JP2012531904A5 - - Google Patents

Download PDF

Info

Publication number
JP2012531904A5
JP2012531904A5 JP2012518126A JP2012518126A JP2012531904A5 JP 2012531904 A5 JP2012531904 A5 JP 2012531904A5 JP 2012518126 A JP2012518126 A JP 2012518126A JP 2012518126 A JP2012518126 A JP 2012518126A JP 2012531904 A5 JP2012531904 A5 JP 2012531904A5
Authority
JP
Japan
Prior art keywords
amino acid
tcr
seq
sequence
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012518126A
Other languages
English (en)
Japanese (ja)
Other versions
JP5872464B2 (ja
JP2012531904A (ja
Filing date
Publication date
Priority claimed from GBGB0911566.8A external-priority patent/GB0911566D0/en
Application filed filed Critical
Publication of JP2012531904A publication Critical patent/JP2012531904A/ja
Publication of JP2012531904A5 publication Critical patent/JP2012531904A5/ja
Application granted granted Critical
Publication of JP5872464B2 publication Critical patent/JP5872464B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012518126A 2009-07-03 2010-07-01 T細胞レセプター Active JP5872464B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0911566.8 2009-07-03
GBGB0911566.8A GB0911566D0 (en) 2009-07-03 2009-07-03 T cell receptors
PCT/GB2010/001277 WO2011001152A1 (en) 2009-07-03 2010-07-01 T cell receptors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015196799A Division JP6186412B2 (ja) 2009-07-03 2015-10-02 T細胞レセプター

Publications (3)

Publication Number Publication Date
JP2012531904A JP2012531904A (ja) 2012-12-13
JP2012531904A5 true JP2012531904A5 (enExample) 2013-06-27
JP5872464B2 JP5872464B2 (ja) 2016-03-01

Family

ID=41008692

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012518126A Active JP5872464B2 (ja) 2009-07-03 2010-07-01 T細胞レセプター
JP2015196799A Active JP6186412B2 (ja) 2009-07-03 2015-10-02 T細胞レセプター

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015196799A Active JP6186412B2 (ja) 2009-07-03 2015-10-02 T細胞レセプター

Country Status (19)

Country Link
US (2) US8519100B2 (enExample)
EP (1) EP2448963B1 (enExample)
JP (2) JP5872464B2 (enExample)
CN (3) CN102574906A (enExample)
AU (1) AU2010267758C1 (enExample)
BR (1) BR112012000107A2 (enExample)
CA (1) CA2766505C (enExample)
DK (1) DK2448963T3 (enExample)
EA (1) EA026918B1 (enExample)
ES (1) ES2498190T3 (enExample)
FI (1) FIC20220037I1 (enExample)
FR (1) FR22C1046I2 (enExample)
GB (1) GB0911566D0 (enExample)
LU (1) LUC00278I2 (enExample)
MX (1) MX2012000155A (enExample)
NL (1) NL301193I2 (enExample)
PT (1) PT2448963E (enExample)
WO (1) WO2011001152A1 (enExample)
ZA (1) ZA201109522B (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
GB0908613D0 (en) 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
JP2014530009A (ja) * 2011-09-29 2014-11-17 エーピーオー‐ティー ビー.ヴイ. 異常細胞を標的とする多重特異性結合分子
EP2802356A1 (en) 2012-01-13 2014-11-19 Apo-T B.V. Aberrant cell-restricted immunoglobulins provided with a toxic moiety
US9790278B2 (en) 2012-05-07 2017-10-17 The Trustees Of Dartmouth College Anti-B7-H6 antibody, fusion proteins, and methods of using the same
EP2897631A4 (en) 2012-08-31 2016-10-05 Univ Virginia Patent Found TARGET PEPTIDES FOR IMMUNOTHERAPY AND DIAGNOSTICS
AU2013312529A1 (en) 2012-09-05 2015-04-16 The University Of Birmingham Target peptides for colorectal cancer therapy and diagnostics
GB2508414A (en) * 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
WO2014118236A2 (en) 2013-01-29 2014-08-07 Max-Delbrück-Centrum Für Moledulare Medizin (Mdc) Berlin-Buch High avidity antigen recognizing constructs
WO2014206304A1 (zh) * 2013-06-26 2014-12-31 广州市香雪制药股份有限公司 高稳定性的t细胞受体及其制法和应用
WO2015077615A1 (en) * 2013-11-22 2015-05-28 The Board Of Trustees Of The University Of Illinois Engineered high-affinity human t cell receptors
DE202014002754U1 (de) 2014-03-31 2015-07-03 Christian Piotrowski Ausgusssystem mit Pullring der mit der Folie verbunden ist.
CA2945816A1 (en) 2014-04-15 2015-10-22 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
CN106459176B (zh) * 2014-06-18 2018-07-06 广东香雪精准医疗技术有限公司 高亲和力hcv t细胞受体
CA2955984A1 (en) 2014-07-22 2016-01-28 The University Of Notre Dame Du Lac Molecular constructs and uses thereof
EP3177314B1 (en) * 2014-08-04 2020-10-07 Fred Hutchinson Cancer Research Center T cell immunotherapy specific for wt-1
AU2014407539B2 (en) * 2014-10-02 2020-10-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation
GB201417803D0 (en) * 2014-10-08 2014-11-19 Adaptimmune Ltd T cell receptors
JP7372728B2 (ja) * 2014-10-31 2023-11-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 改変t細胞に関する方法および組成物
EP3215164A1 (en) 2014-11-03 2017-09-13 Immures S.r.l. T cell receptors
GB201506642D0 (en) * 2015-04-20 2015-06-03 Ucl Business Plc T cell receptor
CN108026171A (zh) * 2015-06-01 2018-05-11 基因医疗免疫疗法有限责任公司 T细胞受体特异性抗体
HK1253694A1 (zh) * 2015-06-01 2019-06-28 Medigene Immunotherapies Gmbh T细胞受体文库
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
GB201515321D0 (en) * 2015-08-28 2015-10-14 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
ES2968802T3 (es) 2016-03-16 2024-05-14 Immatics Biotechnologies Gmbh Células T transfectadas y receptores de células T para su uso en inmunoterapia contra el cáncer
LT3430037T (lt) 2016-03-16 2022-12-12 Immatics Biotechnologies Gmbh Transfekuotos t ląstelės ir t ląstelių receptoriai, skirti naudoti vėžio gydymui taikant imunoterapiją
GB201604953D0 (en) 2016-03-23 2016-05-04 Immunocore Ltd T cell receptors
RU2736512C2 (ru) 2016-03-28 2020-11-17 Дау Глоубл Текнолоджиз Ллк Двухкомпонентные адгезивные композиции, не содержащие растворителя, и способы их получения
SI3464380T1 (sl) 2016-06-02 2025-03-31 Immunocore Limited Režim doziranja za gp100-specifični tcr - anti-cd3 scfv fuzijski protein
NZ750479A (en) 2016-08-17 2021-12-24 Immatics Biotechnologies Gmbh T cell receptors and immune therapy using the same
DE102016115246C5 (de) 2016-08-17 2018-12-20 Immatics Biotechnologies Gmbh Neue t-zellrezeptoren und deren verwendung in immuntherapie
JP2020501508A (ja) * 2016-09-15 2020-01-23 クアドルセプト バイオ リミテッド 多量体、四量体および八量体
GB201617714D0 (en) 2016-10-19 2016-11-30 Ucl Business Plc T Cell receptor
JP7037577B2 (ja) 2017-03-15 2022-03-16 フレッド ハッチンソン キャンサー リサーチ センター 高親和性mage-a1特異的tcr及びその使用
DE102017106305A1 (de) 2017-03-23 2018-09-27 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapien gegen prame-positive Krebsarten
GB201709866D0 (en) * 2017-06-20 2017-08-02 Immunocore Ltd T cell receptors
MX2020003144A (es) * 2017-09-22 2020-07-28 Wuxi Biologics Ireland Ltd Nuevos complejos de polipeptidos biespecificos cd3/cd19.
KR102839644B1 (ko) 2017-09-22 2025-07-31 우시 바이올로직스 아일랜드 리미티드 신규한 이중특이적 폴리펩티드 복합체
US20200308279A1 (en) 2017-10-06 2020-10-01 Oslo Universitetssykehus Hf Chimeric antigen receptors
CN109776671B (zh) * 2017-11-14 2022-05-27 杭州康万达医药科技有限公司 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用
US20210371849A1 (en) * 2018-07-31 2021-12-02 Janux Therapeutics, Inc. Inhibitory t cell receptor peptides and discovery methods
JP7558151B2 (ja) * 2018-09-05 2024-09-30 アダプティミューン・リミテッド T細胞改変
DK3911298T3 (da) 2019-01-17 2024-01-29 Immunocore Ltd Formuleringer
GB201901305D0 (en) 2019-01-30 2019-03-20 Immunocore Ltd Specific binding molecules
GB201901306D0 (en) 2019-01-30 2019-03-20 Immunocore Ltd Multi-domain binding molecules
GB201902277D0 (en) 2019-02-19 2019-04-03 King S College London Therapeutic agents
WO2020247871A2 (en) * 2019-06-06 2020-12-10 Janux Therapeutics, Inc. Compositions and methods relating to tumor activated t cell engagers
TW202118781A (zh) * 2019-07-30 2021-05-16 大學健康網絡 Ii類mhc分子及其使用方法
CN111234004B (zh) * 2020-02-28 2023-03-28 陕西九州新药评价研究有限公司(西安新药评价研究中心) 识别wt1抗原短肽的t细胞受体及其应用
GB202006629D0 (en) * 2020-05-05 2020-06-17 Immunocore Ltd Specific binding molecules
WO2021236548A1 (en) * 2020-05-18 2021-11-25 Board Of Regents, The University Of Texas System Engineered t cell receptors and methods of use
CN112239495B (zh) * 2020-10-29 2022-04-12 上海药明生物技术有限公司 稳定的tcr结构及应用
CN114853879A (zh) * 2021-02-03 2022-08-05 香雪生命科学技术(广东)有限公司 一种识别hpv的t细胞受体
WO2022258606A1 (en) 2021-06-07 2022-12-15 Gadeta B.V. Delta T-cell or Gamma T-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
US12103971B2 (en) 2022-02-20 2024-10-01 Immunocore Limited HIV specific binding molecules
WO2023227594A1 (en) 2022-05-24 2023-11-30 Gadeta Bv Novel deltat-cell receptor chains, gammat-cell receptor chains, or parts thereof
WO2023237541A1 (en) 2022-06-07 2023-12-14 Gadeta B.V. Delta t-cell or gamma t-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
WO2023246911A1 (zh) * 2022-06-24 2023-12-28 北京可瑞生物科技有限公司 基于t细胞受体的双特异性多肽分子及其用途
US20240075068A1 (en) 2022-07-15 2024-03-07 Gadeta B.V. Novel soluble gamma T-cell (or soluble delta T-cell) receptor chains (or soluble gammadelta T-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
CA3264727A1 (en) 2022-08-18 2024-02-22 Immunocore Limited MULTI-DOMAIN BONDING MOLECULES
AU2023326819A1 (en) 2022-08-18 2025-03-06 Immunocore Limited Multi-domain binding molecules
AU2023326804A1 (en) 2022-08-18 2025-03-06 Immunocore Limited Multi-domain binding molecules
WO2024067821A1 (zh) * 2022-09-30 2024-04-04 瑅安生物医药(杭州)有限公司 一种修饰细胞及其用途
EP4634216A1 (en) 2022-12-16 2025-10-22 Repertoire Immune Medicines, Inc. T cell receptors binding hpv-16 epitopes
WO2024260454A1 (zh) * 2023-06-21 2024-12-26 北京可瑞生物科技有限公司 经修饰的tcr恒定区及其在tcr融合蛋白中的用途
GB202315181D0 (en) 2023-10-03 2023-11-15 Immunocore Ltd Peptide-HLA binding molecules
TW202530269A (zh) * 2023-10-27 2025-08-01 大陸商北京可瑞生物科技有限公司 基於t細胞受體的多特異性多肽分子及其組合物和用途
WO2025094054A1 (en) 2023-11-01 2025-05-08 Immunocore Limited Method for purifying small multi-domain proteins
GB202320012D0 (en) 2023-12-22 2024-02-07 Immunocore Ltd Bispecific molecules
CN118108833B (zh) * 2024-03-12 2025-05-02 缇纱(合肥)生物技术有限公司 引入外源二硫键的tcr恒定区及其产品和应用
WO2025224692A1 (en) 2024-04-25 2025-10-30 Immunocore Limited Method of treating cancer using a gene expression signature
GB2641580A (en) 2024-06-07 2025-12-10 T Therapeutics Ltd Tumour-transforming multispecific proteins

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688747A (en) 1994-08-22 1997-11-18 Becton Dickinson And Company Water based lubricant solution
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
NZ507886A (en) * 1998-05-19 2003-05-30 Avidex Ltd Multivalent T cell receptor complexes
CA2457652C (en) * 2001-08-31 2012-08-07 Avidex Limited Soluble t cell receptor
WO2004044004A2 (en) 2002-11-09 2004-05-27 Avidex Limited T cell receptor display
GB0227351D0 (en) * 2002-11-22 2002-12-31 Isis Innovation Soluble T-cell receptors
US7534427B2 (en) * 2002-12-31 2009-05-19 Immunomedics, Inc. Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
CN101035561A (zh) * 2004-03-24 2007-09-12 特罗斯药品公司 作为改善对疫苗的免疫反应的佐剂的组合物和使用方法
GB0411125D0 (en) * 2004-05-19 2004-06-23 Avidex Ltd Method of improving T-cell receptors
JP4972549B2 (ja) 2004-05-19 2012-07-11 イムノコア リミテッド T細胞レセプターを改善する方法
ATE475669T1 (de) 2004-06-29 2010-08-15 Immunocore Ltd Einen modifizierten t-zellen-rezeptor exprimierende zellen
US20060045884A1 (en) * 2004-08-26 2006-03-02 Board Of Regents Vaccines for autoimmune and infectious disease
CA2580412A1 (en) * 2004-09-13 2006-03-23 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Compositions comprising t cell receptors and methods of use thereof
WO2006054096A2 (en) * 2004-11-18 2006-05-26 Avidex Ltd Soluble bifunctional proteins
ES2829566T3 (es) * 2005-03-03 2021-06-01 Immunomedics Inc Anticuerpos L243 humanizados
GB0511124D0 (en) 2005-06-01 2005-07-06 Avidex Ltd High affinity melan-a t cell receptors
EP1795599A1 (en) * 2005-12-09 2007-06-13 Schuler, Gerold, Prof. Dr. Methods for generating antigen-specific effector T cells
PT2016102E (pt) 2006-05-03 2012-05-15 Us Gov Health & Human Serv Recetores de célula t quimérica e materiais relacionados e métodos de uso
WO2008038002A2 (en) 2006-09-29 2008-04-03 Medigene Limited T cell therapies
US8216565B2 (en) 2007-01-12 2012-07-10 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services GP100-specific T cell receptors and related materials and methods of use
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors

Similar Documents

Publication Publication Date Title
JP2012531904A5 (enExample)
Garboczi et al. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2
Talkington et al. Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)
AU2003271904B2 (en) Single chain recombinant T cell receptors
RU2017135599A (ru) Белки, специфичные в отношении cd137
JP2006502741A5 (enExample)
JP2008509090A5 (enExample)
NZ600278A (en) Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto
JP2011501951A5 (enExample)
EA201270135A1 (ru) T-клеточные рецепторы
JP2018519803A5 (enExample)
CA2457652A1 (en) Soluble t cell receptor
JP2013519721A5 (enExample)
JP2018532725A5 (enExample)
IL275497B (en) Serum proteins with type iii fibronectin binding domains
MX2010012695A (es) Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico.
JP2018515084A5 (enExample)
NZ704192A (en) Cell-penetrating peptides and uses therof
JP2008535826A5 (enExample)
MX2007003910A (es) Receptores de celulas t que contienen un enlace entre cadenas bisulfuro no nativo ligado a agentes terapeuticos.
RU2015129640A (ru) Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1
JP2014502149A5 (enExample)
HRP20210076T1 (hr) Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma ezofagusa i drugih karcinoma
JP2013529080A5 (enExample)
RU2015137158A (ru) МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2,hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ