JP2012518988A5 - - Google Patents
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- JP2012518988A5 JP2012518988A5 JP2011536662A JP2011536662A JP2012518988A5 JP 2012518988 A5 JP2012518988 A5 JP 2012518988A5 JP 2011536662 A JP2011536662 A JP 2011536662A JP 2011536662 A JP2011536662 A JP 2011536662A JP 2012518988 A5 JP2012518988 A5 JP 2012518988A5
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- 210000004027 cell Anatomy 0.000 claims 17
- 210000001082 somatic cell Anatomy 0.000 claims 15
- 239000000126 substance Substances 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 102100033575 Doublesex- and mab-3-related transcription factor B1 Human genes 0.000 claims 9
- 101000871973 Homo sapiens Doublesex- and mab-3-related transcription factor B1 Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 241000131390 Glis Species 0.000 claims 6
- 239000000463 material Substances 0.000 claims 6
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 5
- 101150086694 SLC22A3 gene Proteins 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 101000857270 Homo sapiens Zinc finger protein GLIS1 Proteins 0.000 claims 4
- 102100023527 Iroquois-class homeodomain protein IRX-6 Human genes 0.000 claims 4
- 101710136138 Iroquois-class homeodomain protein IRX-6 Proteins 0.000 claims 4
- 102100036090 Pituitary homeobox 2 Human genes 0.000 claims 4
- 102100025883 Zinc finger protein GLIS1 Human genes 0.000 claims 4
- 101000595669 Homo sapiens Pituitary homeobox 2 Proteins 0.000 claims 3
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 3
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 3
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 3
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 3
- 108091057508 Myc family Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000000411 inducer Substances 0.000 claims 2
- 101100257372 Caenorhabditis elegans sox-3 gene Proteins 0.000 claims 1
- 101100310657 Mus musculus Sox1 gene Proteins 0.000 claims 1
- 101100310648 Mus musculus Sox17 gene Proteins 0.000 claims 1
- 101100310650 Mus musculus Sox18 gene Proteins 0.000 claims 1
- 101100257376 Mus musculus Sox3 gene Proteins 0.000 claims 1
- 101100043062 Mus musculus Sox7 gene Proteins 0.000 claims 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 claims 1
- 102100030124 N-myc proto-oncogene protein Human genes 0.000 claims 1
- 101710106040 Pituitary homeobox 2 Proteins 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 238000011419 induction treatment Methods 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20885309P | 2009-02-27 | 2009-02-27 | |
| US61/208,853 | 2009-02-27 | ||
| US27612309P | 2009-09-08 | 2009-09-08 | |
| US61/276,123 | 2009-09-08 | ||
| PCT/JP2010/053024 WO2010098419A1 (en) | 2009-02-27 | 2010-02-19 | Novel nuclear reprogramming substance |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518988A JP2012518988A (ja) | 2012-08-23 |
| JP2012518988A5 true JP2012518988A5 (https=) | 2013-02-21 |
| JP5553289B2 JP5553289B2 (ja) | 2014-07-16 |
Family
ID=42665623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536662A Active JP5553289B2 (ja) | 2009-02-27 | 2010-02-19 | 新規核初期化物質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8951801B2 (https=) |
| EP (2) | EP2401372A4 (https=) |
| JP (1) | JP5553289B2 (https=) |
| KR (1) | KR101764100B1 (https=) |
| CN (1) | CN102388136B (https=) |
| CA (1) | CA2753845C (https=) |
| IL (1) | IL214833A (https=) |
| SG (1) | SG173876A1 (https=) |
| WO (1) | WO2010098419A1 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010098419A1 (en) | 2009-02-27 | 2010-09-02 | Kyoto University | Novel nuclear reprogramming substance |
| CA2789749C (en) | 2010-02-16 | 2018-09-04 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US9506039B2 (en) | 2010-12-03 | 2016-11-29 | Kyoto University | Efficient method for establishing induced pluripotent stem cells |
| WO2012074106A1 (ja) | 2010-12-03 | 2012-06-07 | 国立大学法人京都大学 | 多能性幹細胞からの好酸球の製造方法 |
| WO2012137970A1 (ja) | 2011-04-08 | 2012-10-11 | 国立大学法人大阪大学 | 改変ラミニンおよびその利用 |
| WO2012141181A1 (ja) * | 2011-04-11 | 2012-10-18 | 国立大学法人京都大学 | 核初期化物質 |
| KR101334404B1 (ko) * | 2011-04-28 | 2013-12-12 | 포항공과대학교 산학협력단 | 배아줄기세포 유래의 인공 마이크로베시클을 이용한 역분화 유도만능줄기세포의 제조방법 |
| CN107988381B (zh) | 2011-07-25 | 2021-05-28 | 国立大学法人京都大学 | 筛选诱导的多能干细胞的方法 |
| WO2013058403A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
| JP5999658B2 (ja) | 2011-11-25 | 2016-09-28 | 国立大学法人京都大学 | 多能性幹細胞の培養方法 |
| PL2852671T3 (pl) | 2012-05-21 | 2019-06-28 | The Regents Of The University Of California | Wytwarzanie ludzkich komórek ips z użyciem syntetycznego samoreplikującego się rna |
| JP6495658B2 (ja) | 2013-02-08 | 2019-04-03 | 国立大学法人京都大学 | 巨核球及び血小板の製造方法 |
| US9738861B2 (en) | 2013-03-06 | 2017-08-22 | Kyoto University | Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells |
| JP6473077B2 (ja) | 2013-03-21 | 2019-02-20 | 国立大学法人京都大学 | 神経分化誘導用の多能性幹細胞 |
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| KR102145967B1 (ko) | 2013-06-11 | 2020-08-19 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 신장 전구세포의 제조 방법 및 신장 전구세포를 포함하는 의약 |
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| US10100283B2 (en) | 2013-11-01 | 2018-10-16 | Kyoto University | Efficient chondrocyte induction method |
| EP3170901B1 (en) | 2014-07-14 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Method for producing dendritic cells from stem cells |
| JP6715482B2 (ja) | 2014-07-18 | 2020-07-01 | 国立大学法人京都大学 | 多能性幹細胞から免疫細胞療法用ｔ細胞を誘導する方法 |
| US10711249B2 (en) | 2014-12-26 | 2020-07-14 | Kyoto University | Method for inducing hepatocytes |
| JP2016202172A (ja) | 2015-04-16 | 2016-12-08 | 国立大学法人京都大学 | 疑似膵島の製造方法 |
| EP3356520B1 (en) | 2015-10-02 | 2022-03-23 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentiviral protein delivery system for rna-guided genome editing |
| LT3444334T (lt) | 2016-04-15 | 2021-12-10 | Kyoto University | Antigenui specifinių cd8 teigiamų t ląstelių indikavimo būdas |
| JP7011260B2 (ja) | 2016-04-22 | 2022-02-10 | 国立大学法人京都大学 | ドーパミン産生神経前駆細胞の製造方法 |
| KR102537361B1 (ko) | 2016-12-27 | 2023-05-26 | 스미또모 가가꾸 가부시키가이샤 | 인공 다능성 줄기 세포의 평가 방법 및 선발 방법, 그리고 인공 다능성 줄기 세포의 제조 방법 |
| CN110199017A (zh) | 2017-01-20 | 2019-09-03 | 国立大学法人京都大学 | CD8α+β+细胞毒性T细胞的制备方法 |
| JP7162537B2 (ja) | 2017-01-26 | 2022-10-28 | 国立大学法人大阪大学 | 幹細胞の中胚葉系細胞への分化誘導用培地および中胚葉系細胞の製造方法 |
| JP7171055B2 (ja) | 2017-03-14 | 2022-11-15 | 国立大学法人京都大学 | 多能性幹細胞からヘルパーｔ細胞を製造する方法 |
| EP3633026A4 (en) | 2017-05-25 | 2021-03-10 | Kyoto University | METHOD FOR INDUCING THE DIFFERENTIATION OF A MESODERMAL INTERMEDIATE CELL TO A KIDNEY PRECURSOR CELL AND METHOD FOR INDUCING THE DIFFERENTIATION OF A PLURIPOTENT STEM CELL FROM A KIDNEY PRECURSOR CELL |
| US20200172969A1 (en) | 2017-06-19 | 2020-06-04 | Foundation For Biomedical Research And Innovation At Kobe | Method for predicting differentiation ability of pluripotent stem cell, and reagent for same |
| EP3699267A4 (en) | 2017-10-17 | 2021-10-27 | Kyoto University | PROCESS FOR OBTAINING AN ARTIFICIAL NEUROMUSCULAR JUNCTION FROM PLURIPOTENT STEM CELLS |
| TW202020145A (zh) | 2018-07-13 | 2020-06-01 | 國立大學法人京都大學 | γδＴ細胞的製造方法 |
| US20210299331A1 (en) | 2018-07-19 | 2021-09-30 | Kyoto University | Pluripotent stem cell-derived plate-shaped cartilage and method for producing the same |
| JP7357369B2 (ja) | 2018-07-23 | 2023-10-06 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| CN113195710A (zh) | 2018-12-06 | 2021-07-30 | 麒麟控股株式会社 | T细胞或nk细胞的制造方法、t细胞或nk细胞的培养用培养基、t细胞或nk细胞的培养方法、维持未分化t细胞的未分化状态的方法和t细胞或nk细胞的增殖促进剂 |
| WO2020130147A1 (ja) | 2018-12-21 | 2020-06-25 | 国立大学法人京都大学 | ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物 |
| WO2020138371A1 (ja) | 2018-12-26 | 2020-07-02 | キリンホールディングス株式会社 | 改変ｔｃｒ及びその製造方法 |
| JP7692610B2 (ja) | 2019-02-26 | 2025-06-16 | 国立大学法人東北大学 | ｉＰＳ細胞を用いた骨芽細胞塊の作製法 |
| EP3970795A4 (en) | 2019-05-15 | 2023-06-14 | Ajinomoto Co., Inc. | Method for purifying neural crest cells or corneal epithelial cells |
| JPWO2020235319A1 (https=) | 2019-05-20 | 2020-11-26 | ||
| JP7058431B2 (ja) | 2019-12-12 | 2022-04-22 | 国立大学法人千葉大学 | 巨核球および血小板を含む凍結乾燥製剤 |
| US12351824B2 (en) | 2020-02-28 | 2025-07-08 | Takeda Pharmaceutical Company Limited | Method for producing natural killer cells from pluripotent stem cells |
| US20230257705A1 (en) | 2020-06-17 | 2023-08-17 | Kyoto University | Chimeric antigen receptor-expressing immunocompetent cells |
| US20230256024A1 (en) | 2020-07-13 | 2023-08-17 | Kyoto University | Skeletal muscle precursor cells and method for purifying same, composition for treating myogenic diseases, and method for producing cell group containing skeletal muscle precursor cells |
| EP4180514A4 (en) | 2020-07-20 | 2024-09-04 | Aichi Medical University | COMPOSITION FOR UNDIFFERENTIATED MAINTENANCE CULTURE OF PLURIPOTENT CELLS, MEDIUM FOR UNDIFFERENTIATED MAINTENANCE CULTURE OF PLURIPOTENT CELLS, METHOD FOR MAINTENANCE CULTURE IN UNDIFFERENTIATED STATE OF PLURIPOTENT CELLS, AND METHOD FOR PRODUCING PLURIPOTENT CELLS |
| US20240271088A1 (en) | 2020-08-18 | 2024-08-15 | Kyoto University | Method for maintaining and amplifying human primordial germ cells / human primordial germ cell-like cells |
| EP4310176A4 (en) | 2021-03-17 | 2025-03-26 | Astellas Pharma Inc. | Pericyte with basic fibroblast growth factor (BFGF) gene inserted into it |
| KR20230159550A (ko) | 2021-03-25 | 2023-11-21 | 블루록 테라퓨틱스 엘피 | 유도 만능 줄기 세포 수득 방법 |
| CN117597433A (zh) | 2021-04-30 | 2024-02-23 | 国立研究开发法人理化学研究所 | 视网膜色素上皮细胞的条状聚集体、用于制造其的装置和制造方法、以及含有该条状聚集体的治疗药物 |
| WO2022255489A1 (ja) | 2021-06-04 | 2022-12-08 | キリンホールディングス株式会社 | 細胞組成物、細胞組成物の製造方法及び細胞組成物を含む医薬組成物 |
| EP4353243A4 (en) | 2021-06-10 | 2025-06-25 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING MESENCHYMAL STEM CELLS |
| CA3222770A1 (en) | 2021-06-15 | 2022-12-22 | Takeda Pharmaceutical Company Limited | Method for producing natural killer cells from pluripotent stem cells |
| EP4372079A4 (en) | 2021-07-15 | 2025-07-30 | Astellas Pharma Inc | PERICYTE-LIKE CELLS EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AT A HIGH LEVEL |
| WO2023286834A1 (ja) | 2021-07-15 | 2023-01-19 | アステラス製薬株式会社 | 血管内皮増殖因子（ｖｅｇｆ）高発現ペリサイト様細胞 |
| EP4386083A4 (en) | 2021-08-11 | 2025-11-12 | Univ Kyoto | METHOD FOR PRODUCING RENAL INTERSTITIAL PROGENITOR CELLS, ERYTHROPOIETIN-PRODUCING CELLS AND METHOD FOR PRODUCING RENIIN-PRODUCING CELLS |
| CN118265792A (zh) | 2021-11-11 | 2024-06-28 | 希里欧斯株式会社 | 基因修饰多能干细胞、来自其的免疫活性细胞、它们的制造方法和它们的用途 |
| CN118679244A (zh) | 2022-02-09 | 2024-09-20 | 住友制药株式会社 | 判定培养液中的细胞在由多能干细胞向中脑底板区域的神经系统细胞的分化中的分化能力的方法 |
| JPWO2023210713A1 (https=) | 2022-04-27 | 2023-11-02 | ||
| CN119365606A (zh) | 2022-06-10 | 2025-01-24 | 国立大学法人京都大学 | 未分化多能干细胞的检测方法和检测试剂 |
| JPWO2024248023A1 (https=) | 2023-05-29 | 2024-12-05 | ||
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
| JPWO2024248157A1 (https=) | 2023-05-31 | 2024-12-05 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| ES2288473T3 (es) | 1999-05-18 | 2008-01-16 | Dnavec Research Inc. | Vector de virus deficiente en el gen de la envoltura de paramyxoviridae. |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| JP5813321B2 (ja) * | 2007-03-23 | 2015-11-17 | ウィスコンシン アラムニ リサーチ ファンデーション | 体細胞の再プログラム化 |
| CN105861443A (zh) * | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| EP2164951A2 (en) * | 2007-05-30 | 2010-03-24 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| KR101564044B1 (ko) | 2007-10-31 | 2015-10-28 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 핵초기화 방법 |
| JPWO2010027062A1 (ja) | 2008-09-04 | 2012-02-02 | 独立行政法人理化学研究所 | Ｂ細胞由来ｉＰＳ細胞およびその用途 |
| EP2336303B1 (en) | 2008-09-08 | 2015-07-15 | Riken | NKT CELL-DERIVED iPS CELLS AND NKT CELLS DERIVED THEREFROM |
| WO2010098419A1 (en) | 2009-02-27 | 2010-09-02 | Kyoto University | Novel nuclear reprogramming substance |
| CN101613717B (zh) | 2009-04-17 | 2012-01-11 | 中国科学院广州生物医药与健康研究院 | 用猪成纤维细胞生成诱导的多能性干细胞的方法 |
| CA2770412C (en) | 2009-08-07 | 2018-09-11 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| CA2789749C (en) | 2010-02-16 | 2018-09-04 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
-
2010
- 2010-02-19 WO PCT/JP2010/053024 patent/WO2010098419A1/en not_active Ceased
- 2010-02-19 KR KR1020117022584A patent/KR101764100B1/ko active Active
- 2010-02-19 CN CN201080011401.7A patent/CN102388136B/zh active Active
- 2010-02-19 EP EP10746298A patent/EP2401372A4/en not_active Withdrawn
- 2010-02-19 JP JP2011536662A patent/JP5553289B2/ja active Active
- 2010-02-19 SG SG2011061959A patent/SG173876A1/en unknown
- 2010-02-19 US US13/203,735 patent/US8951801B2/en active Active
- 2010-02-19 CA CA2753845A patent/CA2753845C/en active Active
- 2010-02-19 EP EP13158495.5A patent/EP2607476B1/en active Active
-
2011
- 2011-08-25 IL IL214833A patent/IL214833A/en active IP Right Grant
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