JP2012524724A5 - - Google Patents

Download PDF

Info

Publication number
JP2012524724A5
JP2012524724A5 JP2012506290A JP2012506290A JP2012524724A5 JP 2012524724 A5 JP2012524724 A5 JP 2012524724A5 JP 2012506290 A JP2012506290 A JP 2012506290A JP 2012506290 A JP2012506290 A JP 2012506290A JP 2012524724 A5 JP2012524724 A5 JP 2012524724A5
Authority
JP
Japan
Prior art keywords
indomethacin
povidone
formulation
separately
nano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012506290A
Other languages
English (en)
Other versions
JP6027890B2 (ja
JP2012524724A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/AU2010/000472 external-priority patent/WO2010121328A1/en
Publication of JP2012524724A publication Critical patent/JP2012524724A/ja
Publication of JP2012524724A5 publication Critical patent/JP2012524724A5/ja
Application granted granted Critical
Publication of JP6027890B2 publication Critical patent/JP6027890B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Description

実施例１３：インドメタシンナノ製剤カプセルの製造
実施例１３（ａ）：２０ｍｇ
インドメタシン粉砕粉末（７５０．０ｇ、実施例９、サンプルＴ）を、ＫＧ−５高剪断造粒機のボウルに装入した。別途、４７．８ｇのポビドンを１１１．６ｇの純水に溶解させることにより、ポビドンＫ３０の３０％純水溶液を調製した。
実施例１３（ｂ）：４０ｍｇ
２つの顆粒サブロットを別々に製造し、合わせて、インドメタシンナノ製剤カプセル（４０ｍｇ）を作製した。
JP2012506290A 2009-04-24 2010-04-23 インドメタシンの新規製剤 Expired - Fee Related JP6027890B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17229509P 2009-04-24 2009-04-24
US61/172,295 2009-04-24
AU2009901745A AU2009901745A0 (en) 2009-04-24 A Novel Formulation of Indomethacin
AU2009901745 2009-04-24
PCT/AU2010/000472 WO2010121328A1 (en) 2009-04-24 2010-04-23 A novel formulation of indomethacin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014227872A Division JP6043329B2 (ja) 2009-04-24 2014-11-10 インドメタシンの新規製剤

Publications (3)

Publication Number Publication Date
JP2012524724A JP2012524724A (ja) 2012-10-18
JP2012524724A5 true JP2012524724A5 (ja) 2014-12-25
JP6027890B2 JP6027890B2 (ja) 2016-11-16

Family

ID=43010611

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012506290A Expired - Fee Related JP6027890B2 (ja) 2009-04-24 2010-04-23 インドメタシンの新規製剤
JP2014227872A Expired - Fee Related JP6043329B2 (ja) 2009-04-24 2014-11-10 インドメタシンの新規製剤
JP2016177675A Expired - Fee Related JP6239709B2 (ja) 2009-04-24 2016-09-12 インドメタシンの新規製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014227872A Expired - Fee Related JP6043329B2 (ja) 2009-04-24 2014-11-10 インドメタシンの新規製剤
JP2016177675A Expired - Fee Related JP6239709B2 (ja) 2009-04-24 2016-09-12 インドメタシンの新規製剤

Country Status (22)

Country Link
US (8) US20120135048A1 (ja)
EP (1) EP2421513B1 (ja)
JP (3) JP6027890B2 (ja)
KR (3) KR101743847B1 (ja)
CN (2) CN103932988A (ja)
AP (2) AP3628A (ja)
AU (1) AU2010239081C1 (ja)
BR (1) BRPI1014275B8 (ja)
CA (1) CA2759125C (ja)
CO (1) CO6470807A2 (ja)
DK (1) DK2421513T3 (ja)
EA (1) EA201171286A1 (ja)
IL (2) IL215872A (ja)
MA (1) MA33296B1 (ja)
MX (1) MX351930B (ja)
MY (1) MY159208A (ja)
NZ (3) NZ595986A (ja)
SG (2) SG10201401695VA (ja)
TN (1) TN2011000544A1 (ja)
UA (1) UA106231C2 (ja)
WO (1) WO2010121328A1 (ja)
ZA (1) ZA201108646B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008000042A1 (en) 2006-06-30 2008-01-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
EA201171281A1 (ru) * 2009-04-24 2012-05-30 Айсьютика Пти Лтд. Производство инкапсулированных наночастиц в коммерческих масшатабах
NZ595986A (en) * 2009-04-24 2014-04-30 Iceutica Pty Ltd A novel formulation of indomethacin
EP2421516A4 (en) * 2009-04-24 2012-11-07 Iceutica Pty Ltd METHOD FOR ENHANCING THE DISSOLUTION PROFILE OF A BIOLOGICALLY ACTIVE MATERIAL
EP2608878A4 (en) 2010-08-23 2017-11-15 President and Fellows of Harvard College Acoustic waves in microfluidics
JP2013538212A (ja) * 2010-08-23 2013-10-10 プレジデント アンド フェロウズ オブ ハーバード カレッジ 薬物送達および他の用途のための粒子
JP5909796B2 (ja) * 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
CA2907415C (en) * 2013-03-15 2022-04-05 Iceutica Inc. Abiraterone acetate formulation
US20150246060A1 (en) 2013-03-15 2015-09-03 Iceutica Inc. Abiraterone Acetate Formulation and Methods of Use
US20150157646A1 (en) 2013-09-27 2015-06-11 Iceutica Inc. Abiraterone Steroid Formulation
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
US10258987B2 (en) 2014-06-26 2019-04-16 President And Fellows Of Harvard College Fluid infection using acoustic waves
JP6657379B2 (ja) 2015-08-27 2020-03-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 弾性波による分離
CN108697700B (zh) 2016-02-04 2021-08-17 辛多美制药有限公司 氘代多潘立酮组合物和用于治疗病症的方法
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation
US11197830B2 (en) 2019-02-27 2021-12-14 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetaminophen and ibuprofen
US11701658B2 (en) 2019-08-09 2023-07-18 President And Fellows Of Harvard College Systems and methods for microfluidic particle selection, encapsulation, and injection using surface acoustic waves
TR202017034A2 (tr) * 2020-10-26 2021-09-21 Hacettepe Ueniversitesi Rektoerluek Kuru öğütme yöntemi̇ i̇le hazirlanan ve çözünme hizi arttirilmiş selekoksi̇b i̇çeren farmasöti̇k kompozi̇syonlar

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3172546A (en) 1961-05-19 1965-03-09 Union Carbide Corp Size reduction of biological substances
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4200631A (en) * 1975-12-17 1980-04-29 Richter Gedeon Vegyeszeti Gyar Rt. Treating mammalian subject sensitive to indomethacin ulcerogenisis
IT1082518B (it) 1977-01-25 1985-05-21 Fiat Spa Specchio a cristallo liquido da impiegare particolarmente come retrovisore per veicoli
NL175882C (nl) * 1977-03-28 Procter & Gamble Farmaceutisch preparaat, dat een verbinding met ontstekingtegengaande werking bevat.
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
DE3312671A1 (de) 1983-04-08 1984-10-11 Heinz Finzer KG, 7880 Bad Säckingen Stanz- und biegewerkzeug-aggregat
GB8403359D0 (en) * 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical compositions
US4851228A (en) * 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
IT1227626B (it) 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
JP2642486B2 (ja) 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU660852B2 (en) 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
US5298262A (en) 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5336507A (en) 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
ZA951497B (en) 1994-03-02 1996-08-23 Lilly Co Eli Orally administerable pharmaceutical formulations
US5478705A (en) 1994-05-25 1995-12-26 Eastman Kodak Company Milling a compound useful in imaging elements using polymeric milling media
US5500331A (en) 1994-05-25 1996-03-19 Eastman Kodak Company Comminution with small particle milling media
US5631369A (en) 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5534270A (en) 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5591456A (en) 1995-02-10 1997-01-07 Nanosystems L.L.C. Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
TW487582B (en) 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US6458811B1 (en) 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
US6713494B1 (en) 1996-08-28 2004-03-30 Eli Lilly And Company Amorphous benzothiophenes, methods of preparation and methods of use
WO1998035666A1 (en) 1997-02-13 1998-08-20 Nanosystems Llc Formulations of nanoparticle naproxen tablets
JP4117811B2 (ja) * 1997-04-22 2008-07-16 日本化薬株式会社 フルタミド製剤及びその製法
ZA987800B (en) 1997-08-27 1999-06-09 Hexal Ag Pharmaceutical composition of meloxicam
JPH11130698A (ja) * 1997-10-31 1999-05-18 Freunt Ind Co Ltd アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法
US6165506A (en) 1998-09-04 2000-12-26 Elan Pharma International Ltd. Solid dose form of nanoparticulate naproxen
JP2000095674A (ja) 1998-09-22 2000-04-04 Sato Pharmaceutical Co Ltd 口腔内崩壊時間短縮化錠剤の製造方法及び装置
US8293277B2 (en) 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
US20040013613A1 (en) 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6428814B1 (en) 1999-10-08 2002-08-06 Elan Pharma International Ltd. Bioadhesive nanoparticulate compositions having cationic surface stabilizers
EP1066825A1 (en) 1999-06-17 2001-01-10 The Procter & Gamble Company An anti-microbial body care product
DE19932157A1 (de) 1999-07-13 2001-01-18 Pharmasol Gmbh Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
CN100551358C (zh) 2000-06-27 2009-10-21 维克多瑞有限公司 用于药物组合物的颗粒的制备方法
ES2325057T3 (es) 2000-08-31 2009-08-25 Jagotec Ag Particulas molturadas.
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
EP1341521B1 (en) 2000-11-20 2009-01-07 Elan Pharma International Limited Nanoparticulate compositions comprising a drug and copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers
DK1337240T4 (en) 2000-11-30 2015-01-05 Vectura Ltd A process for the preparation of particles for use in a pharmaceutical composition
WO2002045684A2 (en) 2000-12-06 2002-06-13 Pharmacia Corporation Rapidly dispersing pharmaceutical composition comprising effervescent agents
FI20010115A0 (fi) 2001-01-18 2001-01-18 Orion Corp Menetelmä nanopartikkelien valmistamiseksi
EP1401401B1 (en) 2001-06-22 2005-03-30 Marie Lindner Method for high through put screening using a small scale mill or microfluidics
JP2003066613A (ja) 2001-08-22 2003-03-05 Columbia Music Entertainment Inc スタンパの製造方法
WO2003030872A2 (en) 2001-10-12 2003-04-17 Elan Pharma International Ltd. Compositions having a combination of particles for immediate release and for controlled release
US7714006B1 (en) 2001-12-03 2010-05-11 King Pharmaceuticals Research & Development, Inc. Methods of modifying the bioavailability of metaxalone
US6407128B1 (en) 2001-12-03 2002-06-18 Elan Pharmaceuticals, Inc. Method for increasing the bioavailability of metaxalone
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US6825161B2 (en) 2002-04-26 2004-11-30 Salvona Llc Multi component controlled delivery system for soap bars
WO2004019937A1 (en) 2002-09-02 2004-03-11 Sun Pharmaceutical Industries Limited Pharmaceutical composition of metaxalone with enhanced oral bioavailability
JP2004099442A (ja) * 2002-09-04 2004-04-02 Nisshin Pharma Inc 難溶性薬物含有製剤およびその製造方法
CA2499819A1 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
AU2003297151A1 (en) 2002-12-17 2004-07-22 Elan Pharma International Ltd. Milling microgram quantities of nanoparticulate candidate compounds
US20040121003A1 (en) 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US20050163839A1 (en) 2003-01-29 2005-07-28 Sun Pharmaceutical Industries Limited Oral controlled release pharmaceutical composition containing metaxalone as active agent
US8512727B2 (en) 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
US7749533B2 (en) * 2003-05-07 2010-07-06 Akina, Inc. Highly plastic granules for making fast melting tablets
AU2003304242A1 (en) * 2003-06-27 2005-01-13 Bioprogress S.P.A. Composite product obtainable by cogrinding of a active principle with a copolymer n-vinyl-2-pyrrolidone/vinyl-acetate
US20050042177A1 (en) 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
CA2534924A1 (en) 2003-08-08 2005-02-24 Elan Pharma International Ltd. Novel metaxalone compositions
WO2005020933A2 (en) 2003-09-02 2005-03-10 University Of South Florida Nanoparticles for drug-delivery
WO2005032703A1 (fr) 2003-10-01 2005-04-14 Debio Recherche Pharmaceutique S.A. Dispositif et procede pour la fabrication de particules
EP1686962B9 (en) 2003-11-05 2012-10-03 Elan Pharma International Limited Nanoparticulate compositions having a peptide as a surface stabilizer
ES2430849T3 (es) 2004-03-08 2013-11-22 Spiridon Spireas Formas de dosificación sólidas biodisponibles de metaxalona
CN101005828B (zh) 2004-06-17 2012-01-11 维尔恩公司 用于经粘膜递送活性成分的包含粘膜粘附蛋白和所述活性物质的组合物
WO2006009419A1 (es) 2004-07-19 2006-01-26 Luis Cordova Boone Neumáticos con doble banda de rodamiento
KR20060024927A (ko) 2004-09-15 2006-03-20 씨제이 주식회사 기계적 분쇄법에 의한 미크론 사이즈 인삼 분말의제조방법
WO2006041843A2 (en) 2004-10-04 2006-04-20 Dr. Reddy's Laboratories Ltd. Pharmaceutical dosage form comprising meloxicam
CA2582767C (en) * 2004-10-25 2011-05-24 Japan Tobacco Inc. Solid formulation with improved solubility and stability and method for producing said formulation
CA2598204C (en) 2004-11-09 2015-01-13 Board Of Regents, The University Of Texas System Stabilized hme composition with small drug particles
UA89513C2 (uk) 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Стабільна композиція з наночастинок ралоксифену гідрохлориду
US20090028948A1 (en) 2004-12-31 2009-01-29 Iceutica Pty Ltd Nanoparticle composition and methods of synthesis thereof
MX2007014163A (es) 2005-05-10 2008-01-24 Elan Pharma Int Ltd Formulaciones de nanoparticulas de clopidogrel.
JO3352B1 (ar) 2005-06-17 2019-03-13 Apr Applied Pharma Res Sa صيغ دايكلوفيناك وطرق استخدامه
US20080292584A1 (en) 2005-10-14 2008-11-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
PT1973527E (pt) 2005-12-15 2010-01-04 Acusphere Inc Processos de produção de formulações farmacêuticas à base de partículas destinadas a administração parentérica
WO2007070851A2 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
JP2009519970A (ja) * 2005-12-15 2009-05-21 アキュスフィア， インコーポレイテッド 粒子ベースの経口投与用製薬剤形の製造方法
WO2007074477A2 (en) 2005-12-29 2007-07-05 Dabur Pharma Limited Metaxalone polymorphs
JP5543200B2 (ja) 2006-04-28 2014-07-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）−フェノール及びｎｓａｉｄ含む医薬の組合せ
US8420122B2 (en) 2006-04-28 2013-04-16 Merck Sharp & Dohme Corp. Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
AU2007260822B2 (en) 2006-06-23 2012-07-05 Alkermes Pharma Ireland Limited Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone
WO2008000042A1 (en) * 2006-06-30 2008-01-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
TWI645862B (zh) 2006-06-30 2019-01-01 艾修提卡股份有限公司 包含奈米微粒形式生物活性化合物之劑型形式
CN100386312C (zh) 2006-07-18 2008-05-07 上海世景国际贸易有限公司 2，4-二氨基苯磺酸及其盐的合成方法
US20100003332A1 (en) 2006-07-27 2010-01-07 Amorepacific Corporation Process For Preparing Powder Comprising Nanoparticles of Sparingly Soluble Drug
GB0625322D0 (en) * 2006-12-19 2007-01-24 Pharmakodex Ltd Pharmaceutical compositions
AR065802A1 (es) 2007-03-22 2009-07-01 Schering Corp Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas
TWI405590B (zh) * 2007-04-06 2013-08-21 Activus Pharma Co Ltd 微粉碎化有機化合物粒子之製法
AR067997A1 (es) 2007-08-24 2009-10-28 Novartis Ag Compuestos organicos
US8568696B2 (en) 2008-08-06 2013-10-29 Indiana Nanotech Llc Grinding method for the manipulation or preservation of calcium phosphate hybrid properties
EA201171281A1 (ru) 2009-04-24 2012-05-30 Айсьютика Пти Лтд. Производство инкапсулированных наночастиц в коммерческих масшатабах
EP2421516A4 (en) 2009-04-24 2012-11-07 Iceutica Pty Ltd METHOD FOR ENHANCING THE DISSOLUTION PROFILE OF A BIOLOGICALLY ACTIVE MATERIAL
NZ595986A (en) 2009-04-24 2014-04-30 Iceutica Pty Ltd A novel formulation of indomethacin
NZ595902A (en) 2009-04-24 2014-10-31 Iceutica Pty Ltd Method for the production of commercial nanoparticle and microparticle powders
JP6116244B2 (ja) 2009-04-24 2017-04-19 イシューティカ ピーティーワイ リミテッド ナプロキセンの新規製剤
WO2010121324A1 (en) 2009-04-24 2010-10-28 Iceutica Pty Ltd A novel formulation of metaxalone
AP3138A (en) 2009-04-24 2015-02-28 Iceutica Pty Ltd Production of encapsulated nanoparticles at high volume fractions
CN106420667A (zh) 2009-04-24 2017-02-22 伊休蒂卡有限公司 双氯芬酸的新剂型
NZ722319A (en) 2009-04-24 2018-01-26 Iceutica Pty Ltd A novel formulation of meloxicam
JP2011005735A (ja) 2009-06-25 2011-01-13 Olympus Corp 画像記録装置及び画像記録装置の初期化制御方法

Similar Documents

Publication Publication Date Title
JP2012524724A5 (ja)
JP2012255026A5 (ja)
JP2012158592A5 (ja)
EA201300053A1 (ru) Фосфатсвязывающий препарат для удобного приема
EP2477608A4 (en) SOLID ORAL DOSAGE FORM CONTAINING NANOPARTICLES AND PROCESS FOR FORMULATING THE SAME WITH FISH GELATIN
NZ759512A (en) Delayed release compositions of linaclotide
JP2016539953A5 (ja)
WO2011073245A3 (en) Granules for pharmaceutical preparations, methods and apparatus for their production
IL295418B1 (en) Beta-d-2'-deoxy-2' alpha-fluoro-2'-bata-c-modified-2-different-n6-purine modified nucleotides for the treatment of hepatitis c virus
PH12015500823A1 (en) Modified release formulations for oprozomib
MY139086A (en) Use of debranched starch in extrusion-spheronization pharmaceutical pellets
AR067077A1 (es) Preparado solido farmaceutico y metodo de produccion del mismo
WO2011009938A3 (en) Stambomycin and derivatives, their production and their use as drugs
NZ597317A (en) Solid pharmaceutical fixed dose compositions comprising irbesartan and amlodipine, their preparation and their therapeutic application
WO2011037976A3 (en) Pramipexole pharmaceutical formulations
JP2017528473A5 (ja)
HRP20161349T1 (hr) 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]piramidin-2-il]-1,7-diazaspiro[4.4]nonan-6-on
JP2006342148A5 (ja)
WO2009084041A3 (en) Pharmaceutical compositions of dexibuprofen
WO2014144407A8 (en) Dual use oral pharmaceutical composition tablets of sulfate salts and methods of use thereof
JP2011516544A5 (ja)
Jaya et al. Effect of binders on the dissolution rate and dissolution efficiency of ritonavir tablets
WO2009000473A3 (en) Effervescent tablets for inhalatory use
JP2008280345A5 (ja)
JP2016501225A5 (ja)