JP2013505701A5 - - Google Patents

Info

Publication number

JP2013505701A5

JP2013505701A5 JP2012510468A JP2012510468A JP2013505701A5 JP 2013505701 A5 JP2013505701 A5 JP 2013505701A5 JP 2012510468 A JP2012510468 A JP 2012510468A JP 2012510468 A JP2012510468 A JP 2012510468A JP 2013505701 A5 JP2013505701 A5 JP 2013505701A5

Authority

JP

Japan

Prior art keywords

lin28b

nuclear reprogramming

somatic

ips cells

reprogramming substance

Prior art date

2010-09-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims description 10
• 230000008672 reprogramming Effects 0.000 claims description 8
• 210000001082 somatic cell Anatomy 0.000 claims description 8
• 230000000694 effects Effects 0.000 claims description 7
• 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims description 3
• 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims description 3
• 101150086694 SLC22A3 gene Proteins 0.000 claims description 3
• 101150111214 lin-28 gene Proteins 0.000 claims description 3
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 239000000126 substance Substances 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 108091057508 Myc family Proteins 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000004069 differentiation Effects 0.000 claims 1
• 239000000411 inducer Substances 0.000 claims 1
• 238000011419 induction treatment Methods 0.000 claims 1
• 230000000392 somatic effect Effects 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
• 101100074846 Caenorhabditis elegans lin-2 gene Proteins 0.000 description 1
• 101000984033 Homo sapiens Protein lin-28 homolog B Proteins 0.000 description 1
• 101100497386 Mus musculus Cask gene Proteins 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1