JP2022527151A5 - - Google Patents

Info

Publication number
JP2022527151A5
JP2022527151A5 JP2021556712A JP2021556712A JP2022527151A5 JP 2022527151 A5 JP2022527151 A5 JP 2022527151A5 JP 2021556712 A JP2021556712 A JP 2021556712A JP 2021556712 A JP2021556712 A JP 2021556712A JP 2022527151 A5 JP2022527151 A5 JP 2022527151A5
Authority
JP
Japan
Prior art keywords
amino acid
seq
antigen
complex
complex according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021556712A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022527151A (ja
JP7682798B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/023981 external-priority patent/WO2020191342A1/en
Publication of JP2022527151A publication Critical patent/JP2022527151A/ja
Publication of JP2022527151A5 publication Critical patent/JP2022527151A5/ja
Priority to JP2025080863A priority Critical patent/JP2025122026A/ja
Application granted granted Critical
Publication of JP7682798B2 publication Critical patent/JP7682798B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021556712A 2019-03-20 2020-03-20 クローディン6抗体及び薬物複合体 Active JP7682798B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025080863A JP2025122026A (ja) 2019-03-20 2025-05-14 クローディン6抗体及び薬物複合体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962821391P 2019-03-20 2019-03-20
US62/821,391 2019-03-20
PCT/US2020/023981 WO2020191342A1 (en) 2019-03-20 2020-03-20 Claudin-6 antibodies and drug conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025080863A Division JP2025122026A (ja) 2019-03-20 2025-05-14 クローディン6抗体及び薬物複合体

Publications (3)

Publication Number Publication Date
JP2022527151A JP2022527151A (ja) 2022-05-31
JP2022527151A5 true JP2022527151A5 (https=) 2023-03-29
JP7682798B2 JP7682798B2 (ja) 2025-05-26

Family

ID=72521237

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021556712A Active JP7682798B2 (ja) 2019-03-20 2020-03-20 クローディン6抗体及び薬物複合体
JP2025080863A Pending JP2025122026A (ja) 2019-03-20 2025-05-14 クローディン6抗体及び薬物複合体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025080863A Pending JP2025122026A (ja) 2019-03-20 2025-05-14 クローディン6抗体及び薬物複合体

Country Status (19)

Country Link
US (3) US20220162299A1 (https=)
EP (2) EP3941946B1 (https=)
JP (2) JP7682798B2 (https=)
KR (1) KR20210154158A (https=)
CN (1) CN114174340A (https=)
AU (1) AU2020241896A1 (https=)
BR (1) BR112021018608A2 (https=)
CA (1) CA3134055A1 (https=)
DK (1) DK3941946T3 (https=)
ES (1) ES3017207T3 (https=)
FI (1) FI3941946T3 (https=)
HU (1) HUE070544T2 (https=)
IL (1) IL286483A (https=)
MX (1) MX2021011330A (https=)
PL (1) PL3941946T3 (https=)
PT (1) PT3941946T (https=)
SG (1) SG11202109986TA (https=)
SI (1) SI3941946T1 (https=)
WO (1) WO2020191342A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54955A (fr) 2019-02-15 2021-12-22 Integral Molecular Inc Anticorps anti-claudine 6 et leurs utilisations
DK3941946T3 (da) 2019-03-20 2025-03-24 Univ California Claudin-6-antistoffer og lægemiddelkonjugater
US20250277026A1 (en) * 2021-03-02 2025-09-04 Novarock Biotherapeutics, Ltd. Antibodies against claudin-6 and uses thereof
KR20230154317A (ko) * 2021-03-05 2023-11-07 상하이 젠베이스 바이오테크놀로지 씨오., 엘티디. 항-cldn6 항체 및 이의 용도
JP2024542823A (ja) * 2021-12-06 2024-11-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド アンタゴニスト抗npr1抗体およびその使用方法
EP4572785A1 (en) * 2022-08-15 2025-06-25 Dana-Farber Cancer Institute, Inc. Antibodies against cldn4 and methods of use thereof
TW202430574A (zh) 2022-11-30 2024-08-01 美商積分分子股份有限公司 針對密連蛋白6之抗體,包括其雙特異性格式
WO2024165057A1 (en) * 2023-02-07 2024-08-15 LaNova Medicines Limited Antibodies and antibody-drug conjugates targeting claudin 6
WO2024235175A1 (zh) 2023-05-12 2024-11-21 智泽童康(广州)生物科技有限公司 抗cldn6抗体及其用途
IL324834A (en) * 2023-05-25 2026-01-01 Univ California Dosage of claudin-6 conjugates for cancer treatment
WO2025083067A1 (en) * 2023-10-17 2025-04-24 Adc Therapeutics Sa Anti-claudin-6 conjugates

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US581916A (en) 1897-05-04 Harvester
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4342776A (en) 1979-11-05 1982-08-03 Merck & Co., Inc. 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
US4399276A (en) 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839685A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体及びその製造法
JPS58154582A (ja) 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US4526988A (en) 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
EP0184365B1 (en) 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals
US5223608A (en) 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
IL106992A (en) 1988-02-11 1994-06-24 Bristol Myers Squibb Co Acylhydrazone derivatives of anthracycline and methods for their preparation
DK0418099T3 (da) 1989-09-15 2002-04-02 Res Triangle Inst Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6407115B1 (en) 1991-01-16 2002-06-18 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
EP0563475B1 (en) 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
FR2707988B1 (fr) 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
DK0871490T3 (da) 1995-12-22 2003-07-07 Bristol Myers Squibb Co Forgrenede hydrazonlinkere
EP1053752A1 (en) 1998-02-10 2000-11-22 Yoshitomi Pharmaceutical Industries, Ltd. Preparations with controlled release
AU756796B2 (en) 1998-10-16 2003-01-23 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Combination therapy with VIP antagonist
GB2344287A (en) 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
CA2388063C (en) 1999-11-24 2010-06-08 Immunogen, Inc. Cytotoxic agents comprising taxanes and their therapeutic use
WO2001058479A1 (en) 2000-02-08 2001-08-16 The Penn State Research Foundation Immunotherapy using interleukin 13 receptor subunit alpha 2
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US7771951B2 (en) 2001-12-03 2010-08-10 Amgen Fremont Inc. Antibody categorization based on binding characteristics
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
BR0313197A (pt) 2002-08-02 2005-08-09 Immunogen Inc Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico
DE60336149D1 (de) 2002-08-16 2011-04-07 Immunogen Inc Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
AU2003279842A1 (en) 2002-10-04 2004-05-04 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
CA2672581A1 (en) 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same
WO2008130158A1 (en) 2007-04-19 2008-10-30 Dong-A Pharmaceutical. Co., Ltd A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
EP2241578B1 (en) 2008-01-11 2016-04-20 The University of Tokyo Anti-cldn6 antibody
NZ610239A (en) 2008-04-30 2014-11-28 Immunogen Inc Cross-linkers and their uses
SG189817A1 (en) 2008-04-30 2013-05-31 Immunogen Inc Potent conjugates and hydrophilic linkers
US8025098B2 (en) 2008-06-18 2011-09-27 Xyleco, Inc. Processing hydrocarbons
ES3000111T3 (en) 2009-02-13 2025-02-27 Immunomedics Inc Intermediates for preparing conjugates with an intracellularly-cleavable linkage
DK3305813T3 (da) 2009-11-11 2020-04-20 Astellas Pharma Inc Antistoffer, der er specifikke for claudin 6 (cldn6)
US8840902B2 (en) 2010-03-16 2014-09-23 Biontech Ag Tumor vaccination involving a humoral immune response against self-proteins
EP2404936A1 (en) * 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
ES2989943T3 (es) * 2011-05-13 2024-11-28 Astellas Pharma Inc Anticuerpos para el tratamiento de un cáncer que expresa la Claudina 6
ES2773710T3 (es) 2012-10-11 2020-07-14 Daiichi Sankyo Co Ltd Enlazadores para conjugados de anticuerpo - fármaco
WO2014075697A1 (en) * 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
JP6499079B2 (ja) * 2012-11-13 2019-04-10 バイオエヌテック アーゲーBioNTech AG クローディンを発現するガン疾患を処置するための剤
WO2015014376A1 (en) 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
RU2016122041A (ru) 2013-11-06 2017-12-11 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые анти-клаудин антитела и способы их применения
PT3514172T (pt) 2014-04-01 2020-04-21 Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh Imunorrecetores específicos de claudina-6 e epítopos de células t
ES2875274T3 (es) 2015-11-02 2021-11-10 Hoffmann La Roche Procedimientos de preparación de formas fucosiladas y afucosiladas de una proteína
RU2018124319A (ru) 2015-12-04 2020-01-09 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые антитела к клаудину и способы их применения
NO20210351A1 (en) 2017-09-18 2021-03-18 Univ California Claudin6 antibodies and methods of treating cancer
US20220177583A1 (en) 2019-03-20 2022-06-09 The Regents Of The University Of California Claudin-6 bispecific antibodies
DK3941946T3 (da) 2019-03-20 2025-03-24 Univ California Claudin-6-antistoffer og lægemiddelkonjugater

Similar Documents

Publication Publication Date Title
JP2022527151A5 (https=)
CN108368170B (zh) 抗pd-1抗体、可活化抗pd-1抗体及其使用方法
US9758586B2 (en) Chimeric rabbit/human ROR1 antibodies
JP5723279B2 (ja) 抗cxcr4抗体および癌治療のためのそれらの使用
JP2020501531A5 (https=)
JP2022513053A (ja) B7-H3のIgVドメインに対するモノクローナル抗体及びその使用
CN116396386A (zh) Cd3抗体及其药物用途
AU2016233495A2 (en) Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof
JP2010504755A5 (https=)
JP2018512175A5 (https=)
RU2012126138A (ru) Специфические связывающие агенты против в7-н1
WO2003034903B1 (en) Psma antibodies and protein multimers
JP2010501164A5 (https=)
JP7514765B2 (ja) ヒトpd-l1およびpd-l2に対する二重特異性抗体およびその使用方法
WO2018166507A1 (zh) 新型重组双功能融合蛋白及其制备方法和用途
JP2014515600A5 (https=)
CN117062834A (zh) Gpc3人源化抗体及其应用
JP2024509501A5 (https=)
WO2023246701A1 (zh) 一种抗体及其用途
CN115894702A (zh) 一种b7h3/pdl1双特异性抗体及其药物组合物及应用
WO2023222135A9 (en) A method of treating solid tumor
JP2026506070A (ja) 抗cntn4抗体及びその使用
JP2025535104A (ja) B7h3/pdl1二重特異性抗体およびその医薬組成物ならびにその使用
CN118541396A (zh) 靶向p53肿瘤抗原的mana抗体及其使用方法
JP2024508597A5 (https=)