JP2012513953A - 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾 - Google Patents

付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾 Download PDF

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JP2012513953A
JP2012513953A JP2011529188A JP2011529188A JP2012513953A JP 2012513953 A JP2012513953 A JP 2012513953A JP 2011529188 A JP2011529188 A JP 2011529188A JP 2011529188 A JP2011529188 A JP 2011529188A JP 2012513953 A JP2012513953 A JP 2012513953A
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optionally substituted
oligonucleotides
nucleosides
oligonucleotide
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JP2012513953A5 (enExample
Inventor
マノハラン，ムシアー
ジー ラジーフ，カラントタットヒル
剛史 山田
バトラー，デイヴィッド
ナラヤナンナエー ジャヤプラカシュ，ケイ
ジャイラマン，ムスサミー
成夫 松田
ケイ パンディー，ラジェンドラ
ゲン ペン，チャン
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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JP2011529188A 2008-09-23 2009-09-23 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾 Pending JP2012513953A (ja)

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US9949708P 2008-09-23 2008-09-23
US61/099,497 2008-09-23
PCT/US2009/058084 WO2010039548A2 (en) 2008-09-23 2009-09-23 Chemical modifications of monomers and oligonucleotides with cycloaddition

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JP2014185220A Active JP6053735B2 (ja) 2008-09-23 2014-09-11 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
JP2016231739A Active JP6484602B2 (ja) 2008-09-23 2016-11-29 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
JP2019026194A Active JP6885976B2 (ja) 2008-09-23 2019-02-18 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾

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JP2016231739A Active JP6484602B2 (ja) 2008-09-23 2016-11-29 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
JP2019026194A Active JP6885976B2 (ja) 2008-09-23 2019-02-18 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾

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US (3) US8962580B2 (enExample)
EP (2) EP2342616A2 (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
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JP2014240428A (ja) * 2008-09-23 2014-12-25 アルニラム ファーマスーティカルズ インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
WO2016152980A1 (ja) * 2015-03-24 2016-09-29 国立大学法人岐阜大学 オリゴヌクレオチド誘導体及びそれを用いたオリゴヌクレオチド構築物並びにそれらの製造方法
KR20180134364A (ko) * 2016-04-14 2018-12-18 에프. 호프만-라 로슈 아게 트리틸-모노-GalNAc 화합물 및 이의 용도
JP2024504505A (ja) * 2021-01-30 2024-01-31 イー セラピューティクス パブリック リミテッド カンパニー コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用
JP2024504504A (ja) * 2021-01-30 2024-01-31 イー セラピューティクス パブリック リミテッド カンパニー コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用

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US9198972B2 (en) * 2010-01-28 2015-12-01 Alnylam Pharmaceuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
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USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2834260A4 (en) 2012-04-02 2016-08-10 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS
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TW201808342A (zh) * 2012-05-02 2018-03-16 喜納製藥公司 包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法
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