AR076523A1 - Metodos para tratar o prevenir enfermedades oftalmologicas. composicion.compuesto - Google Patents

Metodos para tratar o prevenir enfermedades oftalmologicas. composicion.compuesto

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Publication number
AR076523A1
AR076523A1 ARP100101483A ARP100101483A AR076523A1 AR 076523 A1 AR076523 A1 AR 076523A1 AR P100101483 A ARP100101483 A AR P100101483A AR P100101483 A ARP100101483 A AR P100101483A AR 076523 A1 AR076523 A1 AR 076523A1
Authority
AR
Argentina
Prior art keywords
antibody
pharmaceutically acceptable
antagonist
compound
formula
Prior art date
Application number
ARP100101483A
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English (en)
Inventor
Harvey Masonson
Samir Patel
Original Assignee
Ophthotech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ophthotech Corp filed Critical Ophthotech Corp
Publication of AR076523A1 publication Critical patent/AR076523A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Abstract

Métodos y composiciones de utilidad para el tratamiento o la prevencion de una enfermedad oftalmologica, que comprende la administracion de una cantidad efectiva de un antagonista de PDGF y un antagonista de VEGF a un mamífero que lo necesita. Reivindicacion 1: Un método para tratar o prevenir una enfermedad oftalmologica, que comprende la administracion a un mamífero que lo necesita de una cantidad efectiva de: (a) antagonista A o una de sus sales farmacéuticamente aceptables; y (b) ranibizumab, bevacizumab, aflibercept, proteína de fusion del receptor Fc KH902 VEGF, anticuerpo 2C3, ORA102, pegaptanib, bevasiranib, SIRNA-027, decursina, decursinol, picropodofilina, guggulsterona, PLG101, eicosanoide LXA4, PTK787, pazopanib, axitinib, CDDO-Me, CDDO-Imm, shikonina, beta-hidroxiisovalerilshikonina o gangliosido GM3, anticuerpo DC101, anticuerpo Mab25, anticuerpo Mab73, anticuerpo 4A5, anticuerpo 4E10, anticuerpo 5F12, anticuerpo VA01, anticuerpo BL2, proteína relacionada con VEGF, sFLT01, sFLT02, péptido B3, TG100801, sorafenib o anticuerpo G6-31 o una de sus sales farmacéuticamente aceptables. Reivindicacion 6: El método de acuerdo con la reivindicacion 1, en donde la enfermedad oftalmologica es degeneracion macular relacionada con la edad, vasculopatía coroidal polipoidal, condicion asociada a neovascularizacion coroidal, retinopatía hipertensiva, retinopatía diabética, retinopatía de células falciformes, condicion asociada a neovascularizacion periférica de la retina, retinopatía de la premadurez, enfermedad oclusiva venosa, enfermedad oclusiva arterial, coriorretinopatía serosa central, edema macular cistoide, telangiectasia retiniana, macroaneurisma arterial, angiomatosis retiniana, retinopatía inducida por radiacion, rubeosis iridis o un neoplasma. Reivindicacion 36: El método de acuerdo con la reivindicacion 1, en donde (a) o (b) están presentes en un dispositivo de suministro de fármaco. Reivindicacion 89: El método de acuerdo con la reivindicacion 2, en donde el compuesto de la formula B es el antagonista B o una de sus sales farmacéuticamente aceptables. Reivindicacion 93: El método de acuerdo con la reivindicacion 3, en donde el compuesto de la formula C es el antagonista C o una de sus sales farmacéuticamente aceptables. Reivindicacion 100: Una composicion que comprende una cantidad efectiva de: (a) antagonista A, un compuesto de la formula B, un compuesto de la formula C, antagonista D, un compuesto de la formula E o una de sus sales farmacéuticamente aceptables; (b) ranibizumab, bevacizumab, aflibercept, proteína de fusion del receptor Fc KH902 VEGF, anticuerpo 2C3, ORA102, pegaptanib, bevasiranib, SIRNA-027, decursina, decursinol, picropodofilina, guggulsterona, PLG101, eicosanoide LXA4, PTK787, pazopanib, axitinib, CDDO-Me, CDDO-Imm, shikonina, beta-hidroxiisovalerilshikonina o gangliosido GM3, anticuerpo DC101, anticuerpo Mab25, anticuerpo Mab73, anticuerpo 4A5, anticuerpo 4E10, anticuerpo 5F12, anticuerpo VA01, anticuerpo BL2, proteína relacionada con VEGF, sFLT01, sFLT02, péptido B3, TG100801, sorafenib o anticuerpo G6-31; y (c) un portador o vehículo farmacéuticamente aceptable. Reivindicacion 132: Un compuesto de la formula E o una de sus sales farmacéuticamente aceptables. Reivindicacion 133: Una composicion que comprende: (a) una cantidad efectiva de un compuesto de la formula E o una de sus sales farmacéuticamente aceptables; y (b) un portador o vehículo farmacéuticamente aceptable. Reivindicacion 135: La composicion de acuerdo con la reivindicacion 133, en donde el compuesto es antagonista D.
ARP100101483A 2009-05-01 2010-04-30 Metodos para tratar o prevenir enfermedades oftalmologicas. composicion.compuesto AR076523A1 (es)

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Application Number Priority Date Filing Date Title
US17474609P 2009-05-01 2009-05-01
US17801009P 2009-05-13 2009-05-13
US24578409P 2009-09-25 2009-09-25

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AR076523A1 true AR076523A1 (es) 2011-06-15

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US (3) US20120100136A1 (es)
EP (3) EP2432476A4 (es)
JP (3) JP2012525415A (es)
AR (1) AR076523A1 (es)
CA (1) CA2760687A1 (es)
TW (2) TWI528963B (es)
WO (1) WO2010127029A1 (es)

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