JP2012531212A5 - - Google Patents
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- JP2012531212A5 JP2012531212A5 JP2012517983A JP2012517983A JP2012531212A5 JP 2012531212 A5 JP2012531212 A5 JP 2012531212A5 JP 2012517983 A JP2012517983 A JP 2012517983A JP 2012517983 A JP2012517983 A JP 2012517983A JP 2012531212 A5 JP2012531212 A5 JP 2012531212A5
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- 235000018102 proteins Nutrition 0.000 claims 67
- 102000004169 proteins and genes Human genes 0.000 claims 67
- 108090000623 proteins and genes Proteins 0.000 claims 67
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 22
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 230000001268 conjugating effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 101150047061 tag-72 gene Proteins 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 2
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 2
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 2
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 2
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 2
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 2
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 1
- 229940116978 human epidermal growth factor Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2009903127 | 2009-07-03 | ||
| AU2009903127A AU2009903127A0 (en) | 2009-07-03 | Immuno-conjugates and methods for producing them | |
| US22335309P | 2009-07-06 | 2009-07-06 | |
| US61/223,353 | 2009-07-06 | ||
| US25670309P | 2009-10-30 | 2009-10-30 | |
| US61/256,703 | 2009-10-30 | ||
| PCT/AU2010/000847 WO2011000054A1 (en) | 2009-07-03 | 2010-07-02 | Immuno-conjugates and methods for producing them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015653A Division JP6371319B2 (ja) | 2009-07-03 | 2016-01-29 | イムノコンジュゲート及びその作製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012531212A JP2012531212A (ja) | 2012-12-10 |
| JP2012531212A5 true JP2012531212A5 (https=) | 2013-08-15 |
Family
ID=43410379
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517983A Withdrawn JP2012531212A (ja) | 2009-07-03 | 2010-07-02 | イムノコンジュゲート及びその作製方法 |
| JP2016015653A Active JP6371319B2 (ja) | 2009-07-03 | 2016-01-29 | イムノコンジュゲート及びその作製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015653A Active JP6371319B2 (ja) | 2009-07-03 | 2016-01-29 | イムノコンジュゲート及びその作製方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9290577B2 (https=) |
| EP (1) | EP2448966B1 (https=) |
| JP (2) | JP2012531212A (https=) |
| KR (1) | KR101962476B1 (https=) |
| AU (1) | AU2010268690B2 (https=) |
| CA (1) | CA2766409C (https=) |
| SG (1) | SG176947A1 (https=) |
| WO (1) | WO2011000054A1 (https=) |
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- 2010-07-02 JP JP2012517983A patent/JP2012531212A/ja not_active Withdrawn
- 2010-07-02 US US13/383,578 patent/US9290577B2/en active Active
- 2010-07-02 EP EP10793442.4A patent/EP2448966B1/en active Active
- 2010-07-02 SG SG2011094844A patent/SG176947A1/en unknown
- 2010-07-02 KR KR1020127002857A patent/KR101962476B1/ko active Active
- 2010-07-02 AU AU2010268690A patent/AU2010268690B2/en active Active
- 2010-07-02 CA CA2766409A patent/CA2766409C/en active Active
- 2010-07-02 WO PCT/AU2010/000847 patent/WO2011000054A1/en not_active Ceased
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2016
- 2016-01-29 JP JP2016015653A patent/JP6371319B2/ja active Active
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