JP2012505922A5 - - Google Patents
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- Publication number
- JP2012505922A5 JP2012505922A5 JP2011532295A JP2011532295A JP2012505922A5 JP 2012505922 A5 JP2012505922 A5 JP 2012505922A5 JP 2011532295 A JP2011532295 A JP 2011532295A JP 2011532295 A JP2011532295 A JP 2011532295A JP 2012505922 A5 JP2012505922 A5 JP 2012505922A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- peptide
- muc1
- residues
- consecutive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 70
- 102100034256 Mucin-1 Human genes 0.000 claims description 66
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 62
- 239000000203 mixture Substances 0.000 claims description 56
- 210000004027 cell Anatomy 0.000 claims description 44
- 210000004881 tumor cell Anatomy 0.000 claims description 20
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 10
- 238000011394 anticancer treatment Methods 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 7
- 150000008574 D-amino acids Chemical class 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 150000008575 L-amino acids Chemical class 0.000 claims description 4
- 108010008707 Mucin-1 Proteins 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 4
- 230000026683 transduction Effects 0.000 claims description 4
- 238000010361 transduction Methods 0.000 claims description 4
- 230000003442 weekly effect Effects 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 238000000315 cryotherapy Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000001794 hormone therapy Methods 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000001361 intraarterial administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 230000017074 necrotic cell death Effects 0.000 claims description 2
- 230000025308 nuclear transport Effects 0.000 claims description 2
- 238000006384 oligomerization reaction Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000007910 systemic administration Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 238000000034 method Methods 0.000 description 37
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 238000011319 anticancer therapy Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10638008P | 2008-10-17 | 2008-10-17 | |
| US61/106,380 | 2008-10-17 | ||
| US17710909P | 2009-05-11 | 2009-05-11 | |
| US61/177,109 | 2009-05-11 | ||
| PCT/US2009/061051 WO2010045586A2 (en) | 2008-10-17 | 2009-10-16 | Muc-1 cytoplasmic domain peptides as inhibitors of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238315A Division JP6030622B2 (ja) | 2008-10-17 | 2014-11-26 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505922A JP2012505922A (ja) | 2012-03-08 |
| JP2012505922A5 true JP2012505922A5 (enExample) | 2012-06-21 |
| JP5657549B2 JP5657549B2 (ja) | 2015-01-21 |
Family
ID=42046194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532295A Active JP5657549B2 (ja) | 2008-10-17 | 2009-10-16 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
| JP2014238315A Active JP6030622B2 (ja) | 2008-10-17 | 2014-11-26 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238315A Active JP6030622B2 (ja) | 2008-10-17 | 2014-11-26 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8524669B2 (enExample) |
| EP (2) | EP2352508B1 (enExample) |
| JP (2) | JP5657549B2 (enExample) |
| KR (1) | KR101689408B1 (enExample) |
| CN (1) | CN102245632B (enExample) |
| AU (1) | AU2009305550B2 (enExample) |
| BR (1) | BRPI0920360A2 (enExample) |
| CA (1) | CA2741065C (enExample) |
| DE (1) | DE09740811T9 (enExample) |
| DK (1) | DK2352508T3 (enExample) |
| ES (1) | ES2395028T3 (enExample) |
| IL (1) | IL212383A (enExample) |
| MX (1) | MX2011004082A (enExample) |
| NZ (1) | NZ592537A (enExample) |
| PL (1) | PL2352508T3 (enExample) |
| PT (1) | PT2352508E (enExample) |
| RU (1) | RU2539832C2 (enExample) |
| WO (1) | WO2010045586A2 (enExample) |
| ZA (1) | ZA201103150B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8524669B2 (en) | 2008-10-17 | 2013-09-03 | Dana-Farber Cancer Institute, Inc. | MUC-1 cytoplasmic domain peptides as inhibitors of cancer |
| CA2763327C (en) * | 2009-05-27 | 2019-04-02 | Donald W. Kufe | Inhibition 0f inflammation using antagonists of muc1 |
| WO2011100688A1 (en) * | 2010-02-12 | 2011-08-18 | Dana-Farber Cancer Institute, Inc. | Improved antagonists of muc1 |
| WO2011115819A2 (en) * | 2010-03-15 | 2011-09-22 | Genus Oncology, Llc | Small molecule inhibitors of muc1 and methods of identifying the same |
| CN102958364A (zh) | 2010-05-28 | 2013-03-06 | 德克萨斯大学系统董事会 | 低聚苯甲酰胺化合物及其用途 |
| US8907054B2 (en) * | 2011-08-08 | 2014-12-09 | Marquette University | Dpy-30 binding peptides |
| RU2017143985A (ru) * | 2011-08-17 | 2019-02-14 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей-muc1 и способы их применения |
| EP2753345B1 (en) * | 2011-09-06 | 2016-07-13 | Agency For Science, Technology And Research | Polypeptide vaccine |
| WO2013078277A1 (en) * | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| WO2013078288A1 (en) * | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
| US9044421B2 (en) | 2012-03-28 | 2015-06-02 | Genus Oncology, Llc | Treating MUC1-expressing cancers with combination therapies |
| WO2014164395A1 (en) * | 2013-03-11 | 2014-10-09 | Dana-Farber Cancer Institute, Inc. | Combination anti-estrogen receptor cancer therapy using muc1 peptides and chemotherapeutics |
| WO2014164394A1 (en) * | 2013-03-11 | 2014-10-09 | Dana-Farber Cancer Institute, Inc. | Combination anti-her2 cancer therapy using muc1 peptides and chemotherapeutics |
| MX380864B (es) | 2014-01-29 | 2025-03-12 | Dana Farber Cancer Inst Inc | Anticuerpos contra el dominio extracelular de muc1-c (muc1-c/ecd). |
| US10507227B2 (en) | 2014-04-15 | 2019-12-17 | The Hospital For Sick Children | Cationic antimicrobial peptides |
| EP3542814B1 (en) | 2018-03-21 | 2022-08-24 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Novel peptide-based compounds for use in the prevention, treatment and/or detection of cancer |
| WO2025217515A2 (en) * | 2024-04-12 | 2025-10-16 | Dana-Farber Cancer Institute, Inc. | Identification of muc1-c as a target for the treatment of squamous cell carcinomas |
Family Cites Families (61)
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|---|---|---|---|---|
| AU1570292A (en) | 1991-02-07 | 1992-09-07 | Board Of Trustees Of The University Of Illinois, The | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| US5475085A (en) | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| US5329028A (en) | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
| NZ255256A (en) | 1992-08-27 | 1997-02-24 | Deakin Res Ltd | Synthetic peptide antigen analogues with retro, inverso or retro-inverso modification, their use and antibodies against them |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5446128A (en) | 1993-06-18 | 1995-08-29 | The Board Of Trustees Of The University Of Illinois | Alpha-helix mimetics and methods relating thereto |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| EP0756604A1 (en) * | 1994-04-22 | 1997-02-05 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Melanoma antigens |
| US5912232A (en) | 1994-09-23 | 1999-06-15 | Board Of Regents Of The University Of Nebraska | Anti-inflammatory polypeptide antagonists of human I1-8 |
| US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
| US5597457A (en) | 1995-01-23 | 1997-01-28 | The Regents Of The University Of California | System and method for forming synthetic protein crystals to determine the conformational structure by crystallography |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US5840833A (en) | 1995-10-27 | 1998-11-24 | Molecumetics, Ltd | Alpha-helix mimetics and methods relating thereto |
| NO961031D0 (no) * | 1996-03-13 | 1996-03-13 | Det Norske Radiumshospital Tum | Fremgangsmåte til å drepe uönskede målceller |
| US6093573A (en) | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
| US20020044943A1 (en) | 1997-09-10 | 2002-04-18 | Longenecker B. Michael | MUC-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions |
| AU767185B2 (en) | 1998-03-23 | 2003-11-06 | President And Fellows Of Harvard College | Synthesis of compounds and libraries of compounds |
| AU5483699A (en) | 1998-08-13 | 2000-03-06 | American Home Products Corporation | Crystal structure of escherichia coli gdp-fucose synthetase and methods of its use |
| EP1108055A1 (en) | 1998-08-25 | 2001-06-20 | The Scripps Research Institute | Methods and systems for predicting protein function |
| US20010047183A1 (en) | 2000-04-05 | 2001-11-29 | Salvatore Privitera | Surgical device for the collection of soft tissue |
| EP1159418A2 (en) | 1998-12-11 | 2001-12-05 | Biomira Inc. | Muc-1 antagonists and methods of treating immune disorders |
| US6801860B1 (en) | 1999-02-15 | 2004-10-05 | Genetics Institute, Llc | Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| JP2003528288A (ja) | 1999-05-26 | 2003-09-24 | ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア | 高分子の三次元形状の決定方法 |
| MXPA02001857A (es) * | 1999-08-24 | 2003-07-14 | Cellgate Inc | Composiciones y metodos para incrementar la entrega de drogas a traves y dentro de tejidos epiteliales. |
| JP2003510094A (ja) | 1999-09-08 | 2003-03-18 | トランジェーヌ、ソシエテ、アノニム | Ｍｕｃ−１由来のペプチド |
| JP2003533181A (ja) * | 2000-02-01 | 2003-11-11 | ジ・オースティン・リサーチ・インスティテュート | ムチン−１誘導抗原および免疫療法におけるその使用 |
| EP1317278B1 (en) | 2000-09-11 | 2009-11-11 | Dana-Farber Cancer Institute, Inc. | Muc1 extracellular domain and cancer treatment compositions and methods derived therefrom |
| US7037889B2 (en) | 2000-09-13 | 2006-05-02 | Praecis Pharmaceuticals Inc. | Pharmaceutical compositions for sustained drug delivery |
| WO2002058450A2 (en) * | 2000-12-22 | 2002-08-01 | Dana-Faber Cancer Institute, Inc. | Regulation of cell growth by muc1 |
| WO2002086065A2 (en) | 2001-04-18 | 2002-10-31 | Dana-Farber Cancer Institute, Inc. | Induction of apoptosis by cellular stress |
| US8275595B2 (en) | 2001-08-14 | 2012-09-25 | Dana-Farber Cancer Institute, Inc. | Computer-based methods of designing molecules |
| US7247297B2 (en) | 2001-09-14 | 2007-07-24 | The University Of Chicago | Use of DF3/MUC1 regulated expression in gene therapy |
| AU2002351505B2 (en) | 2001-10-19 | 2008-04-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders |
| JP2004137207A (ja) * | 2002-10-18 | 2004-05-13 | Keio Gijuku | 細胞毒性を抑制する蛋白質 |
| AU2003295420A1 (en) * | 2002-11-07 | 2004-06-03 | Agritech Technology, Ltd. | Novel inhibin-related multiple antigenic peptide compositions that enhance production performance in avians |
| JP2006517790A (ja) * | 2003-01-09 | 2006-08-03 | インヴィトロジェン コーポレーション | ポリペプチド−核酸複合体の細胞の送達および活性化 |
| US7696306B2 (en) | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
| US8129506B2 (en) | 2003-10-24 | 2012-03-06 | Genzyme Corporation | Modulation of the interaction of MUC1 with MUC1 ligands |
| EP1538164A1 (en) | 2003-12-04 | 2005-06-08 | Vectron Therapeutics AG | RGD targeting moiety its production and use |
| WO2005073374A1 (ja) * | 2004-01-29 | 2005-08-11 | Dainippon Sumitomo Pharma Co., Ltd. | 新規腫瘍抗原蛋白質及びその利用 |
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| WO2005101021A1 (en) | 2004-04-13 | 2005-10-27 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled adrenergic alpha-1d-receptor (adra1d) |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| JP2008537095A (ja) | 2005-02-15 | 2008-09-11 | ダナ−ファーバー キャンサー インスティテュート インク． | Ｍｕｃ１活性の調節 |
| AU2006236441B2 (en) | 2005-04-15 | 2011-09-01 | Arizona Cancer Therapeutics, Llc | Therapeutic peptides for the treatment of metastatic cancer |
| US20080311575A1 (en) * | 2005-05-26 | 2008-12-18 | Kufe Donald W | Modulation of Muci-Dependent Anti-Estrogen Resistance |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US8017315B2 (en) | 2005-08-22 | 2011-09-13 | Dana Farber Cancer Institute, Inc. | Mitochondrial localization of MUC1 |
| GB0519303D0 (en) * | 2005-09-21 | 2005-11-02 | Oxford Biomedica Ltd | Chemo-immunotherapy method |
| WO2007119515A1 (ja) * | 2006-03-28 | 2007-10-25 | Dainippon Sumitomo Pharma Co., Ltd. | 新規腫瘍抗原ペプチド |
| WO2008097844A2 (en) | 2007-02-02 | 2008-08-14 | Dana -Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins |
| US7972870B2 (en) | 2007-02-02 | 2011-07-05 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 |
| US8012695B2 (en) | 2007-02-14 | 2011-09-06 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to promoter regulation by MUC1 and KLF proteins |
| EP3159352B1 (en) | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| US8524669B2 (en) * | 2008-10-17 | 2013-09-03 | Dana-Farber Cancer Institute, Inc. | MUC-1 cytoplasmic domain peptides as inhibitors of cancer |
| CA2763327C (en) | 2009-05-27 | 2019-04-02 | Donald W. Kufe | Inhibition 0f inflammation using antagonists of muc1 |
| WO2011100688A1 (en) | 2010-02-12 | 2011-08-18 | Dana-Farber Cancer Institute, Inc. | Improved antagonists of muc1 |
| WO2011115819A2 (en) | 2010-03-15 | 2011-09-22 | Genus Oncology, Llc | Small molecule inhibitors of muc1 and methods of identifying the same |
-
2009
- 2009-10-16 US US12/580,865 patent/US8524669B2/en active Active
- 2009-10-16 MX MX2011004082A patent/MX2011004082A/es active IP Right Grant
- 2009-10-16 NZ NZ592537A patent/NZ592537A/en not_active IP Right Cessation
- 2009-10-16 PL PL09740811T patent/PL2352508T3/pl unknown
- 2009-10-16 PT PT97408116T patent/PT2352508E/pt unknown
- 2009-10-16 WO PCT/US2009/061051 patent/WO2010045586A2/en not_active Ceased
- 2009-10-16 EP EP09740811.6A patent/EP2352508B1/en active Active
- 2009-10-16 RU RU2011119606/10A patent/RU2539832C2/ru not_active IP Right Cessation
- 2009-10-16 DE DE09740811T patent/DE09740811T9/de active Active
- 2009-10-16 ES ES09740811.6T patent/ES2395028T3/es active Active
- 2009-10-16 CA CA2741065A patent/CA2741065C/en active Active
- 2009-10-16 EP EP13194715.2A patent/EP2727601B1/en active Active
- 2009-10-16 BR BRPI0920360-5A patent/BRPI0920360A2/pt not_active IP Right Cessation
- 2009-10-16 CN CN200980149998.9A patent/CN102245632B/zh active Active
- 2009-10-16 AU AU2009305550A patent/AU2009305550B2/en active Active
- 2009-10-16 KR KR1020117011149A patent/KR101689408B1/ko active Active
- 2009-10-16 JP JP2011532295A patent/JP5657549B2/ja active Active
- 2009-10-16 DK DK09740811.6T patent/DK2352508T3/da active
-
2011
- 2011-04-14 IL IL212383A patent/IL212383A/en active IP Right Grant
- 2011-04-29 ZA ZA2011/03150A patent/ZA201103150B/en unknown
-
2012
- 2012-02-24 US US13/404,689 patent/US8957185B2/en active Active
-
2014
- 2014-11-26 JP JP2014238315A patent/JP6030622B2/ja active Active
-
2015
- 2015-02-12 US US14/620,349 patent/US9546201B2/en active Active
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