JP2018513832A5 - - Google Patents
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- Publication number
- JP2018513832A5 JP2018513832A5 JP2017541855A JP2017541855A JP2018513832A5 JP 2018513832 A5 JP2018513832 A5 JP 2018513832A5 JP 2017541855 A JP2017541855 A JP 2017541855A JP 2017541855 A JP2017541855 A JP 2017541855A JP 2018513832 A5 JP2018513832 A5 JP 2018513832A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound according
- hydrogen
- pharmaceutically acceptable
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*(C)N(C1C(*)C1)C(N=C(C1)C1*=C)=C Chemical compound C*(C)N(C1C(*)C1)C(N=C(C1)C1*=C)=C 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510157772 | 2015-04-03 | ||
| CN201510157772.0 | 2015-04-03 | ||
| PCT/CN2016/077519 WO2016155593A1 (zh) | 2015-04-03 | 2016-03-28 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513832A JP2018513832A (ja) | 2018-05-31 |
| JP2018513832A5 true JP2018513832A5 (OSRAM) | 2019-03-28 |
| JP6769000B2 JP6769000B2 (ja) | 2020-10-14 |
Family
ID=57004251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541855A Expired - Fee Related JP6769000B2 (ja) | 2015-04-03 | 2016-03-28 | ４’−チオヌクレオシドの新規な化合物、並びにその調製方法、その医薬組成物及びその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10662214B2 (OSRAM) |
| EP (1) | EP3279207B1 (OSRAM) |
| JP (1) | JP6769000B2 (OSRAM) |
| CN (2) | CN109553651B (OSRAM) |
| AU (1) | AU2016240117C1 (OSRAM) |
| CA (1) | CA2975990A1 (OSRAM) |
| EA (1) | EA034375B1 (OSRAM) |
| WO (1) | WO2016155593A1 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI637963B (zh) | 2012-03-28 | 2018-10-11 | 富士軟片股份有限公司 | １－（２－脫氧－２－氟－４－硫－β－Ｄ－阿拉伯呋喃糖基）胞嘧啶之鹽 |
| RS58568B1 (sr) | 2012-08-13 | 2019-05-31 | Fujifilm Corp | Intermedijer za sintezu 1-(2-deoksi-2-fluoro-4-tio-beta-d-arabinofuranozil) citozina, intermedijer za sintezu tionukleozida, i metode za proizvodnju ovih intermedijera |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| WO2016155593A1 (zh) * | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| KR102198656B1 (ko) | 2016-08-31 | 2021-01-05 | 후지필름 가부시키가이샤 | 항종양제, 항종양 효과 증강제 및 항종양용 키트 |
| CN109952307B (zh) * | 2016-12-22 | 2022-03-25 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代-2’-氟代核苷磷酰胺化合物的固体形式及其制备方法和用途 |
| WO2019001292A1 (zh) * | 2017-06-29 | 2019-01-03 | 四川科伦博泰生物医药股份有限公司 | 4'-硫代核苷的新型化合物的制备方法和此制备方法中的中间体 |
| US11266674B2 (en) | 2017-09-01 | 2022-03-08 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Pharmaceutical composition for tumor treatment or prevention, method, and use thereof |
| TW201932119A (zh) * | 2018-01-29 | 2019-08-16 | 日商富士軟片股份有限公司 | 膽道癌用抗腫瘤劑和膽道癌的處理方法 |
| CN112513061B (zh) * | 2018-04-19 | 2025-01-24 | 南方研究院 | 用于治疗癌症的4’-硫代-核苷酸和-核苷前药 |
| CN112770731A (zh) * | 2018-11-28 | 2021-05-07 | 四川科伦博泰生物医药股份有限公司 | 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
| JP2022542697A (ja) * | 2019-07-30 | 2022-10-06 | ピノットバイオ，インコーポレイテッド | 癌治療用ジヌクレオチド化合物及びその医薬用途 |
| CA3176543A1 (en) | 2020-04-23 | 2021-10-28 | Mark J. Suto | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128458A (en) | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
| JPH1087687A (ja) * | 1996-04-09 | 1998-04-07 | Yamasa Shoyu Co Ltd | ５−置換−１−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）ウラシル |
| ATE224909T1 (de) * | 1996-04-09 | 2002-10-15 | Yamasa Corp | 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| EP1677822B1 (en) | 2003-09-18 | 2014-04-23 | Isis Pharmaceuticals, Inc. | 4'-thionucleosides and oligomeric compounds |
| US7888330B2 (en) * | 2005-11-09 | 2011-02-15 | Wayne State University | Phosphoramidate derivatives of FAU |
| GB201016855D0 (en) * | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| US20140315850A1 (en) * | 2011-07-19 | 2014-10-23 | Nanjing Molecular Research, Inc. | 2',3'-Dideoxy-2'-alpha-Fluoro-2'-beta-C-Methylnucleosides and Prodrugs Thereof |
| WO2014124430A1 (en) * | 2013-02-11 | 2014-08-14 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| EP3004130B1 (en) * | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| TWI678373B (zh) * | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| WO2016155593A1 (zh) * | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
-
2016
- 2016-03-28 WO PCT/CN2016/077519 patent/WO2016155593A1/zh not_active Ceased
- 2016-03-28 EP EP16771348.6A patent/EP3279207B1/en active Active
- 2016-03-28 US US15/558,620 patent/US10662214B2/en active Active
- 2016-03-28 CA CA2975990A patent/CA2975990A1/en not_active Abandoned
- 2016-03-28 EA EA201791535A patent/EA034375B1/ru unknown
- 2016-03-28 CN CN201811577363.6A patent/CN109553651B/zh active Active
- 2016-03-28 JP JP2017541855A patent/JP6769000B2/ja not_active Expired - Fee Related
- 2016-03-28 CN CN201680001812.5A patent/CN106661077B/zh active Active
- 2016-03-28 AU AU2016240117A patent/AU2016240117C1/en not_active Ceased
-
2020
- 2020-04-17 US US16/851,217 patent/US20200262860A1/en not_active Abandoned
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