JP7057976B2 - 被験体において胸部大動脈瘤(TAA)を同定するin vitro方法 - Google Patents

被験体において胸部大動脈瘤(TAA)を同定するin vitro方法 Download PDF

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JP7057976B2
JP7057976B2 JP2018566633A JP2018566633A JP7057976B2 JP 7057976 B2 JP7057976 B2 JP 7057976B2 JP 2018566633 A JP2018566633 A JP 2018566633A JP 2018566633 A JP2018566633 A JP 2018566633A JP 7057976 B2 JP7057976 B2 JP 7057976B2
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JP2019510081A (ja
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モジャ ファン ミゲル レドンド
ネレア メンデス-バルベロ
ペドロサ ホルヘ オジェル
ガルシア ミゲル ラモン カンパネーロ
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075Nitric-oxide synthase (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96419Metalloendopeptidases (3.4.24)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/329Diseases of the aorta or its branches, e.g. aneurysms, aortic dissection

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  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018566633A 2016-03-07 2016-12-30 被験体において胸部大動脈瘤(TAA)を同定するin vitro方法 Active JP7057976B2 (ja)

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EP16382103.6 2016-03-07
EP16382103 2016-03-07
PCT/EP2016/082925 WO2017153023A1 (en) 2016-03-07 2016-12-30 In vitro method for identifying thoracic aortic aneurysms (taa) in a subject

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JP2019510081A JP2019510081A (ja) 2019-04-11
JP2019510081A5 JP2019510081A5 (enExample) 2020-02-13
JP7057976B2 true JP7057976B2 (ja) 2022-04-21

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US (2) US10907135B2 (enExample)
EP (1) EP3427061B1 (enExample)
JP (1) JP7057976B2 (enExample)
AU (1) AU2016396401B2 (enExample)
BR (1) BR112018068045A2 (enExample)
CA (1) CA3017042C (enExample)
ES (1) ES2965961T3 (enExample)
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ES2555790B1 (es) 2014-06-05 2016-10-13 Consejo Superior De Investigaciones Científicas (Csic) Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso
US11143659B2 (en) 2015-01-27 2021-10-12 Arterez, Inc. Biomarkers of vascular disease
US11459612B2 (en) 2015-12-01 2022-10-04 Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) Method for diagnosing cardiomyopathies
BR112020010316A2 (pt) 2017-11-24 2020-10-20 Consejo Superior De Investigaciones Científicas (Csic) cepa de vacina de brucella modificada para o tratamento de brucelose
JP2021513993A (ja) * 2018-02-19 2021-06-03 ザ ジェネラル ホスピタル コーポレイション 血管疾患を処置するための方法および組成物
EP3830293B1 (en) * 2018-07-27 2025-01-15 The Regents of the University of California Tetrahydrobiopterin as biomarker for thoracic aortic aneurysm
WO2021140019A1 (en) * 2020-01-10 2021-07-15 Deutsches Herzzentrum München Des Freistaates Bayern Klinik An Der Technischen Universität München Diagnosis of an aortic dissection by detecting a specific biomarker in a blood sample
US20210318336A1 (en) * 2020-04-09 2021-10-14 The Trustees Of The University Of Pennsylvania Methods for treating aortic aneurysm disease
WO2022219196A1 (en) * 2021-04-16 2022-10-20 Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) Method for the diagnosis, prognosis and/or treatment of thoracic aortic aneurysm

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US20030109522A1 (en) * 2001-09-24 2003-06-12 Manning Pamela T. Ophthalmologic treatment methods using selective iNOS inhibitors
US20150203916A1 (en) * 2012-06-27 2015-07-23 Music Foundation For Research Development Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm
ES2555790B1 (es) 2014-06-05 2016-10-13 Consejo Superior De Investigaciones Científicas (Csic) Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso
ES2612340B1 (es) 2015-10-27 2018-03-09 Consejo Superior De Investigaciones Científicas (Csic) Sensor, aparato y procedimiento para la determinación de la concentración de solutos en disoluciones
US11459612B2 (en) 2015-12-01 2022-10-04 Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) Method for diagnosing cardiomyopathies
RU2018141858A (ru) 2016-04-29 2020-05-29 Универсидад Аутонома Де Мадрид Составы с липидными системами, несущими биоактивные соединения для применения в качестве иммунотерапевтического потенцирующего средства или адъюванта для пациентов с раком или иммунологическими нарушениями
US10683493B2 (en) 2016-05-18 2020-06-16 Consejo Superior De Investigaciones Científicas Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein
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US20210363501A1 (en) 2021-11-25
US20190112582A1 (en) 2019-04-18
BR112018068045A2 (pt) 2019-01-08
ES2965961T3 (es) 2024-04-17
CA3017042A1 (en) 2017-09-14
EP3427061A1 (en) 2019-01-16
US12163161B2 (en) 2024-12-10
AU2016396401B2 (en) 2023-07-13
US10907135B2 (en) 2021-02-02
JP2019510081A (ja) 2019-04-11
WO2017153023A1 (en) 2017-09-14
EP3427061B1 (en) 2023-12-06
CA3017042C (en) 2024-02-20
AU2016396401A1 (en) 2018-10-25
EP3427061C0 (en) 2023-12-06

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