JP2012509983A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012509983A5 JP2012509983A5 JP2011538669A JP2011538669A JP2012509983A5 JP 2012509983 A5 JP2012509983 A5 JP 2012509983A5 JP 2011538669 A JP2011538669 A JP 2011538669A JP 2011538669 A JP2011538669 A JP 2011538669A JP 2012509983 A5 JP2012509983 A5 JP 2012509983A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- block
- hydrophobic
- hydrophilic
- block copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001400 block copolymer Polymers 0.000 claims 25
- 230000002209 hydrophobic effect Effects 0.000 claims 23
- 239000000693 micelle Substances 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 229920002125 Sokalan® Polymers 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 229920002873 Polyethylenimine Polymers 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 5
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 5
- 229920000805 Polyaspartic acid Polymers 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 5
- 150000004676 glycans Chemical class 0.000 claims 5
- 229920002674 hyaluronan Polymers 0.000 claims 5
- 229960003160 hyaluronic acid Drugs 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 229920001603 poly (alkyl acrylates) Polymers 0.000 claims 5
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims 5
- 229920002401 polyacrylamide Polymers 0.000 claims 5
- 229920002643 polyglutamic acid Polymers 0.000 claims 5
- 229920001451 polypropylene glycol Polymers 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 5
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims 4
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical group C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 4
- 229920000359 diblock copolymer Polymers 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920006030 multiblock copolymer Polymers 0.000 claims 4
- 229920001713 poly(ethylene-co-vinyl alcohol) Polymers 0.000 claims 4
- 229920000917 poly(propylene sulfide) Polymers 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- OQXNUCOGMMHHNA-UHFFFAOYSA-N 4-methyl-1,3,2-dioxathiolane 2,2-dioxide Chemical compound CC1COS(=O)(=O)O1 OQXNUCOGMMHHNA-UHFFFAOYSA-N 0.000 claims 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- -1 acyl hydrazone Chemical class 0.000 claims 1
- 229940009456 adriamycin Drugs 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229920001038 ethylene copolymer Polymers 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11789208P | 2008-11-25 | 2008-11-25 | |
| US61/117,892 | 2008-11-25 | ||
| PCT/US2009/065693 WO2010068432A1 (en) | 2008-11-25 | 2009-11-24 | Block copolymers and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217197A Division JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509983A JP2012509983A (ja) | 2012-04-26 |
| JP2012509983A5 true JP2012509983A5 (https=) | 2013-01-17 |
| JP5814793B2 JP5814793B2 (ja) | 2015-11-17 |
Family
ID=42243027
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538669A Active JP5814793B2 (ja) | 2008-11-25 | 2009-11-24 | ブロックコポリマーおよびその使用 |
| JP2014217197A Active JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
| JP2016100375A Active JP6409020B2 (ja) | 2008-11-25 | 2016-05-19 | ブロックコポリマーおよびその使用 |
| JP2018119659A Active JP6641423B2 (ja) | 2008-11-25 | 2018-06-25 | ブロックコポリマーおよびその使用 |
| JP2019238237A Pending JP2020073678A (ja) | 2008-11-25 | 2019-12-27 | ブロックコポリマーおよびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217197A Active JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
| JP2016100375A Active JP6409020B2 (ja) | 2008-11-25 | 2016-05-19 | ブロックコポリマーおよびその使用 |
| JP2018119659A Active JP6641423B2 (ja) | 2008-11-25 | 2018-06-25 | ブロックコポリマーおよびその使用 |
| JP2019238237A Pending JP2020073678A (ja) | 2008-11-25 | 2019-12-27 | ブロックコポリマーおよびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (5) | US9271929B2 (https=) |
| EP (1) | EP2356228B1 (https=) |
| JP (5) | JP5814793B2 (https=) |
| WO (1) | WO2010068432A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1891141B1 (en) | 2005-05-31 | 2016-11-16 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| JP5814793B2 (ja) * | 2008-11-25 | 2015-11-17 | エコール ポリテクニク フェデラル ド ローザンヌ（エーペーエフエル） | ブロックコポリマーおよびその使用 |
| EP2572780B1 (en) * | 2010-05-21 | 2018-07-11 | Japan Science And Technology Agency | Vesicles with encapsulated substance and production method therefor |
| EP2591792B1 (en) * | 2010-07-09 | 2016-12-21 | The University of Tokyo | Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid |
| WO2014134203A1 (en) * | 2013-02-26 | 2014-09-04 | The Regents Of The University Of California | Amphiphilic derivatives of thioether containing block copolypeptides |
| US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
| WO2015058141A1 (en) * | 2013-10-18 | 2015-04-23 | Virginia Tech Intellectual Properties, Inc. | Nucleobase-containing monomers and copolymers |
| JP2017505104A (ja) * | 2013-11-08 | 2017-02-16 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | インビボにおける薬剤送達のための核酸ナノ構造体 |
| US10351591B2 (en) | 2015-03-20 | 2019-07-16 | The Regents Of The University Of California | Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| EP3124495A1 (en) | 2015-07-31 | 2017-02-01 | Centre National de la Recherche Scientifique (C.N.R.S.) | Derivatives of elastin-like polypeptides and uses thereof |
| US11414694B2 (en) | 2016-03-11 | 2022-08-16 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| WO2017189860A1 (en) | 2016-04-27 | 2017-11-02 | The Regents Of The University Of California | Preparation of functional homocysteine residues in polypeptides and peptides |
| ES2865481T3 (es) | 2016-04-29 | 2021-10-15 | Poseida Therapeutics Inc | Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos |
| KR101913146B1 (ko) * | 2016-06-16 | 2018-11-01 | 주식회사 엘지화학 | 양친성 트리블록 고분자 |
| WO2018022457A1 (en) * | 2016-07-29 | 2018-02-01 | The Regents Of The University Of California | Accelerated healing by injectable multi-arm branched amphiphilic scaffolds loaded with hydrophobic drugs |
| CN115948505B (zh) | 2016-08-02 | 2025-07-25 | 哈佛学院院长及董事 | 交叉协同自组装体 |
| JP6912876B2 (ja) * | 2016-10-06 | 2021-08-04 | 三洋化成工業株式会社 | アクリル系医薬固形製剤用添加剤 |
| CN107236106B (zh) * | 2017-06-13 | 2020-01-07 | 青岛科技大学 | 含酰腙键的芳香族端羟基扩链剂、自修复聚氨酯及其制备方法 |
| US10376468B2 (en) * | 2017-12-05 | 2019-08-13 | International Business Machines Corporation | Block copolymers and self-assembling nanoparticles formed therefrom |
| CN108904446B (zh) * | 2018-06-11 | 2021-05-11 | 中山大学 | 一种动脉斑块微环境响应的载药纳米胶束的制备方法及应用 |
| JP7154568B2 (ja) * | 2018-06-22 | 2022-10-18 | 国立大学法人福井大学 | 両親媒性高分子、およびその利用 |
| CN113226379A (zh) * | 2018-10-22 | 2021-08-06 | 武田药品工业株式会社 | 靶向内体中g蛋白偶联受体的纳米颗粒封装 |
| WO2020210468A1 (en) | 2019-04-10 | 2020-10-15 | President And Fellows Of Harvard College | Nucleic acid nanostructures crosslinked with oligolysine |
| KR102329966B1 (ko) * | 2020-03-23 | 2021-11-23 | 전남대학교산학협력단 | 양친성 고분자 화합물, 이를 이용한 약물 전달체 및 종양 치료 시스템 |
| WO2022051713A1 (en) * | 2020-09-04 | 2022-03-10 | The University Of Chicago | Materials and methods of treating viral infection with amphiphilic block copolymers |
| KR102418116B1 (ko) * | 2020-10-08 | 2022-07-06 | 강원대학교산학협력단 | 양친매성 공중합체로 안정화된 산화 응답성 에멀젼 |
| EP4374885A4 (en) * | 2021-07-21 | 2025-07-16 | Samyang Holdings Corp | POWDER FORMULATION FOR TISSUE REPAIR, PREPARATION METHOD THEREOF, AND INJECTABLE COMPOSITION FOR TISSUE REPAIR COMPRISING THE SAME |
| WO2025145010A1 (en) * | 2023-12-29 | 2025-07-03 | The University Of Chicago | Amphiphilic block copolymers, polymersomes, and methods of use |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203577A (en) | 1966-10-27 | 1970-08-26 | Dunlop Co Ltd | Improvements in or relating to the preparation of polymerized episulphides |
| CA992105A (en) | 1970-03-26 | 1976-06-29 | Exxon Research And Engineering Company | Polythioethers formed by anionic ring opening of episulfides |
| JPS5835612B2 (ja) * | 1978-10-04 | 1983-08-03 | テルモ株式会社 | 新規なブロック共重合体の製造方法 |
| US4618400A (en) | 1984-12-28 | 1986-10-21 | Shell Oil Company | Wastepaper deinking process |
| US4923924A (en) | 1985-12-06 | 1990-05-08 | Borg-Warner Chemicals, Inc. | Thermoplastic impact modified polyamide-polyphenylene ether composition |
| US4732938A (en) | 1985-12-06 | 1988-03-22 | Borg-Warner Chemicals, Inc. | Thermoplastic polyamide--polyphenylene ether compositions |
| CN1046741A (zh) | 1988-04-30 | 1990-11-07 | 三井东圧化学株式会社 | 以多硫化物为基础的树脂，含有该树脂的塑料透镜以及制造该种透镜的方法 |
| US5575815A (en) | 1988-08-24 | 1996-11-19 | Endoluminal Therapeutics, Inc. | Local polymeric gel therapy |
| US5247041A (en) | 1989-02-22 | 1993-09-21 | Toray Industries, Inc. | Thiol methacrylate or acrylate resin obtained by polymerizing a thiol methacrylate or acrylate compound |
| US5268305A (en) | 1989-06-15 | 1993-12-07 | Biocircuits Corporation | Multi-optical detection system |
| US5330911A (en) | 1989-09-28 | 1994-07-19 | Board Of Regents, The University Of Texas System | Surfaces having desirable cell adhesive effects |
| US5852182A (en) | 1990-01-11 | 1998-12-22 | Isis Pharmaceuticals Inc. | Thiol-derivatized oligonucleosides |
| US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| WO1993024476A1 (en) | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| JP4091654B2 (ja) | 1992-08-25 | 2008-05-28 | ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー | レトロウイルスプロテアーゼ阻害剤として有用なスルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド |
| WO1994005282A1 (en) | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
| US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
| BR9405798A (pt) | 1993-02-22 | 1995-12-12 | Vivorx Pharmaceuticals Inc | Métodos para liberação in vivo de material biológico e composições úteis dos mesmos |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5502102A (en) | 1994-08-09 | 1996-03-26 | General Electric Company | Epoxy modified blends of poly(arylenesulfide) and polyetherimide resins |
| US6353055B1 (en) | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5702717A (en) * | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
| US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| ATE330644T1 (de) | 1995-12-18 | 2006-07-15 | Angiotech Biomaterials Corp | Vernetzten polymerisatmassen und verfahren für ihre verwendung |
| FR2746035B1 (fr) | 1996-03-15 | 1998-06-12 | Microparticules de gel composite susceptibles d'etre utilisees comme vecteur(s) de principe(s) actif(s), l'un de leurs procedes de preparation et leurs applications | |
| US5914182A (en) | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
| US6013855A (en) | 1996-08-06 | 2000-01-11 | United States Surgical | Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces |
| US20020064546A1 (en) | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
| US6224903B1 (en) | 1996-10-11 | 2001-05-01 | Sequus Pharmaceuticals, Inc. | Polymer-lipid conjugate for fusion of target membranes |
| TW520297B (en) | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6258351B1 (en) | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
| DE69800640T2 (de) | 1997-01-29 | 2001-07-05 | Polymasc Pharmaceuticals Plc, London | Pegylationsverfahren |
| EP1003527A4 (en) | 1997-08-01 | 2003-07-16 | Supratek Pharma Inc | POLYNUCLEOTIDE COMPOSITIONS |
| US5945457A (en) | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
| CA2305621C (en) * | 1997-10-03 | 2009-01-20 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6884842B2 (en) * | 1997-10-14 | 2005-04-26 | Alnis Biosciences, Inc. | Molecular compounds having complementary surfaces to targets |
| JP3786832B2 (ja) | 1998-01-07 | 2006-06-14 | デビオ ルシェルシュ ファルマシュティーク ソシエテ アノニム | 分解性のヘテロ二官能性ポリ（エチレングリコール）アクリレート及びそれから誘導されるゲル及び複合体 |
| JPH11335267A (ja) * | 1998-05-27 | 1999-12-07 | Nano Career Kk | 水難溶性薬物を含有するポリマーミセル系 |
| US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| ES2368988T3 (es) | 1999-02-01 | 2011-11-24 | Eidgenössische Technische Hochschule Zürich | Bio-materiales formados por reacción de adición nucleófila a grupos insaturados conjugados. |
| US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| GB9912077D0 (en) | 1999-05-24 | 1999-07-21 | Unilever Plc | Polysiloxane block copolymers in topical cosmetic and personal care compositions |
| JO2291B1 (en) | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
| US6916488B1 (en) * | 1999-11-05 | 2005-07-12 | Biocure, Inc. | Amphiphilic polymeric vesicles |
| US20020041898A1 (en) * | 2000-01-05 | 2002-04-11 | Unger Evan C. | Novel targeted delivery systems for bioactive agents |
| JP3523821B2 (ja) * | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
| US7550157B2 (en) * | 2000-05-12 | 2009-06-23 | Samyang Corporation | Method for the preparation of polymeric micelle via phase separation of block copolymer |
| ATE541587T1 (de) | 2000-06-02 | 2012-02-15 | Eidgenoess Tech Hochschule | Konjugat-additionsreaktionen zur kontrollierten abgabe von pharmazeutisch wirksamen substanzen |
| FR2809617B1 (fr) | 2000-06-05 | 2002-07-12 | Rhodia Chimie Sa | Composition aqueuse bucco-dentaire antiplaque |
| US7465790B2 (en) * | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| EP1355965B1 (en) | 2000-10-19 | 2012-09-19 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method of synthesizing block copolymers for multifunctional self-assembled systems |
| CA2440844A1 (en) | 2001-03-20 | 2002-09-26 | Universitat Zurich | Two-phase processing of thermosensitive polymers for use as biomaterials |
| CA2450949C (en) * | 2001-06-28 | 2009-04-28 | John Samuel | Methods and compositions for polyene antibiotics with reduced toxicity |
| KR100527291B1 (ko) * | 2001-07-14 | 2005-11-09 | 주식회사 삼양사 | 약물 전달체용 양이온기-함유 양친성 블록 공중합체 및그의 음이온성 약물과의 복합체 |
| WO2003011226A2 (en) * | 2001-08-01 | 2003-02-13 | Smithkline Beecham Corporation | Products and drug delivery vehicles |
| CA2460928A1 (en) * | 2001-09-18 | 2003-03-27 | Eidgenossische Technische Hochschule Zurich | Methods and apparatus for coating surfaces |
| US7060498B1 (en) * | 2001-11-28 | 2006-06-13 | Genta Salus Llc | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
| JP4208723B2 (ja) | 2002-04-09 | 2009-01-14 | サビック・イノベーティブ・プラスチックス・アイピー・ベスローテン・フェンノートシャップ | 熱硬化性組成物、方法及び物品 |
| US20030215588A1 (en) | 2002-04-09 | 2003-11-20 | Yeager Gary William | Thermoset composition, method, and article |
| AU2003249317B2 (en) | 2002-07-19 | 2007-08-02 | Institute Of Materials Research And Engineering | Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from |
| US7521414B2 (en) * | 2003-06-20 | 2009-04-21 | The Regents Of The University Of California | Polyol macrolide antitumor-antibiotics from the marine actinomycete strain CNQ140 |
| JP2006199590A (ja) * | 2003-09-04 | 2006-08-03 | Nano Career Kk | 水溶性の塩基性薬物内包ナノ粒子含有組成物 |
| SG113562A1 (en) * | 2004-01-12 | 2005-08-29 | Agency Science Tech & Res | Polyalkyleneimine-graft-biodegradable polymers for delivery of bioactive agents |
| EP1555278A1 (en) | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Biodegradable multi-block co-polymers |
| JP2005298542A (ja) | 2004-04-06 | 2005-10-27 | Dainippon Ink & Chem Inc | ブロックコポリマー及びその製造方法 |
| US7495052B2 (en) | 2004-09-15 | 2009-02-24 | Bausch & Lomb Incorporated | Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
| US20060057215A1 (en) | 2004-09-15 | 2006-03-16 | Raiche Adrian T | Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
| US20060165810A1 (en) * | 2004-12-28 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Controlled release from block co-polymer worm micelles |
| US20060224095A1 (en) | 2005-04-05 | 2006-10-05 | University Of New Hampshire | Biocompatible polymeric vesicles self assembled from triblock copolymers |
| EP1871343A2 (en) * | 2005-04-12 | 2008-01-02 | Wisconsin Alumni Research Foundation | Micelle composition of polymer and passenger drug |
| WO2006109945A1 (en) | 2005-04-13 | 2006-10-19 | Sungkyunkwan University Foundation For Corporate Collaboration | Temperature and ph sensitive block copolymer and polymeric hydrogles using the same |
| EP1891141B1 (en) | 2005-05-31 | 2016-11-16 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| CA2624174A1 (en) * | 2005-09-28 | 2007-04-05 | The Trustees Of The University Of Pennsylvania | Self-assembled biodegradable polymersomes |
| AU2006300451A1 (en) | 2005-10-05 | 2007-04-19 | National University Corporation Gunma University | Biocompatible block copolymer, use thereof, and production method thereof |
| US8021689B2 (en) * | 2006-02-21 | 2011-09-20 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | Nanoparticles for immunotherapy |
| WO2007099660A1 (ja) * | 2006-03-01 | 2007-09-07 | The University Of Tokyo | 核酸内包高分子ミセル複合体 |
| US8367113B2 (en) * | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| WO2008062909A1 (en) * | 2006-11-22 | 2008-05-29 | The University Of Tokyo | ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE |
| WO2008070141A2 (en) * | 2006-12-06 | 2008-06-12 | Wisconsin Alumni Research Foundation | Compositions for delivery of therapeutic agents |
| US20090068271A1 (en) * | 2007-09-12 | 2009-03-12 | Boston Scientific Scimed, Inc. | Embolization particles |
| US8323696B2 (en) * | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
| JP5814793B2 (ja) | 2008-11-25 | 2015-11-17 | エコール ポリテクニク フェデラル ド ローザンヌ（エーペーエフエル） | ブロックコポリマーおよびその使用 |
| US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
-
2009
- 2009-11-24 JP JP2011538669A patent/JP5814793B2/ja active Active
- 2009-11-24 US US13/130,892 patent/US9271929B2/en active Active
- 2009-11-24 WO PCT/US2009/065693 patent/WO2010068432A1/en not_active Ceased
- 2009-11-24 EP EP09832335.5A patent/EP2356228B1/en active Active
-
2014
- 2014-10-24 JP JP2014217197A patent/JP5995939B2/ja active Active
-
2016
- 2016-02-05 US US15/017,028 patent/US10335499B2/en active Active
- 2016-05-19 JP JP2016100375A patent/JP6409020B2/ja active Active
-
2018
- 2018-06-25 JP JP2018119659A patent/JP6641423B2/ja active Active
-
2019
- 2019-07-01 US US16/459,039 patent/US20200000936A1/en not_active Abandoned
- 2019-12-27 JP JP2019238237A patent/JP2020073678A/ja active Pending
-
2021
- 2021-07-02 US US17/366,846 patent/US20220168448A1/en not_active Abandoned
-
2024
- 2024-02-05 US US18/432,899 patent/US20250001005A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012509983A5 (https=) | ||
| US8668933B2 (en) | Polyion complex of double-stranded ribonucleic acid | |
| CN105579584B (zh) | 用于将rna引入细胞的组合物 | |
| Yang et al. | The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles | |
| Rinkenauer et al. | The influence of polymer architecture on in vitro pDNA transfection | |
| EP3449004B1 (en) | Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids | |
| JP4302509B2 (ja) | 水溶性安定性の自己集合体高分子電解質 | |
| Beyerle et al. | Comparative in vivo study of poly (ethylene imine)/siRNA complexes for pulmonary delivery in mice | |
| JP7164576B2 (ja) | 抗微生物化合物およびナノ構造物 | |
| RU2011150787A (ru) | КОНЪЮГАТ миРНК И СПОСОБ ЕГО ПОЛУЧЕНИЯ | |
| JP2007537284A5 (https=) | ||
| JP2011256203A5 (https=) | ||
| CN105792814B (zh) | 用于药物递送的载有芳香族n-杂环的聚碳酸酯 | |
| BR112014016562B1 (pt) | Estrutura de oligo-rna de dupla hélice, nanopartícula e método de preparação | |
| CN102516552B (zh) | 一种可降解的酸敏感高分子两亲性阳离子嵌段共聚物与胶束粒子及其制备方法 | |
| JP2004532893A (ja) | イオン化可能な内核を持つ単分子の高分子ミセル | |
| JP5804453B2 (ja) | 結晶性ポリオール微粒子及びその調製方法 | |
| Guo et al. | Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: In vitro investigations | |
| US20240325315A1 (en) | Lipid nanoparticle compositions for delivery of mrna and long nucleic acids | |
| JP2010504318A5 (https=) | ||
| Gu et al. | Facile approach for DNA encapsulation in functional polyion complex for triggered intracellular gene delivery: design, synthesis, and mechanism | |
| CN102935239A (zh) | 用于预防或治疗肺癌的制剂及其制备方法与应用 | |
| CN104031268B (zh) | 聚乙烯亚胺三嵌段共聚物及其在基因载体中的用途 | |
| CN102369282B (zh) | 核酸复合体及核酸转运用组合物 | |
| EP4175676A1 (en) | Mucopenetrating formulations |