JP2008535826A5 - - Google Patents
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- Publication number
- JP2008535826A5 JP2008535826A5 JP2008503585A JP2008503585A JP2008535826A5 JP 2008535826 A5 JP2008535826 A5 JP 2008535826A5 JP 2008503585 A JP2008503585 A JP 2008503585A JP 2008503585 A JP2008503585 A JP 2008503585A JP 2008535826 A5 JP2008535826 A5 JP 2008535826A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- chain variable
- seq
- sequence
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091008874 T cell receptors Proteins 0.000 claims 28
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 28
- 235000001014 amino acid Nutrition 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims 1
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims 1
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims 1
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0506760A GB0506760D0 (en) | 2005-04-01 | 2005-04-01 | High affinity HIV TCRS |
| GB0516487A GB0516487D0 (en) | 2005-08-10 | 2005-08-10 | High affinity HIV T cell receptors |
| PCT/GB2006/001147 WO2006103429A2 (en) | 2005-04-01 | 2006-03-29 | High affinity hiv t cell receptors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012049174A Division JP5612623B2 (ja) | 2005-04-01 | 2012-03-06 | 高親和性ｈｉｖｔ細胞レセプター |
| JP2014094723A Division JP5885220B2 (ja) | 2005-04-01 | 2014-05-01 | 高親和性ｈｉｖｔ細胞レセプター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535826A JP2008535826A (ja) | 2008-09-04 |
| JP2008535826A5 true JP2008535826A5 (enExample) | 2009-05-14 |
Family
ID=37053744
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503585A Pending JP2008535826A (ja) | 2005-04-01 | 2006-03-29 | 高親和性ｈｉｖｔ細胞レセプター |
| JP2012049174A Expired - Fee Related JP5612623B2 (ja) | 2005-04-01 | 2012-03-06 | 高親和性ｈｉｖｔ細胞レセプター |
| JP2014094723A Expired - Fee Related JP5885220B2 (ja) | 2005-04-01 | 2014-05-01 | 高親和性ｈｉｖｔ細胞レセプター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012049174A Expired - Fee Related JP5612623B2 (ja) | 2005-04-01 | 2012-03-06 | 高親和性ｈｉｖｔ細胞レセプター |
| JP2014094723A Expired - Fee Related JP5885220B2 (ja) | 2005-04-01 | 2014-05-01 | 高親和性ｈｉｖｔ細胞レセプター |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8378074B2 (enExample) |
| EP (4) | EP2301964A1 (enExample) |
| JP (3) | JP2008535826A (enExample) |
| CN (2) | CN105461802A (enExample) |
| AU (1) | AU2006228308B2 (enExample) |
| CA (1) | CA2602463C (enExample) |
| CY (1) | CY1118160T1 (enExample) |
| DK (1) | DK2275441T3 (enExample) |
| ES (2) | ES2699320T3 (enExample) |
| HU (1) | HUE032037T2 (enExample) |
| LT (1) | LT2275441T (enExample) |
| NZ (2) | NZ561338A (enExample) |
| PL (1) | PL2275441T3 (enExample) |
| PT (1) | PT2275441T (enExample) |
| SI (1) | SI2275441T1 (enExample) |
| WO (1) | WO2006103429A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| AU2003216341A1 (en) | 2002-02-20 | 2003-09-09 | Dyax Corporation | Mhc-peptide complex binding ligands |
| WO2006036445A2 (en) | 2004-09-24 | 2006-04-06 | Trustees Of Dartmouth College | Chimeric nk receptor and methods for treating cancer |
| WO2008042814A2 (en) * | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| JP5292550B2 (ja) * | 2007-03-23 | 2013-09-18 | 静岡県 | Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
| WO2009125394A1 (en) * | 2008-04-09 | 2009-10-15 | Technion Research & Development Foundation Ltd. | Anti human immunodeficiency antibodies and uses thereof |
| GB0816096D0 (en) * | 2008-09-04 | 2008-10-15 | Medigene Ltd | Diabetes t cell receptors |
| ES2625985T3 (es) | 2009-03-25 | 2017-07-21 | Altor Bioscience Corporation | Receptores de linfocitos T específicos de la vpr del VIH |
| WO2011044186A1 (en) * | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| US12492376B2 (en) | 2009-10-29 | 2025-12-09 | The Trustees Of Dartmouth College | T-cell receptor-deficient T cell compositions |
| GB201016672D0 (en) | 2010-10-04 | 2010-11-17 | Electronic Shipping Solutions Ltd | Secure exchange/authentication of electronic documents |
| EP2502934B1 (en) | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| CN104395344B (zh) | 2012-05-07 | 2019-08-13 | 达特茅斯大学理事会 | 抗b7-h6抗体、融合蛋白及其使用方法 |
| NZ741124A (en) * | 2012-07-27 | 2019-11-29 | Univ Illinois | Engineering t-cell receptors |
| PT3149031T (pt) * | 2014-05-29 | 2020-03-25 | Us Health | Receptores de células t anti-e7 do papilomavírus humano 16 |
| WO2016014725A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| GB201516272D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| EP3211003A1 (en) * | 2016-02-24 | 2017-08-30 | Institut Pasteur | T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof |
| GB201604953D0 (en) * | 2016-03-23 | 2016-05-04 | Immunocore Ltd | T cell receptors |
| IL308831A (en) | 2016-04-08 | 2024-01-01 | Immunocore Ltd | T cell receptors |
| DE102017115966A1 (de) * | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| US20190016802A1 (en) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Dual specificity polypeptide molecule |
| WO2019217837A1 (en) * | 2018-05-11 | 2019-11-14 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting pik3ca mutations and uses thereof |
| US12606816B2 (en) * | 2018-07-31 | 2026-04-21 | Janux Therapeutics, Inc. | Inhibitory T cell receptor peptides and discovery methods |
| US12234473B2 (en) | 2020-12-31 | 2025-02-25 | Immatics US, Inc. | CD8 polypeptides, compositions, and methods of using thereof |
| JP2025508738A (ja) * | 2022-02-20 | 2025-04-10 | イムノコア リミテッド | Ｈｉｖ特異的結合分子及びｔｃｒ |
| US12103971B2 (en) | 2022-02-20 | 2024-10-01 | Immunocore Limited | HIV specific binding molecules |
| WO2024038165A1 (en) | 2022-08-18 | 2024-02-22 | Immunocore Ltd | T cell receptor fusion proteins specific for mage a4 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| NZ507886A (en) * | 1998-05-19 | 2003-05-30 | Avidex Ltd | Multivalent T cell receptor complexes |
| PT1421115E (pt) * | 2001-08-31 | 2005-07-29 | Avidex Ltd | Receptor de celulas t soluvel |
| US7751825B2 (en) | 2002-06-27 | 2010-07-06 | Qualcomm Incorporated | Controlling geographic location information of devices operating in wireless communication systems |
| AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
| EP2048159B1 (en) | 2002-11-09 | 2014-01-01 | Immunocore Ltd. | T cell receptor display |
| NZ550815A (en) * | 2004-05-19 | 2009-04-30 | Immunocore Ltd | Method of improving T cell receptors |
-
2006
- 2006-03-29 CN CN201510785932.6A patent/CN105461802A/zh active Pending
- 2006-03-29 ES ES15171918T patent/ES2699320T3/es not_active Expired - Lifetime
- 2006-03-29 EP EP10014971A patent/EP2301964A1/en not_active Withdrawn
- 2006-03-29 WO PCT/GB2006/001147 patent/WO2006103429A2/en not_active Ceased
- 2006-03-29 CN CN201210563915.4A patent/CN103059128B/zh not_active Expired - Fee Related
- 2006-03-29 EP EP15171918.4A patent/EP2985291B1/en not_active Expired - Lifetime
- 2006-03-29 CA CA2602463A patent/CA2602463C/en not_active Expired - Fee Related
- 2006-03-29 NZ NZ561338A patent/NZ561338A/en not_active IP Right Cessation
- 2006-03-29 NZ NZ584523A patent/NZ584523A/en not_active IP Right Cessation
- 2006-03-29 PL PL10008612T patent/PL2275441T3/pl unknown
- 2006-03-29 EP EP06726555A patent/EP1863842A2/en not_active Withdrawn
- 2006-03-29 ES ES10008612.3T patent/ES2599010T3/es not_active Expired - Lifetime
- 2006-03-29 US US11/887,536 patent/US8378074B2/en not_active Expired - Fee Related
- 2006-03-29 DK DK10008612.3T patent/DK2275441T3/en active
- 2006-03-29 JP JP2008503585A patent/JP2008535826A/ja active Pending
- 2006-03-29 HU HUE10008612A patent/HUE032037T2/en unknown
- 2006-03-29 EP EP10008612.3A patent/EP2275441B8/en not_active Expired - Lifetime
- 2006-03-29 SI SI200632107A patent/SI2275441T1/sl unknown
- 2006-03-29 AU AU2006228308A patent/AU2006228308B2/en not_active Ceased
- 2006-03-29 LT LTEP10008612.3T patent/LT2275441T/lt unknown
- 2006-03-29 PT PT100086123T patent/PT2275441T/pt unknown
-
2012
- 2012-03-06 JP JP2012049174A patent/JP5612623B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-03 US US13/733,545 patent/US9255135B2/en not_active Expired - Fee Related
-
2014
- 2014-05-01 JP JP2014094723A patent/JP5885220B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-26 CY CY20161101092T patent/CY1118160T1/el unknown
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