JP2013049690A5 - - Google Patents

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Publication number
JP2013049690A5
JP2013049690A5 JP2012235328A JP2012235328A JP2013049690A5 JP 2013049690 A5 JP2013049690 A5 JP 2013049690A5 JP 2012235328 A JP2012235328 A JP 2012235328A JP 2012235328 A JP2012235328 A JP 2012235328A JP 2013049690 A5 JP2013049690 A5 JP 2013049690A5
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JP
Japan
Prior art keywords
mixture
ethanol
solvent
compound
methanol
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JP2012235328A
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English (en)
Japanese (ja)
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JP5785923B2 (ja
JP2013049690A (ja
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Priority claimed from GB0613692A external-priority patent/GB0613692D0/en
Priority claimed from GB0613694A external-priority patent/GB0613694D0/en
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Publication of JP2013049690A publication Critical patent/JP2013049690A/ja
Publication of JP2013049690A5 publication Critical patent/JP2013049690A5/ja
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JP2012235328A 2006-07-10 2012-10-25 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態 Active JP5785923B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0613692A GB0613692D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts
GB0613694A GB0613694D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts
GB0613694.9 2006-07-10
GB0613692.3 2006-07-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2009518952A Division JP5433413B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態

Publications (3)

Publication Number Publication Date
JP2013049690A JP2013049690A (ja) 2013-03-14
JP2013049690A5 true JP2013049690A5 (OSRAM) 2013-09-05
JP5785923B2 JP5785923B2 (ja) 2015-09-30

Family

ID=38535381

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009518952A Active JP5433413B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態
JP2012235328A Active JP5785923B2 (ja) 2006-07-10 2012-10-25 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2009518952A Active JP5433413B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態

Country Status (17)

Country Link
US (7) US9193730B2 (OSRAM)
EP (1) EP2081921B1 (OSRAM)
JP (2) JP5433413B2 (OSRAM)
KR (3) KR20150081370A (OSRAM)
CN (3) CN103288834B (OSRAM)
AT (1) ATE480532T1 (OSRAM)
AU (1) AU2007274054B2 (OSRAM)
BR (1) BRPI0714886B8 (OSRAM)
CA (1) CA2657347C (OSRAM)
DE (1) DE602007009128D1 (OSRAM)
DK (1) DK2081921T3 (OSRAM)
MX (1) MX2009000404A (OSRAM)
PL (1) PL2081921T3 (OSRAM)
PT (1) PT2081921E (OSRAM)
RU (1) RU2470935C2 (OSRAM)
SI (1) SI2081921T1 (OSRAM)
WO (1) WO2008007071A1 (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
DK2081921T3 (da) 2006-07-10 2011-01-03 Paion Uk Ltd Korttidsvirkende benzodiazepinsalte og deres polymorfe former
EP2305647A1 (en) * 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
PT2852389T (pt) 2012-05-22 2017-12-13 Paion Uk Ltd Composições que compreendem benzodiazepinas de ação rápida
BR112015004477A8 (pt) * 2012-08-31 2019-08-27 Paion Uk Ltd uso de composto na preparação de um sedativo e composição farmacêutica
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
PL3162804T3 (pl) * 2014-07-23 2020-04-30 Jiangsu Nhwaluokang Pharmaceutical Research And Development Co., Ltd. Nowa pochodna benzodiazepiny i jej zastosowanie
US20170081954A1 (en) * 2015-09-23 2017-03-23 Tesco Corporation Pipe joint location detection system and method
CN110511224A (zh) * 2016-04-08 2019-11-29 四川科伦药物研究院有限公司 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途
WO2017178663A1 (en) * 2016-04-14 2017-10-19 Paion Uk Limited Orally inhaled and nasal benzodiazepines
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
EP3580219B1 (en) 2017-02-09 2022-04-13 Assia Chemical Industries Ltd. Process for the preparation of remimazolam and solid state forms of remimazolam salts
CN108948018B (zh) * 2017-05-17 2021-03-30 四川科伦博泰生物医药股份有限公司 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途
US11708368B2 (en) 2018-02-13 2023-07-25 Jiangsu Nhwaluokang Pharmaceutical Research And Development Co., Ltd. Crystal form of ethyl (S)-3-(8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-4-yl)propanoate hydrochloride
CN110398514B (zh) * 2018-04-24 2023-04-28 恒天纤维集团有限公司 一种快速判断纤维素胶液中金属杂质含量的方法
ES2803099B2 (es) 2019-07-22 2021-11-08 Moehs Iberica Sl Procedimiento de obtención de besilato de remimazolam amorfo
CN114478535B (zh) * 2020-10-23 2024-02-09 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法
WO2023037237A1 (en) * 2021-09-09 2023-03-16 Wavelength Enterprises Ltd Process for the preparation of remimazolam
EP4504731A1 (en) 2022-04-08 2025-02-12 Fresenius Kabi Oncology Ltd An improved process for the preparation of remimazolam
CN115448927A (zh) * 2022-10-20 2022-12-09 重庆瑞泊莱医药科技有限公司 一种氢溴酸依匹斯汀晶型ii及其制备方法
WO2025052259A1 (en) 2023-09-05 2025-03-13 Reena Patel Ready to use compositions of remimazolam

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520877A (en) 1967-10-02 1970-07-21 Hoffmann La Roche 3-carbonyl amino acetic acid ethyl ester substituted benzodiazepines
BR6915069D0 (pt) 1969-02-28 1973-08-16 Upjohn Co Compostos organicos e processo
DK124481B (da) 1969-09-01 1972-10-23 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater samt deres 4-N-oxyder og salte.
DE2156472A1 (de) 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
US3933794A (en) 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
FR2183716A1 (en) 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
IE41197B1 (en) 1973-05-29 1979-11-07 Squibb & Sons Inc 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones
CH608234A5 (en) 1974-08-30 1978-12-29 Crc Ricerca Chim Process for the preparation of lithium salts of 1,4-benzodiazepines
DE2900017A1 (de) 1978-01-10 1979-07-12 Clin Midy 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
MC1528A1 (fr) 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
IT1165588B (it) 1983-03-23 1987-04-22 Medosan Ind Biochimi 1,4 benzodiazepine terapeuticamente attive
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4724237A (en) 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
CA1332410C (en) 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4755508A (en) 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
DE3435973A1 (de) 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
ES2084577T3 (es) 1986-10-24 1996-05-16 Abbott Lab Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas.
WO1989010127A1 (en) 1988-04-29 1989-11-02 Baker Cummins Pharmaceuticals, Inc. Method of safely providing anesthesia or conscious sedation
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
JPH0374328A (ja) 1989-08-04 1991-03-28 Warner Lambert Co 薬学的活性を有する中枢コレシストキニン拮抗剤
DE122009000062I2 (de) 1989-10-20 2011-01-13 Otsuka Pharma Co Ltd Benzoheterozyklische verbindungen
CA2032427A1 (en) 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepines analogs
IL96613A0 (en) 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
US5324726A (en) 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
US5220017A (en) 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5185331A (en) 1991-05-14 1993-02-09 Merck & Co., Inc. Triazolobenzodiazepines
EP0523845A3 (en) 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
GB9117852D0 (en) 1991-08-19 1991-10-09 Merck Sharp & Dohme Therapeutic agents
CA2120939A1 (en) 1991-10-11 1993-04-15 Tetsuya Tahara Therapeutic agent for osteoporosis and diazepine compound
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US5834464A (en) 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
BR9606823A (pt) 1995-01-06 1997-12-30 Hoffmann La Roche Hidroximetil-imidazoazepinas e seus èsteres
WO1996023790A1 (de) 1995-02-02 1996-08-08 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepine
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
JP2000510155A (ja) 1996-06-28 2000-08-08 メルク エンド カンパニー インコーポレーテッド 医薬製剤
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP0881235A1 (fr) 1997-05-26 1998-12-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles
US6440959B1 (en) 1999-04-21 2002-08-27 Hoffman-La Roche Inc. Pyrazolobenzodiazepines
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
IL161134A0 (en) 2002-02-28 2004-08-31 Japan Tobacco Inc Ester compound and medical use thereof
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
IN2012DN03921A (OSRAM) 2004-02-11 2015-09-04 Amylin Pharmaceuticals Inc
US7687736B2 (en) 2004-04-29 2010-03-30 Smart Technologies Ulc Tensioned touch panel and method of making same
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
RU2007117741A (ru) 2004-10-13 2008-11-20 Мерк энд Ко., Инк. (US) Антагонисты рецептора cgrp
WO2006078554A2 (en) 2005-01-18 2006-07-27 Merck & Co., Inc. Cgrp receptor antagonists
MX2007009915A (es) 2005-02-15 2007-11-06 Elan Pharma Int Ltd Formulaciones en aerosol e inyectables de benzodiazepina nanoparticulada.
US20070040501A1 (en) 2005-08-18 2007-02-22 Aitken Bruce G Method for inhibiting oxygen and moisture degradation of a device and the resulting device
GB0613692D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts
DK2081921T3 (da) 2006-07-10 2011-01-03 Paion Uk Ltd Korttidsvirkende benzodiazepinsalte og deres polymorfe former
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
WO2008147815A1 (en) 2007-05-22 2008-12-04 Chemocentryx, Inc. 3-(imidazolyl)-pyrazolo[3,4-b]pyridines
WO2009145323A1 (ja) 2008-05-30 2009-12-03 日産化学工業株式会社 多環式化合物を用いるアルコールの酸化方法
JP2012505843A (ja) 2008-10-16 2012-03-08 パイオン ユーケー リミテッド 術後疼痛管理のための極性オピオイドの投与スキーム
US8865886B2 (en) 2009-03-30 2014-10-21 Nippon Paper Industries Co., Ltd. Method for recovery/reuse of N-oxyl compound
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
DK2496582T3 (en) 2009-11-05 2016-03-21 Glaxosmithkline Llc Benzodiazepine-BROMDOMAeNEINHIBITOR.
JP5635275B2 (ja) 2010-01-28 2014-12-03 日清紡ホールディングス株式会社 アルコールの酸化方法
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
JP5585597B2 (ja) 2012-01-27 2014-09-10 株式会社デンソー 車輪位置検出装置およびそれを備えたタイヤ空気圧検出装置
PT2852389T (pt) 2012-05-22 2017-12-13 Paion Uk Ltd Composições que compreendem benzodiazepinas de ação rápida
BR112015004477A8 (pt) 2012-08-31 2019-08-27 Paion Uk Ltd uso de composto na preparação de um sedativo e composição farmacêutica
CN107659350A (zh) 2012-09-28 2018-02-02 华为技术有限公司 信道状态信息进程处理方法、网络设备和用户设备
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

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