JP2013010792A5 - - Google Patents
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- Publication number
- JP2013010792A5 JP2013010792A5 JP2012226367A JP2012226367A JP2013010792A5 JP 2013010792 A5 JP2013010792 A5 JP 2013010792A5 JP 2012226367 A JP2012226367 A JP 2012226367A JP 2012226367 A JP2012226367 A JP 2012226367A JP 2013010792 A5 JP2013010792 A5 JP 2013010792A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims 38
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 229910052731 fluorine Inorganic materials 0.000 claims 9
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 8
- 239000011737 fluorine Substances 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- -1 COOR' Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 230000001066 destructive effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003900 neurotrophic factor Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 0 Cc1cnc2[n]cc(C(N=C(*)*)=NC(*)=I)c2c1 Chemical compound Cc1cnc2[n]cc(C(N=C(*)*)=NC(*)=I)c2c1 0.000 description 20
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- PSDSIQPUXJCFBK-UHFFFAOYSA-N C(C1C2)C3C11C4C2C3CC1C4 Chemical compound C(C1C2)C3C11C4C2C3CC1C4 PSDSIQPUXJCFBK-UHFFFAOYSA-N 0.000 description 1
- VVRCYUOEOIOIEK-UHFFFAOYSA-O CC(C(N(C)CC(F)(F)F)=O)Nc1nc(C2=C[NH2+]c3ncccc23)ncc1 Chemical compound CC(C(N(C)CC(F)(F)F)=O)Nc1nc(C2=C[NH2+]c3ncccc23)ncc1 VVRCYUOEOIOIEK-UHFFFAOYSA-O 0.000 description 1
- DZDNCAJEJCQSMR-UHFFFAOYSA-N CC(C)(C)C1N(C)CSC1 Chemical compound CC(C)(C)C1N(C)CSC1 DZDNCAJEJCQSMR-UHFFFAOYSA-N 0.000 description 1
- GDHIUXDCYFUUAE-INIZCTEOSA-N CC(C)[C@@H](NCOCNCC(F)(F)F)Nc1ccnc(-c2c[nH]c3ncccc23)n1 Chemical compound CC(C)[C@@H](NCOCNCC(F)(F)F)Nc1ccnc(-c2c[nH]c3ncccc23)n1 GDHIUXDCYFUUAE-INIZCTEOSA-N 0.000 description 1
- QOVARRUAEFTPOJ-UHFFFAOYSA-O CC(CC1C([NH2+]CC(F)(F)F)=O)(CN1c1nc(-c2c[nH]c3ncccc23)ncc1)F Chemical compound CC(CC1C([NH2+]CC(F)(F)F)=O)(CN1c1nc(-c2c[nH]c3ncccc23)ncc1)F QOVARRUAEFTPOJ-UHFFFAOYSA-O 0.000 description 1
- RJCGAHHUKISJIM-UHFFFAOYSA-N CC(CCC1)(C(NCC(CCF)F)=O)N1c1ccnc(-c2c[nH]c3ncccc23)n1 Chemical compound CC(CCC1)(C(NCC(CCF)F)=O)N1c1ccnc(-c2c[nH]c3ncccc23)n1 RJCGAHHUKISJIM-UHFFFAOYSA-N 0.000 description 1
- GGFKQOQFSGPWBG-UHFFFAOYSA-N CC(NCC(F)(F)F)=O Chemical compound CC(NCC(F)(F)F)=O GGFKQOQFSGPWBG-UHFFFAOYSA-N 0.000 description 1
- MKPZDBNKUJHYCK-UHFFFAOYSA-N CC1N(C)CC1 Chemical compound CC1N(C)CC1 MKPZDBNKUJHYCK-UHFFFAOYSA-N 0.000 description 1
- HPFBCTLYLKRWHC-LJQANCHMSA-N CCCN(C[C@H](C(NCC(F)(F)[F]C)=O)Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(C=C(C)C)=O Chemical compound CCCN(C[C@H](C(NCC(F)(F)[F]C)=O)Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(C=C(C)C)=O HPFBCTLYLKRWHC-LJQANCHMSA-N 0.000 description 1
- RAZUSFPITOYAFO-UHFFFAOYSA-N CCN(CCCCC(NCC(F)(F)F)=O)c1nc(-c2cnc3ncccc23)ncc1F Chemical compound CCN(CCCCC(NCC(F)(F)F)=O)c1nc(-c2cnc3ncccc23)ncc1F RAZUSFPITOYAFO-UHFFFAOYSA-N 0.000 description 1
- CQUBJFQPRYBVRL-MRVPVSSYSA-N C[C@H](C(NCC(F)(F)F)=O)Nc1nc(-c2c[nH]c3ncccc23)ncn1 Chemical compound C[C@H](C(NCC(F)(F)F)=O)Nc1nc(-c2c[nH]c3ncccc23)ncn1 CQUBJFQPRYBVRL-MRVPVSSYSA-N 0.000 description 1
- TYGGIVKWEZXSEO-UHFFFAOYSA-O FC(C[NH2+]CC(CSC1)N1c1nc(-c2c[nH]c3ncccc23)ncc1)(F)F Chemical compound FC(C[NH2+]CC(CSC1)N1c1nc(-c2c[nH]c3ncccc23)ncc1)(F)F TYGGIVKWEZXSEO-UHFFFAOYSA-O 0.000 description 1
- KYSLPFWJGHXTEG-UHFFFAOYSA-O Fc1cnc(C2=C[NH2+]c3ncccc23)nc1N1CCNCC1 Chemical compound Fc1cnc(C2=C[NH2+]c3ncccc23)nc1N1CCNCC1 KYSLPFWJGHXTEG-UHFFFAOYSA-O 0.000 description 1
- DKMRYSYNTIZLMX-UHFFFAOYSA-P NC(CC(C1)F)(C([NH2+]CC(F)(F)F)=O)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1 Chemical compound NC(CC(C1)F)(C([NH2+]CC(F)(F)F)=O)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1 DKMRYSYNTIZLMX-UHFFFAOYSA-P 0.000 description 1
- PGHMUTCFECJKIO-UHFFFAOYSA-P O=C(C(CSC1)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1)[NH2+]CC(F)(F)F Chemical compound O=C(C(CSC1)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1)[NH2+]CC(F)(F)F PGHMUTCFECJKIO-UHFFFAOYSA-P 0.000 description 1
- OLYGQFHFXLFKDY-GFCCVEGCSA-N O=C([C@@H](CC(C1)(F)F)N1c1nc(-c2c[nH]c3ncccc23)ncc1F)NCC(F)(F)F Chemical compound O=C([C@@H](CC(C1)(F)F)N1c1nc(-c2c[nH]c3ncccc23)ncc1F)NCC(F)(F)F OLYGQFHFXLFKDY-GFCCVEGCSA-N 0.000 description 1
- CZCYCVDAGWFZSN-TVQRCGJNSA-N O[C@@H](C[C@@H]1C(NCC(F)(F)F)=O)CN1c1nc(-c2c[nH]c3ncccc23)ncc1F Chemical compound O[C@@H](C[C@@H]1C(NCC(F)(F)F)=O)CN1c1nc(-c2c[nH]c3ncccc23)ncc1F CZCYCVDAGWFZSN-TVQRCGJNSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75936706P | 2006-01-17 | 2006-01-17 | |
| US60/759,367 | 2006-01-17 | ||
| US84247106P | 2006-09-06 | 2006-09-06 | |
| US60/842,471 | 2006-09-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551353A Division JP5591471B2 (ja) | 2006-01-17 | 2007-01-17 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167160A Division JP2014210823A (ja) | 2006-01-17 | 2014-08-20 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013010792A JP2013010792A (ja) | 2013-01-17 |
| JP2013010792A5 true JP2013010792A5 (OSRAM) | 2014-10-02 |
| JP5728454B2 JP5728454B2 (ja) | 2015-06-03 |
Family
ID=38197739
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551353A Expired - Fee Related JP5591471B2 (ja) | 2006-01-17 | 2007-01-17 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2012226368A Ceased JP2013010793A (ja) | 2006-01-17 | 2012-10-11 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2012226367A Expired - Fee Related JP5728454B2 (ja) | 2006-01-17 | 2012-10-11 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2014167160A Pending JP2014210823A (ja) | 2006-01-17 | 2014-08-20 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551353A Expired - Fee Related JP5591471B2 (ja) | 2006-01-17 | 2007-01-17 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2012226368A Ceased JP2013010793A (ja) | 2006-01-17 | 2012-10-11 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167160A Pending JP2014210823A (ja) | 2006-01-17 | 2014-08-20 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US7767816B2 (OSRAM) |
| EP (3) | EP2537849A3 (OSRAM) |
| JP (4) | JP5591471B2 (OSRAM) |
| KR (3) | KR101235103B1 (OSRAM) |
| CN (3) | CN104650077A (OSRAM) |
| AR (1) | AR060316A1 (OSRAM) |
| AU (1) | AU2007207533B8 (OSRAM) |
| BR (2) | BRPI0706537A2 (OSRAM) |
| CA (1) | CA2636189A1 (OSRAM) |
| CL (1) | CL2008002140A1 (OSRAM) |
| HK (1) | HK1210780A1 (OSRAM) |
| IL (1) | IL191902A0 (OSRAM) |
| NO (1) | NO20083501L (OSRAM) |
| NZ (3) | NZ592968A (OSRAM) |
| RU (2) | RU2453548C2 (OSRAM) |
| TW (4) | TWI424999B (OSRAM) |
| UA (1) | UA95940C2 (OSRAM) |
| WO (1) | WO2007084557A2 (OSRAM) |
| ZA (2) | ZA200805053B (OSRAM) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005027825D1 (de) | 2004-03-30 | 2011-06-16 | Vertex Pharma | Als inhibitoren von jak und anderen proteinkinasen geeignete azaindole |
| US8921376B2 (en) * | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| WO2007038215A1 (en) | 2005-09-22 | 2007-04-05 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| ATE525374T1 (de) | 2005-12-13 | 2011-10-15 | Incyte Corp | Heteroarylsubstituierte pyrroloä2,3-büpyridine und pyrroloä2,3-büpyrimidine als januskinaseinhibitoren |
| EP2537849A3 (en) | 2006-01-17 | 2013-04-03 | Vertex Pharmaceuticals, Inc. | Azaindoles useful as inhibitors of janus kinases |
| CA2648250A1 (en) * | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| US7754838B2 (en) * | 2006-08-08 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide |
| NZ577798A (en) | 2006-12-21 | 2012-04-27 | Vertex Pharma | 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| JP5492565B2 (ja) | 2006-12-22 | 2014-05-14 | インサイト・コーポレイション | Ｊａｎｕｓキナーゼ阻害剤としての置換複素環 |
| JP5642973B2 (ja) | 2007-03-22 | 2014-12-17 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｊａｋ阻害薬として有用なｎ−複素環式化合物 |
| ES2467665T5 (es) | 2007-06-13 | 2022-11-03 | Incyte Holdings Corp | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
| SG191660A1 (en) | 2008-03-11 | 2013-07-31 | Incyte Corp | Azetidine and cyclobutane derivatives as jak inhibitors |
| MX2011000839A (es) * | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa. |
| JP6172939B2 (ja) | 2009-05-22 | 2017-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｋ阻害薬としての３−［４−（７ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）−１ｈ−ピラゾール−１−イル］オクタン−またはヘプタン−ニトリル |
| WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
| SG10201405826RA (en) | 2009-06-17 | 2014-12-30 | Vertex Pharma | Inhibitors of influenza viruses replication |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| KR101805936B1 (ko) | 2009-10-09 | 2017-12-07 | 인사이트 홀딩스 코포레이션 | 3-（4-（7Ｈ-피롤로〔2,3-ｄ〕피리미딘-4-일）-1Ｈ-피라졸-1-일）-3-사이클로펜틸프로판니트릴의 하이드록실, 케토 및 글루쿠로나이드 유도체 |
| SG181857A1 (en) | 2009-12-23 | 2012-07-30 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| PE20130038A1 (es) | 2010-03-10 | 2013-01-28 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de jak1 |
| US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| US20130040933A1 (en) * | 2010-04-27 | 2013-02-14 | Brandon Cash | Azaindoles as janus kinase inhibitors |
| CA2798970A1 (en) | 2010-05-20 | 2011-11-24 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine derivatives as syk and jak inhibitors |
| KR102303885B1 (ko) | 2010-05-21 | 2021-09-24 | 인사이트 홀딩스 코포레이션 | Ｊａｋ 저해제에 대한 국소 제형 |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EA026201B1 (ru) | 2010-11-19 | 2017-03-31 | Инсайт Холдингс Корпорейшн | Циклобутилзамещенные производные пирролопиридина и пирролопиримидина как ингибиторы jak |
| KR20130128436A (ko) | 2010-12-16 | 2013-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
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| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| DE102011009961A1 (de) * | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
| CN103732226B (zh) | 2011-02-18 | 2016-01-06 | 诺瓦提斯药物公司 | mTOR/JAK抑制剂组合疗法 |
| AU2012232658B2 (en) | 2011-03-22 | 2016-06-09 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| JP2014515368A (ja) | 2011-05-26 | 2014-06-30 | 第一三共株式会社 | プロテインキナーゼ阻害剤としての複素環化合物 |
| CA2839767A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| CN106432311A (zh) | 2011-07-05 | 2017-02-22 | 沃泰克斯药物股份有限公司 | 生产氮杂吲哚类的方法和中间体 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| HK1198579A1 (en) | 2011-08-10 | 2015-04-30 | Novartis Pharma Ag | Jak p13k/mtor combination therapy |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
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-
2015
- 2015-07-29 US US14/812,158 patent/US20160008359A1/en not_active Abandoned
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