JP2012140442A5 - - Google Patents

Download PDF

Info

Publication number
JP2012140442A5
JP2012140442A5 JP2012036919A JP2012036919A JP2012140442A5 JP 2012140442 A5 JP2012140442 A5 JP 2012140442A5 JP 2012036919 A JP2012036919 A JP 2012036919A JP 2012036919 A JP2012036919 A JP 2012036919A JP 2012140442 A5 JP2012140442 A5 JP 2012140442A5
Authority
JP
Japan
Prior art keywords
amount
pathway
dna
treated
initial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012036919A
Other languages
English (en)
Other versions
JP2012140442A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012140442A publication Critical patent/JP2012140442A/ja
Publication of JP2012140442A5 publication Critical patent/JP2012140442A5/ja
Pending legal-status Critical Current

Links

Claims (2)

  1. 治療すべきガン細胞におけるＤＮＡ−ＰＫ経路の、少なくとも１つの構成タンパク質の始めの量を測定すること、及び該始めの量と２回目の量とを比較することを含む方法。
  2. 前記始めの量が治療前の量であり、前記２回目の量が治療すべきガンと同じ組織に由来する正常細胞における、ＤＮＡ−ＰＫ経路の構成タンパク質の量である、請求項３３記載の方法。
JP2012036919A 2004-03-15 2012-02-23 Ｓｎｓ−５９５、及びその使用方法 Pending JP2012140442A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55357804P 2004-03-15 2004-03-15
US60/553,578 2004-03-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007503972A Division JP5096913B2 (ja) 2004-03-15 2005-03-14 Ｓｎｓ−５９５、及びその使用方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014091125A Division JP5856644B2 (ja) 2004-03-15 2014-04-25 Ｓｎｓ−５９５、及びその使用方法

Publications (2)

Publication Number Publication Date
JP2012140442A JP2012140442A (ja) 2012-07-26
JP2012140442A5 true JP2012140442A5 (ja) 2013-04-04

Family

ID=34993432

Family Applications (9)

Application Number Title Priority Date Filing Date
JP2007503972A Expired - Fee Related JP5096913B2 (ja) 2004-03-15 2005-03-14 Ｓｎｓ−５９５、及びその使用方法
JP2007503987A Expired - Fee Related JP5317472B2 (ja) 2004-03-15 2005-03-14 Ｓｎｓ−５９５、及びその使用方法
JP2011135675A Pending JP2011225590A (ja) 2004-03-15 2011-06-17 Ｓｎｓ−５９５、及びその使用方法
JP2012036919A Pending JP2012140442A (ja) 2004-03-15 2012-02-23 Ｓｎｓ−５９５、及びその使用方法
JP2014091125A Expired - Fee Related JP5856644B2 (ja) 2004-03-15 2014-04-25 Ｓｎｓ−５９５、及びその使用方法
JP2014180862A Expired - Fee Related JP6261477B2 (ja) 2004-03-15 2014-09-05 Ｓｎｓ−５９５、及びその使用方法
JP2015140309A Expired - Fee Related JP6352863B2 (ja) 2004-03-15 2015-07-14 Ｓｎｓ−５９５、及びその使用方法
JP2016248041A Pending JP2017095471A (ja) 2004-03-15 2016-12-21 Ｓｎｓ−５９５、及びその使用方法
JP2018038834A Pending JP2018119977A (ja) 2004-03-15 2018-03-05 Ｓｎｓ−５９５、及びその使用方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2007503972A Expired - Fee Related JP5096913B2 (ja) 2004-03-15 2005-03-14 Ｓｎｓ−５９５、及びその使用方法
JP2007503987A Expired - Fee Related JP5317472B2 (ja) 2004-03-15 2005-03-14 Ｓｎｓ−５９５、及びその使用方法
JP2011135675A Pending JP2011225590A (ja) 2004-03-15 2011-06-17 Ｓｎｓ−５９５、及びその使用方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2014091125A Expired - Fee Related JP5856644B2 (ja) 2004-03-15 2014-04-25 Ｓｎｓ−５９５、及びその使用方法
JP2014180862A Expired - Fee Related JP6261477B2 (ja) 2004-03-15 2014-09-05 Ｓｎｓ−５９５、及びその使用方法
JP2015140309A Expired - Fee Related JP6352863B2 (ja) 2004-03-15 2015-07-14 Ｓｎｓ−５９５、及びその使用方法
JP2016248041A Pending JP2017095471A (ja) 2004-03-15 2016-12-21 Ｓｎｓ−５９５、及びその使用方法
JP2018038834A Pending JP2018119977A (ja) 2004-03-15 2018-03-05 Ｓｎｓ−５９５、及びその使用方法

Country Status (24)

Country Link
US (12) US7968565B2 (ja)
EP (4) EP3053579A1 (ja)
JP (9) JP5096913B2 (ja)
KR (1) KR101169825B1 (ja)
CN (5) CN103083316B (ja)
AT (2) ATE451924T1 (ja)
AU (3) AU2005222607B2 (ja)
BR (1) BRPI0508700A (ja)
CA (3) CA2559652C (ja)
CY (2) CY1109741T1 (ja)
DE (2) DE602005025738D1 (ja)
DK (3) DK2295056T5 (ja)
ES (3) ES2334802T3 (ja)
HK (1) HK1097196A1 (ja)
HU (1) HUE027266T2 (ja)
IL (2) IL177946A (ja)
MX (2) MXPA06010382A (ja)
NO (3) NO338058B1 (ja)
NZ (2) NZ549557A (ja)
PL (3) PL1725233T3 (ja)
PT (2) PT1725233E (ja)
SI (2) SI1729770T1 (ja)
WO (2) WO2005089757A1 (ja)
ZA (1) ZA200607248B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1725233T3 (pl) 2004-03-15 2011-05-31 Sunesis Pharmaceuticals Inc Kompozycja farmaceutyczna zawierająca SNS-595 i jej zastosowanie
KR100989029B1 (ko) * 2004-09-17 2010-10-25 사일린 파마슈티칼스, 인크 세포 증식 억제제로서의 퀴놀론 동족체
US7652134B2 (en) * 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
JP2009504192A (ja) * 2005-08-19 2009-02-05 サイリーン ファーマシューティカルズ インコーポレーティッド ヒトリボソームＤＮＡ（ｒＤＮＡ）およびリボソームＲＮＡ（ｒＲＮＡ）核酸ならびにそれらの使用
WO2007028171A1 (en) * 2005-09-02 2007-03-08 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
JP5374153B2 (ja) * 2005-09-02 2013-12-25 サネシス ファーマシューティカルズ， インコーポレイテッド 癌の治療のための（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸を使用する方法
MX2008015775A (es) * 2006-06-12 2009-04-17 Sunesis Pharmaceuticals Inc Compuestos y composiciones para tratamiento de cancer.
US20100048609A1 (en) * 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
WO2008016702A2 (en) * 2006-08-02 2008-02-07 Sunesis Pharmaceuticals, Inc. Combined use of (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1(2-thiazolyl)-1,8-naphthyridine-3-carboxylic
EP2209380A4 (en) * 2007-10-09 2011-09-14 Mark T Hamann METHOD OF USE OF COMPOSITIONS WITH ANTIDEPRESSIVE EFFICACY, MOOD EFFICACY AND OTHER NEUROLOGICAL EFFECTIVENESS AND COMPOSITIONS THEREOF
AU2014277779B2 (en) * 2007-10-22 2016-05-19 Sunesis Pharmaceuticals, Inc. METHODS OF USING (+)-1,4-DIHYDRO-7-[(3s,4s)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY
CN103720701A (zh) * 2007-10-22 2014-04-16 逊尼希思制药公司 在联合治疗中使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸的方法
AU2008335772B2 (en) * 2007-12-10 2014-11-27 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
SG10201504789RA (en) 2008-12-31 2015-07-30 Sunesis Pharmaceuticals Inc Method Of Preparing (+)-1,4-Dihydro-7-[(3s,4s)-3methoxy-4-(Methylamino)-1-Pyrrolidinyl]-4-Oxo-1-(2-Thiazolyl)-1,8-Naphthyridine-3-Carboxylic Acid
EP2400959A1 (en) * 2009-02-27 2012-01-04 Sunesis Pharmaceuticals, Inc. Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
UA110465C2 (en) * 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
CN108551828B (zh) 2012-02-27 2021-04-30 阿吉齐科技公司 土壤条件的监测与控制
RS61664B1 (sr) 2012-04-24 2021-04-29 Vertex Pharma Inhibitori dna-pk
RS58374B1 (sr) 2013-03-12 2019-03-29 Vertex Pharma Inhibitori dnk-pk
US20160067182A1 (en) * 2013-04-09 2016-03-10 Merrimack Pharmaceuticals, Inc. Methods and compositions for improving outcomes of liposomal chemotherapy
EP3016659A4 (en) * 2013-07-02 2017-03-15 Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro) Method for preventing and/or treating chronic traumatic encephalopathy-iii
EP3057953B1 (en) 2013-10-17 2018-08-15 Vertex Pharmaceuticals Incorporated Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
KR101775356B1 (ko) * 2015-07-06 2017-09-06 재단법인 아산사회복지재단 Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법
TW201815418A (zh) 2016-09-27 2018-05-01 Vertex Pharma 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US216316A (en) * 1879-06-10 Improvement in latches
US3021A (en) * 1843-03-30 Stove with elevated ovejst
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
JP3391796B2 (ja) * 1994-06-14 2003-03-31 大日本製薬株式会社 新規化合物、その製法および抗腫瘍剤
JP4323574B2 (ja) * 1995-12-13 2009-09-02 大日本住友製薬株式会社 抗腫瘍剤
GB2322193B (en) * 1997-01-13 1999-09-29 Cancer Res Campaign Tech Assays,agents,therapy and diagnosis relating to modulation of cellular dna repair activity
US20020032216A1 (en) * 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
EP1003856A1 (en) * 1997-06-05 2000-05-31 Board of Regents, The University of Texas System Apaf-1, the ced-4 human homolog, an activator of caspase-3
US6171857B1 (en) * 1997-10-17 2001-01-09 Brown University Research Foundatiion Leucine zipper protein, KARP-1 and methods of regulating DNA dependent protein kinase activity
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
IL124015A0 (en) * 1998-04-08 1999-01-26 Yeda Res & Dev Pharmaceutical compositions comprising a protein
JP4294121B2 (ja) 1998-06-05 2009-07-08 大日本住友製薬株式会社 ピリドンカルボン酸誘導体の製造方法およびその中間体
JP2002519010A (ja) * 1998-06-30 2002-07-02 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ Ｄｎａ−ｐｋの使用法
US6670144B1 (en) * 1999-02-26 2003-12-30 Cyclacel, Ltd. Compositions and methods for monitoring the phosphorylation of natural binding partners
MXPA01008626A (es) 1999-02-26 2002-04-24 Univ Johns Hopkins Inhibidor novedoso de muerte programada de celula.
US7163801B2 (en) * 1999-09-01 2007-01-16 The Burnham Institute Methods for determining the prognosis for cancer patients using tucan
US6479541B1 (en) * 2000-03-30 2002-11-12 Baxter International Amiodarone-containing parenteral administration
AU2001256530A1 (en) * 2000-05-20 2001-12-03 Cancer Research Technology Limited Drug screening systems and assays
AU2001288432A1 (en) * 2000-09-01 2002-03-22 Icos Corporation Materials and methods to potentiate cancer treatment
US6696483B2 (en) * 2000-10-03 2004-02-24 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
CN1473055A (zh) * 2000-11-02 2004-02-04 ˹¡-�����ְ�֢�о��� 通过使用hsp90抑制剂提高细胞毒剂效力的方法
WO2003089573A2 (en) * 2002-04-05 2003-10-30 Fishel Richard A Methods of identifying compounds that modulate a dna repair pathway and/or retroviral infectivity, the compounds, and uses thereof
CA2523178C (en) 2003-03-24 2012-10-23 Luitpold Pharmaceuticals, Inc. Materials and methods to potentiate cancer treatment
PL1725233T3 (pl) 2004-03-15 2011-05-31 Sunesis Pharmaceuticals Inc Kompozycja farmaceutyczna zawierająca SNS-595 i jej zastosowanie
US8580814B2 (en) 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
WO2007028171A1 (en) 2005-09-02 2007-03-08 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
MX2008015775A (es) * 2006-06-12 2009-04-17 Sunesis Pharmaceuticals Inc Compuestos y composiciones para tratamiento de cancer.
US20100048609A1 (en) 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
WO2008016702A2 (en) * 2006-08-02 2008-02-07 Sunesis Pharmaceuticals, Inc. Combined use of (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1(2-thiazolyl)-1,8-naphthyridine-3-carboxylic
CN103720701A (zh) 2007-10-22 2014-04-16 逊尼希思制药公司 在联合治疗中使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸的方法
AU2008335772B2 (en) 2007-12-10 2014-11-27 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
SG10201504789RA (en) 2008-12-31 2015-07-30 Sunesis Pharmaceuticals Inc Method Of Preparing (+)-1,4-Dihydro-7-[(3s,4s)-3methoxy-4-(Methylamino)-1-Pyrrolidinyl]-4-Oxo-1-(2-Thiazolyl)-1,8-Naphthyridine-3-Carboxylic Acid
EP2400959A1 (en) 2009-02-27 2012-01-04 Sunesis Pharmaceuticals, Inc. Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
CN101631081B (zh) 2009-08-12 2011-06-08 华为技术有限公司 一种多级交换网
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer

Similar Documents

Publication Publication Date Title
JP2012140442A5 (ja)
EP3082840A4 (en) Methods and assays relating to circulating tumor cells
EP2850675A4 (en) ELECTROCHEMICAL CELLS AND METHODS OF MAKING THE SAME
WO2013006490A3 (en) Antibodies that specifically bind to tim3
EP2853597A4 (en) NUCLEIC ACID MOLECULE INDUCING INTERFERING RNA CAPABLE OF PENETRATING IN CELLS AND USE THEREOF
EP3083658A4 (en) Methods and assays relating to circulating tumor cells
CL2015000084A1 (es) Célula huésped, particularmente de hongo filamentoso, deficiente en la producción de proteína agse; y método de producción de la célula.
EP2827842A4 (en) CYCLODEXTRIN MICROEMULSIONS AND DERMATOLOGICAL USES THEREOF
CL2013000238A1 (es) Uso de inhibores de la succinato deshidrogenasa y/o inhibidores del complejo iii para mejorar la relacion entre microorganismos dañinos y beneficiosos.
JP2012144538A5 (ja)
EP3063267A4 (en) Cardiac neural crest cells and methods of use thereof
HK1214624A1 (zh) 心臟幹細胞和其識別方法和用途
HK1205185A1 (en) Methods and composition related to brown adipose-like cells
TR201911039T4 (tr) Ptp1b ile ilişkili bir hastalığın tedavisine yönelik aminosteroidler.
EP2807209A4 (de) Kompositmaterial, dessen herstellung und dessen verwendung in separatoren für elektrochemische zellen
WO2014205266A3 (en) Compositions and methods for detecting and treating glioblastoma
DK2920282T3 (da) Alkylenkoblede phenoler til anvendelse i biodieselmotorer
PL2853849T3 (pl) Pomieszczenie suche, zwłaszcza do zastosowania w produkcji ogniw litowo-jonowych
EP3094956A4 (en) Preparation of cells, cell aggregates, and tissue fragments
IL232642A0 (en) A method for characterizing circulating cells and its use in diagnosis
PT2859092T (pt) ¿vacina terapêutica para tratamento de diabetes tipo 1 em crianças, aplicação do separador de células e método de multiplicação de células treg para produzir a vacina terapêutica para tratamento de diabetes tipo 1¿
EP2845898A4 (en) METHOD FOR CULTIVATING NEURAL CREST STEM CELLS, AND USE THEREOF
CO6801702A2 (es) El uso de la vinaza en el proceso de sacrificación de la biomasa lignocelulósica
WO2012068038A3 (en) Caffeic acid derivatives and their use in improving neuronal cell viability
EP2826085A4 (de) Kompositmaterialien, ihre herstellung und verwendung in elektrochemischen zellen