JP2012509348A5 - - Google Patents
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- JP2012509348A5 JP2012509348A5 JP2011537624A JP2011537624A JP2012509348A5 JP 2012509348 A5 JP2012509348 A5 JP 2012509348A5 JP 2011537624 A JP2011537624 A JP 2011537624A JP 2011537624 A JP2011537624 A JP 2011537624A JP 2012509348 A5 JP2012509348 A5 JP 2012509348A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- pharmaceutically acceptable
- acceptable salt
- composition
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08169462 | 2008-11-19 | ||
| EP08169462.2 | 2008-11-19 | ||
| PCT/US2009/065188 WO2010059853A1 (en) | 2008-11-19 | 2009-11-19 | Tgr5 modulators and method of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088019A Division JP2014159456A (ja) | 2008-11-19 | 2014-04-22 | Ｔｇｒ５モジュレーターおよびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509348A JP2012509348A (ja) | 2012-04-19 |
| JP2012509348A5 true JP2012509348A5 (enExample) | 2012-12-13 |
| JP5535233B2 JP5535233B2 (ja) | 2014-07-02 |
Family
ID=41668454
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537624A Expired - Fee Related JP5535233B2 (ja) | 2008-11-19 | 2009-11-19 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2014088019A Withdrawn JP2014159456A (ja) | 2008-11-19 | 2014-04-22 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2015160141A Pending JP2015232020A (ja) | 2008-11-19 | 2015-08-14 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2017083045A Withdrawn JP2017132803A (ja) | 2008-11-19 | 2017-04-19 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2018059922A Withdrawn JP2018100304A (ja) | 2008-11-19 | 2018-03-27 | Ｔｇｒ５モジュレーターおよびその使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088019A Withdrawn JP2014159456A (ja) | 2008-11-19 | 2014-04-22 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2015160141A Pending JP2015232020A (ja) | 2008-11-19 | 2015-08-14 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2017083045A Withdrawn JP2017132803A (ja) | 2008-11-19 | 2017-04-19 | Ｔｇｒ５モジュレーターおよびその使用方法 |
| JP2018059922A Withdrawn JP2018100304A (ja) | 2008-11-19 | 2018-03-27 | Ｔｇｒ５モジュレーターおよびその使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US8114862B2 (enExample) |
| EP (2) | EP2376519B1 (enExample) |
| JP (5) | JP5535233B2 (enExample) |
| KR (2) | KR101789960B1 (enExample) |
| CN (2) | CN104370990A (enExample) |
| AU (1) | AU2009316566B9 (enExample) |
| BR (1) | BRPI0921983B8 (enExample) |
| CA (1) | CA2744189C (enExample) |
| DK (2) | DK2376519T3 (enExample) |
| EA (2) | EA020140B1 (enExample) |
| ES (2) | ES2663948T3 (enExample) |
| HK (1) | HK1205132A1 (enExample) |
| HU (1) | HUE039171T2 (enExample) |
| IL (3) | IL212969A (enExample) |
| LT (1) | LT2698375T (enExample) |
| MX (1) | MX2011005295A (enExample) |
| NO (1) | NO2698375T3 (enExample) |
| PL (2) | PL2698375T3 (enExample) |
| PT (2) | PT2698375T (enExample) |
| SG (1) | SG10201400162QA (enExample) |
| SI (1) | SI2698375T1 (enExample) |
| WO (1) | WO2010059853A1 (enExample) |
| ZA (1) | ZA201104077B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002308295B2 (en) | 2001-03-12 | 2007-08-23 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for FXR |
| EP1734970B1 (en) | 2004-03-12 | 2014-12-31 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using fxr ligands |
| US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| AU2008209566C1 (en) | 2007-01-19 | 2013-02-14 | Intercept Pharmaceuticals, Inc. | 23-substituted bile acids as TGR5 modulators and methods of use thereof |
| EA020310B1 (ru) | 2008-07-30 | 2014-10-30 | Интерсепт Фармасьютикалз, Инк. | Модуляторы рецептора tgr5 и их применение |
| ES2663948T3 (es) * | 2008-11-19 | 2018-04-17 | Intercept Pharmaceuticals, Inc. | Moduladores de TGR5 y método de uso de los mismos |
| WO2010062861A2 (en) | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| CA2744697C (en) | 2008-11-26 | 2016-06-21 | Satiogen Pharmaceuticals, Inc. | Use of compositions comprising bile acids, salts, and mimics thereof for the treatment of obesity or diabetes |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| NZ734451A (en) | 2012-06-19 | 2018-12-21 | Intercept Pharmaceuticals Inc | Preparation, uses and solid forms of obeticholic acid |
| US9982008B2 (en) | 2012-06-19 | 2018-05-29 | Intercept Pharmaceuticals, Inc. | Preparation and uses of obeticholic acid |
| US10302630B2 (en) | 2012-10-09 | 2019-05-28 | The Procter & Gamble Company | Method of identifying or evaluating beneficial actives and compositions containing the same |
| JP6189962B2 (ja) | 2012-10-09 | 2017-08-30 | ザ プロクター アンド ギャンブル カンパニー | 相乗作用する美容成分の組み合わせを特定する方法 |
| US9884066B2 (en) | 2013-06-06 | 2018-02-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Bile acid-basic amino acid conjugates and uses thereof |
| CN105636984A (zh) * | 2013-06-13 | 2016-06-01 | 法斯特弗沃德制药有限公司 | 用于治疗慢性炎症和预防胃肠道癌或纤维化的cd40信号转导抑制剂和其他化合物，该其他化合物是胆汁酸、胆汁酸衍生物、tgr5受体激动剂、fxr激动剂或其组合 |
| SI3071696T1 (sl) | 2013-11-22 | 2019-11-29 | Mina Therapeutics Ltd | C/EBP alfa kratko delujoči RNA sestavki in postopki uporabe |
| US10407462B2 (en) | 2014-05-29 | 2019-09-10 | Bar Pharmaceuticals S.R.L. | Cholane derivatives for use in the treatment and/or prevention of FXR and TGR5/GPBAR1 mediated diseases |
| WO2016054208A1 (en) * | 2014-10-03 | 2016-04-07 | Mayo Foundation For Medical Education And Research | Targeting tgr5 to treat disease |
| WO2016073767A1 (en) * | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
| KR102526631B1 (ko) | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 fxr 조절인자를 제조하기 위한 중간체로서의 6-알킬-7-하이드록시-4-엔-3-온 스테로이드 |
| TWI688571B (zh) | 2014-11-19 | 2020-03-21 | 英商Ｎｚｐ英國有限公司 | 化合物（四） |
| US10538550B2 (en) | 2014-11-19 | 2020-01-21 | NZP UK Limited | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators |
| US10131688B2 (en) | 2014-11-19 | 2018-11-20 | NZP UK Limited | 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators |
| CN105985396A (zh) * | 2015-02-16 | 2016-10-05 | 苏州泽璟生物制药有限公司 | 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物 |
| CN111116699B (zh) * | 2015-04-28 | 2023-02-28 | 江苏豪森药业集团有限公司 | 胆酸衍生物及其制备方法和医药用途 |
| EP3310801B1 (en) * | 2015-06-19 | 2021-04-07 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| US10800807B2 (en) | 2015-06-19 | 2020-10-13 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| EP3353189A4 (en) * | 2015-09-24 | 2019-06-19 | Intercept Pharmaceuticals, Inc. | METHOD AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF GALLENIC ACID DERIVATIVES |
| EP3981779A1 (en) * | 2015-10-07 | 2022-04-13 | Intercept Pharmaceuticals, Inc. | Farnesoid x receptor modulators |
| CN106008639B (zh) * | 2016-03-11 | 2019-01-08 | 深圳市塔吉瑞生物医药有限公司 | 用于预防或治疗fxr-介导疾病的胆烷酸化合物 |
| WO2017180577A1 (en) | 2016-04-13 | 2017-10-19 | Intercept Pharmaceuticals, Inc. | Methods of treating cancer |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| CN108990420B (zh) | 2016-05-29 | 2022-06-24 | 深圳市绘云生物科技有限公司 | 肝病相关生物标志物和其使用方法 |
| WO2018005794A2 (en) * | 2016-07-01 | 2018-01-04 | Venenum Biodesign Llc | Novel non-systemic tgr5 agonists |
| WO2018222701A1 (en) * | 2017-05-30 | 2018-12-06 | Intercept Pharmaceuticals, Inc. | Treatment of renal diseases with a bile acid derivative |
| CN109021056B (zh) * | 2017-06-09 | 2021-03-09 | 博瑞生物医药（苏州）股份有限公司 | 法尼酯x受体激动剂 |
| WO2019023103A1 (en) | 2017-07-24 | 2019-01-31 | Intercept Pharmaceuticals, Inc. | BILIARY ACID DERIVATIVES WITH ISOTOPIC MARKING |
| WO2019048632A1 (en) | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| WO2020163201A1 (en) * | 2019-02-04 | 2020-08-13 | Intercept Pharmaceuticals, Inc. | Treatment and prevention of intestinal inflammatory diseases with a bile acid derivative |
| CN116925168A (zh) | 2019-08-23 | 2023-10-24 | 深圳云合医药科技合伙企业(有限合伙) | 胆汁酸衍生物及其组合物和应用 |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| KR102693566B1 (ko) * | 2020-07-03 | 2024-08-08 | 주식회사 큐라클 | 지방간 질환의 예방 또는 치료를 위한 약학적 조성물 |
| CN113774142A (zh) * | 2021-10-11 | 2021-12-10 | 北京化工大学 | Tgr5在制备治疗肠癌药物及诊断性试剂盒中的应用 |
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| DE3366932D1 (en) | 1982-07-29 | 1986-11-20 | Lehner Ag | New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same |
| IT1206112B (it) | 1983-04-29 | 1989-04-14 | Lehner Ag | Nuovi derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
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| EP0433899B1 (en) * | 1989-12-13 | 1995-04-12 | Mitsubishi Chemical Corporation | New pyrazolyl acrylic acid derivatives, useful as systemic fungicides for plant and material protection |
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| JP4253126B2 (ja) | 1998-01-29 | 2009-04-08 | アムジェン インコーポレイテッド | Ｐｐａｒ−ガンマ調節剤 |
| JP2002528721A (ja) | 1998-10-23 | 2002-09-03 | グラクソ グループ リミテッド | 核内受容体のリガンド用のアッセイ |
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| EP1473042B1 (en) | 1999-03-26 | 2006-06-21 | City of Hope | Screening for FXR receptor modulators |
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| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| PT2040713E (pt) | 2006-06-27 | 2014-10-13 | Intercept Pharmaceuticals Inc | Para a prevenção ou o tratamento de doenças ou estados clínicos mediados por fxr |
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| EP1947108A1 (en) | 2007-01-19 | 2008-07-23 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| ES2663948T3 (es) * | 2008-11-19 | 2018-04-17 | Intercept Pharmaceuticals, Inc. | Moduladores de TGR5 y método de uso de los mismos |
-
2009
- 2009-11-19 ES ES13192394T patent/ES2663948T3/es active Active
- 2009-11-19 NO NO13192394A patent/NO2698375T3/no unknown
- 2009-11-19 BR BRPI0921983A patent/BRPI0921983B8/pt not_active IP Right Cessation
- 2009-11-19 CA CA2744189A patent/CA2744189C/en active Active
- 2009-11-19 SG SG10201400162QA patent/SG10201400162QA/en unknown
- 2009-11-19 EP EP09760057.1A patent/EP2376519B1/en active Active
- 2009-11-19 ES ES09760057.1T patent/ES2458168T3/es active Active
- 2009-11-19 CN CN201410532890.0A patent/CN104370990A/zh active Pending
- 2009-11-19 EA EA201170714A patent/EA020140B1/ru unknown
- 2009-11-19 WO PCT/US2009/065188 patent/WO2010059853A1/en not_active Ceased
- 2009-11-19 LT LTEP13192394.8T patent/LT2698375T/lt unknown
- 2009-11-19 MX MX2011005295A patent/MX2011005295A/es active IP Right Grant
- 2009-11-19 PL PL13192394T patent/PL2698375T3/pl unknown
- 2009-11-19 JP JP2011537624A patent/JP5535233B2/ja not_active Expired - Fee Related
- 2009-11-19 CN CN200980154713.0A patent/CN102325784B/zh active Active
- 2009-11-19 KR KR1020167028159A patent/KR101789960B1/ko not_active Expired - Fee Related
- 2009-11-19 US US12/622,123 patent/US8114862B2/en active Active
- 2009-11-19 KR KR1020117014037A patent/KR101667436B1/ko not_active Expired - Fee Related
- 2009-11-19 PT PT131923948T patent/PT2698375T/pt unknown
- 2009-11-19 DK DK09760057.1T patent/DK2376519T3/da active
- 2009-11-19 DK DK13192394.8T patent/DK2698375T3/en active
- 2009-11-19 HU HUE13192394A patent/HUE039171T2/hu unknown
- 2009-11-19 AU AU2009316566A patent/AU2009316566B9/en active Active
- 2009-11-19 EP EP13192394.8A patent/EP2698375B1/en active Active
- 2009-11-19 EA EA201400258A patent/EA030681B1/ru not_active IP Right Cessation
- 2009-11-19 PL PL09760057T patent/PL2376519T3/pl unknown
- 2009-11-19 SI SI200931820T patent/SI2698375T1/sl unknown
- 2009-11-19 PT PT97600571T patent/PT2376519E/pt unknown
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2011
- 2011-05-18 IL IL212969A patent/IL212969A/en active IP Right Grant
- 2011-06-01 ZA ZA2011/04077A patent/ZA201104077B/en unknown
- 2011-12-07 US US13/313,689 patent/US8445472B2/en not_active Expired - Fee Related
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2013
- 2013-04-26 US US13/871,492 patent/US9650409B2/en not_active Expired - Fee Related
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2014
- 2014-04-22 JP JP2014088019A patent/JP2014159456A/ja not_active Withdrawn
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2015
- 2015-06-10 HK HK15105499.8A patent/HK1205132A1/xx unknown
- 2015-08-14 JP JP2015160141A patent/JP2015232020A/ja active Pending
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2016
- 2016-03-29 IL IL244812A patent/IL244812B/en active IP Right Grant
-
2017
- 2017-04-07 US US15/482,107 patent/US20180016295A1/en not_active Abandoned
- 2017-04-19 JP JP2017083045A patent/JP2017132803A/ja not_active Withdrawn
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2018
- 2018-03-27 JP JP2018059922A patent/JP2018100304A/ja not_active Withdrawn
-
2019
- 2019-02-12 IL IL264796A patent/IL264796B/en active IP Right Grant
-
2020
- 2020-11-09 US US17/092,612 patent/US20210269473A1/en not_active Abandoned
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