JP2012506702A5 - - Google Patents
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- JP2012506702A5 JP2012506702A5 JP2011533384A JP2011533384A JP2012506702A5 JP 2012506702 A5 JP2012506702 A5 JP 2012506702A5 JP 2011533384 A JP2011533384 A JP 2011533384A JP 2011533384 A JP2011533384 A JP 2011533384A JP 2012506702 A5 JP2012506702 A5 JP 2012506702A5
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- 239000013598 vector Substances 0.000 claims description 23
- 210000004027 cell Anatomy 0.000 claims description 21
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims description 15
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims description 11
- 230000008672 reprogramming Effects 0.000 claims description 10
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims description 9
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims description 9
- 238000010361 transduction Methods 0.000 claims description 7
- 230000026683 transduction Effects 0.000 claims description 7
- 101000984042 Homo sapiens Protein lin-28 homolog A Proteins 0.000 claims description 4
- -1 IRES2 Proteins 0.000 claims 13
- 241000288906 Primates Species 0.000 claims 12
- 210000001082 somatic cell Anatomy 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 210000003754 fetus Anatomy 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 3
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 3
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 3
- 101001128090 Homo sapiens Homeobox protein NANOG Proteins 0.000 claims 2
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 claims 2
- 101001094700 Homo sapiens POU domain, class 5, transcription factor 1 Proteins 0.000 claims 2
- 102000051629 human Lin28A Human genes 0.000 claims 2
- 102000053563 human MYC Human genes 0.000 claims 2
- 102000054643 human NANOG Human genes 0.000 claims 2
- 102000047444 human SOX2 Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 101100510266 Homo sapiens KLF4 gene Proteins 0.000 claims 1
- 108700002232 Immediate-Early Genes Proteins 0.000 claims 1
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims 1
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 description 14
- 210000003953 foreskin Anatomy 0.000 description 8
- 239000002609 medium Substances 0.000 description 5
- 108700019146 Transgenes Proteins 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 description 2
- 102100025460 Protein lin-28 homolog A Human genes 0.000 description 2
- 238000000339 bright-field microscopy Methods 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000001671 embryonic stem cell Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 108010067041 Zebrafish Proteins Proteins 0.000 description 1
- 239000003636 conditioned culture medium Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 108010082117 matrigel Proteins 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10836208P | 2008-10-24 | 2008-10-24 | |
| US61/108,362 | 2008-10-24 | ||
| PCT/US2009/061935 WO2010048567A1 (en) | 2008-10-24 | 2009-10-23 | Pluripotent stem cells obtained by non-viral reprogramming |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015165051A Division JP6312638B2 (ja) | 2008-10-24 | 2015-08-24 | 非ウイルス性再プログラムによる多能性幹細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012506702A JP2012506702A (ja) | 2012-03-22 |
| JP2012506702A5 true JP2012506702A5 (enExample) | 2014-12-25 |
Family
ID=41698343
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533384A Withdrawn JP2012506702A (ja) | 2008-10-24 | 2009-10-23 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2015165051A Active JP6312638B2 (ja) | 2008-10-24 | 2015-08-24 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2016165793A Pending JP2016220686A (ja) | 2008-10-24 | 2016-08-26 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2018155983A Active JP6861189B2 (ja) | 2008-10-24 | 2018-08-23 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2021055183A Active JP7165228B2 (ja) | 2008-10-24 | 2021-03-29 | 非ウイルス性再プログラムによる多能性幹細胞 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015165051A Active JP6312638B2 (ja) | 2008-10-24 | 2015-08-24 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2016165793A Pending JP2016220686A (ja) | 2008-10-24 | 2016-08-26 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2018155983A Active JP6861189B2 (ja) | 2008-10-24 | 2018-08-23 | 非ウイルス性再プログラムによる多能性幹細胞 |
| JP2021055183A Active JP7165228B2 (ja) | 2008-10-24 | 2021-03-29 | 非ウイルス性再プログラムによる多能性幹細胞 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8268620B2 (enExample) |
| EP (2) | EP3450545B1 (enExample) |
| JP (5) | JP2012506702A (enExample) |
| CN (2) | CN102239249A (enExample) |
| CA (1) | CA2741090C (enExample) |
| DK (2) | DK2356221T3 (enExample) |
| ES (1) | ES2959327T3 (enExample) |
| IL (1) | IL212433B (enExample) |
| SG (1) | SG10201600234PA (enExample) |
| WO (1) | WO2010048567A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| EP2137296A2 (en) | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| ES2722198T3 (es) | 2008-05-02 | 2019-08-08 | Univ Kyoto | Método de reprogramación nuclear |
| EP3447128A1 (en) | 2008-06-04 | 2019-02-27 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of ips cells using non-viral approach |
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| EP3450545B1 (en) * | 2008-10-24 | 2023-08-23 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
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| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| DK1226233T3 (da) * | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| CA2515108A1 (en) | 2003-02-07 | 2004-08-26 | Wisconsin Alumni Research Foundation | Directed genetic modifications of human stem cells |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| EP2137296A2 (en) * | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| EP2072618A1 (en) | 2007-12-14 | 2009-06-24 | Johannes Gutenberg-Universität Mainz | Use of RNA for reprogramming somatic cells |
| CN101250502A (zh) * | 2008-04-01 | 2008-08-27 | 中国科学院上海生命科学研究院 | 一种诱导的多潜能干细胞的制备方法 |
| ES2722198T3 (es) * | 2008-05-02 | 2019-08-08 | Univ Kyoto | Método de reprogramación nuclear |
| EP3447128A1 (en) * | 2008-06-04 | 2019-02-27 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of ips cells using non-viral approach |
| WO2009157201A1 (en) * | 2008-06-26 | 2009-12-30 | Osaka University | Method and kit for preparing ips cells |
| WO2010012077A1 (en) | 2008-07-28 | 2010-02-04 | Mount Sinai Hospital | Compositions, methods and kits for reprogramming somatic cells |
| EP3450545B1 (en) * | 2008-10-24 | 2023-08-23 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
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2009
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