000902 placebo Substances 0.000 claims 3
- 229940068196 placebo Drugs 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000010998 test method Methods 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 230000000112 colonic effect Effects 0.000 claims 2
- 238000011156 evaluation Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9296608P | 2008-08-29 | 2008-08-29 | |
| US61/092,966 | 2008-08-29 | ||
| PCT/US2009/055323 WO2010025340A2 (en) | 2008-08-29 | 2009-08-28 | Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012501452A JP2012501452A (ja) | 2012-01-19 |
| JP2012501452A5 true JP2012501452A5 (https=) | 2012-06-28 |
| JP5586607B2 JP5586607B2 (ja) | 2014-09-10 |
Family
ID=41722298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525223A Active JP5586607B2 (ja) | 2008-08-29 | 2009-08-28 | ２０個の遺伝子パネルを用いて潰瘍性大腸炎及び関連疾患を評価し治療するためのマーカー及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100069256A1 (https=) |
| EP (1) | EP2329259B1 (https=) |
| JP (1) | JP5586607B2 (https=) |
| CN (1) | CN102165315B (https=) |
| AU (1) | AU2009285644B2 (https=) |
| BR (1) | BRPI0917379A2 (https=) |
| CA (1) | CA2734519C (https=) |
| DK (1) | DK2329259T3 (https=) |
| ES (1) | ES2581774T3 (https=) |
| IL (1) | IL211154A0 (https=) |
| RU (1) | RU2011111748A (https=) |
| WO (1) | WO2010025340A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008028044A2 (en) * | 2006-08-30 | 2008-03-06 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel |
| AU2012253422B2 (en) * | 2011-05-10 | 2015-08-13 | Société des Produits Nestlé S.A. | Methods of disease activity profiling for personalized therapy management |
| CA2964857A1 (en) * | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
| WO2016092045A1 (en) * | 2014-12-11 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting medically refractory acute severe colitis |
| GB2547406A (en) * | 2015-11-20 | 2017-08-23 | Folkersen Lasse | Apparatus and methods of using of biomarkers for predicting TNF-inhibitor response |
| WO2017175228A1 (en) | 2016-04-06 | 2017-10-12 | Technion Research & Development Foundation Limited | Infiltrating immune cell proportions predict anti-tnf response in colon biopsies |
| EP3458466B1 (en) | 2016-05-20 | 2024-08-07 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease based on genes |
| JP2019520071A (ja) * | 2016-06-14 | 2019-07-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 急性重症大腸炎の処置応答を予測するための方法 |
| EP3612843A1 (en) | 2017-05-31 | 2020-02-26 | Prometheus Biosciences, Inc. | Methods for assessing mucosal healing in crohn's disease patients |
| US20210262032A1 (en) * | 2018-07-15 | 2021-08-26 | Rambam Med-Tech Ltd. | Determining responders to inflammation treatment |
| CA3116005A1 (en) * | 2018-10-19 | 2020-04-23 | Children's Hospital Medical Center | Use of mucosal transcriptomes for assessing severity of ulcerative colitis and responsiveness to treatment |
| EA202191354A1 (ru) * | 2018-11-15 | 2021-08-11 | Янссен Байотек, Инк. | Способы и композиции для прогнозирования ответа на терапию воспалительного заболевания кишечника |
| CN114015689B (zh) * | 2021-10-26 | 2024-06-07 | 江苏大学 | 一种特异性抑制GOS2基因表达的shRNA序列及其应用 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5721098A (en) | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| EP1134293A3 (en) | 1992-03-04 | 2004-01-07 | The Regents of The University of California | Comparative genomic hybridization (CGH) |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| ATE214633T1 (de) | 1993-10-28 | 2002-04-15 | Houston Advanced Res Ct | Mikrofabriziertes poröses durchflussgerät |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5723320A (en) | 1995-08-29 | 1998-03-03 | Dehlinger; Peter J. | Position-addressable polynucleotide arrays |
| US5843655A (en) | 1995-09-18 | 1998-12-01 | Affymetrix, Inc. | Methods for testing oligonucleotide arrays |
| US6022963A (en) | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
| US6057100A (en) | 1996-06-07 | 2000-05-02 | Eos Biotechnology, Inc. | Oligonucleotide arrays |
| US6083697A (en) | 1996-11-14 | 2000-07-04 | Affymetrix, Inc. | Chemical amplification for the synthesis of patterned arrays |
| EP1012335A4 (en) | 1997-08-15 | 2004-06-09 | Hyseq Inc | EXPERIENCE AND COMPOSITIONS FOR DETECTING OR QUANTIFYING NUCLEIC ACID SPECIES |
| US6197503B1 (en) | 1997-11-26 | 2001-03-06 | Ut-Battelle, Llc | Integrated circuit biochip microsystem containing lens |
| US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| US6087103A (en) | 1998-03-04 | 2000-07-11 | Lifespan Biosciences, Inc. | Tagged ligand arrays for identifying target-ligand interactions |
| CA2323638A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
| US6048695A (en) | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
| US6093370A (en) | 1998-06-11 | 2000-07-25 | Hitachi, Ltd. | Polynucleotide separation method and apparatus therefor |
| US6087112A (en) | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
| US6174684B1 (en) | 1999-08-11 | 2001-01-16 | Trustees Of The University Of Pennsylvania | CYP3A4 NFSE variant and methods of use therefore |
| JP2004500867A (ja) | 2000-06-07 | 2004-01-15 | ベイラー カレッジ オブ メディシン | アレイ利用型核酸ハイブリダイゼーションのための新規な組成物および方法 |
| US20040077020A1 (en) | 2001-11-30 | 2004-04-22 | Mannick Elizabeth E. | Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis |
| CA2490409A1 (en) | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
| EP1815021A2 (en) * | 2004-11-03 | 2007-08-08 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
| CA2644517A1 (en) * | 2006-03-03 | 2007-09-13 | University Of Southern California | Genetic markers for predicting disease and treatment outcome |
| WO2008028044A2 (en) * | 2006-08-30 | 2008-03-06 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel |
| US20090186772A1 (en) * | 2007-04-30 | 2009-07-23 | Frederic Baribaud | Markers and Methods for Assessing and Treating Ulcerative Colitis and Related Disorders Using a 19 Gene Panel |
| ES2445892T3 (es) * | 2008-08-25 | 2014-03-05 | Janssen Biotech, Inc. | Biomarcadores para el tratamiento anti-TNF en colitis ulcerosa y trastornos relacionados |
-
2009
- 2009-08-28 DK DK09810643.8T patent/DK2329259T3/en active
- 2009-08-28 BR BRPI0917379A patent/BRPI0917379A2/pt not_active Application Discontinuation
- 2009-08-28 CA CA2734519A patent/CA2734519C/en active Active
- 2009-08-28 WO PCT/US2009/055323 patent/WO2010025340A2/en not_active Ceased
- 2009-08-28 JP JP2011525223A patent/JP5586607B2/ja active Active
- 2009-08-28 EP EP09810643.8A patent/EP2329259B1/en active Active
- 2009-08-28 AU AU2009285644A patent/AU2009285644B2/en not_active Ceased
- 2009-08-28 ES ES09810643.8T patent/ES2581774T3/es active Active
- 2009-08-28 RU RU2011111748/15A patent/RU2011111748A/ru unknown
- 2009-08-28 CN CN200980134148.1A patent/CN102165315B/zh active Active
- 2009-08-31 US US12/550,703 patent/US20100069256A1/en not_active Abandoned
-
2011
- 2011-02-10 IL IL211154A patent/IL211154A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012501452A5 (https=) | ||
| DK2329259T3 (en) | MARKERS AND PROCEDURES FOR ASSESSING AND TREATING ULCERATIVE COLITIS AND RELATED DISEASES USING A 20-GEN PANEL | |
| CN102171365B (zh) | 用于溃疡性结肠炎和相关疾病的抗tnf治疗的生物标记物 | |
| KR101566368B1 (ko) | 암 검출을 위한 소변 유전자 발현 비율 | |
| RU2015138992A (ru) | Способы прогнозирования риска интерстициальной пневмонии | |
| JP2009543552A5 (https=) | ||
| JP2015528295A5 (https=) | ||
| KR20100072283A (ko) | 환자의 유전자-베이스 알고리즘적 암 예후 및 임상적 결과 | |
| US10724097B2 (en) | Methods and compositions for diagnosis and management of diabetes and metabolic syndrome | |
| WO2017039359A1 (ko) | 트립토파닐 티알엔에이 합성효소를 이용한 감염 질환 또는 감염 합병증의 진단용 조성물과 진단 마커 검출 방법 | |
| JP2019507594A (ja) | 大腸がん診断用組成物と診断マーカー検出方法 | |
| CN101978069A (zh) | 评估及治疗重度或持续性哮喘的标记物和方法 | |
| KR102788019B1 (ko) | 췌장암의 진단용 조성물 | |
| KR101657051B1 (ko) | 만성폐쇄성폐질환 진단용 마커 조성물 | |
| WO2009150491A2 (en) | Interferon epsilon (ifne1) as a marker for targeted cancer therapy | |
| US20030152972A1 (en) | Gene expression associated with psychiatric disorders | |
| CN115058512A (zh) | 铁死亡相关基因在鉴定缺血性脑卒中的应用 | |
| US20230357856A1 (en) | Methods and compositions for prognosing glioblastoma or breast cancer | |
| WO2007053659A2 (en) | Method of screening for hepatocellular carcinoma | |
| JP2022025456A (ja) | 多発性硬化症を検査する方法 | |
| WO2019065609A1 (ja) | Ｐｒｄｍ１４発現を確認する方法 | |
| KR102326119B1 (ko) | 암의 면역 치료 후 예후 예측용 바이오 마커 | |
| CN119570928A (zh) | 用于结直肠癌诊断和预后预测的lncRNA组合 | |
| CN119193847A (zh) | Gsdmd在诊断胰腺癌中的应用 | |
| JP2012511323A (ja) | 腫瘍中のｅｒｂｂ２の変化を特定するための方法 |