ES2699320T3 - Receptores de linfocitos T para el VIH de alta afinidad - Google Patents

Receptores de linfocitos T para el VIH de alta afinidad Download PDF

Info

Publication number
ES2699320T3
ES2699320T3 ES15171918T ES15171918T ES2699320T3 ES 2699320 T3 ES2699320 T3 ES 2699320T3 ES 15171918 T ES15171918 T ES 15171918T ES 15171918 T ES15171918 T ES 15171918T ES 2699320 T3 ES2699320 T3 ES 2699320T3
Authority
ES
Spain
Prior art keywords
tcr
chain
sequence
variable region
tcrs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES15171918T
Other languages
English (en)
Spanish (es)
Inventor
Bent Karsten Jakobsen
Steven Mark Dunn
Yi Li
Peter Eamon Molloy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunocore Ltd
Adaptimmune Ltd
Original Assignee
Immunocore Ltd
Adaptimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0506760A external-priority patent/GB0506760D0/en
Priority claimed from GB0516487A external-priority patent/GB0516487D0/en
Application filed by Immunocore Ltd, Adaptimmune Ltd filed Critical Immunocore Ltd
Application granted granted Critical
Publication of ES2699320T3 publication Critical patent/ES2699320T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ES15171918T 2005-04-01 2006-03-29 Receptores de linfocitos T para el VIH de alta afinidad Expired - Lifetime ES2699320T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0506760A GB0506760D0 (en) 2005-04-01 2005-04-01 High affinity HIV TCRS
GB0516487A GB0516487D0 (en) 2005-08-10 2005-08-10 High affinity HIV T cell receptors

Publications (1)

Publication Number Publication Date
ES2699320T3 true ES2699320T3 (es) 2019-02-08

Family

ID=37053744

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15171918T Expired - Lifetime ES2699320T3 (es) 2005-04-01 2006-03-29 Receptores de linfocitos T para el VIH de alta afinidad
ES10008612.3T Expired - Lifetime ES2599010T3 (es) 2005-04-01 2006-03-29 Receptores de linfocitos T con alta afinidad por el VIH

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES10008612.3T Expired - Lifetime ES2599010T3 (es) 2005-04-01 2006-03-29 Receptores de linfocitos T con alta afinidad por el VIH

Country Status (16)

Country Link
US (2) US8378074B2 (enExample)
EP (4) EP2301964A1 (enExample)
JP (3) JP2008535826A (enExample)
CN (2) CN105461802A (enExample)
AU (1) AU2006228308B2 (enExample)
CA (1) CA2602463C (enExample)
CY (1) CY1118160T1 (enExample)
DK (1) DK2275441T3 (enExample)
ES (2) ES2699320T3 (enExample)
HU (1) HUE032037T2 (enExample)
LT (1) LT2275441T (enExample)
NZ (2) NZ561338A (enExample)
PL (1) PL2275441T3 (enExample)
PT (1) PT2275441T (enExample)
SI (1) SI2275441T1 (enExample)
WO (1) WO2006103429A2 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
AU2003216341A1 (en) 2002-02-20 2003-09-09 Dyax Corporation Mhc-peptide complex binding ligands
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
WO2008042814A2 (en) * 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
JP5292550B2 (ja) * 2007-03-23 2013-09-18 静岡県 Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子
WO2009125394A1 (en) * 2008-04-09 2009-10-15 Technion Research & Development Foundation Ltd. Anti human immunodeficiency antibodies and uses thereof
GB0816096D0 (en) * 2008-09-04 2008-10-15 Medigene Ltd Diabetes t cell receptors
ES2625985T3 (es) 2009-03-25 2017-07-21 Altor Bioscience Corporation Receptores de linfocitos T específicos de la vpr del VIH
WO2011044186A1 (en) * 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
GB201016672D0 (en) 2010-10-04 2010-11-17 Electronic Shipping Solutions Ltd Secure exchange/authentication of electronic documents
EP2502934B1 (en) 2011-03-24 2018-01-17 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
CN104395344B (zh) 2012-05-07 2019-08-13 达特茅斯大学理事会 抗b7-h6抗体、融合蛋白及其使用方法
NZ741124A (en) * 2012-07-27 2019-11-29 Univ Illinois Engineering t-cell receptors
PT3149031T (pt) * 2014-05-29 2020-03-25 Us Health Receptores de células t anti-e7 do papilomavírus humano 16
WO2016014725A1 (en) 2014-07-22 2016-01-28 The University Of Notre Dame Du Lac Molecular constructs and uses thereof
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
GB201516272D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
EP3211003A1 (en) * 2016-02-24 2017-08-30 Institut Pasteur T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof
GB201604953D0 (en) * 2016-03-23 2016-05-04 Immunocore Ltd T cell receptors
IL308831A (en) 2016-04-08 2024-01-01 Immunocore Ltd T cell receptors
DE102017115966A1 (de) * 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Polypeptidmolekül mit verbesserter zweifacher Spezifität
US20190016802A1 (en) 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Dual specificity polypeptide molecule
WO2019217837A1 (en) * 2018-05-11 2019-11-14 Memorial Sloan-Kettering Cancer Center T cell receptors targeting pik3ca mutations and uses thereof
US12606816B2 (en) * 2018-07-31 2026-04-21 Janux Therapeutics, Inc. Inhibitory T cell receptor peptides and discovery methods
US12234473B2 (en) 2020-12-31 2025-02-25 Immatics US, Inc. CD8 polypeptides, compositions, and methods of using thereof
JP2025508738A (ja) * 2022-02-20 2025-04-10 イムノコア リミテッド Ｈｉｖ特異的結合分子及びｔｃｒ
US12103971B2 (en) 2022-02-20 2024-10-01 Immunocore Limited HIV specific binding molecules
WO2024038165A1 (en) 2022-08-18 2024-02-22 Immunocore Ltd T cell receptor fusion proteins specific for mage a4

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
NZ507886A (en) * 1998-05-19 2003-05-30 Avidex Ltd Multivalent T cell receptor complexes
PT1421115E (pt) * 2001-08-31 2005-07-29 Avidex Ltd Receptor de celulas t soluvel
US7751825B2 (en) 2002-06-27 2010-07-06 Qualcomm Incorporated Controlling geographic location information of devices operating in wireless communication systems
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
EP2048159B1 (en) 2002-11-09 2014-01-01 Immunocore Ltd. T cell receptor display
NZ550815A (en) * 2004-05-19 2009-04-30 Immunocore Ltd Method of improving T cell receptors

Also Published As

Publication number Publication date
PT2275441T (pt) 2016-11-18
CN105461802A (zh) 2016-04-06
EP2275441B8 (en) 2016-10-19
US9255135B2 (en) 2016-02-09
JP5612623B2 (ja) 2014-10-22
CY1118160T1 (el) 2017-06-28
JP2014205671A (ja) 2014-10-30
HUE032037T2 (en) 2017-08-28
CN103059128B (zh) 2016-01-20
SI2275441T1 (sl) 2016-11-30
ES2599010T3 (es) 2017-01-31
JP2012144543A (ja) 2012-08-02
EP2985291B1 (en) 2018-09-19
CA2602463C (en) 2018-09-04
EP2985291A1 (en) 2016-02-17
DK2275441T3 (en) 2016-12-12
US20130295063A1 (en) 2013-11-07
PL2275441T3 (pl) 2017-07-31
WO2006103429A2 (en) 2006-10-05
AU2006228308B2 (en) 2012-05-17
NZ584523A (en) 2010-11-26
NZ561338A (en) 2010-04-30
EP2275441A1 (en) 2011-01-19
WO2006103429A3 (en) 2007-03-15
EP2275441B1 (en) 2016-08-24
JP2008535826A (ja) 2008-09-04
US20090214551A1 (en) 2009-08-27
CA2602463A1 (en) 2006-10-05
JP5885220B2 (ja) 2016-03-15
US8378074B2 (en) 2013-02-19
EP2275441A9 (en) 2011-09-14
LT2275441T (lt) 2016-12-12
EP2301964A1 (en) 2011-03-30
EP1863842A2 (en) 2007-12-12
AU2006228308A1 (en) 2006-10-05
CN103059128A (zh) 2013-04-24

Similar Documents

Publication Publication Date Title
JP5612623B2 (ja) 高親和性ｈｉｖｔ細胞レセプター
ES2914648T3 (es) Receptores de células T
CN101189261B (zh) 高亲和力Melan-A T细胞受体
ES2965715T3 (es) Receptores de células T
ES2360598T3 (es) Receptores de linfocitos t que se unen especificamente a vygfvracl-hla-a24.
CN106336457B (zh) 识别mage‑a3抗原短肽的t细胞受体
US20080274133A1 (en) Soluble Bifunctional Proteins
CN101155829B (zh) 高亲和力hiv t细胞受体
JP2008510678A (ja) 高親和性テロメラーゼｔ細胞受容体
AU2012211503B2 (en) High affinity HIV T cell receptors
AU2013202288B2 (en) High affinity HIV T cell receptors
WO2022206861A1 (zh) 识别afp的t细胞受体