JP2012528857A - 純粋ｐｅｇ−脂質コンジュゲート - Google Patents

純粋ｐｅｇ−脂質コンジュゲート Download PDF

Info

Publication number
JP2012528857A
JP2012528857A JP2012513928A JP2012513928A JP2012528857A JP 2012528857 A JP2012528857 A JP 2012528857A JP 2012513928 A JP2012513928 A JP 2012513928A JP 2012513928 A JP2012513928 A JP 2012513928A JP 2012528857 A JP2012528857 A JP 2012528857A
Authority
JP
Japan
Prior art keywords
peg
glycerol
lipid
glycol
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012513928A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012528857A5 (cg-RX-API-DMAC10.html
Inventor
ウー，ニエン
ケラー，ブライアン，チャールズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2012528857A publication Critical patent/JP2012528857A/ja
Publication of JP2012528857A5 publication Critical patent/JP2012528857A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
    • C08L63/10—Epoxy resins modified by unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
JP2012513928A 2009-06-02 2010-06-01 純粋ｐｅｇ−脂質コンジュゲート Pending JP2012528857A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21762709P 2009-06-02 2009-06-02
US61/217,627 2009-06-02
US28406509P 2009-12-12 2009-12-12
US61/284,065 2009-12-12
PCT/US2010/001590 WO2010141069A2 (en) 2009-06-02 2010-06-01 Pure peg-lipid conjugates

Publications (2)

Publication Number Publication Date
JP2012528857A true JP2012528857A (ja) 2012-11-15
JP2012528857A5 JP2012528857A5 (cg-RX-API-DMAC10.html) 2013-08-15

Family

ID=43298359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012513928A Pending JP2012528857A (ja) 2009-06-02 2010-06-01 純粋ｐｅｇ−脂質コンジュゲート

Country Status (15)

Country Link
US (1) US20110040113A1 (cg-RX-API-DMAC10.html)
EP (1) EP2437756A2 (cg-RX-API-DMAC10.html)
JP (1) JP2012528857A (cg-RX-API-DMAC10.html)
KR (1) KR20120039564A (cg-RX-API-DMAC10.html)
CN (1) CN102665685A (cg-RX-API-DMAC10.html)
AP (1) AP2012006053A0 (cg-RX-API-DMAC10.html)
AU (1) AU2010257181A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI1010175A2 (cg-RX-API-DMAC10.html)
CA (1) CA2763819A1 (cg-RX-API-DMAC10.html)
CL (1) CL2011003049A1 (cg-RX-API-DMAC10.html)
CO (1) CO6511284A2 (cg-RX-API-DMAC10.html)
IL (1) IL216719A0 (cg-RX-API-DMAC10.html)
MX (1) MX2011012823A (cg-RX-API-DMAC10.html)
WO (1) WO2010141069A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201109366B (cg-RX-API-DMAC10.html)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013100492A (ja) * 2011-10-17 2013-05-23 Nof Corp ジアシルグリセロールと結合した分岐型ポリエチレングリコール、その製造方法およびポリエチレングリコール修飾リポソーム
JP2016539165A (ja) * 2013-12-05 2016-12-15 ウー, ニエンWU, Nian 薬物転送技術のための高分子−炭水化物共役体
JP2018521152A (ja) * 2015-06-23 2018-08-02 ウー, ニエンWU, Nian 高分子−シクロデキストリン−脂質共役体
WO2019181984A1 (ja) * 2018-03-20 2019-09-26 日油株式会社 分岐型単分散ポリエチレングリコール、中間体およびその製造方法
JP2019172993A (ja) * 2018-03-29 2019-10-10 日油株式会社 トリチル基含有単分散ポリエチレングリコールの精製方法
JP2022041088A (ja) * 2020-08-31 2022-03-11 ジェイ－ネットワーク，インコーポレイテッド 表皮内の保湿関連物質の発現増強剤
JP2025513901A (ja) * 2022-04-22 2025-04-30 ティエンジン アシムケム ファーマシューティカルズ カンパニー リミテッド ポリエチレングリコール－グリセリン誘導体及びその中間体それぞれの製造方法

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393315B2 (en) * 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
US20120202890A1 (en) * 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
WO2012122144A1 (en) * 2011-03-07 2012-09-13 Wu Nian Highly monodisperse branched peg-lipid conjugates
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
US8883177B2 (en) 2011-06-28 2014-11-11 Nian Wu Pharmaceutical compositions for parenteral administration
BR112015003658B1 (pt) * 2012-08-21 2022-09-27 Opko Pharmaceuticals, Llc Formulação oftálmica, uso da dita formulação no tratamento de doença oftálmica do segmento posterior, formulação de lipossomas e suspensão oftálmica lipossomal
US11458199B2 (en) 2012-08-21 2022-10-04 Opko Pharmaceuticals, Llc Liposome formulations
PL2887923T3 (pl) 2012-08-24 2023-08-14 Sun Pharmaceutical Industries Limited Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
CA2930505C (en) * 2013-12-20 2019-06-18 F. Hoffman-La Roche Ag Compounds comprising one or more hydrophobic domains and a hydrophilic domain comprising peg moieties, useful for binding cells
CN105829886B (zh) 2013-12-20 2018-04-03 豪夫迈·罗氏有限公司 使用包含聚乙二醇部分的化合物在支持物上固定细胞的方法
JP6461973B2 (ja) * 2013-12-20 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用
AU2015360794B2 (en) 2014-12-08 2021-07-08 The Board Of Regents Of The University Of Texas System Lipocationic polymers and uses thereof
KR102764250B1 (ko) 2015-09-14 2025-02-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 지질양이온성 덴드리머 및 이의 용도
DK3373976T3 (da) 2015-11-10 2024-04-02 Sun Pharmaceutical Ind Ltd Topiske formuleringer og anvendelser deraf
DK3386484T3 (da) 2015-12-10 2022-07-04 Modernatx Inc Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler
CN106905120B (zh) * 2015-12-21 2020-04-28 北京键凯科技股份有限公司 Y型多缩乙二醇衍生物及其制备方法
NZ785158A (en) 2016-02-29 2025-03-28 Sun Pharmaceutical Ind Ltd Topical cyclosporine-containing formulations and uses thereof
PL3458074T3 (pl) 2016-05-16 2024-11-12 Board Of Regents Of The University Of Texas System KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA
CN114656378A (zh) 2016-05-16 2022-06-24 得克萨斯州大学系统董事会 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质
WO2018170270A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Varicella zoster virus (vzv) vaccine
WO2019191597A1 (en) * 2018-03-30 2019-10-03 The Board Of Regents Of The University Of Oklahoma Very long chain saturated fatty acid compounds, compositions containing same, and methods of use
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
GB2600800B (en) 2018-09-04 2023-08-16 Univ Texas Compositions and methods for organ specific delivery of nucleic acids
GB2606038B (en) 2018-09-04 2023-05-03 Univ Texas Compositions and methods for organ specific delivery of nucleic acids
CN112996854B (zh) * 2018-09-19 2024-08-30 摩登纳特斯有限公司 高纯度peg脂质和其用途
IL320367A (en) 2020-10-09 2025-06-01 Univ Texas Prefusion-stabilized hmpv f proteins
JP6860739B1 (ja) * 2020-11-20 2021-04-21 ジェイ−ネットワーク，インコーポレイテッド 表皮内の抗酸化物質の発現増強剤
JP7826934B2 (ja) * 2020-12-15 2026-03-10 東洋紡エムシー株式会社 ポリエステル樹脂
CN114685778B (zh) * 2020-12-30 2023-10-17 苏州艾博生物科技有限公司 长循环阳离子脂质体的合成方法
US20240123076A1 (en) 2021-02-08 2024-04-18 The Board Of Regents Of The University Of Texas System Unsaturated dendrimers compositions, related formulations, and methods of use thereof
MX2023011243A (es) 2021-03-23 2023-12-14 Recode Therapeutics Inc Composiciones de polinucleotidos, formulaciones relacionadas y metodos de uso de los mismos.
JP2024516164A (ja) 2021-04-22 2024-04-12 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 正確なインビボｈｄｒ介在性遺伝子編集を可能にするオールインワンデンドリマーベース脂質ナノ粒子
EP4342929B1 (en) 2021-06-30 2026-02-04 Jenkem Technology Co. Ltd. (Tianjin) Polyethylene glycol lipid and use thereof
CN113461929B (zh) * 2021-07-13 2023-04-21 浙江倍合德制药有限公司 一种tpgs系列产品的精制提纯方法
US20250188455A1 (en) * 2021-09-02 2025-06-12 Vanderbilt University Lipophilic oligonucleotide conjugates
KR20240117084A (ko) 2021-11-29 2024-07-31 더 거버닝 카운실 오브 더 유니버시티 오브 토론토 멀티-모티프 덴드론 및 이의 초분자 구조체 그리고 이들의 용도
CN116410460B (zh) * 2021-12-29 2025-08-05 辅必成（上海）医药科技有限公司 一种1,2-二肉豆蔻酰-rac-甘油-3-甲氧基聚乙二醇2000的制备方法
CN114507342B (zh) * 2022-03-18 2024-03-19 江苏东南纳米材料有限公司 一种1,2-二肉豆蔻酰-rac-甘油-3-甲氧基聚乙二醇及其中间体的制备方法
US20250235404A1 (en) * 2022-04-05 2025-07-24 Capstan Therapeutics, Inc. Peg-lipids and lipid nanoparticles
CN117003807B (zh) * 2022-04-28 2026-05-26 北京科兴中维生物技术有限公司 一种结构脂质化合物及其制备方法和用途
AU2023382536A1 (en) * 2022-11-15 2025-06-26 Evonik Operations Gmbh Polyoxyalkylene-1,2-dimyristoyl-glycerol compounds, wherein the polyoxyalkylene is a poly(ethylene oxide) having c1 to c3-alkyloxymethyl side chains
IL321026A (en) 2022-12-08 2025-07-01 Recode Therapeutics Inc Nanoparticle formulations and their uses
KR20250133660A (ko) 2023-01-09 2025-09-08 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 융합 전 안정화된 인간 파라인플루엔자 바이러스 3 f 단백질
CN116178733B (zh) * 2023-03-03 2023-08-01 浙江博美生物技术有限公司 一种基于三官能团氨基酸的支化单分散peg衍生物、制备方法和应用
CN117126386A (zh) * 2023-08-18 2023-11-28 中国科学技术大学 单一分子量聚乙二醇脂质及其应用
US12553042B2 (en) 2023-12-01 2026-02-17 Recode Therapeutics, Inc. Method for quantifying an amount of capped messenger RNA
US12364773B2 (en) 2023-12-01 2025-07-22 Recode Therapeutics, Inc. Lipid nanoparticle compositions and uses thereof
US12539279B2 (en) 2023-12-11 2026-02-03 The Governing Council Of The University Of Toronto Supramolecular ionizable lipid molecules with heteroatomic tuning for nucleic acid delivery
WO2025137646A1 (en) 2023-12-22 2025-06-26 Recode Therapeutics, Inc. Gene editing methods and compositions for treating cystic fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
CN1882693B (zh) * 2003-09-15 2012-08-15 普洛体维生物治疗公司 聚乙二醇修饰的脂质化合物及其应用
WO2006007712A1 (en) * 2004-07-19 2006-01-26 Protiva Biotherapeutics, Inc. Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
WO2006051405A2 (en) * 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
CA2705797A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013100492A (ja) * 2011-10-17 2013-05-23 Nof Corp ジアシルグリセロールと結合した分岐型ポリエチレングリコール、その製造方法およびポリエチレングリコール修飾リポソーム
JP2016539165A (ja) * 2013-12-05 2016-12-15 ウー, ニエンWU, Nian 薬物転送技術のための高分子−炭水化物共役体
JP7196378B2 (ja) 2015-06-23 2022-12-27 ウー，ニエン 高分子－シクロデキストリン－脂質共役体
JP2018521152A (ja) * 2015-06-23 2018-08-02 ウー, ニエンWU, Nian 高分子−シクロデキストリン−脂質共役体
JP7216332B2 (ja) 2018-03-20 2023-02-01 日油株式会社 分岐型単分散ポリエチレングリコール、中間体およびその製造方法
JP2019167532A (ja) * 2018-03-20 2019-10-03 日油株式会社 分岐型単分散ポリエチレングリコール、中間体およびその製造方法
WO2019181984A1 (ja) * 2018-03-20 2019-09-26 日油株式会社 分岐型単分散ポリエチレングリコール、中間体およびその製造方法
US11905367B2 (en) 2018-03-20 2024-02-20 Nof Corporation Branched monodispersed polyethylene glycol, intermediate and methods for producing same
JP2019172993A (ja) * 2018-03-29 2019-10-10 日油株式会社 トリチル基含有単分散ポリエチレングリコールの精製方法
JP7177392B2 (ja) 2018-03-29 2022-11-24 日油株式会社 トリチル基含有単分散ポリエチレングリコールの精製方法
US11680137B2 (en) 2018-03-29 2023-06-20 Nof Corporation Method for purifying trityl group-containing monodispersed polyethylene glycol
JP2022041088A (ja) * 2020-08-31 2022-03-11 ジェイ－ネットワーク，インコーポレイテッド 表皮内の保湿関連物質の発現増強剤
JP2025513901A (ja) * 2022-04-22 2025-04-30 ティエンジン アシムケム ファーマシューティカルズ カンパニー リミテッド ポリエチレングリコール－グリセリン誘導体及びその中間体それぞれの製造方法

Also Published As

Publication number Publication date
KR20120039564A (ko) 2012-04-25
AP2012006053A0 (en) 2012-02-29
CA2763819A1 (en) 2010-12-09
BRPI1010175A2 (pt) 2016-03-29
EP2437756A2 (en) 2012-04-11
US20110040113A1 (en) 2011-02-17
ZA201109366B (en) 2012-08-29
WO2010141069A3 (en) 2012-04-12
IL216719A0 (en) 2012-02-29
CL2011003049A1 (es) 2012-07-13
MX2011012823A (es) 2012-06-25
CN102665685A (zh) 2012-09-12
AU2010257181A1 (en) 2012-01-12
WO2010141069A2 (en) 2010-12-09
CO6511284A2 (es) 2012-08-31

Similar Documents

Publication Publication Date Title
US20110040113A1 (en) Pure PEG-lipid conjugates
WO2012122144A1 (en) Highly monodisperse branched peg-lipid conjugates
KR20230144574A (ko) 폴리옥사졸린-지질 접합체, 및 이를 포함하는 지질 나노입자 및 제약 조성물
EP3077006B1 (en) Polymer-carbohydrate conjugates for drug delivery technology
JP2003509386A (ja) タキサン・プロドラッグ
CZ2002928A3 (cs) Taxanová proléčiva
JPH10513187A (ja) 高分子量のポリマーを基剤とするプロドラッグ
KR20100022000A (ko) 소수성 제제를 캡슐화하기 위해 사용되는 혼합 입체화학을 가지는 혼성 블록 공중합체 미셀
AU717922B2 (en) Selectively functionalizable desdendrimers
JP7683120B2 (ja) 核酸トランスフェクション用シクロヘキサンリピドイドおよびその使用方法
WO2024198497A1 (zh) 氨基脂质、脂质纳米颗粒及其应用
EP4644379A1 (en) Lipid compound and lipid nanoparticle composition
WO2025180343A1 (zh) 喹啉类脂质衍生物及其用途
JP2025540651A (ja) 活性物質送達のための脂質化合物および組成物
CN114213346A (zh) 一种双价可电离脂质化合物、组合物及其应用
TW202206106A (zh) 一類載藥的大分子及其製備方法
EP2561891A2 (en) Means and methods of enhancing delivery to biological systems
AU2023379598A1 (en) Ionizable lipids and lipid nanoparticle compositions for the delivery of nucleic acids
JP3538606B2 (ja) パクリタキセルまたはその誘導体の残基を含む水溶性プロドラッグ化合物、その製造方法及びそれを含む薬剤組成物
CN101485887A (zh) 5-氟尿嘧啶-sn2-磷脂酰胆碱共聚物及其制备方法和用途
WO2011139343A2 (en) Amino acid linked peg-lipid conjugates
CN113214171B (zh) 两亲性树形分子、合成及其作为药物递送系统的应用
US11806407B2 (en) Refillable drug delivery by affinity homing
WO2024131717A1 (zh) 一种阳离子脂质材料的制备及应用
CA3079121A1 (en) Macromolecular platform for targeting scavenger receptor a1

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130603

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130603

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20131015