CA3017042C - In vitro method for identifying thoracic aortic aneurysms (taa) in a subject - Google Patents
In vitro method for identifying thoracic aortic aneurysms (taa) in a subject Download PDFInfo
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- CA3017042C CA3017042C CA3017042A CA3017042A CA3017042C CA 3017042 C CA3017042 C CA 3017042C CA 3017042 A CA3017042 A CA 3017042A CA 3017042 A CA3017042 A CA 3017042A CA 3017042 C CA3017042 C CA 3017042C
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- 230000010415 tropism Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000002883 vasorelaxation effect Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
- C12N9/0075—Nitric-oxide synthase (1.14.13.39)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
- C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
- G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
- G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
- G01N2333/96419—Metalloendopeptidases (3.4.24)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/329—Diseases of the aorta or its branches, e.g. aneurysms, aortic dissection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382103.6 | 2016-03-07 | ||
| EP16382103 | 2016-03-07 | ||
| PCT/EP2016/082925 WO2017153023A1 (en) | 2016-03-07 | 2016-12-30 | In vitro method for identifying thoracic aortic aneurysms (taa) in a subject |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3017042A1 CA3017042A1 (en) | 2017-09-14 |
| CA3017042C true CA3017042C (en) | 2024-02-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3017042A Active CA3017042C (en) | 2016-03-07 | 2016-12-30 | In vitro method for identifying thoracic aortic aneurysms (taa) in a subject |
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| Country | Link |
|---|---|
| US (2) | US10907135B2 (enExample) |
| EP (1) | EP3427061B1 (enExample) |
| JP (1) | JP7057976B2 (enExample) |
| AU (1) | AU2016396401B2 (enExample) |
| BR (1) | BR112018068045A2 (enExample) |
| CA (1) | CA3017042C (enExample) |
| ES (1) | ES2965961T3 (enExample) |
| WO (1) | WO2017153023A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2555790B1 (es) | 2014-06-05 | 2016-10-13 | Consejo Superior De Investigaciones Científicas (Csic) | Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso |
| US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
| US11459612B2 (en) | 2015-12-01 | 2022-10-04 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for diagnosing cardiomyopathies |
| BR112020010316A2 (pt) | 2017-11-24 | 2020-10-20 | Consejo Superior De Investigaciones Científicas (Csic) | cepa de vacina de brucella modificada para o tratamento de brucelose |
| JP2021513993A (ja) * | 2018-02-19 | 2021-06-03 | ザ ジェネラル ホスピタル コーポレイション | 血管疾患を処置するための方法および組成物 |
| EP3830293B1 (en) * | 2018-07-27 | 2025-01-15 | The Regents of the University of California | Tetrahydrobiopterin as biomarker for thoracic aortic aneurysm |
| WO2021140019A1 (en) * | 2020-01-10 | 2021-07-15 | Deutsches Herzzentrum München Des Freistaates Bayern Klinik An Der Technischen Universität München | Diagnosis of an aortic dissection by detecting a specific biomarker in a blood sample |
| US20210318336A1 (en) * | 2020-04-09 | 2021-10-14 | The Trustees Of The University Of Pennsylvania | Methods for treating aortic aneurysm disease |
| WO2022219196A1 (en) * | 2021-04-16 | 2022-10-20 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for the diagnosis, prognosis and/or treatment of thoracic aortic aneurysm |
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| US20030109522A1 (en) * | 2001-09-24 | 2003-06-12 | Manning Pamela T. | Ophthalmologic treatment methods using selective iNOS inhibitors |
| US20150203916A1 (en) * | 2012-06-27 | 2015-07-23 | Music Foundation For Research Development | Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm |
| ES2555790B1 (es) | 2014-06-05 | 2016-10-13 | Consejo Superior De Investigaciones Científicas (Csic) | Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso |
| ES2612340B1 (es) | 2015-10-27 | 2018-03-09 | Consejo Superior De Investigaciones Científicas (Csic) | Sensor, aparato y procedimiento para la determinación de la concentración de solutos en disoluciones |
| US11459612B2 (en) | 2015-12-01 | 2022-10-04 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for diagnosing cardiomyopathies |
| RU2018141858A (ru) | 2016-04-29 | 2020-05-29 | Универсидад Аутонома Де Мадрид | Составы с липидными системами, несущими биоактивные соединения для применения в качестве иммунотерапевтического потенцирующего средства или адъюванта для пациентов с раком или иммунологическими нарушениями |
| US10683493B2 (en) | 2016-05-18 | 2020-06-16 | Consejo Superior De Investigaciones Científicas | Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein |
| EP3681515A1 (en) | 2017-09-15 | 2020-07-22 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mafg as a potential therapeutic target to restore chemosensitivity in platinum-resistant cancer cells |
| US20200345701A1 (en) | 2017-11-02 | 2020-11-05 | Consejo Superior De Investigaciones Cientificas (Csic) | Use of statins in overcoming resistance to beta-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway |
| BR112020010316A2 (pt) | 2017-11-24 | 2020-10-20 | Consejo Superior De Investigaciones Científicas (Csic) | cepa de vacina de brucella modificada para o tratamento de brucelose |
| WO2019234189A1 (en) | 2018-06-06 | 2019-12-12 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Enhanced trained immunity in myeloid cells by ship-1 inhibition |
| JP7260341B2 (ja) | 2019-03-06 | 2023-04-18 | スタンレー電気株式会社 | 車両用灯具の制御装置、車両用灯具の制御方法、車両用灯具システム |
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2016
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- 2016-12-30 US US16/083,165 patent/US10907135B2/en active Active
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2020
- 2020-12-15 US US17/122,962 patent/US12163161B2/en active Active
Also Published As
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| US20210363501A1 (en) | 2021-11-25 |
| US20190112582A1 (en) | 2019-04-18 |
| BR112018068045A2 (pt) | 2019-01-08 |
| ES2965961T3 (es) | 2024-04-17 |
| CA3017042A1 (en) | 2017-09-14 |
| EP3427061A1 (en) | 2019-01-16 |
| US12163161B2 (en) | 2024-12-10 |
| AU2016396401B2 (en) | 2023-07-13 |
| US10907135B2 (en) | 2021-02-02 |
| JP2019510081A (ja) | 2019-04-11 |
| WO2017153023A1 (en) | 2017-09-14 |
| EP3427061B1 (en) | 2023-12-06 |
| AU2016396401A1 (en) | 2018-10-25 |
| EP3427061C0 (en) | 2023-12-06 |
| JP7057976B2 (ja) | 2022-04-21 |
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