JP2017538689A5 - - Google Patents
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- Publication number
- JP2017538689A5 JP2017538689A5 JP2017527664A JP2017527664A JP2017538689A5 JP 2017538689 A5 JP2017538689 A5 JP 2017538689A5 JP 2017527664 A JP2017527664 A JP 2017527664A JP 2017527664 A JP2017527664 A JP 2017527664A JP 2017538689 A5 JP2017538689 A5 JP 2017538689A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- sulfur
- oxygen
- partially unsaturated
- heteroatoms independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052717 sulfur Inorganic materials 0.000 claims 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 16
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 13
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 13
- 125000005842 heteroatom Chemical group 0.000 claims 13
- 239000001301 oxygen Chemical group 0.000 claims 13
- 239000011593 sulfur Chemical group 0.000 claims 13
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 12
- 229920006395 saturated elastomer Polymers 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 102000000562 Monocarboxylic Acid Transporters Human genes 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 101710204259 Monocarboxylic acid transporter Proteins 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
- 0 B*(C)CC(C)N(CC)*C*1cc*c2c1N(*)C(*)=C(C(**)=*)C2=* Chemical compound B*(C)CC(C)N(CC)*C*1cc*c2c1N(*)C(*)=C(C(**)=*)C2=* 0.000 description 7
- ARHOUOIHKWELMD-UHFFFAOYSA-N C=Cc1cc(C(F)(F)F)ccc1 Chemical compound C=Cc1cc(C(F)(F)F)ccc1 ARHOUOIHKWELMD-UHFFFAOYSA-N 0.000 description 1
- IRTAKXXVODBLQO-UHFFFAOYSA-N Cc([nH]nc1C(F)(F)F)c1I Chemical compound Cc([nH]nc1C(F)(F)F)c1I IRTAKXXVODBLQO-UHFFFAOYSA-N 0.000 description 1
- MZZXIXHKDJNBJQ-UHFFFAOYSA-N Cc([nH]nc1C)c1I Chemical compound Cc([nH]nc1C)c1I MZZXIXHKDJNBJQ-UHFFFAOYSA-N 0.000 description 1
- UNUPJXYGLDBNFA-UHFFFAOYSA-N Cc1cc(C)n[n]1I Chemical compound Cc1cc(C)n[n]1I UNUPJXYGLDBNFA-UHFFFAOYSA-N 0.000 description 1
- DVFVNJHIVAPTMS-UHFFFAOYSA-N Cc1ccccc1C(F)(F)F Chemical compound Cc1ccccc1C(F)(F)F DVFVNJHIVAPTMS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080703P | 2014-11-17 | 2014-11-17 | |
| US62/080,703 | 2014-11-17 | ||
| PCT/US2015/061101 WO2016081464A1 (en) | 2014-11-17 | 2015-11-17 | Monocarboxylate transport modulators and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538689A JP2017538689A (ja) | 2017-12-28 |
| JP2017538689A5 true JP2017538689A5 (OSRAM) | 2018-12-27 |
Family
ID=56014456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527664A Pending JP2017538689A (ja) | 2014-11-17 | 2015-11-17 | モノカルボン酸輸送修飾薬およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10766863B2 (OSRAM) |
| EP (1) | EP3221295B1 (OSRAM) |
| JP (1) | JP2017538689A (OSRAM) |
| CN (1) | CN107406390B (OSRAM) |
| WO (1) | WO2016081464A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018011017A1 (de) | 2016-07-11 | 2018-01-18 | Bayer Pharma Aktiengesellschaft | 7-substituierte 1-pyridyl-naphthyridin-3-carbonsäureamide und ihre verwendung |
| JOP20190045A1 (ar) | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
| EP3296298A1 (de) | 2016-09-14 | 2018-03-21 | Bayer Pharma Aktiengesellschaft | 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung |
| CN106892869A (zh) * | 2017-03-21 | 2017-06-27 | 厦门法茉维特动物药业有限公司 | 一种制备盐酸二氟沙星的方法 |
| CN108484577B (zh) * | 2018-03-05 | 2021-03-30 | 复旦大学 | 一种嘧啶-喹诺酮类杂合物及其制备方法和用途 |
| WO2020033019A2 (en) * | 2018-04-25 | 2020-02-13 | Charles R. Drew University Of Medicine And Science | Novel mct4 inhibitors and uses thereof |
| TW202039425A (zh) | 2018-12-21 | 2020-11-01 | 德商馬克專利公司 | 雙取代炔類衍生物、包含其之藥物組成及組、及用於製備其之製程 |
| WO2021061929A1 (en) * | 2019-09-25 | 2021-04-01 | Nirogy Therapeutics, Inc. | Bicyclic carboxylates as modulators of transporters and uses thereof |
| CN111533729B (zh) * | 2020-05-07 | 2022-07-26 | 盐城工学院 | 一种四氮唑取代的喹啉酮衍生物及其制备方法与应用 |
| EP4340843A1 (en) | 2021-05-21 | 2024-03-27 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | 1,2,4-triazolo[1,5-a]pyrimidine-based slc16a3 inhibitors and their therapeutic use |
| WO2022243574A1 (en) | 2021-05-21 | 2022-11-24 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 3-(phthalazin-1-yl)benzenesulfonamide-based slc16a3 inhibitors and their therapeutic use |
| CN113845476B (zh) * | 2021-11-08 | 2024-04-30 | 中国药科大学 | 一种喹诺酮衍生物及其制备方法和用途 |
| JP2023088096A (ja) * | 2021-12-14 | 2023-06-26 | 株式会社 バイオミメティクスシンパシーズ | 線維化関連遺伝子の発現を抑制するための組成物 |
| CN114324870A (zh) * | 2021-12-22 | 2022-04-12 | 中国人民解放军空军军医大学 | 靶向髓系细胞乳酸转运信号的肺癌生物标志物和检测试剂盒 |
| CN118206539A (zh) * | 2024-03-18 | 2024-06-18 | 西南大学 | 喹诺酮氨基噻二唑类化合物及其制备方法和医药应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1070333A (en) * | 1964-04-24 | 1967-06-01 | Lilly Industries Ltd | New quinolone derivatives and compositions comprising them |
| US3472859A (en) * | 1966-11-01 | 1969-10-14 | Sterling Drug Inc | 1-alkyl-1,4-dihydro-4-oxo-3 quinoline-carboxylic acids and esters |
| GB8429142D0 (en) * | 1984-11-19 | 1984-12-27 | Fujisawa Pharmaceutical Co | Quinolone compounds |
| SE9904108D0 (sv) | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
| AR042095A1 (es) | 2002-11-20 | 2005-06-08 | Japan Tobacco Inc | Compuesto 4-oxoquinolina y aplicacion del mismo como inhibidor de integrasa de vih |
| CN100375742C (zh) * | 2002-11-20 | 2008-03-19 | 日本烟草产业株式会社 | 4-氧代喹啉化合物及其用途 |
| MXPA06000675A (es) * | 2003-07-24 | 2006-04-19 | Astellas Pharma Inc | Derivado de quinolona o sal del mismo. |
| DE102004004973A1 (de) * | 2004-01-31 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | 7-Phenylamino-4-chinolon-3-carbonsäure-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7402674B2 (en) * | 2004-01-31 | 2008-07-22 | Sanofi-Aventis Deutschland Gmbh, | 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments |
| JP2010037198A (ja) * | 2006-11-22 | 2010-02-18 | Astellas Pharma Inc | キノロン誘導体又はその製薬学的に許容される塩 |
| EP3330255B1 (en) * | 2009-03-20 | 2020-12-09 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| WO2010114919A2 (en) * | 2009-04-02 | 2010-10-07 | Stc.Unm | Metnase and intnase inhibitors and their use in treating cancer |
-
2015
- 2015-11-17 US US15/527,137 patent/US10766863B2/en not_active Expired - Fee Related
- 2015-11-17 WO PCT/US2015/061101 patent/WO2016081464A1/en not_active Ceased
- 2015-11-17 JP JP2017527664A patent/JP2017538689A/ja active Pending
- 2015-11-17 EP EP15861509.6A patent/EP3221295B1/en active Active
- 2015-11-17 CN CN201580073081.0A patent/CN107406390B/zh not_active Expired - Fee Related
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