JP2013514788A5 - - Google Patents
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- JP2013514788A5 JP2013514788A5 JP2012545018A JP2012545018A JP2013514788A5 JP 2013514788 A5 JP2013514788 A5 JP 2013514788A5 JP 2012545018 A JP2012545018 A JP 2012545018A JP 2012545018 A JP2012545018 A JP 2012545018A JP 2013514788 A5 JP2013514788 A5 JP 2013514788A5
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- 235000018102 proteins Nutrition 0.000 claims 50
- 102000004169 proteins and genes Human genes 0.000 claims 50
- 108090000623 proteins and genes Proteins 0.000 claims 50
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 26
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims 1
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 1
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940116978 human epidermal growth factor Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 101150047061 tag-72 gene Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28949709P | 2009-12-23 | 2009-12-23 | |
| US61/289,497 | 2009-12-23 | ||
| PCT/AU2010/001737 WO2011075786A1 (en) | 2009-12-23 | 2010-12-23 | Immuno-conjugates and methods for producing them 2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000559A Division JP6484259B2 (ja) | 2009-12-23 | 2017-01-05 | イムノコンジュゲート及びその作製方法２ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013514788A JP2013514788A (ja) | 2013-05-02 |
| JP2013514788A5 true JP2013514788A5 (https=) | 2014-02-13 |
Family
ID=44194832
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545018A Pending JP2013514788A (ja) | 2009-12-23 | 2010-12-23 | イムノコンジュゲート及びその作製方法２ |
| JP2017000559A Active JP6484259B2 (ja) | 2009-12-23 | 2017-01-05 | イムノコンジュゲート及びその作製方法２ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000559A Active JP6484259B2 (ja) | 2009-12-23 | 2017-01-05 | イムノコンジュゲート及びその作製方法２ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9315581B2 (https=) |
| EP (1) | EP2516462B1 (https=) |
| JP (2) | JP2013514788A (https=) |
| KR (1) | KR101961495B1 (https=) |
| AU (1) | AU2010336029B2 (https=) |
| CA (1) | CA2784610C (https=) |
| SG (1) | SG181814A1 (https=) |
| WO (1) | WO2011075786A1 (https=) |
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| EP3189057A1 (en) | 2014-09-03 | 2017-07-12 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
| ES2815353T3 (es) | 2014-09-03 | 2021-03-29 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
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| TW202413360A (zh) | 2017-12-28 | 2024-04-01 | 美商伊繆諾金公司 | 苯二氮平衍生物 |
| ES2958933T3 (es) | 2018-03-13 | 2024-02-16 | Zymeworks Bc Inc | Conjugados de anticuerpo biparatópico anti-HER2-fármaco y métodos de uso |
| US11833214B2 (en) | 2019-03-21 | 2023-12-05 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| EP3947395A1 (en) | 2019-03-29 | 2022-02-09 | ImmunoGen, Inc. | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases |
| JP7561141B2 (ja) | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
| TW202120537A (zh) * | 2019-08-15 | 2021-06-01 | 美商健生生物科技公司 | 用於經改善的單鏈可變片段之材料及方法 |
| WO2021031930A1 (zh) * | 2019-08-19 | 2021-02-25 | 沈阳药科大学 | 抗体的突变体及其应用 |
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-
2010
- 2010-12-23 SG SG2012045241A patent/SG181814A1/en unknown
- 2010-12-23 EP EP20100838426 patent/EP2516462B1/en active Active
- 2010-12-23 AU AU2010336029A patent/AU2010336029B2/en active Active
- 2010-12-23 US US13/383,836 patent/US9315581B2/en active Active
- 2010-12-23 JP JP2012545018A patent/JP2013514788A/ja active Pending
- 2010-12-23 CA CA2784610A patent/CA2784610C/en active Active
- 2010-12-23 KR KR1020127018914A patent/KR101961495B1/ko active Active
- 2010-12-23 WO PCT/AU2010/001737 patent/WO2011075786A1/en not_active Ceased
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2017
- 2017-01-05 JP JP2017000559A patent/JP6484259B2/ja active Active
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