JP2019510081A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019510081A5 JP2019510081A5 JP2018566633A JP2018566633A JP2019510081A5 JP 2019510081 A5 JP2019510081 A5 JP 2019510081A5 JP 2018566633 A JP2018566633 A JP 2018566633A JP 2018566633 A JP2018566633 A JP 2018566633A JP 2019510081 A5 JP2019510081 A5 JP 2019510081A5
- Authority
- JP
- Japan
- Prior art keywords
- taa
- composition
- patient
- composition according
- inos inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000008982 Thoracic Aortic Aneurysm Diseases 0.000 claims 13
- 208000007474 aortic aneurysm Diseases 0.000 claims 12
- 208000003457 familial thoracic 1 aortic aneurysm Diseases 0.000 claims 12
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 claims 8
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 208000001826 Marfan syndrome Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- MOLOJNHYNHBPCW-ZETCQYMHSA-N (2s)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid Chemical compound CC(=N)NCCSCC[C@H](N)C(O)=O MOLOJNHYNHBPCW-ZETCQYMHSA-N 0.000 claims 2
- UBDZFAGVPPMTIT-UHFFFAOYSA-N 2-aminoguanidine;hydron;chloride Chemical compound [Cl-].NC(N)=N[NH3+] UBDZFAGVPPMTIT-UHFFFAOYSA-N 0.000 claims 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- 101001124991 Homo sapiens Nitric oxide synthase, inducible Proteins 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 229930064664 L-arginine Natural products 0.000 claims 2
- 235000014852 L-arginine Nutrition 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 2
- 229960004022 clotrimazole Drugs 0.000 claims 2
- 208000016470 familial thoracic aortic aneurysm and aortic dissection Diseases 0.000 claims 2
- 102000055708 human NOS2 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- DDGULJZAQPDKQZ-ZCFIWIBFSA-N (2s)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfonyl]propanoic acid Chemical compound CC(=N)NCCS(=O)(=O)C[C@@H](N)C(O)=O DDGULJZAQPDKQZ-ZCFIWIBFSA-N 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010002899 Aortic injury Diseases 0.000 claims 1
- 206010004552 Bicuspid aortic valve Diseases 0.000 claims 1
- 208000002251 Dissecting Aneurysm Diseases 0.000 claims 1
- ONYFNWIHJBLQKE-ZETCQYMHSA-N N(6)-acetimidoyl-L-lysine Chemical compound CC(=N)NCCCC[C@H](N)C(O)=O ONYFNWIHJBLQKE-ZETCQYMHSA-N 0.000 claims 1
- KCWZGJVSDFYRIX-YFKPBYRVSA-N N(gamma)-nitro-L-arginine methyl ester Chemical compound COC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O KCWZGJVSDFYRIX-YFKPBYRVSA-N 0.000 claims 1
- RODUKNYOEVZQPR-UHFFFAOYSA-N N-[3-(aminomethyl)benzyl]acetamidine Chemical group CC(=N)NCC1=CC=CC(CN)=C1 RODUKNYOEVZQPR-UHFFFAOYSA-N 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 210000002376 aorta thoracic Anatomy 0.000 claims 1
- 206010002895 aortic dissection Diseases 0.000 claims 1
- 208000021654 bicuspid aortic valve disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 238000002224 dissection Methods 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382103.6 | 2016-03-07 | ||
| EP16382103 | 2016-03-07 | ||
| PCT/EP2016/082925 WO2017153023A1 (en) | 2016-03-07 | 2016-12-30 | In vitro method for identifying thoracic aortic aneurysms (taa) in a subject |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510081A JP2019510081A (ja) | 2019-04-11 |
| JP2019510081A5 true JP2019510081A5 (enExample) | 2020-02-13 |
| JP7057976B2 JP7057976B2 (ja) | 2022-04-21 |
Family
ID=55524277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566633A Active JP7057976B2 (ja) | 2016-03-07 | 2016-12-30 | 被験体において胸部大動脈瘤（ＴＡＡ）を同定するｉｎ ｖｉｔｒｏ方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10907135B2 (enExample) |
| EP (1) | EP3427061B1 (enExample) |
| JP (1) | JP7057976B2 (enExample) |
| AU (1) | AU2016396401B2 (enExample) |
| BR (1) | BR112018068045A2 (enExample) |
| CA (1) | CA3017042C (enExample) |
| ES (1) | ES2965961T3 (enExample) |
| WO (1) | WO2017153023A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2555790B1 (es) | 2014-06-05 | 2016-10-13 | Consejo Superior De Investigaciones Científicas (Csic) | Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso |
| US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
| US11459612B2 (en) | 2015-12-01 | 2022-10-04 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for diagnosing cardiomyopathies |
| BR112020010316A2 (pt) | 2017-11-24 | 2020-10-20 | Consejo Superior De Investigaciones Científicas (Csic) | cepa de vacina de brucella modificada para o tratamento de brucelose |
| JP2021513993A (ja) * | 2018-02-19 | 2021-06-03 | ザ ジェネラル ホスピタル コーポレイション | 血管疾患を処置するための方法および組成物 |
| EP3830293B1 (en) * | 2018-07-27 | 2025-01-15 | The Regents of the University of California | Tetrahydrobiopterin as biomarker for thoracic aortic aneurysm |
| WO2021140019A1 (en) * | 2020-01-10 | 2021-07-15 | Deutsches Herzzentrum München Des Freistaates Bayern Klinik An Der Technischen Universität München | Diagnosis of an aortic dissection by detecting a specific biomarker in a blood sample |
| US20210318336A1 (en) * | 2020-04-09 | 2021-10-14 | The Trustees Of The University Of Pennsylvania | Methods for treating aortic aneurysm disease |
| WO2022219196A1 (en) * | 2021-04-16 | 2022-10-20 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for the diagnosis, prognosis and/or treatment of thoracic aortic aneurysm |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109522A1 (en) * | 2001-09-24 | 2003-06-12 | Manning Pamela T. | Ophthalmologic treatment methods using selective iNOS inhibitors |
| US20150203916A1 (en) * | 2012-06-27 | 2015-07-23 | Music Foundation For Research Development | Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm |
| ES2555790B1 (es) | 2014-06-05 | 2016-10-13 | Consejo Superior De Investigaciones Científicas (Csic) | Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso |
| ES2612340B1 (es) | 2015-10-27 | 2018-03-09 | Consejo Superior De Investigaciones Científicas (Csic) | Sensor, aparato y procedimiento para la determinación de la concentración de solutos en disoluciones |
| US11459612B2 (en) | 2015-12-01 | 2022-10-04 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for diagnosing cardiomyopathies |
| RU2018141858A (ru) | 2016-04-29 | 2020-05-29 | Универсидад Аутонома Де Мадрид | Составы с липидными системами, несущими биоактивные соединения для применения в качестве иммунотерапевтического потенцирующего средства или адъюванта для пациентов с раком или иммунологическими нарушениями |
| US10683493B2 (en) | 2016-05-18 | 2020-06-16 | Consejo Superior De Investigaciones Científicas | Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein |
| EP3681515A1 (en) | 2017-09-15 | 2020-07-22 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mafg as a potential therapeutic target to restore chemosensitivity in platinum-resistant cancer cells |
| US20200345701A1 (en) | 2017-11-02 | 2020-11-05 | Consejo Superior De Investigaciones Cientificas (Csic) | Use of statins in overcoming resistance to beta-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway |
| BR112020010316A2 (pt) | 2017-11-24 | 2020-10-20 | Consejo Superior De Investigaciones Científicas (Csic) | cepa de vacina de brucella modificada para o tratamento de brucelose |
| WO2019234189A1 (en) | 2018-06-06 | 2019-12-12 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Enhanced trained immunity in myeloid cells by ship-1 inhibition |
| JP7260341B2 (ja) | 2019-03-06 | 2023-04-18 | スタンレー電気株式会社 | 車両用灯具の制御装置、車両用灯具の制御方法、車両用灯具システム |
-
2016
- 2016-12-30 WO PCT/EP2016/082925 patent/WO2017153023A1/en not_active Ceased
- 2016-12-30 US US16/083,165 patent/US10907135B2/en active Active
- 2016-12-30 CA CA3017042A patent/CA3017042C/en active Active
- 2016-12-30 EP EP16826369.7A patent/EP3427061B1/en active Active
- 2016-12-30 ES ES16826369T patent/ES2965961T3/es active Active
- 2016-12-30 AU AU2016396401A patent/AU2016396401B2/en not_active Ceased
- 2016-12-30 JP JP2018566633A patent/JP7057976B2/ja active Active
- 2016-12-30 BR BR112018068045A patent/BR112018068045A2/pt not_active Application Discontinuation
-
2020
- 2020-12-15 US US17/122,962 patent/US12163161B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019510081A5 (enExample) | ||
| JP2019519533A5 (enExample) | ||
| JP2020522529A5 (enExample) | ||
| JP2009533356A5 (enExample) | ||
| CN110139865A (zh) | Fgfr抑制剂 | |
| CN108026053A8 (zh) | 作为mIDH1抑制剂的稠合的咪唑类化合物 | |
| CN112424200A (zh) | 作为溴区结构域蛋白抑制剂的亚氨基砜类化合物、药物组合物及其医药用途 | |
| CN111683928A (zh) | 作为fgfr抑制剂的吡嗪-2(1h)-酮类化合物 | |
| CN113939514A (zh) | 吡咯并嘧啶类化合物及其应用 | |
| CN114072404A (zh) | Ret选择性抑制剂及其制备方法和用途 | |
| JP2017530163A5 (enExample) | ||
| CN109937200A (zh) | 一种苯并呋喃类衍生物游离碱的晶型及制备方法 | |
| CN111788205A (zh) | 吡唑并嘧啶衍生物及其用途 | |
| CN111566100A (zh) | 嘧啶类化合物、其制备方法及其医药用途 | |
| CN109790123A (zh) | 新型衣壳蛋白装配抑制剂 | |
| EA201201496A1 (ru) | Способ ингибирования интегразы вич, способ улучшения фармакокинетики 6-(3-хлор-2-фторбензил)-1-[(2s)-1-гидрокси-3-метилбутан-2-ил]-7-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновой кислоты (варианты), набор, фармацевтическая композиция (варианты) и антиретровирусный агент (варианты) | |
| CN114728967A (zh) | 作为jak抑制剂的三并杂环类化合物及其应用 | |
| JP2009532434A5 (enExample) | ||
| CN111148515A (zh) | 2,6-二氧杂螺[4,5]癸烷类衍生物、其制备方法及其在医药上的应用 | |
| CN114206836A (zh) | 新型吡咯化合物 | |
| JP2013535391A5 (enExample) | ||
| CN112105620A (zh) | 用于治疗肺癌的tlr7激动剂及其药物组合 | |
| CN111615515A (zh) | 杂环化合物、制备方法及其在医药上的应用 | |
| JP2015509917A5 (enExample) | ||
| CN115485276A (zh) | 氘代akt激酶抑制剂 |