JP2012508223A5 - - Google Patents
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- Publication number
- JP2012508223A5 JP2012508223A5 JP2011535182A JP2011535182A JP2012508223A5 JP 2012508223 A5 JP2012508223 A5 JP 2012508223A5 JP 2011535182 A JP2011535182 A JP 2011535182A JP 2011535182 A JP2011535182 A JP 2011535182A JP 2012508223 A5 JP2012508223 A5 JP 2012508223A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- triazin
- alkyl
- pyridin
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 25
- 125000000623 heterocyclic group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 16
- 125000004452 carbocyclyl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 10
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 9
- 229910052731 fluorine Inorganic materials 0.000 claims 9
- 229910052740 iodine Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 230000003796 beauty Effects 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000003463 hyperproliferative effect Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
- 125000003860 C1-C20 alkoxy group Chemical group 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 2
- 208000006029 Cardiomegaly Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 230000006044 T cell activation Effects 0.000 claims 2
- 108090000190 Thrombin Proteins 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 230000001066 destructive effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 208000033065 inborn errors of immunity Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 208000028529 primary immunodeficiency disease Diseases 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- 229960004072 thrombin Drugs 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- WMHAVCWMHYZXHG-UHFFFAOYSA-N 3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenol Chemical compound OC1=CC=CC(C=2N=C(N=C(N=2)N2CCOCC2)N2CCOCC2)=C1 WMHAVCWMHYZXHG-UHFFFAOYSA-N 0.000 claims 1
- CONLCFVHCYLZKW-UHFFFAOYSA-N 3-[4-morpholin-4-yl-6-(pyridin-2-ylmethylamino)-1,3,5-triazin-2-yl]phenol Chemical compound OC1=CC=CC(C=2N=C(N=C(NCC=3N=CC=CC=3)N=2)N2CCOCC2)=C1 CONLCFVHCYLZKW-UHFFFAOYSA-N 0.000 claims 1
- KAMYTFFDGJCUCA-UHFFFAOYSA-N 4-(1h-benzimidazol-4-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=3N=CNC=3C=CC=2)=NC=1N1CCOCC1 KAMYTFFDGJCUCA-UHFFFAOYSA-N 0.000 claims 1
- NNOOIRJOIGXMEE-UHFFFAOYSA-N 4-(1h-indazol-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=C3C=NNC3=CC=2)=NC=1N1CCOCC1 NNOOIRJOIGXMEE-UHFFFAOYSA-N 0.000 claims 1
- AZIIYUJTCFFXTJ-UHFFFAOYSA-N 4-(1h-indol-4-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=3C=CNC=3C=CC=2)=NC=1N1CCOCC1 AZIIYUJTCFFXTJ-UHFFFAOYSA-N 0.000 claims 1
- WRVPFLBQQXTMEU-UHFFFAOYSA-N 4-(1h-indol-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=C3C=CNC3=CC=2)=NC=1N1CCOCC1 WRVPFLBQQXTMEU-UHFFFAOYSA-N 0.000 claims 1
- MDHMXHNFPXWJEG-UHFFFAOYSA-N 4-(2-aminopyrimidin-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C1=NC(N)=NC=C1C1=NC(NCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 MDHMXHNFPXWJEG-UHFFFAOYSA-N 0.000 claims 1
- VMXPZMLXTHXGLQ-UHFFFAOYSA-N 4-(3h-benzimidazol-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=C3N=CNC3=CC=2)=NC=1N1CCOCC1 VMXPZMLXTHXGLQ-UHFFFAOYSA-N 0.000 claims 1
- CAVNILDGKKVJSJ-UHFFFAOYSA-N 4-(6-aminopyridin-3-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C1=NC(N)=CC=C1C1=NC(NCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 CAVNILDGKKVJSJ-UHFFFAOYSA-N 0.000 claims 1
- BBDMJQBDNFISIX-UHFFFAOYSA-N 4-[4-(1h-benzimidazol-4-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=3N=CNC=3C=CC=2)=NC=1N1CCOCC1 BBDMJQBDNFISIX-UHFFFAOYSA-N 0.000 claims 1
- UPZKDZOZSLCPDX-UHFFFAOYSA-N 4-[4-(1h-indazol-4-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=3C=NNC=3C=CC=2)=NC=1N1CCOCC1 UPZKDZOZSLCPDX-UHFFFAOYSA-N 0.000 claims 1
- AYCPQGCCBNIKNU-UHFFFAOYSA-N 4-[4-(1h-indazol-5-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=C3C=NNC3=CC=2)=NC=1N1CCOCC1 AYCPQGCCBNIKNU-UHFFFAOYSA-N 0.000 claims 1
- BWHGEHLHWRIFSI-UHFFFAOYSA-N 4-[4-(1h-indol-4-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=3C=CNC=3C=CC=2)=NC=1N1CCOCC1 BWHGEHLHWRIFSI-UHFFFAOYSA-N 0.000 claims 1
- DDQOBEBNFDEMIW-UHFFFAOYSA-N 4-[4-(1h-indol-5-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=C3C=CNC3=CC=2)=NC=1N1CCOCC1 DDQOBEBNFDEMIW-UHFFFAOYSA-N 0.000 claims 1
- ADGGYDAFIHSYFI-UHFFFAOYSA-N 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=N1 ADGGYDAFIHSYFI-UHFFFAOYSA-N 0.000 claims 1
- IFPHRQQBRZZIOQ-UHFFFAOYSA-N 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine Chemical compound FC(F)(F)C1=NC(N)=NC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=N1 IFPHRQQBRZZIOQ-UHFFFAOYSA-N 0.000 claims 1
- OCKCSFKWKYZXKV-UHFFFAOYSA-N 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-6-(trifluoromethyl)pyridin-2-amine Chemical compound FC(F)(F)C1=NC(N)=CC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=N1 OCKCSFKWKYZXKV-UHFFFAOYSA-N 0.000 claims 1
- WIVHSFPCDNBXSB-UHFFFAOYSA-N 5-[4-morpholin-4-yl-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]pyridin-2-amine Chemical compound C1=NC(N)=CC=C1C1=NC(OCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 WIVHSFPCDNBXSB-UHFFFAOYSA-N 0.000 claims 1
- HGNGQAXXKVMOMI-UHFFFAOYSA-N 5-[4-morpholin-4-yl-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]pyrimidin-2-amine Chemical compound C1=NC(N)=NC=C1C1=NC(OCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 HGNGQAXXKVMOMI-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- VEFTXXDQMDONGC-UHFFFAOYSA-N C1COCCN1C2N=CN=C(N2C3=CC4=C(C=C3)N=CN4)OCC5=CC=CC=N5 Chemical compound C1COCCN1C2N=CN=C(N2C3=CC4=C(C=C3)N=CN4)OCC5=CC=CC=N5 VEFTXXDQMDONGC-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000002952 polymeric resin Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 229920003002 synthetic resin Polymers 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 *C(*1)C(C2N=C(N3C(*)C(*)OC(*)C3*)N=C(*)C2)=C(*)N=C1N* Chemical compound *C(*1)C(C2N=C(N3C(*)C(*)OC(*)C3*)N=C(*)C2)=C(*)N=C1N* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08211219.3 | 2008-11-10 | ||
| GB0821219A GB2465405A (en) | 2008-11-10 | 2008-11-10 | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| PCT/IB2009/007404 WO2010052569A2 (en) | 2008-11-10 | 2009-11-10 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015020319A Division JP6047184B2 (ja) | 2008-11-10 | 2015-02-04 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508223A JP2012508223A (ja) | 2012-04-05 |
| JP2012508223A5 true JP2012508223A5 (cg-RX-API-DMAC7.html) | 2012-12-27 |
| JP5738768B2 JP5738768B2 (ja) | 2015-06-24 |
Family
ID=40230564
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535182A Active JP5738768B2 (ja) | 2008-11-10 | 2009-11-10 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
| JP2015020319A Active JP6047184B2 (ja) | 2008-11-10 | 2015-02-04 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015020319A Active JP6047184B2 (ja) | 2008-11-10 | 2015-02-04 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
Country Status (22)
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3086695B2 (ja) | 1990-07-20 | 2000-09-11 | 株式会社東芝 | ガスタービン制御装置 |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| MX2011010105A (es) | 2009-03-27 | 2012-01-12 | Pathway Therapeutics Inc | Sulfonamidas de pirimidinilo y 1,3,5-triazinilo benzimidazol y su uso en terapia de cancer. |
| UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| AR080945A1 (es) | 2009-07-07 | 2012-05-23 | Pathway Therapeutics Inc | Pirimidinil y 1,3,5-triazinil benzimidazoles y su uso en la terapia contra el cancer |
| IN2012DN01325A (cg-RX-API-DMAC7.html) * | 2009-08-20 | 2015-06-05 | Karus Therapeutics Ltd | |
| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| WO2011107585A1 (en) | 2010-03-04 | 2011-09-09 | Cellzome Limited | Morpholino substituted urea derivatives as mtor inhibitors |
| BR112013006272A2 (pt) | 2010-09-17 | 2019-09-24 | Purdue Pharma Lp | compostos de piridina e seus usos |
| JP5775171B2 (ja) * | 2010-12-16 | 2015-09-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 三環系ｐｉ３ｋ阻害剤化合物及びその使用方法 |
| AU2015268776B2 (en) * | 2010-12-16 | 2017-04-13 | Genentech, Inc. | Tricyclic PI3k inhibitor compounds and methods of use |
| KR20130119964A (ko) * | 2010-12-22 | 2013-11-01 | 퍼듀 퍼머 엘피 | 나트륨 채널 차단제로서의 치환된 피리딘 |
| EP2667874A4 (en) * | 2011-01-27 | 2014-07-30 | Univ Princeton | MTOR KINASE HEMMER AS ANTIVIRUS AGENT |
| WO2012122383A2 (en) * | 2011-03-09 | 2012-09-13 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
| CA2831582C (en) | 2011-03-28 | 2019-01-08 | Mei Pharma, Inc. | (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
| CN102389430B (zh) * | 2011-09-07 | 2013-08-28 | 苏州大学 | 一种小分子化合物在制备抗肺癌药物中的应用 |
| WO2013041652A1 (en) * | 2011-09-21 | 2013-03-28 | Cellzome Limited | Morpholino substituted urea or carbamate derivatives as mtor inhibitors |
| AP3907A (en) | 2011-09-27 | 2016-11-23 | Novartis Ag | 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
| WO2013050508A1 (en) * | 2011-10-07 | 2013-04-11 | Cellzome Limited | Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mtor inhibitors |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| CA2867452C (en) * | 2012-03-19 | 2020-04-14 | Council Of Scientific & Industrial Research | Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta. |
| EP2874632B1 (en) * | 2012-07-23 | 2020-06-17 | Sphaera Pharma Pte. Ltd | Triazine compound having pi3k-alpha and mtor inhibiting activity |
| CN107573363A (zh) | 2012-09-20 | 2018-01-12 | Udc 爱尔兰有限责任公司 | 供电子应用的氮杂二苯并呋喃和包含氮杂二苯并呋喃的电子器件 |
| CN102875558A (zh) * | 2012-11-05 | 2013-01-16 | 贵州大学 | 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途 |
| NZ707366A (en) | 2012-11-07 | 2018-11-30 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| CN105050602B (zh) * | 2013-01-12 | 2018-05-25 | 张大为 | 作为pi3激酶抑制剂的吡啶化合物 |
| WO2014141104A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| WO2014177060A1 (en) | 2013-05-01 | 2014-11-06 | F.Hoffmann-La Roche Ag | Biheteroaryl compounds and uses thereof |
| NZ714283A (en) | 2013-05-10 | 2020-04-24 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
| CN103483345B (zh) * | 2013-09-25 | 2016-07-06 | 中山大学 | Pi3k激酶抑制剂、包含其的药物组合物及其应用 |
| WO2015088564A1 (en) * | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds |
| WO2015088565A1 (en) * | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds and methods of use thereof |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| US9982123B2 (en) | 2014-04-02 | 2018-05-29 | Ineos Styrolution Group Gmbh | Process for producing thermoplastic moulding compositions with improved mechanical properties |
| CN106458968B (zh) | 2014-04-22 | 2019-06-25 | 巴塞尔大学 | 三嗪、嘧啶和吡啶衍生物的新制备方法 |
| KR102287012B1 (ko) * | 2014-05-28 | 2021-08-09 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
| US10689383B2 (en) | 2014-08-04 | 2020-06-23 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| CN104151256B (zh) * | 2014-08-14 | 2016-08-24 | 西安交通大学 | 二取代苯甲酰胺类化合物及其合成方法和应用 |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| MA40933A (fr) * | 2014-11-11 | 2017-09-19 | Piqur Therapeutics Ag | Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines |
| CN104473923B (zh) * | 2014-12-29 | 2016-08-17 | 巩春智 | 一种防治慢性心力衰竭的药物组合物及其应用 |
| SG11201706146UA (en) | 2015-02-02 | 2017-08-30 | Forma Therapeutics Inc | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| CN104860956B (zh) * | 2015-04-30 | 2017-05-10 | 华南师范大学 | 一种荧光多功能单体及其合成方法与应用 |
| CN106279211B (zh) * | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| MX391850B (es) | 2015-12-10 | 2025-03-19 | Ptc Therapeutics Inc | Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington |
| CN113999249B (zh) * | 2015-12-16 | 2025-03-25 | 基因泰克公司 | 用于制备三环pi3k抑制剂化合物的方法及用其治疗癌症的方法 |
| GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| KR101919189B1 (ko) * | 2016-02-18 | 2018-11-15 | 경북대학교 산학협력단 | 다중치환 4H-티아졸로[4,5-e][1,4]다이아제핀-5,8-다이온 유도체 및 이의 용도 |
| CN108698996B (zh) | 2016-02-19 | 2021-10-01 | 思普瑞特生物科学公司 | 可用于治疗癌症和糖尿病的6-芳基-4-吗啉-1-基吡啶酮化合物 |
| AU2017219847B2 (en) | 2016-02-19 | 2021-02-04 | Sprint Bioscience Ab | 6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| WO2017198346A1 (en) * | 2016-05-18 | 2017-11-23 | Piqur Therapeutics Ag | Treatment of neurological disorders |
| EP3458035A1 (en) * | 2016-05-18 | 2019-03-27 | PIQUR Therapeutics AG | Treatment of skin lesions |
| KR102483630B1 (ko) * | 2016-05-18 | 2023-01-02 | 토르쿠르 아게 | 피부 병변의 치료 |
| WO2017210545A1 (en) | 2016-06-02 | 2017-12-07 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| WO2017218950A1 (en) | 2016-06-17 | 2017-12-21 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| KR20190049691A (ko) | 2016-07-07 | 2019-05-09 | 카듀리온 파마슈티칼스, 엘엘씨 | 심부전의 치료 방법 |
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| US10829452B2 (en) | 2016-12-22 | 2020-11-10 | Global Blood Therapeutics, Inc. | Histone methyltransferase inhibitors |
| PL3571193T3 (pl) | 2017-01-23 | 2022-04-25 | Cadent Therapeutics, Inc. | Modulatory kanału potasowego |
| US11718589B2 (en) | 2017-02-06 | 2023-08-08 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase |
| GB201702938D0 (en) | 2017-02-23 | 2017-04-12 | Univ Southampton | Methods of generating and screening compartmentalised peptides libraries |
| CN117860758A (zh) | 2017-05-23 | 2024-04-12 | 梅制药公司 | 联合疗法 |
| CN107216344B (zh) * | 2017-05-27 | 2019-06-21 | 无锡捷化医药科技有限公司 | 一种5-溴-噻唑并[4,5-d]嘧啶的制备方法 |
| SG11201911615WA (en) | 2017-06-05 | 2020-01-30 | Ptc Therapeutics Inc | Compounds for treating huntington's disease |
| US11111243B2 (en) | 2017-06-09 | 2021-09-07 | Global Blood Therapeutics, Inc. | Azaindole compounds as histone methyltransferase inhibitors |
| CN107266422A (zh) * | 2017-06-12 | 2017-10-20 | 西安交通大学 | 2‑（5‑嘧啶基）‑4‑吗啉基‑6‑取代均三嗪类化合物及其盐、制备方法和应用 |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| WO2019005980A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| KR20200041358A (ko) | 2017-08-14 | 2020-04-21 | 메이 파마, 아이엔씨. | 병용 요법 |
| CN109651341A (zh) * | 2017-10-11 | 2019-04-19 | 上海医药工业研究院 | 二吗啉氰基嘧(吡)啶类衍生物及作为抗肿瘤药物应用 |
| CN111315384A (zh) | 2017-11-23 | 2020-06-19 | 皮奎尔治疗公司 | 皮肤病的治疗 |
| DK3753937T3 (da) | 2018-02-07 | 2024-02-12 | Wuxi Biocity Biopharmaceutics Co Ltd | Atr-hæmmer og anvendelse deraf |
| AU2019243048A1 (en) * | 2018-03-27 | 2020-10-15 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| CN112189012B (zh) * | 2018-04-10 | 2024-02-13 | 神经孔疗法股份有限公司 | 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物 |
| BR112020021153A2 (pt) | 2018-04-17 | 2021-03-23 | Cardurion Pharmaceuticals, Llc | sais de meglumina de tienopirimidinas |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| BR112020026534A2 (pt) | 2018-06-27 | 2021-03-23 | Ptc Therapeutics, Inc. | Compostos de heteroarila para o tratamento da doença de huntington |
| MX2020014098A (es) | 2018-06-27 | 2021-05-27 | Ptc Therapeutics Inc | Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington. |
| WO2020030708A1 (en) | 2018-08-07 | 2020-02-13 | Piqur Therapeutics Ag | Treatment of squamous cell carcinoma |
| BR112021007552A2 (pt) | 2018-10-22 | 2021-07-27 | Cadent Therapeutics, Inc. | formas cristalinas de moduladores de canal de potássio |
| CN113507931B (zh) | 2018-11-21 | 2025-05-27 | 卡斯西部储备大学 | 调节短链脱氢酶活性的组合物和方法 |
| JP7458406B2 (ja) | 2018-12-21 | 2024-03-29 | セルジーン コーポレーション | Ｒｉｐｋ２のチエノピリジン阻害剤 |
| CA3125625A1 (en) * | 2019-01-04 | 2020-07-09 | Bellbrook Labs, Llc | Inhibitors of cgas activity as therapeutic agents |
| MA54907A (fr) * | 2019-02-06 | 2022-05-11 | Venthera Inc | Inhibiteurs de phosphoinositide 3-kinase topiques |
| CN109942562B (zh) * | 2019-02-27 | 2022-02-08 | 江西科技师范大学 | 含芳基结构的五元杂环联三嗪类化合物及其制备方法和应用 |
| US12358932B2 (en) * | 2019-07-03 | 2025-07-15 | Borah, Inc. | Chemical compounds |
| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| PE20230240A1 (es) | 2019-12-20 | 2023-02-07 | Nuevolution As | Compuestos activos frente a receptores nucleares |
| EP4090426B1 (en) | 2020-01-13 | 2025-12-31 | Verge Analytics, Inc. | Substitutes for pyrazolos and pyrimidines and their uses |
| JP7713954B2 (ja) | 2020-03-31 | 2025-07-28 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
| AU2021245397A1 (en) | 2020-03-31 | 2022-10-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CN117255687A (zh) | 2020-11-25 | 2023-12-19 | 德西费拉制药有限责任公司 | 吗啉衍生物作为vsp34抑制剂用于治疗病毒感染 |
| US20250188062A1 (en) * | 2021-01-25 | 2025-06-12 | Athos Therapeutics, Inc. | Triazine compounds and methods of making and using the same |
| CN117396470A (zh) * | 2021-04-09 | 2024-01-12 | 巴塞尔大学 | 作为pi3k的可逆和不可逆共价抑制剂的三嗪衍生物 |
| WO2022214701A1 (en) * | 2021-04-09 | 2022-10-13 | Universität Basel | Triazine derivative as covalent inhibitors of pi3k |
| KR20240008312A (ko) * | 2021-04-09 | 2024-01-18 | 유니버시타트 바셀 | Pi3k의 가역적 및 비가역적 공유 억제제로서의 트리아진 유도체 |
| CN117751127A (zh) * | 2021-08-20 | 2024-03-22 | 南京大美生物制药有限公司 | 一种五元含氮杂环并杂芳基类衍生物及其用途 |
| MX2024007010A (es) * | 2021-12-08 | 2024-08-26 | Kineta Inc | Pirimidinas y metodos para su uso. |
| WO2024015531A2 (en) * | 2022-07-13 | 2024-01-18 | University Of Kentucky Research Foundation | Triazine lipids, lipid synthesis, and methods for inhibiting canonical nf kb transcriptional activity |
| CN114933594A (zh) * | 2022-07-20 | 2022-08-23 | 北京科翔中升医药科技有限公司 | 一种氟代三嗪类化合物、药物组合物及用途 |
| CN116003448B (zh) * | 2022-11-07 | 2024-06-11 | 淮阴工学院 | 一种含吲哚啉多烯键识别Aβ纤维的BODIPY近红外荧光探针及其制备方法 |
| WO2024187321A1 (zh) * | 2023-03-10 | 2024-09-19 | 甫康（上海）健康科技有限责任公司 | 含有egfr抑制剂的药物组合物及其制备方法和应用 |
| US20250206729A1 (en) * | 2023-12-22 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Dual raf and tubulin inhibitors and methods of use thereof |
| WO2025181366A1 (en) * | 2024-03-01 | 2025-09-04 | Torqur Ag | Topical formulations of dual pi3k/mtor inhibitors |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670550B2 (de) * | 1967-02-17 | 1973-04-26 | Deutsche Gold und Silber Scheide anstalt vormals Roessler, 6000 Frank fürt | Substituierte 2-amino-4-hydrazino6-piperazino-s-triazine |
| DE2013357A1 (en) * | 1970-03-20 | 1971-10-07 | Farbenfabriken Bayer AG,5O9O Lever kusen | Iminocarboxylic acid derivs in prepn of s-triazines |
| DE2712686C2 (de) * | 1977-03-23 | 1986-09-04 | Bayer Ag, 5090 Leverkusen | 4-Triazinyl-4'-benzoxazolyl- bzw. 4'-phenyl-stilben-derivate |
| JPS59145250A (ja) * | 1983-02-04 | 1984-08-20 | Mitsubishi Chem Ind Ltd | アントラキノン化合物及びアントラキノン染料 |
| GB8612062D0 (en) * | 1986-05-17 | 1986-06-25 | Fbc Ltd | Herbicides |
| WO1993017009A1 (fr) * | 1992-02-28 | 1993-09-02 | Zenyaku Kogyo Kabushiki Kaisha | DERIVE DE s-TRIAZINE ET REMEDE CONTRE DES MALADIES DEPENDENTES DE L'×STROGENE LE CONTENANT COMME INGREDIENT ACTIF |
| BR9508539A (pt) * | 1994-08-08 | 1997-10-28 | Nippon Shinyaku Co Ltd | Derivado de triazina e medicamento |
| EP1126843A4 (en) * | 1998-10-29 | 2005-06-15 | Bristol Myers Squibb Co | AMINO-CELL DERIVATIVE COMPOUNDS INHIBITORS OF ENZYME IMPDH |
| JP4709388B2 (ja) * | 1999-01-25 | 2011-06-22 | 全薬工業株式会社 | 複素環式化合物及びそれを有効成分とする抗腫瘍剤 |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| CA2445395C (en) * | 2001-04-27 | 2010-03-30 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compound and antitumor agent comprising the same as effective component |
| WO2003078427A1 (en) * | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
| RU2312859C2 (ru) * | 2002-05-30 | 2007-12-20 | Солвей Фармасьютикалс Б.В. | Производные 1,3,5-триазина, фармацевтическая композиция на их основе и их применение |
| WO2004000820A2 (en) * | 2002-06-21 | 2003-12-31 | Cellular Genomics, Inc. | Certain aromatic monocycles as kinase modulators |
| WO2004072063A1 (en) * | 2003-02-07 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl substituted pyrolls useful as inhibitors of protein kinases |
| WO2005011703A1 (en) * | 2003-08-04 | 2005-02-10 | Akzo Nobel N.V. | 2-cyano-1,3,5-triazine-4,6-diamine derivatives |
| PE20050952A1 (es) * | 2003-09-24 | 2005-12-19 | Novartis Ag | Derivados de isoquinolina como inhibidores de b-raf |
| CA2599879C (en) * | 2005-03-11 | 2013-07-02 | Zenyaku Kogyo Kabushikikaisha | Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient |
| KR20080063809A (ko) * | 2005-09-30 | 2008-07-07 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나아제의 억제제로서 유용한 데아자퓨린 |
| GB0520657D0 (en) * | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
| CL2007001167A1 (es) * | 2006-04-26 | 2008-01-25 | Genentech Inc | Compuestos derivados de pirimidina condensada, inhibidores de p13-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicionfarmaceutica. |
| CA2659604C (en) | 2006-08-08 | 2015-04-28 | Chugai Seiyaku Kabushiki Kaisha | Pyrimidine derivative as pi3k inhibitor and use thereof |
| WO2008032033A1 (en) * | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008072850A1 (en) * | 2006-12-11 | 2008-06-19 | Amorepacific Corporation | Triazine derivatives having inhibitory activity against acetyl-coa carboxylase |
| AU2008213808B2 (en) * | 2007-02-06 | 2011-11-10 | Novartis Ag | PI 3-kinase inhibitors and methods of their use |
| WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| EP2082777A1 (en) * | 2008-01-27 | 2009-07-29 | Oncotherm Kft. | Flexible and porous large-area electrode for heating |
| DE202008001253U1 (de) * | 2008-01-28 | 2008-04-10 | Mirror Image Ag | Bildanzeigegerät |
| EP2294072B1 (en) * | 2008-05-23 | 2017-03-29 | Wyeth LLC | Triazine compounds as p13 kinase and mtor inhibitors |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
-
2008
- 2008-11-10 GB GB0821219A patent/GB2465405A/en not_active Withdrawn
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2009
- 2009-11-10 CN CN200980144674.6A patent/CN102209714B/zh active Active
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- 2009-11-10 KR KR1020117013081A patent/KR101749192B1/ko active Active
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- 2009-11-10 RU RU2011114559/04A patent/RU2537945C2/ru active
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