JP2012525415A - 眼科疾患を処置または予防するための方法 - Google Patents
眼科疾患を処置または予防するための方法 Download PDFInfo
- Publication number
- JP2012525415A JP2012525415A JP2012508655A JP2012508655A JP2012525415A JP 2012525415 A JP2012525415 A JP 2012525415A JP 2012508655 A JP2012508655 A JP 2012508655A JP 2012508655 A JP2012508655 A JP 2012508655A JP 2012525415 A JP2012525415 A JP 2012525415A
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutically acceptable
- acceptable salt
- antagonist
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts or implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3183—Diol linkers, e.g. glycols or propanediols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17474609P | 2009-05-01 | 2009-05-01 | |
| US61/174,746 | 2009-05-01 | ||
| US17801009P | 2009-05-13 | 2009-05-13 | |
| US61/178,010 | 2009-05-13 | ||
| US24578409P | 2009-09-25 | 2009-09-25 | |
| US61/245,784 | 2009-09-25 | ||
| PCT/US2010/032816 WO2010127029A1 (en) | 2009-05-01 | 2010-04-28 | Methods for treating or preventing ophthalmological diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015115569A Division JP2015199749A (ja) | 2009-05-01 | 2015-06-08 | 眼科疾患を処置または予防するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012525415A true JP2012525415A (ja) | 2012-10-22 |
| JP2012525415A5 JP2012525415A5 (https=) | 2013-06-20 |
Family
ID=43032543
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508655A Pending JP2012525415A (ja) | 2009-05-01 | 2010-04-28 | 眼科疾患を処置または予防するための方法 |
| JP2015115569A Pending JP2015199749A (ja) | 2009-05-01 | 2015-06-08 | 眼科疾患を処置または予防するための方法 |
| JP2016246245A Pending JP2017081955A (ja) | 2009-05-01 | 2016-12-20 | 眼科疾患を処置または予防するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015115569A Pending JP2015199749A (ja) | 2009-05-01 | 2015-06-08 | 眼科疾患を処置または予防するための方法 |
| JP2016246245A Pending JP2017081955A (ja) | 2009-05-01 | 2016-12-20 | 眼科疾患を処置または予防するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20120100136A1 (https=) |
| EP (3) | EP3028707A1 (https=) |
| JP (3) | JP2012525415A (https=) |
| AR (1) | AR076523A1 (https=) |
| CA (1) | CA2760687A1 (https=) |
| TW (2) | TWI528963B (https=) |
| WO (1) | WO2010127029A1 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523956A (ja) * | 2013-07-11 | 2016-08-12 | ノバルティス アーゲー | 未熟児網膜症の治療におけるvegfアンタゴニストの使用 |
| JP2016531901A (ja) * | 2013-07-12 | 2016-10-13 | オプソテック コーポレイションOphthotech Corporation | 眼科症状を処置するまたは予防するための方法 |
| WO2017065559A1 (ko) * | 2015-10-15 | 2017-04-20 | (주)알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
| JP2017524034A (ja) * | 2014-08-08 | 2017-08-24 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 |
| RU2676274C2 (ru) * | 2013-07-11 | 2018-12-27 | Новартис Аг | Применение антагониста vegf при лечении хориоретинальных неоваскулярных нарушений и нарушений проницаемости у педиатрических пациентов |
| WO2022154356A1 (ko) * | 2021-01-14 | 2022-07-21 | 국민대학교 산학협력단 | (7s)-(+)-시클로펜틸 카바믹산, 8,8-디메틸-2-옥소-6,7-디히드로-2h,8h-피라노[3,2-g]크로멘-7-일-에스테르를 유효성분으로 포함하는 안질환의 예방, 개선 또는 치료용 조성물 |
| US11414476B2 (en) | 2015-10-15 | 2022-08-16 | Alteogen, Inc. | Method for producing fusion protein having IgG Fc domain |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| WO2009129546A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| KR20140044324A (ko) * | 2011-04-26 | 2014-04-14 | 레가도 바이오사이언스, 인코포레이티드 | 페길화된 올리고뉴클레오티드의 제조방법 |
| WO2013000909A1 (en) | 2011-06-28 | 2013-01-03 | Bayer Intellectual Property Gmbh | Topical ophthalmological pharmaceutical composition containing sorafenib |
| KR20140048218A (ko) | 2011-06-28 | 2014-04-23 | 바이엘 헬스케어 엘엘씨 | 레고라페닙을 함유하는 국소 안과용 약학 조성물 |
| US20130142796A1 (en) * | 2011-12-05 | 2013-06-06 | Subhransu Ray | Treatment for angiogenic disorders |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| TWI588560B (zh) | 2012-04-05 | 2017-06-21 | 布萊恩荷登視覺協會 | 用於屈光不正之鏡片、裝置、方法及系統 |
| JP6410710B2 (ja) | 2012-04-27 | 2018-10-24 | リアタ ファーマシューティカルズ インコーポレイテッド | バルドキソロンメチルの2,2−ジフルオロプロピオンアミド誘導体、その多形体および使用方法 |
| AU2013267310A1 (en) * | 2012-06-01 | 2014-12-11 | Ophthotech Corporation | Compositions comprising an anti-PDGF aptamer and a VEGF antagonist |
| RS61391B1 (sr) | 2012-06-08 | 2021-02-26 | Alkermes Pharma Ireland Ltd | Ligandi modifikovani primenom cirkularnog permutiranja kao agonisti i antagonisti |
| HK1204992A1 (en) | 2012-06-25 | 2015-12-11 | Bayer Healthcare Llc | Topical ophthalmological pharmaceutical composition containing sunitinib |
| EP2863888A1 (en) * | 2012-06-25 | 2015-04-29 | Bayer HealthCare LLC | Topical ophthalmological pharmaceutical composition containing axitinib |
| AU2013100071C4 (en) * | 2012-07-03 | 2013-05-02 | Novartis Ag | Device |
| DE202013000688U1 (de) * | 2012-07-03 | 2013-03-05 | Novartis Ag | Glas-Spritze |
| US9201250B2 (en) | 2012-10-17 | 2015-12-01 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| HK1212194A1 (en) | 2012-10-17 | 2016-06-10 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| US9681805B2 (en) * | 2012-11-05 | 2017-06-20 | Babak Kamkar | Afferent pupil tester |
| UY35183A (es) | 2012-12-21 | 2014-07-31 | Bayer Healthcare Llc | Composición farmacéutica oftalmológica tópica que contiene regorafenib |
| JO3405B1 (ar) | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
| PT2956476T (pt) | 2013-02-18 | 2020-02-21 | Vegenics Pty Ltd | Moléculas de ligação e usos destas |
| WO2014152031A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Ribonucleic acid purification |
| WO2014152027A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Manufacturing methods for production of rna transcripts |
| WO2014152030A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Removal of dna fragments in mrna production process |
| WO2014144767A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法 |
| EP2994758B1 (en) | 2013-05-08 | 2017-12-20 | Opthea Limited | Biomarkers for age-related macular degeneration (amd) |
| JP2016522249A (ja) * | 2013-06-20 | 2016-07-28 | ノバルティス アーゲー | 脈絡膜血管新生の治療におけるvegfアンタゴニストの使用 |
| JP2016522248A (ja) * | 2013-06-20 | 2016-07-28 | ノバルティス アーゲー | ポリープ状脈絡膜血管症の治療 |
| SMT202100691T1 (it) | 2013-07-11 | 2022-01-10 | Modernatx Inc | Composizioni 5 comprendenti polinucleotidi sintetici che codificano proteine correlate a crispr e sgrna sintetici e metodi d'uso |
| JP6463361B2 (ja) | 2013-09-08 | 2019-01-30 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | 第viii因子両性イオンポリマーコンジュゲート |
| US20170250927A1 (en) * | 2013-12-23 | 2017-08-31 | Dali Systems Co. Ltd. | Virtual radio access network using software-defined network of remotes and digital multiplexing switches |
| WO2015196128A2 (en) * | 2014-06-19 | 2015-12-23 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules and uses thereof |
| WO2015196130A2 (en) * | 2014-06-19 | 2015-12-23 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules and uses thereof |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| US10407683B2 (en) | 2014-07-16 | 2019-09-10 | Modernatx, Inc. | Circular polynucleotides |
| CN108064175A (zh) * | 2014-08-04 | 2018-05-22 | 米拉根医疗股份有限公司 | Myh7b的抑制剂及其用途 |
| CN106852125A (zh) * | 2014-08-11 | 2017-06-13 | 奥普索特克公司 | 用于治疗或预防眼科病的方法 |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| DK3268480T3 (da) * | 2015-03-09 | 2021-07-26 | Sinai Health Sys | Værktøjer og fremgangsmåder til anvendelse af celledelingsloci til at styre celleproliferation |
| IL298067A (en) * | 2015-08-25 | 2023-01-01 | Histide Ag | Compounds for inducing tissue formation and their uses |
| WO2017049286A1 (en) | 2015-09-17 | 2017-03-23 | Moderna Therapeutics, Inc. | Polynucleotides containing a morpholino linker |
| PL3350333T3 (pl) | 2015-09-17 | 2022-03-07 | Modernatx, Inc. | Polinukleotydy zawierające region stabilizujący ogon |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| KR101795650B1 (ko) | 2016-05-12 | 2017-11-09 | 인제대학교 산학협력단 | 아플리버셉트-콜라겐 타입 ii 펩타이드의 키메라 단백질을 유효성분으로 함유하는 혈관신생 억제용 조성물 |
| KR101795653B1 (ko) | 2016-05-19 | 2017-11-09 | 인제대학교 산학협력단 | 콜라겐 타입 ii 펩타이드-아플리버셉트의 키메라 단백질을 유효성분으로 함유하는 혈관신생 억제용 조성물 |
| WO2017223176A1 (en) | 2016-06-24 | 2017-12-28 | Modernatx, Inc. | Methods and apparatus for filtration |
| CA3040179A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| CN106778685A (zh) * | 2017-01-12 | 2017-05-31 | 司马大大(北京)智能系统有限公司 | 心电图图像识别方法、装置及服务终端 |
| CN109428697B (zh) * | 2017-08-25 | 2021-12-28 | 华为技术有限公司 | 数据传输方法、网络设备及终端设备 |
| CN108256457B (zh) * | 2018-01-09 | 2021-06-04 | 东北大学 | 一种基于深度神经网络的心冲击信号深瓶颈特征提取方法 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CN108920529A (zh) * | 2018-06-07 | 2018-11-30 | 北京金山安全软件有限公司 | 一种数据提取方法、装置及电子设备 |
| KR20220024153A (ko) | 2019-05-24 | 2022-03-03 | 엠피리코 인크. | 안지오포이에틴 유사 7(angptl7) 관련 질환의 치료 |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| CN110257383B (zh) * | 2019-06-24 | 2023-05-26 | 湖北师范大学 | 特异性识别邻苯二甲酸二(2-乙基)己酯的核酸适配体及其筛选方法与应用 |
| CN110522902B (zh) * | 2019-09-25 | 2022-10-11 | 南京农业大学 | 一种用于建立慢性肾病模型的组合物及其应用 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| EP4065585B1 (en) | 2019-11-25 | 2025-08-20 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| WO2021198034A1 (en) | 2020-03-30 | 2021-10-07 | F. Hoffmann-La Roche Ag | Antibody that binds to vegf and pdgf-b and methods of use |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CN112675158A (zh) * | 2021-01-26 | 2021-04-20 | 苏州市立医院 | 紫草醌在制备脉络膜新生血管治疗药物中的作用 |
| IL306074A (en) | 2021-03-24 | 2023-11-01 | Alkermes Inc | UPAR antibodies and fusion proteins with them |
| CN112852749A (zh) * | 2021-03-27 | 2021-05-28 | 哈尔滨元亨生物药业有限公司 | 高效分泌犬细小病毒单克隆抗体杂交瘤细胞株c68及利用生物反应器对其进行生产的方法 |
| MX2023014041A (es) | 2021-05-28 | 2023-12-15 | Shanghai Regenelead Therapies Co Ltd | Virus adenoasociado recombinante que tiene una capsida variante y su aplicacion. |
| CN113466782B (zh) * | 2021-06-08 | 2022-09-13 | 同济大学 | 一种基于深度学习(dl)的互耦校正doa估计方法 |
| US20250197859A1 (en) * | 2022-03-28 | 2025-06-19 | Empirico Inc. | Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases |
| KR20240163743A (ko) * | 2022-03-28 | 2024-11-19 | 엠피리코 인크. | 변형된 올리고뉴클레오티드 |
| WO2023239415A1 (en) * | 2022-06-08 | 2023-12-14 | Angrow Company Limited | Compositions including cannabinoid and use thereof in the manufacture of a medicament for the treatment of inflammation in a subject |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| CN118766879B (zh) * | 2024-07-12 | 2025-10-10 | 华中科技大学 | 蒽醌类化合物aloesaponarin II在制备CVB3病毒抑制剂中的应用 |
| CN118898773B (zh) * | 2024-10-09 | 2024-12-17 | 江西师范大学 | 基于多尺度特征融合的医学图像分割方法和设备 |
| CN121177569B (zh) * | 2025-11-21 | 2026-02-24 | 重庆医科大学附属口腔医院(重庆市口腔医院) | 一种感染性骨缺损仿生修复水凝胶支架及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582918B2 (en) * | 1995-06-07 | 2003-06-24 | Gilead Sciences, Inc. | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
| JP2007503451A (ja) * | 2003-08-27 | 2007-02-22 | (オーエスアイ)アイテツク・インコーポレーテツド | 眼血管新生疾患の治療のための併用療法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7306799B2 (en) * | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
| US20040253243A1 (en) * | 2003-01-21 | 2004-12-16 | David Epstein | Aptamer therapeutics useful in ocular pharmacotherapy |
| US10100316B2 (en) * | 2002-11-21 | 2018-10-16 | Archemix Llc | Aptamers comprising CPG motifs |
| PL1745062T3 (pl) * | 2004-04-22 | 2014-10-31 | Regado Biosciences Inc | Ulepszone modulatory czynników krzepnięcia |
| EP3034089A1 (en) * | 2004-11-02 | 2016-06-22 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| AU2006213856B2 (en) * | 2005-02-11 | 2011-03-17 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a VEGF antagonist (VEGF trap) and an anti-hypertensive agent |
| PT2029746E (pt) * | 2006-06-12 | 2012-10-15 | Exegenics Inc D B A Opko Health Inc | Composições e métodos para a inibição do sirna de angiogenese |
| JP2010532749A (ja) * | 2007-06-07 | 2010-10-14 | サーモディクス ファーマシューティカルズ, インコーポレイテッド | 質量を削減した長時間作用剤形 |
-
2010
- 2010-04-28 EP EP16150606.8A patent/EP3028707A1/en not_active Withdrawn
- 2010-04-28 JP JP2012508655A patent/JP2012525415A/ja active Pending
- 2010-04-28 EP EP16202643.9A patent/EP3165606A1/en not_active Withdrawn
- 2010-04-28 CA CA2760687A patent/CA2760687A1/en not_active Abandoned
- 2010-04-28 WO PCT/US2010/032816 patent/WO2010127029A1/en not_active Ceased
- 2010-04-28 EP EP10770279A patent/EP2432476A4/en not_active Withdrawn
- 2010-04-30 AR ARP100101483A patent/AR076523A1/es unknown
- 2010-04-30 TW TW103128351A patent/TWI528963B/zh not_active IP Right Cessation
- 2010-04-30 TW TW099113908A patent/TW201102071A/zh unknown
-
2011
- 2011-10-28 US US13/284,221 patent/US20120100136A1/en not_active Abandoned
-
2013
- 2013-08-09 US US13/963,872 patent/US20140179621A1/en not_active Abandoned
-
2015
- 2015-06-08 JP JP2015115569A patent/JP2015199749A/ja active Pending
- 2015-10-20 US US14/918,047 patent/US20160264969A1/en not_active Abandoned
-
2016
- 2016-12-20 JP JP2016246245A patent/JP2017081955A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582918B2 (en) * | 1995-06-07 | 2003-06-24 | Gilead Sciences, Inc. | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
| JP2007503451A (ja) * | 2003-08-27 | 2007-02-22 | (オーエスアイ)アイテツク・インコーポレーテツド | 眼血管新生疾患の治療のための併用療法 |
Non-Patent Citations (3)
| Title |
|---|
| JPN6014021404; MOLECULAR VISION VOL.14, 2008, P.37-49 * |
| JPN6014021405; GENE THERAPY VOL.16, 2009, P.10-16 * |
| JPN6014021407; BR.J.OPHTHALMOL. VOL.93, NO.2, 200902, P.144-149 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523956A (ja) * | 2013-07-11 | 2016-08-12 | ノバルティス アーゲー | 未熟児網膜症の治療におけるvegfアンタゴニストの使用 |
| RU2676274C2 (ru) * | 2013-07-11 | 2018-12-27 | Новартис Аг | Применение антагониста vegf при лечении хориоретинальных неоваскулярных нарушений и нарушений проницаемости у педиатрических пациентов |
| JP2016531901A (ja) * | 2013-07-12 | 2016-10-13 | オプソテック コーポレイションOphthotech Corporation | 眼科症状を処置するまたは予防するための方法 |
| US12016875B2 (en) | 2013-07-12 | 2024-06-25 | Iveric Bio, Inc. | Methods for treating or preventing ophthalmological conditions |
| US11273171B2 (en) | 2013-07-12 | 2022-03-15 | Iveric Bio, Inc. | Methods for treating or preventing ophthalmological conditions |
| JP2020079275A (ja) * | 2014-08-08 | 2020-05-28 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 |
| US10363255B2 (en) | 2014-08-08 | 2019-07-30 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
| US10765677B2 (en) | 2014-08-08 | 2020-09-08 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
| JP2017524034A (ja) * | 2014-08-08 | 2017-08-24 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 |
| US11414476B2 (en) | 2015-10-15 | 2022-08-16 | Alteogen, Inc. | Method for producing fusion protein having IgG Fc domain |
| WO2017065559A1 (ko) * | 2015-10-15 | 2017-04-20 | (주)알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
| WO2022154356A1 (ko) * | 2021-01-14 | 2022-07-21 | 국민대학교 산학협력단 | (7s)-(+)-시클로펜틸 카바믹산, 8,8-디메틸-2-옥소-6,7-디히드로-2h,8h-피라노[3,2-g]크로멘-7-일-에스테르를 유효성분으로 포함하는 안질환의 예방, 개선 또는 치료용 조성물 |
| US12558339B2 (en) | 2021-01-14 | 2026-02-24 | Inspharmtech Inc. | Composition comprising (7S)-(+)-cyclopentyl carbarmic acid, 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester as active ingredient for prevention, alleviation, or treatment of eye disease |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017081955A (ja) | 2017-05-18 |
| EP2432476A1 (en) | 2012-03-28 |
| EP3028707A1 (en) | 2016-06-08 |
| EP2432476A4 (en) | 2013-03-20 |
| TW201102071A (en) | 2011-01-16 |
| TW201521741A (zh) | 2015-06-16 |
| US20140179621A1 (en) | 2014-06-26 |
| EP3165606A1 (en) | 2017-05-10 |
| TWI528963B (zh) | 2016-04-11 |
| JP2015199749A (ja) | 2015-11-12 |
| US20160264969A1 (en) | 2016-09-15 |
| CA2760687A1 (en) | 2010-11-04 |
| US20120100136A1 (en) | 2012-04-26 |
| WO2010127029A1 (en) | 2010-11-04 |
| AR076523A1 (es) | 2011-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017081955A (ja) | 眼科疾患を処置または予防するための方法 | |
| JP7457068B2 (ja) | 眼科症状を処置するまたは予防するための方法 | |
| KR20150033620A (ko) | 항-pdgf 압타머 및 vegf 길항제를 포함하는 조성물 | |
| US20160038589A1 (en) | Methods for treating or preventing ophthalmological conditions | |
| HK1224931A1 (en) | Methods for treating or preventing ophthalmological diseases | |
| BR122024010134A2 (pt) | Uso de um agente anti-c5 para reduzir o crescimento de uma lesão de atrofia geográfica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130425 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130425 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140527 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140804 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140811 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20150210 |