JP2012502974A5 - - Google Patents
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- Publication number
- JP2012502974A5 JP2012502974A5 JP2011527431A JP2011527431A JP2012502974A5 JP 2012502974 A5 JP2012502974 A5 JP 2012502974A5 JP 2011527431 A JP2011527431 A JP 2011527431A JP 2011527431 A JP2011527431 A JP 2011527431A JP 2012502974 A5 JP2012502974 A5 JP 2012502974A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ylmethoxy
- dihydroxy
- biphenyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 22
- 125000001072 heteroaryl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002947 alkylene group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000001475 halogen functional group Chemical group 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- -1 -OH Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- HKHLJBBDUOPRQN-ACJLOTCBSA-N (2s,3r)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]butanamide Chemical compound C1=CC(CO[C@@](C)([C@H](O)C)C(=O)NO)=CC=C1C1=CC=CC=C1 HKHLJBBDUOPRQN-ACJLOTCBSA-N 0.000 claims 1
- SIXFEBVKDCSUST-ICSRJNTNSA-N (2s,3r)-n,3-dihydroxy-2-methyl-3-(1,2-oxazol-5-yl)-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1ON=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 SIXFEBVKDCSUST-ICSRJNTNSA-N 0.000 claims 1
- SYCHQJMHORHPDP-FPOVZHCZSA-N (2s,3s)-3-(furan-2-yl)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1OC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 SYCHQJMHORHPDP-FPOVZHCZSA-N 0.000 claims 1
- GSUWLVYTJTWUHP-ICSRJNTNSA-N (2s,3s)-3-cyclopropyl-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C1CC1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 GSUWLVYTJTWUHP-ICSRJNTNSA-N 0.000 claims 1
- JCZKNQBVKSRKGG-WMZOPIPTSA-N (2s,3s)-5,5,5-trifluoro-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CC(F)(F)F)C(=O)NO)=CC=C1C1=CC=CC=C1 JCZKNQBVKSRKGG-WMZOPIPTSA-N 0.000 claims 1
- KXQHQOVKEMSLRA-FPOVZHCZSA-N (2s,3s)-5-ethoxy-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CCOCC)C(=O)NO)=CC=C1C1=CC=CC=C1 KXQHQOVKEMSLRA-FPOVZHCZSA-N 0.000 claims 1
- OEIHVBMZXNURRL-ICSRJNTNSA-N (2s,3s)-n,3-dihydroxy-2,4-dimethyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)C(C)C)C(=O)NO)=CC=C1C1=CC=CC=C1 OEIHVBMZXNURRL-ICSRJNTNSA-N 0.000 claims 1
- JGQMWGGZNFCDEO-UNMCSNQZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]-3-pyridin-2-ylpropanamide Chemical compound O([C@@](C)([C@@H](O)C=1N=CC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 JGQMWGGZNFCDEO-UNMCSNQZSA-N 0.000 claims 1
- XDHPXTDIDHKVFF-UNMCSNQZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]-3-pyridin-3-ylpropanamide Chemical compound O([C@@](C)([C@@H](O)C=1C=NC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 XDHPXTDIDHKVFF-UNMCSNQZSA-N 0.000 claims 1
- RKDZGGUXXBBZTR-FPOVZHCZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]-3-pyrimidin-5-ylpropanamide Chemical compound O([C@@](C)([C@@H](O)C=1C=NC=NC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 RKDZGGUXXBBZTR-FPOVZHCZSA-N 0.000 claims 1
- HKHLJBBDUOPRQN-UGSOOPFHSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]butanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)C)C(=O)NO)=CC=C1C1=CC=CC=C1 HKHLJBBDUOPRQN-UGSOOPFHSA-N 0.000 claims 1
- LPHYIYSLVMHHIT-FPOVZHCZSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]heptanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CCCC)C(=O)NO)=CC=C1C1=CC=CC=C1 LPHYIYSLVMHHIT-FPOVZHCZSA-N 0.000 claims 1
- UZEYYYATUXVBCZ-ICSRJNTNSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]hexanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CCC)C(=O)NO)=CC=C1C1=CC=CC=C1 UZEYYYATUXVBCZ-ICSRJNTNSA-N 0.000 claims 1
- VKJROWRLVCWQPU-HKUYNNGSSA-N (2s,3s)-n,3-dihydroxy-2-methyl-2-[(4-phenylphenyl)methoxy]pentanamide Chemical compound C1=CC(CO[C@@](C)([C@@H](O)CC)C(=O)NO)=CC=C1C1=CC=CC=C1 VKJROWRLVCWQPU-HKUYNNGSSA-N 0.000 claims 1
- WFVASGYQNPHMCF-GMAHTHKFSA-N (2s,3s)-n,3-dihydroxy-2-methyl-3-phenyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1C=CC=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 WFVASGYQNPHMCF-GMAHTHKFSA-N 0.000 claims 1
- IYOHQOLEWXCJEG-ICSRJNTNSA-N (2s,3s)-n,3-dihydroxy-3-(1h-imidazol-5-yl)-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1N=CNC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 IYOHQOLEWXCJEG-ICSRJNTNSA-N 0.000 claims 1
- MRYZMLDBJLIIPW-UNMCSNQZSA-N (2s,3s)-n,3-dihydroxy-3-[5-(hydroxymethyl)furan-2-yl]-2-methyl-2-[(4-phenylphenyl)methoxy]propanamide Chemical compound O([C@@](C)([C@@H](O)C=1OC(CO)=CC=1)C(=O)NO)CC(C=C1)=CC=C1C1=CC=CC=C1 MRYZMLDBJLIIPW-UNMCSNQZSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- KIXXNPCYAPCLLP-UHFFFAOYSA-N CCC(C)C(C1)N1NN Chemical compound CCC(C)C(C1)N1NN KIXXNPCYAPCLLP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9824908P | 2008-09-19 | 2008-09-19 | |
| US61/098,249 | 2008-09-19 | ||
| PCT/IB2009/053809 WO2010032147A2 (en) | 2008-09-19 | 2009-09-01 | Hydroxamic acid derivatives useful as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502974A JP2012502974A (ja) | 2012-02-02 |
| JP2012502974A5 true JP2012502974A5 (OSRAM) | 2012-10-04 |
| JP5524215B2 JP5524215B2 (ja) | 2014-06-18 |
Family
ID=41664561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527431A Expired - Fee Related JP5524215B2 (ja) | 2008-09-19 | 2009-09-01 | 抗菌剤として有用なヒドロキサム酸誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8722686B2 (OSRAM) |
| EP (1) | EP2334636A2 (OSRAM) |
| JP (1) | JP5524215B2 (OSRAM) |
| CA (1) | CA2735929C (OSRAM) |
| WO (1) | WO2010032147A2 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101765585B (zh) | 2007-06-12 | 2017-03-15 | 尔察祯有限公司 | 抗菌剂 |
| EP2334636A2 (en) | 2008-09-19 | 2011-06-22 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| JP5793766B2 (ja) | 2009-12-16 | 2015-10-14 | ファイザー・インク | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
| AU2011243597B2 (en) | 2010-04-20 | 2014-05-08 | Taisho Pharmaceutical Co., Ltd. | Novel hydroxamic acid derivative |
| WO2012120397A1 (en) | 2011-03-07 | 2012-09-13 | Pfizer Inc. | Fluoro-pyridinone derivatives useful as antibacterial agents |
| CN103492368A (zh) * | 2011-04-08 | 2014-01-01 | 辉瑞大药厂 | 用作抗菌剂的咪唑、吡唑和噻唑衍生物 |
| MX2013011526A (es) * | 2011-04-08 | 2013-12-06 | Pfizer | Derivados de isoxazol utiles como agentes antibacteriales . |
| EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| CN102993052B (zh) * | 2012-12-29 | 2014-07-09 | 吉首大学 | 芳基丙酰氧肟酸类尿素酶抑制剂及其合成和用途 |
| CN103012207B (zh) * | 2012-12-29 | 2015-05-27 | 吉首大学 | 二芳基丙酰-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途 |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| SMT201900323T1 (it) | 2013-03-15 | 2019-07-11 | Fujifilm Toyama Chemical Co Ltd | Nuovo derivato di acido idrossammico o suo sale |
| CN105683163B (zh) * | 2013-10-04 | 2018-11-09 | 诺华股份有限公司 | RNA干扰中使用的RNAi剂的3’端帽 |
| WO2015050871A2 (en) | 2013-10-04 | 2015-04-09 | Novartis Ag | Organic compounds to treat hepatitis b virus |
| ES2687393T3 (es) | 2014-04-22 | 2018-10-25 | Novartis Ag | Derivados del ácido hidroxámico de isoxazolina como inhibidores de LpxC |
| CN106794162A (zh) | 2014-09-12 | 2017-05-31 | 富山化学工业株式会社 | 组合使用新的异羟肟酸衍生物和抗菌性物质的方法 |
| WO2016039433A1 (ja) | 2014-09-12 | 2016-03-17 | 富山化学工業株式会社 | 新規なヒドロキサム酸誘導体またはその塩を含有する医薬組成物 |
| LT3233843T (lt) | 2014-12-16 | 2019-12-10 | Novartis Ag | Izoksazolo hidroksamido rūgšties junginiai, kaip lpxc inhibitoriai |
| US20180194769A1 (en) | 2015-07-06 | 2018-07-12 | Rodin Therapeutics, Inc. | Hetero-halo inhibitors of histone deacetylase |
| US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| JP6941630B2 (ja) | 2016-06-14 | 2021-09-29 | ノバルティス アーゲー | 抗菌剤としての（ｒ）−４（５−（シクロプロピルエチニル）イソオキサゾール−３−イル）−ｎ−ヒドロキシ−２−メチル−２−（メチルスルホニル）ブタンアミドの結晶形 |
| WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
| DK3570834T3 (en) | 2017-01-11 | 2022-02-28 | Alkermes Inc | Bicyclic inhibitors of histone deacetylase |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| CN107226845B (zh) * | 2017-05-31 | 2020-10-09 | 成都雅途生物技术有限公司 | 一种抗多重耐药菌的化合物yt-011及其制备方法 |
| AU2018313094A1 (en) | 2017-08-07 | 2020-02-20 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| CA3077474A1 (en) | 2017-10-02 | 2019-04-11 | Arixa Pharmaceuticals, Inc. | Aztreonam derivatives and uses thereof |
| JP7437847B2 (ja) | 2018-10-01 | 2024-02-26 | アリクサ ファーマシューティカルズ、インコーポレイテッド | レレバクタムの誘導体およびその使用 |
| JP2022524118A (ja) | 2019-03-12 | 2022-04-27 | アリクサ ファーマシューティカルズ、インコーポレイテッド | アビバクタム誘導体の結晶形 |
| WO2020219258A1 (en) | 2019-04-25 | 2020-10-29 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
| CN116348448A (zh) * | 2020-07-24 | 2023-06-27 | 明德赛特制药公司 | 赛洛辛和赛洛西宾的可扩展合成路线 |
| CN116730870B (zh) * | 2023-08-08 | 2023-10-13 | 中国医学科学院医药生物技术研究所 | 异羟肟酸类化合物或其可药用盐、及其用途和制备方法 |
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| JPS50121218A (OSRAM) * | 1974-03-01 | 1975-09-23 | ||
| US4769461A (en) * | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| US5110831A (en) * | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
| GB2349884A (en) * | 1998-02-07 | 2000-11-15 | British Biotech Pharm | Antibacterial agents |
| GB9925470D0 (en) * | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
| WO2002074298A1 (en) * | 2001-03-21 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Il-6 production inhibitors |
| ES2180456B1 (es) | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| SG2012000667A (en) | 2003-01-08 | 2015-03-30 | Univ Washington | Antibacterial agents |
| GB0302431D0 (en) * | 2003-01-30 | 2003-03-05 | Glaxo Group Ltd | Novel compounds |
| BRPI0518984A2 (pt) | 2004-12-10 | 2008-12-16 | Univ Emory | anÁlogos de nucleosÍdeo de ciclobutil substituÍdos em 2' e 3' para tratamento de infecÇÕes virais e proliferaÇço celular anormal |
| WO2006118155A1 (ja) | 2005-04-27 | 2006-11-09 | Ishihara Sangyo Kaisha, Ltd. | ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤 |
| WO2006124897A2 (en) | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Methods and compositions for improving cognition |
| JP2009520695A (ja) | 2005-12-15 | 2009-05-28 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するｎ−ヒドロキシアミド誘導体 |
| CA2642406A1 (en) | 2006-02-14 | 2007-08-23 | Pfizer Products Inc. | Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents |
| WO2008045671A1 (en) | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica, N.V. | Matrix metalloprotease inhibitors |
| CN101016270B (zh) | 2006-12-30 | 2012-05-09 | 天津药物研究院 | 取代的哌嗪基苯基异噁唑啉衍生物及其用途 |
| WO2009008905A1 (en) | 2007-02-01 | 2009-01-15 | Panthera Biopharma, Llc. | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| WO2008105515A1 (ja) | 2007-02-28 | 2008-09-04 | Taisho Pharmaceutical Co., Ltd. | 新規なヒドロキサム酸誘導体 |
| US20080234297A1 (en) * | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| EP2315746A1 (en) | 2008-08-04 | 2011-05-04 | Schering Corporation | Urea derivatives as antibacterial agents |
| WO2010024356A1 (ja) | 2008-08-27 | 2010-03-04 | 大正製薬株式会社 | ナフチリジン－ｎ－オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| EP2334636A2 (en) | 2008-09-19 | 2011-06-22 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| JP5793766B2 (ja) | 2009-12-16 | 2015-10-14 | ファイザー・インク | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
| WO2012120397A1 (en) | 2011-03-07 | 2012-09-13 | Pfizer Inc. | Fluoro-pyridinone derivatives useful as antibacterial agents |
| MX2013011526A (es) | 2011-04-08 | 2013-12-06 | Pfizer | Derivados de isoxazol utiles como agentes antibacteriales . |
| CN103492368A (zh) | 2011-04-08 | 2014-01-01 | 辉瑞大药厂 | 用作抗菌剂的咪唑、吡唑和噻唑衍生物 |
-
2009
- 2009-09-01 EP EP09787063A patent/EP2334636A2/en not_active Withdrawn
- 2009-09-01 US US13/119,484 patent/US8722686B2/en not_active Expired - Fee Related
- 2009-09-01 WO PCT/IB2009/053809 patent/WO2010032147A2/en not_active Ceased
- 2009-09-01 CA CA2735929A patent/CA2735929C/en not_active Expired - Fee Related
- 2009-09-01 JP JP2011527431A patent/JP5524215B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-24 US US14/223,061 patent/US9340493B2/en not_active Expired - Fee Related