JP2012509348A5 - - Google Patents
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- JP2012509348A5 JP2012509348A5 JP2011537624A JP2011537624A JP2012509348A5 JP 2012509348 A5 JP2012509348 A5 JP 2012509348A5 JP 2011537624 A JP2011537624 A JP 2011537624A JP 2011537624 A JP2011537624 A JP 2011537624A JP 2012509348 A5 JP2012509348 A5 JP 2012509348A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- pharmaceutically acceptable
- acceptable salt
- composition
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08169462 | 2008-11-19 | ||
| EP08169462.2 | 2008-11-19 | ||
| PCT/US2009/065188 WO2010059853A1 (en) | 2008-11-19 | 2009-11-19 | Tgr5 modulators and method of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088019A Division JP2014159456A (ja) | 2008-11-19 | 2014-04-22 | Tgr5モジュレーターおよびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509348A JP2012509348A (ja) | 2012-04-19 |
| JP2012509348A5 true JP2012509348A5 (enExample) | 2012-12-13 |
| JP5535233B2 JP5535233B2 (ja) | 2014-07-02 |
Family
ID=41668454
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537624A Expired - Fee Related JP5535233B2 (ja) | 2008-11-19 | 2009-11-19 | Tgr5モジュレーターおよびその使用方法 |
| JP2014088019A Withdrawn JP2014159456A (ja) | 2008-11-19 | 2014-04-22 | Tgr5モジュレーターおよびその使用方法 |
| JP2015160141A Pending JP2015232020A (ja) | 2008-11-19 | 2015-08-14 | Tgr5モジュレーターおよびその使用方法 |
| JP2017083045A Withdrawn JP2017132803A (ja) | 2008-11-19 | 2017-04-19 | Tgr5モジュレーターおよびその使用方法 |
| JP2018059922A Withdrawn JP2018100304A (ja) | 2008-11-19 | 2018-03-27 | Tgr5モジュレーターおよびその使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088019A Withdrawn JP2014159456A (ja) | 2008-11-19 | 2014-04-22 | Tgr5モジュレーターおよびその使用方法 |
| JP2015160141A Pending JP2015232020A (ja) | 2008-11-19 | 2015-08-14 | Tgr5モジュレーターおよびその使用方法 |
| JP2017083045A Withdrawn JP2017132803A (ja) | 2008-11-19 | 2017-04-19 | Tgr5モジュレーターおよびその使用方法 |
| JP2018059922A Withdrawn JP2018100304A (ja) | 2008-11-19 | 2018-03-27 | Tgr5モジュレーターおよびその使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US8114862B2 (enExample) |
| EP (2) | EP2698375B1 (enExample) |
| JP (5) | JP5535233B2 (enExample) |
| KR (2) | KR101667436B1 (enExample) |
| CN (2) | CN102325784B (enExample) |
| AU (1) | AU2009316566B9 (enExample) |
| BR (1) | BRPI0921983B8 (enExample) |
| CA (1) | CA2744189C (enExample) |
| DK (2) | DK2376519T3 (enExample) |
| EA (2) | EA030681B1 (enExample) |
| ES (2) | ES2663948T3 (enExample) |
| HK (1) | HK1205132A1 (enExample) |
| HU (1) | HUE039171T2 (enExample) |
| IL (3) | IL212969A (enExample) |
| LT (1) | LT2698375T (enExample) |
| MX (1) | MX2011005295A (enExample) |
| NO (1) | NO2698375T3 (enExample) |
| PL (2) | PL2698375T3 (enExample) |
| PT (2) | PT2698375T (enExample) |
| SG (1) | SG10201400162QA (enExample) |
| SI (1) | SI2698375T1 (enExample) |
| WO (1) | WO2010059853A1 (enExample) |
| ZA (1) | ZA201104077B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1392714T3 (da) | 2001-03-12 | 2006-01-09 | Intercept Pharmaceuticals Inc | Steroider som agonister for FXR |
| US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
| DK1734970T3 (en) | 2004-03-12 | 2015-02-16 | Intercept Pharmaceuticals Inc | Treatment of fibrosis using FXR ligands |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| KR101555716B1 (ko) | 2007-01-19 | 2015-09-25 | 인터셉트 파마슈티컬즈, 인크. | Tgr5 조절제로서의 23-치환 담즙산 및 이의 사용 방법 |
| BRPI0916735B8 (pt) | 2008-07-30 | 2021-05-25 | Intercept Pharmaceuticals Inc | compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos |
| PL2698375T3 (pl) * | 2008-11-19 | 2018-08-31 | Intercept Pharmaceuticals, Inc. | Modulatory TGR5 i sposób ich zastosowania |
| JP2012509891A (ja) | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ,インク. | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| CN102316889B (zh) * | 2008-11-26 | 2014-11-26 | 萨蒂奥根制药公司 | 组合物及使用方法 |
| EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| PL2771003T3 (pl) | 2011-10-28 | 2017-10-31 | Lumena Pharmaceuticals Llc | Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby |
| KR20210131431A (ko) | 2011-10-28 | 2021-11-02 | 샤이어 휴먼 지네틱 테라피즈 인크. | 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 |
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| US9982008B2 (en) | 2012-06-19 | 2018-05-29 | Intercept Pharmaceuticals, Inc. | Preparation and uses of obeticholic acid |
| WO2014059008A1 (en) | 2012-10-09 | 2014-04-17 | The Procter & Gamble Company | Method of identifying or evaluating beneficial actives and compositions containing the same |
| CN104703585A (zh) | 2012-10-09 | 2015-06-10 | 宝洁公司 | 鉴定协同化妆品组合的方法 |
| EP3004132A4 (en) | 2013-06-06 | 2017-01-18 | Yissum, Research Development Company of the Hebrew | Bile acid-basic amino acid conjugates and uses thereof |
| WO2014200349A1 (en) | 2013-06-13 | 2014-12-18 | Fast Forward Pharmaceutical B.V. | Cd40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an tgr5-receptor agonist, an fxr agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis. |
| KR102688720B1 (ko) | 2013-11-22 | 2024-07-29 | 미나 테라퓨틱스 리미티드 | C/ebp 알파 짧은 활성화 rna 조성물 및 사용 방법 |
| KR102491556B1 (ko) * | 2014-05-29 | 2023-01-25 | 바 파마슈티컬스 에스.알.엘. | Fxr 및 tgr5/gpbar1 매개 질환의 치료 및/또는 예방에 사용하기 위한 콜란 유도체 |
| US20180236064A1 (en) * | 2014-10-03 | 2018-08-23 | Mayo Foundation For Medical Education And Research | Targeting tgr5 to treat disease |
| SG11201703717SA (en) * | 2014-11-06 | 2017-06-29 | Enanta Pharm Inc | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
| DK3221332T3 (da) | 2014-11-19 | 2019-07-29 | Nzp Uk Ltd | Fremstilling af steroide fxr-modulatorer |
| CN107207558B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇 |
| DK3221333T3 (da) | 2014-11-19 | 2019-09-30 | Nzp Uk Ltd | 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer |
| WO2016079517A1 (en) | 2014-11-19 | 2016-05-26 | Dextra Laboratories Limited | 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators |
| CN105985396A (zh) * | 2015-02-16 | 2016-10-05 | 苏州泽璟生物制药有限公司 | 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物 |
| JP2018519246A (ja) * | 2015-04-28 | 2018-07-19 | ジエンス ハンセン ファーマセウティカル グループ カンパニー リミテッド | コール酸誘導体、及びその製造方法及び医薬用途 |
| ES2873088T3 (es) | 2015-06-19 | 2021-11-03 | Intercept Pharmaceuticals Inc | Moduladores de TGR5 y métodos para su uso |
| PT3310801T (pt) * | 2015-06-24 | 2021-06-18 | Intercept Pharmaceuticals Inc | Moduladores de tgr5 e métodos de utilização dos mesmos |
| EP3353189A4 (en) * | 2015-09-24 | 2019-06-19 | Intercept Pharmaceuticals, Inc. | METHOD AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF GALLENIC ACID DERIVATIVES |
| US11034717B2 (en) | 2015-10-07 | 2021-06-15 | Intercept Pharmaceuticals, Inc. | Farnesoid X receptor modulators |
| CN106008639B (zh) * | 2016-03-11 | 2019-01-08 | 深圳市塔吉瑞生物医药有限公司 | 用于预防或治疗fxr-介导疾病的胆烷酸化合物 |
| WO2017180577A1 (en) | 2016-04-13 | 2017-10-19 | Intercept Pharmaceuticals, Inc. | Methods of treating cancer |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| EP3465218A4 (en) | 2016-05-29 | 2020-06-17 | Human Metabolomics Institute, Inc. | BIOMARKERS RELATED TO HEPATIC DISEASES AND METHODS OF USE |
| WO2018005794A2 (en) * | 2016-07-01 | 2018-01-04 | Venenum Biodesign Llc | Novel non-systemic tgr5 agonists |
| WO2018222701A1 (en) * | 2017-05-30 | 2018-12-06 | Intercept Pharmaceuticals, Inc. | Treatment of renal diseases with a bile acid derivative |
| CN109021056B (zh) * | 2017-06-09 | 2021-03-09 | 博瑞生物医药(苏州)股份有限公司 | 法尼酯x受体激动剂 |
| US11472831B2 (en) | 2017-07-24 | 2022-10-18 | Intercept Pharmaceuticals, Inc. | Isotopically labeled bile acid derivatives |
| CA3075205A1 (en) | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | Stabilized hnf4a sarna compositions and methods of use |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| WO2020163201A1 (en) * | 2019-02-04 | 2020-08-13 | Intercept Pharmaceuticals, Inc. | Treatment and prevention of intestinal inflammatory diseases with a bile acid derivative |
| CN116925168A (zh) | 2019-08-23 | 2023-10-24 | 深圳云合医药科技合伙企业(有限合伙) | 胆汁酸衍生物及其组合物和应用 |
| EP4041722A4 (en) | 2019-10-07 | 2023-12-13 | Kallyope, Inc. | GPR119 AGONISTS |
| CA3173731A1 (en) | 2020-02-28 | 2021-09-02 | Kallyope, Inc. | Gpr40 agonists |
| CN116323608A (zh) | 2020-05-19 | 2023-06-23 | 卡尔优普公司 | Ampk活化剂 |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| KR102693566B1 (ko) * | 2020-07-03 | 2024-08-08 | 주식회사 큐라클 | 지방간 질환의 예방 또는 치료를 위한 약학적 조성물 |
| CN113774142A (zh) * | 2021-10-11 | 2021-12-10 | 北京化工大学 | Tgr5在制备治疗肠癌药物及诊断性试剂盒中的应用 |
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| EP0101554B1 (en) | 1982-07-29 | 1986-10-15 | Lehner A.G. | New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same |
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| KR101555716B1 (ko) | 2007-01-19 | 2015-09-25 | 인터셉트 파마슈티컬즈, 인크. | Tgr5 조절제로서의 23-치환 담즙산 및 이의 사용 방법 |
| PL2698375T3 (pl) * | 2008-11-19 | 2018-08-31 | Intercept Pharmaceuticals, Inc. | Modulatory TGR5 i sposób ich zastosowania |
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2009
- 2009-11-19 PL PL13192394T patent/PL2698375T3/pl unknown
- 2009-11-19 EA EA201400258A patent/EA030681B1/ru not_active IP Right Cessation
- 2009-11-19 BR BRPI0921983A patent/BRPI0921983B8/pt not_active IP Right Cessation
- 2009-11-19 ES ES13192394T patent/ES2663948T3/es active Active
- 2009-11-19 EA EA201170714A patent/EA020140B1/ru unknown
- 2009-11-19 PT PT131923948T patent/PT2698375T/pt unknown
- 2009-11-19 PT PT97600571T patent/PT2376519E/pt unknown
- 2009-11-19 LT LTEP13192394.8T patent/LT2698375T/lt unknown
- 2009-11-19 JP JP2011537624A patent/JP5535233B2/ja not_active Expired - Fee Related
- 2009-11-19 PL PL09760057T patent/PL2376519T3/pl unknown
- 2009-11-19 MX MX2011005295A patent/MX2011005295A/es active IP Right Grant
- 2009-11-19 US US12/622,123 patent/US8114862B2/en active Active
- 2009-11-19 SG SG10201400162QA patent/SG10201400162QA/en unknown
- 2009-11-19 KR KR1020117014037A patent/KR101667436B1/ko not_active Expired - Fee Related
- 2009-11-19 HU HUE13192394A patent/HUE039171T2/hu unknown
- 2009-11-19 CN CN200980154713.0A patent/CN102325784B/zh active Active
- 2009-11-19 WO PCT/US2009/065188 patent/WO2010059853A1/en not_active Ceased
- 2009-11-19 DK DK09760057.1T patent/DK2376519T3/da active
- 2009-11-19 ES ES09760057.1T patent/ES2458168T3/es active Active
- 2009-11-19 CA CA2744189A patent/CA2744189C/en active Active
- 2009-11-19 EP EP13192394.8A patent/EP2698375B1/en active Active
- 2009-11-19 CN CN201410532890.0A patent/CN104370990A/zh active Pending
- 2009-11-19 SI SI200931820T patent/SI2698375T1/sl unknown
- 2009-11-19 EP EP09760057.1A patent/EP2376519B1/en active Active
- 2009-11-19 NO NO13192394A patent/NO2698375T3/no unknown
- 2009-11-19 KR KR1020167028159A patent/KR101789960B1/ko not_active Expired - Fee Related
- 2009-11-19 DK DK13192394.8T patent/DK2698375T3/en active
- 2009-11-19 AU AU2009316566A patent/AU2009316566B9/en active Active
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2011
- 2011-05-18 IL IL212969A patent/IL212969A/en active IP Right Grant
- 2011-06-01 ZA ZA2011/04077A patent/ZA201104077B/en unknown
- 2011-12-07 US US13/313,689 patent/US8445472B2/en not_active Expired - Fee Related
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2013
- 2013-04-26 US US13/871,492 patent/US9650409B2/en not_active Expired - Fee Related
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2014
- 2014-04-22 JP JP2014088019A patent/JP2014159456A/ja not_active Withdrawn
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2015
- 2015-06-10 HK HK15105499.8A patent/HK1205132A1/xx unknown
- 2015-08-14 JP JP2015160141A patent/JP2015232020A/ja active Pending
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2016
- 2016-03-29 IL IL244812A patent/IL244812B/en active IP Right Grant
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2017
- 2017-04-07 US US15/482,107 patent/US20180016295A1/en not_active Abandoned
- 2017-04-19 JP JP2017083045A patent/JP2017132803A/ja not_active Withdrawn
-
2018
- 2018-03-27 JP JP2018059922A patent/JP2018100304A/ja not_active Withdrawn
-
2019
- 2019-02-12 IL IL264796A patent/IL264796B/en active IP Right Grant
-
2020
- 2020-11-09 US US17/092,612 patent/US20210269473A1/en not_active Abandoned
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