JP2017524733A5 - - Google Patents
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- Publication number
- JP2017524733A5 JP2017524733A5 JP2017519756A JP2017519756A JP2017524733A5 JP 2017524733 A5 JP2017524733 A5 JP 2017524733A5 JP 2017519756 A JP2017519756 A JP 2017519756A JP 2017519756 A JP2017519756 A JP 2017519756A JP 2017524733 A5 JP2017524733 A5 JP 2017524733A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- sulfur
- oxygen
- independently selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 92
- 150000001875 compounds Chemical class 0.000 claims description 88
- 229910052760 oxygen Inorganic materials 0.000 claims description 80
- 229910052717 sulfur Inorganic materials 0.000 claims description 80
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 64
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 64
- 125000005842 heteroatom Chemical group 0.000 claims description 64
- 229910052757 nitrogen Inorganic materials 0.000 claims description 64
- 239000001301 oxygen Substances 0.000 claims description 64
- 239000011593 sulfur Substances 0.000 claims description 64
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 36
- 125000001931 aliphatic group Chemical group 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 229920006395 saturated elastomer Polymers 0.000 claims description 28
- 125000000623 heterocyclic group Chemical group 0.000 claims description 27
- 125000004429 atom Chemical group 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 claims description 7
- 101000862396 Homo sapiens Follicle-stimulating hormone receptor Proteins 0.000 claims description 7
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 7
- 230000001404 mediated effect Effects 0.000 claims description 5
- 125000002837 carbocyclic group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- -1 pyridyl compound Chemical class 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 125000004011 3 membered carbocyclic group Chemical group 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 208000021267 infertility disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/080519 WO2015196335A1 (en) | 2014-06-23 | 2014-06-23 | Pyrazole compounds as modulators of fshr and uses thereof |
| CNPCT/CN2014/080519 | 2014-06-23 | ||
| PCT/CN2014/094459 WO2015196759A1 (en) | 2014-06-23 | 2014-12-22 | Pyrazole compounds as modulators of fshr and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129171A Division JP2019196375A (ja) | 2014-06-23 | 2019-07-11 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524733A JP2017524733A (ja) | 2017-08-31 |
| JP2017524733A5 true JP2017524733A5 (OSRAM) | 2018-01-18 |
| JP6557331B2 JP6557331B2 (ja) | 2019-08-07 |
Family
ID=54936412
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519756A Active JP6557331B2 (ja) | 2014-06-23 | 2014-12-22 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
| JP2019129171A Pending JP2019196375A (ja) | 2014-06-23 | 2019-07-11 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
| JP2020191715A Pending JP2021038245A (ja) | 2014-06-23 | 2020-11-18 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129171A Pending JP2019196375A (ja) | 2014-06-23 | 2019-07-11 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
| JP2020191715A Pending JP2021038245A (ja) | 2014-06-23 | 2020-11-18 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10208055B2 (OSRAM) |
| EP (1) | EP3157929B1 (OSRAM) |
| JP (3) | JP6557331B2 (OSRAM) |
| KR (1) | KR102416279B1 (OSRAM) |
| CN (1) | CN106573937B (OSRAM) |
| AU (3) | AU2014398875B2 (OSRAM) |
| CA (1) | CA2955415A1 (OSRAM) |
| DK (1) | DK3157929T3 (OSRAM) |
| ES (1) | ES2972131T3 (OSRAM) |
| MX (1) | MX389867B (OSRAM) |
| RU (1) | RU2752173C2 (OSRAM) |
| WO (2) | WO2015196335A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| CN106866692A (zh) * | 2017-03-30 | 2017-06-20 | 毛阿龙 | 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法 |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| ES2971712T3 (es) | 2017-12-22 | 2024-06-06 | Hibercell Inc | Derivados de cromenopiridina como inhibidores de la fosfatidilinositol fosfato cinasa |
| MY208400A (en) | 2018-05-03 | 2025-05-07 | Shanghai hengrui pharmaceutical co ltd | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ror) and pharmaceutical uses thereof |
| TW202112784A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物 |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| WO2022007924A1 (zh) * | 2020-07-09 | 2022-01-13 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| JP2023536442A (ja) | 2020-07-29 | 2023-08-25 | 江蘇恒瑞医薬股▲ふん▼有限公司 | オキサアザスピロ環系誘導体、その調製方法及びその医薬的応用 |
| PE20242113A1 (es) | 2021-10-14 | 2024-10-28 | Incyte Corp | Compuestos de quinolina como inhibidores de kras |
| WO2024044778A2 (en) * | 2022-08-26 | 2024-02-29 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| EP4598928A1 (en) * | 2022-10-05 | 2025-08-13 | Radionetics Oncology, Inc. | Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof |
| KR20250157379A (ko) | 2023-03-08 | 2025-11-04 | 훼링 비.브이. | 소분자 fsh 수용체 조절제 |
| WO2024263803A2 (en) * | 2023-06-21 | 2024-12-26 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| AU2001278006A1 (en) | 2000-07-27 | 2002-02-13 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| EP1427706B1 (en) * | 2001-09-19 | 2007-05-30 | Pharmacia Corporation | Substituted pyrazolo compounds for the treatment of inflammation |
| CA2515119A1 (en) * | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
| CA2607882A1 (en) * | 2005-05-12 | 2006-11-23 | Wyeth | Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| IT1394400B1 (it) * | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | Composizioni farmaceutiche |
| IT1393930B1 (it) | 2009-02-25 | 2012-05-17 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | （二氫）咪唑並異〔５，１－ａ〕喹啉類 |
| WO2011058149A1 (en) | 2009-11-13 | 2011-05-19 | Merck Serono S.A. | Tricyclic pyrazol amine derivatives |
| WO2013006308A2 (en) | 2011-07-01 | 2013-01-10 | Merck Patent Gmbh | Dihydropyrazoles |
| ES2649995T3 (es) | 2011-07-18 | 2018-01-16 | Merck Patent Gmbh | Benzamidas |
| CN104080784B (zh) | 2012-01-10 | 2017-07-18 | 默克专利有限公司 | 用作卵泡刺激素调节剂的苯甲酰胺衍生物 |
| JP6386382B2 (ja) | 2012-02-08 | 2018-09-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 卵胞刺激ホルモン受容体のアゴニストとしての重水素化されたチアゾリジノン類似体 |
| RU2663898C2 (ru) | 2013-06-24 | 2018-08-13 | Мерк Патент Гмбх | Пиразольные соединения в качестве модуляторов fshr и их применение |
| CN105658650B (zh) | 2013-06-24 | 2019-01-08 | 默克专利有限公司 | 用作卵泡刺激素受体调节剂的咪唑化合物及其用途 |
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
-
2014
- 2014-06-23 WO PCT/CN2014/080519 patent/WO2015196335A1/en not_active Ceased
- 2014-12-22 RU RU2017101829A patent/RU2752173C2/ru active
- 2014-12-22 DK DK14896199.8T patent/DK3157929T3/da active
- 2014-12-22 EP EP14896199.8A patent/EP3157929B1/en active Active
- 2014-12-22 CN CN201480081442.1A patent/CN106573937B/zh not_active Expired - Fee Related
- 2014-12-22 KR KR1020177001959A patent/KR102416279B1/ko active Active
- 2014-12-22 US US15/321,249 patent/US10208055B2/en active Active
- 2014-12-22 AU AU2014398875A patent/AU2014398875B2/en not_active Ceased
- 2014-12-22 ES ES14896199T patent/ES2972131T3/es active Active
- 2014-12-22 JP JP2017519756A patent/JP6557331B2/ja active Active
- 2014-12-22 MX MX2017000182A patent/MX389867B/es unknown
- 2014-12-22 WO PCT/CN2014/094459 patent/WO2015196759A1/en not_active Ceased
- 2014-12-22 CA CA2955415A patent/CA2955415A1/en active Pending
-
2018
- 2018-12-21 US US16/229,119 patent/US10941152B2/en not_active Expired - Fee Related
-
2019
- 2019-07-11 JP JP2019129171A patent/JP2019196375A/ja active Pending
-
2020
- 2020-02-20 AU AU2020201240A patent/AU2020201240A1/en not_active Abandoned
- 2020-11-18 JP JP2020191715A patent/JP2021038245A/ja active Pending
-
2021
- 2021-01-05 US US17/141,621 patent/US20220402929A1/en not_active Abandoned
- 2021-07-09 AU AU2021204814A patent/AU2021204814B2/en not_active Ceased
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