ES2965961T3 - Uso de inhibidores selectivos de INOS para el tratamiento de aneurismas de la aorta torácica (TAA) en un sujeto - Google Patents
Uso de inhibidores selectivos de INOS para el tratamiento de aneurismas de la aorta torácica (TAA) en un sujeto Download PDFInfo
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- ES2965961T3 ES2965961T3 ES16826369T ES16826369T ES2965961T3 ES 2965961 T3 ES2965961 T3 ES 2965961T3 ES 16826369 T ES16826369 T ES 16826369T ES 16826369 T ES16826369 T ES 16826369T ES 2965961 T3 ES2965961 T3 ES 2965961T3
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- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
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- 150000003536 tetrazoles Chemical class 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
- C12N9/0075—Nitric-oxide synthase (1.14.13.39)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
- C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
- G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
- G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
- G01N2333/96419—Metalloendopeptidases (3.4.24)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/329—Diseases of the aorta or its branches, e.g. aneurysms, aortic dissection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Zoology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382103 | 2016-03-07 | ||
| PCT/EP2016/082925 WO2017153023A1 (en) | 2016-03-07 | 2016-12-30 | In vitro method for identifying thoracic aortic aneurysms (taa) in a subject |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2965961T3 true ES2965961T3 (es) | 2024-04-17 |
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| Country | Link |
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| US (2) | US10907135B2 (enExample) |
| EP (1) | EP3427061B1 (enExample) |
| JP (1) | JP7057976B2 (enExample) |
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| ES2555790B1 (es) | 2014-06-05 | 2016-10-13 | Consejo Superior De Investigaciones Científicas (Csic) | Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso |
| WO2016123163A2 (en) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarkers of vascular disease |
| US11459612B2 (en) | 2015-12-01 | 2022-10-04 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for diagnosing cardiomyopathies |
| BR112020010316A2 (pt) | 2017-11-24 | 2020-10-20 | Consejo Superior De Investigaciones Científicas (Csic) | cepa de vacina de brucella modificada para o tratamento de brucelose |
| JP2021513993A (ja) * | 2018-02-19 | 2021-06-03 | ザ ジェネラル ホスピタル コーポレイション | 血管疾患を処置するための方法および組成物 |
| CN112752851B (zh) * | 2018-07-27 | 2025-06-17 | 加利福尼亚大学董事会 | 胸主动脉瘤的生物标志物 |
| JP2023510811A (ja) * | 2020-01-10 | 2023-03-15 | ドイチェス ヘルツェントラム ミュンヘン デス フライスターテス バイエルン クリニク アン デア テヒニシェン ウニベルジテート ミュンヘン | 血液サンプルにおける特異的なバイオマーカーの検出による大動脈解離の診断 |
| US20210318336A1 (en) * | 2020-04-09 | 2021-10-14 | The Trustees Of The University Of Pennsylvania | Methods for treating aortic aneurysm disease |
| WO2022219196A1 (en) * | 2021-04-16 | 2022-10-20 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for the diagnosis, prognosis and/or treatment of thoracic aortic aneurysm |
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| US20030109522A1 (en) | 2001-09-24 | 2003-06-12 | Manning Pamela T. | Ophthalmologic treatment methods using selective iNOS inhibitors |
| US20150203916A1 (en) | 2012-06-27 | 2015-07-23 | Music Foundation For Research Development | Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm |
| ES2555790B1 (es) | 2014-06-05 | 2016-10-13 | Consejo Superior De Investigaciones Científicas (Csic) | Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso |
| ES2612340B1 (es) | 2015-10-27 | 2018-03-09 | Consejo Superior De Investigaciones Científicas (Csic) | Sensor, aparato y procedimiento para la determinación de la concentración de solutos en disoluciones |
| US11459612B2 (en) | 2015-12-01 | 2022-10-04 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Method for diagnosing cardiomyopathies |
| RU2021104805A (ru) | 2016-04-29 | 2021-03-23 | Универсидад Аутонома Де Мадрид | Составы с липидными системами, несущими биоактивные соединения для применения в качестве иммунотерапевтического потенцирующего средства или адъюванта для пациентов с раком или иммунологическими нарушениями |
| US10683493B2 (en) | 2016-05-18 | 2020-06-16 | Consejo Superior De Investigaciones Científicas | Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein |
| EP3681515A1 (en) | 2017-09-15 | 2020-07-22 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mafg as a potential therapeutic target to restore chemosensitivity in platinum-resistant cancer cells |
| US20200345701A1 (en) | 2017-11-02 | 2020-11-05 | Consejo Superior De Investigaciones Cientificas (Csic) | Use of statins in overcoming resistance to beta-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway |
| BR112020010316A2 (pt) | 2017-11-24 | 2020-10-20 | Consejo Superior De Investigaciones Científicas (Csic) | cepa de vacina de brucella modificada para o tratamento de brucelose |
| EP3801555A1 (en) | 2018-06-06 | 2021-04-14 | Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) | Enhanced trained immunity in myeloid cells by ship-1 inhibition |
| JP7260341B2 (ja) | 2019-03-06 | 2023-04-18 | スタンレー電気株式会社 | 車両用灯具の制御装置、車両用灯具の制御方法、車両用灯具システム |
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- 2016-12-30 AU AU2016396401A patent/AU2016396401B2/en not_active Ceased
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Also Published As
| Publication number | Publication date |
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| JP2019510081A (ja) | 2019-04-11 |
| BR112018068045A2 (pt) | 2019-01-08 |
| JP7057976B2 (ja) | 2022-04-21 |
| CA3017042A1 (en) | 2017-09-14 |
| CA3017042C (en) | 2024-02-20 |
| US12163161B2 (en) | 2024-12-10 |
| US20210363501A1 (en) | 2021-11-25 |
| WO2017153023A1 (en) | 2017-09-14 |
| US10907135B2 (en) | 2021-02-02 |
| EP3427061B1 (en) | 2023-12-06 |
| EP3427061C0 (en) | 2023-12-06 |
| AU2016396401A1 (en) | 2018-10-25 |
| AU2016396401B2 (en) | 2023-07-13 |
| EP3427061A1 (en) | 2019-01-16 |
| US20190112582A1 (en) | 2019-04-18 |
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