MX2019001021A - Formulaciones de liposomas. - Google Patents

Formulaciones de liposomas.

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Publication number
MX2019001021A
MX2019001021A MX2019001021A MX2019001021A MX2019001021A MX 2019001021 A MX2019001021 A MX 2019001021A MX 2019001021 A MX2019001021 A MX 2019001021A MX 2019001021 A MX2019001021 A MX 2019001021A MX 2019001021 A MX2019001021 A MX 2019001021A
Authority
MX
Mexico
Prior art keywords
formulations
disorders
liposome formulations
angiogenic
ranibizumab
Prior art date
Application number
MX2019001021A
Other languages
English (en)
Inventor
Arturo Santos
Phillip Frost
Original Assignee
Opko Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50150466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019001021(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Pharmaceuticals Llc filed Critical Opko Pharmaceuticals Llc
Publication of MX2019001021A publication Critical patent/MX2019001021A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K2039/55511—Organic adjuvants
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)

Abstract

La presente invención se refiere a formulaciones farmacéuticas que comprenden un compuesto antiangiogénico tal como un anticuerpo monoclonal o fragmento del mismo seleccionado de por ejemplo, ranibizumab, que es un aglutinante del factor de crecimiento endotelial vascular que inhibe la acción de VEGF, y un agente de suministro seleccionado de un liposoma farmacéuticamente aceptable. Las formulaciones son útiles en el tratamiento de una variedad de trastornos y enfermedades angiogénicos en animales y personas, y preferentemente, en trastornos oftálmicos seleccionados de degeneración macular relacionada con la edad, edema macular diabético y neovascularización corneal.
MX2019001021A 2012-08-21 2015-02-19 Formulaciones de liposomas. MX2019001021A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261691455P 2012-08-21 2012-08-21
US201361791693P 2013-03-15 2013-03-15
US201361862300P 2013-08-05 2013-08-05

Publications (1)

Publication Number Publication Date
MX2019001021A true MX2019001021A (es) 2021-11-16

Family

ID=50150466

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015002233A MX363822B (es) 2012-08-21 2013-08-15 Formulaciones de liposomas.
MX2019001021A MX2019001021A (es) 2012-08-21 2015-02-19 Formulaciones de liposomas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015002233A MX363822B (es) 2012-08-21 2013-08-15 Formulaciones de liposomas.

Country Status (16)

Country Link
US (2) US10548841B2 (es)
EP (1) EP2887958B1 (es)
JP (3) JP6336448B2 (es)
KR (2) KR102177437B1 (es)
CN (1) CN104582728A (es)
AR (1) AR092372A1 (es)
BR (1) BR112015003658B1 (es)
CA (2) CA3098856C (es)
CL (1) CL2015000418A1 (es)
ES (1) ES2881671T3 (es)
HU (1) HUE058912T2 (es)
MX (2) MX363822B (es)
PL (1) PL2887958T3 (es)
RU (1) RU2680096C2 (es)
TW (2) TWI683675B (es)
WO (1) WO2014031429A2 (es)

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TW201720446A (zh) * 2015-11-13 2017-06-16 Ｏｈｒ製藥公司 非典型脈絡膜新生血管（ｃｎｖ）之大小做為以角鯊胺治療之預測子
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EP3968949A1 (en) 2019-05-16 2022-03-23 OPKO Pharmaceuticals, LLC Triamcinolone acetonide-loaded liposomes topical ophthalmic formulations for prevention of macular thickening and its associated visual outcomes after lens surgery
CN113546172A (zh) * 2020-04-24 2021-10-26 山东大学齐鲁医院 Vegf抑制剂在制备治疗缺氧相关疾病药物中的应用
EP4164593A1 (en) * 2020-06-15 2023-04-19 OPKO Pharmaceuticals, LLC Triamcinolone acetonide-loaded liposomes topical ophthalmic formulations as primary therapy for macular edema secondary to branch retinal vein occlusion
CN116585304B (zh) * 2023-04-25 2024-04-05 四川大学华西医院 一种急性肝损伤保护药物及其制备方法

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Publication number Publication date
US20200163877A1 (en) 2020-05-28
BR112015003658A2 (pt) 2017-07-04
CA3098856C (en) 2023-10-17
ES2881671T3 (es) 2021-11-30
TWI608848B (zh) 2017-12-21
US10548841B2 (en) 2020-02-04
HUE058912T2 (hu) 2022-09-28
CA3098856A1 (en) 2014-02-27
WO2014031429A2 (en) 2014-02-27
JP2020111589A (ja) 2020-07-27
MX363822B (es) 2019-04-04
KR20150042215A (ko) 2015-04-20
JP6336448B2 (ja) 2018-06-06
AR092372A1 (es) 2015-04-15
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JP2018150329A (ja) 2018-09-27
TW201642838A (zh) 2016-12-16
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US20150224055A1 (en) 2015-08-13
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TW201412346A (zh) 2014-04-01
JP2015526467A (ja) 2015-09-10
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RU2015107317A (ru) 2016-10-10
US11712419B2 (en) 2023-08-01
PL2887958T3 (pl) 2021-11-22
CL2015000418A1 (es) 2015-07-10
RU2680096C2 (ru) 2019-02-15
WO2014031429A3 (en) 2014-04-24
CA2879597A1 (en) 2014-02-27
EP2887958A4 (en) 2016-01-20
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CN104582728A (zh) 2015-04-29
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EP2887958A2 (en) 2015-07-01

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