AU2006228308B2 - High affinity HIV T cell receptors - Google Patents

High affinity HIV T cell receptors Download PDF

Info

Publication number
AU2006228308B2
AU2006228308B2 AU2006228308A AU2006228308A AU2006228308B2 AU 2006228308 B2 AU2006228308 B2 AU 2006228308B2 AU 2006228308 A AU2006228308 A AU 2006228308A AU 2006228308 A AU2006228308 A AU 2006228308A AU 2006228308 B2 AU2006228308 B2 AU 2006228308B2
Authority
AU
Australia
Prior art keywords
tcr
chain variable
seq
variable region
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006228308A
Other languages
English (en)
Other versions
AU2006228308A1 (en
Inventor
Steven Mark Dunn
Bent Karsten Jakobsen
Yi Li
Peter Eamon Molloy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunocore Ltd
Adaptimmune Ltd
Original Assignee
Immunocore Ltd
Adaptimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0506760A external-priority patent/GB0506760D0/en
Priority claimed from GB0516487A external-priority patent/GB0516487D0/en
Application filed by Immunocore Ltd, Adaptimmune Ltd filed Critical Immunocore Ltd
Publication of AU2006228308A1 publication Critical patent/AU2006228308A1/en
Assigned to IMMUNOCORE LIMITED reassignment IMMUNOCORE LIMITED Request for Assignment Assignors: AVIDEX LTD
Application granted granted Critical
Publication of AU2006228308B2 publication Critical patent/AU2006228308B2/en
Priority to AU2012211503A priority Critical patent/AU2012211503B2/en
Assigned to ADAPTIMMUNE LIMITED, IMMUNOCORE LIMITED reassignment ADAPTIMMUNE LIMITED Request for Assignment Assignors: IMMUNOCORE LIMITED
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU2006228308A 2005-04-01 2006-03-29 High affinity HIV T cell receptors Ceased AU2006228308B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012211503A AU2012211503B2 (en) 2005-04-01 2012-08-10 High affinity HIV T cell receptors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0506760A GB0506760D0 (en) 2005-04-01 2005-04-01 High affinity HIV TCRS
GB0506760.8 2005-04-01
GB0516487.6 2005-08-10
GB0516487A GB0516487D0 (en) 2005-08-10 2005-08-10 High affinity HIV T cell receptors
PCT/GB2006/001147 WO2006103429A2 (en) 2005-04-01 2006-03-29 High affinity hiv t cell receptors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012211503A Division AU2012211503B2 (en) 2005-04-01 2012-08-10 High affinity HIV T cell receptors

Publications (2)

Publication Number Publication Date
AU2006228308A1 AU2006228308A1 (en) 2006-10-05
AU2006228308B2 true AU2006228308B2 (en) 2012-05-17

Family

ID=37053744

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006228308A Ceased AU2006228308B2 (en) 2005-04-01 2006-03-29 High affinity HIV T cell receptors

Country Status (16)

Country Link
US (2) US8378074B2 (enExample)
EP (4) EP1863842A2 (enExample)
JP (3) JP2008535826A (enExample)
CN (2) CN105461802A (enExample)
AU (1) AU2006228308B2 (enExample)
CA (1) CA2602463C (enExample)
CY (1) CY1118160T1 (enExample)
DK (1) DK2275441T3 (enExample)
ES (2) ES2599010T3 (enExample)
HU (1) HUE032037T2 (enExample)
LT (1) LT2275441T (enExample)
NZ (2) NZ584523A (enExample)
PL (1) PL2275441T3 (enExample)
PT (1) PT2275441T (enExample)
SI (1) SI2275441T1 (enExample)
WO (1) WO2006103429A2 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
US8119772B2 (en) * 2006-09-29 2012-02-21 California Institute Of Technology MART-1 T cell receptors
JP5292550B2 (ja) * 2007-03-23 2013-09-18 静岡県 Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子
WO2009125394A1 (en) * 2008-04-09 2009-10-15 Technion Research & Development Foundation Ltd. Anti human immunodeficiency antibodies and uses thereof
GB0816096D0 (en) * 2008-09-04 2008-10-15 Medigene Ltd Diabetes t cell receptors
JP2012521761A (ja) 2009-03-25 2012-09-20 アルター・バイオサイエンス・コーポレーション Ｈｉｖｖｐｒ−特異的ｔ細胞受容体
US10464987B2 (en) * 2009-10-06 2019-11-05 Abbvie Inc. Human single-chain T cell receptors
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
GB201016672D0 (en) 2010-10-04 2010-11-17 Electronic Shipping Solutions Ltd Secure exchange/authentication of electronic documents
EP2502934B1 (en) * 2011-03-24 2018-01-17 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
WO2013169691A1 (en) 2012-05-07 2013-11-14 Trustees Of Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
WO2014018863A1 (en) 2012-07-27 2014-01-30 The Board Of Trustees Of The University Of Illinois Engineering t-cell receptors
CN106661098B (zh) * 2014-05-29 2021-05-04 美国卫生和人力服务部 抗人乳头瘤病毒16 e7的t细胞受体
WO2016014725A1 (en) 2014-07-22 2016-01-28 The University Of Notre Dame Du Lac Molecular constructs and uses thereof
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201516272D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
EP3211003A1 (en) * 2016-02-24 2017-08-30 Institut Pasteur T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof
GB201604953D0 (en) * 2016-03-23 2016-05-04 Immunocore Ltd T cell receptors
DK3440105T3 (da) 2016-04-08 2022-06-13 Immunocore Ltd T-cellereceptorer
ES2871146T3 (es) 2017-07-14 2021-10-28 Immatics Biotechnologies Gmbh Molécula de polipéptido con especificidad dual mejorada
DE102017115966A1 (de) * 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Polypeptidmolekül mit verbesserter zweifacher Spezifität
EP4656196A2 (en) * 2018-05-11 2025-12-03 Memorial Sloan-Kettering Cancer Center T cell receptors targeting pik3ca mutations and uses thereof
WO2020028595A2 (en) * 2018-07-31 2020-02-06 Janux Therapeutics, Inc. Inhibitory t cell receptor peptides and discovery methods
US12234473B2 (en) 2020-12-31 2025-02-25 Immatics US, Inc. CD8 polypeptides, compositions, and methods of using thereof
US12103971B2 (en) 2022-02-20 2024-10-01 Immunocore Limited HIV specific binding molecules
IL314832A (en) * 2022-02-20 2024-10-01 Immunocore Ltd Hiv-specific binding molecules and tcr
CN120476137A (zh) 2022-08-18 2025-08-12 英美偌科有限公司 对mage a4具有特异性的t细胞受体融合蛋白

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005114215A2 (en) * 2004-05-19 2005-12-01 Avidex Ltd Method of improving t cell receptors

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
DK1066380T3 (da) * 1998-05-19 2002-01-28 Avidex Ltd Opløselig T-cellereceptor
JP4317940B2 (ja) 2001-08-31 2009-08-19 イミュノコア・リミテッド 物質
US7751825B2 (en) 2002-06-27 2010-07-06 Qualcomm Incorporated Controlling geographic location information of devices operating in wireless communication systems
US7569664B2 (en) 2002-10-09 2009-08-04 Immunocore Limited Single chain recombinant T cell receptors
PT1558643E (pt) * 2002-11-09 2009-08-24 Immunocore Ltd Apresentação de um receptor das células t

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005114215A2 (en) * 2004-05-19 2005-12-01 Avidex Ltd Method of improving t cell receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EMBL accession number AF020642, 4 November 1998. *
EMBL accession number AF020651, 4 November 1998. *
Journal of Clinical Investigation, 1998, 101 (11), 2559-2566. *
Journal of Immunological Methods, 2003, 277, 75-86. *

Also Published As

Publication number Publication date
DK2275441T3 (en) 2016-12-12
CN103059128B (zh) 2016-01-20
JP2014205671A (ja) 2014-10-30
EP2275441B1 (en) 2016-08-24
PL2275441T3 (pl) 2017-07-31
NZ561338A (en) 2010-04-30
WO2006103429A3 (en) 2007-03-15
NZ584523A (en) 2010-11-26
EP2275441A9 (en) 2011-09-14
AU2006228308A1 (en) 2006-10-05
CN103059128A (zh) 2013-04-24
HUE032037T2 (en) 2017-08-28
JP2008535826A (ja) 2008-09-04
CA2602463C (en) 2018-09-04
EP2301964A1 (en) 2011-03-30
US20090214551A1 (en) 2009-08-27
CA2602463A1 (en) 2006-10-05
EP2275441B8 (en) 2016-10-19
ES2599010T3 (es) 2017-01-31
US20130295063A1 (en) 2013-11-07
PT2275441T (pt) 2016-11-18
EP2985291A1 (en) 2016-02-17
CN105461802A (zh) 2016-04-06
WO2006103429A2 (en) 2006-10-05
US8378074B2 (en) 2013-02-19
EP2275441A1 (en) 2011-01-19
LT2275441T (lt) 2016-12-12
EP1863842A2 (en) 2007-12-12
SI2275441T1 (sl) 2016-11-30
JP5612623B2 (ja) 2014-10-22
CY1118160T1 (el) 2017-06-28
US9255135B2 (en) 2016-02-09
JP5885220B2 (ja) 2016-03-15
JP2012144543A (ja) 2012-08-02
ES2699320T3 (es) 2019-02-08
EP2985291B1 (en) 2018-09-19

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: IMMUNOCORE LIMITED

Free format text: FORMER APPLICANT(S): AVIDEX LTD

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: IMMUNOCORE LIMITED; ADAPTIMMUNE LIMITED

Free format text: FORMER OWNER WAS: IMMUNOCORE LIMITED

MK14 Patent ceased section 143(a) (annual fees not paid) or expired