JP2012140442A5 - - Google Patents
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- JP2012140442A5 JP2012140442A5 JP2012036919A JP2012036919A JP2012140442A5 JP 2012140442 A5 JP2012140442 A5 JP 2012140442A5 JP 2012036919 A JP2012036919 A JP 2012036919A JP 2012036919 A JP2012036919 A JP 2012036919A JP 2012140442 A5 JP2012140442 A5 JP 2012140442A5
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- JP
- Japan
- Prior art keywords
- amount
- pathway
- dna
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- initial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55357804P | 2004-03-15 | 2004-03-15 | |
| US60/553,578 | 2004-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503972A Division JP5096913B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014091125A Division JP5856644B2 (ja) | 2004-03-15 | 2014-04-25 | Ｓｎｓ−５９５、及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012140442A JP2012140442A (ja) | 2012-07-26 |
| JP2012140442A5 true JP2012140442A5 (enExample) | 2013-04-04 |
Family
ID=34993432
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503972A Expired - Fee Related JP5096913B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2007503987A Expired - Fee Related JP5317472B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2011135675A Pending JP2011225590A (ja) | 2004-03-15 | 2011-06-17 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2012036919A Pending JP2012140442A (ja) | 2004-03-15 | 2012-02-23 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014091125A Expired - Fee Related JP5856644B2 (ja) | 2004-03-15 | 2014-04-25 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014180862A Expired - Fee Related JP6261477B2 (ja) | 2004-03-15 | 2014-09-05 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2015140309A Expired - Fee Related JP6352863B2 (ja) | 2004-03-15 | 2015-07-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2016248041A Pending JP2017095471A (ja) | 2004-03-15 | 2016-12-21 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2018038834A Pending JP2018119977A (ja) | 2004-03-15 | 2018-03-05 | Ｓｎｓ−５９５、及びその使用方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503972A Expired - Fee Related JP5096913B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2007503987A Expired - Fee Related JP5317472B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2011135675A Pending JP2011225590A (ja) | 2004-03-15 | 2011-06-17 | Ｓｎｓ−５９５、及びその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014091125A Expired - Fee Related JP5856644B2 (ja) | 2004-03-15 | 2014-04-25 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014180862A Expired - Fee Related JP6261477B2 (ja) | 2004-03-15 | 2014-09-05 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2015140309A Expired - Fee Related JP6352863B2 (ja) | 2004-03-15 | 2015-07-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2016248041A Pending JP2017095471A (ja) | 2004-03-15 | 2016-12-21 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2018038834A Pending JP2018119977A (ja) | 2004-03-15 | 2018-03-05 | Ｓｎｓ−５９５、及びその使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (12) | US7989468B2 (enExample) |
| EP (4) | EP1725233B1 (enExample) |
| JP (9) | JP5096913B2 (enExample) |
| KR (1) | KR101169825B1 (enExample) |
| CN (5) | CN104324029A (enExample) |
| AT (2) | ATE451924T1 (enExample) |
| AU (3) | AU2005222607B2 (enExample) |
| BR (1) | BRPI0508700A (enExample) |
| CA (3) | CA2559652C (enExample) |
| CY (2) | CY1109741T1 (enExample) |
| DE (2) | DE602005025738D1 (enExample) |
| DK (3) | DK1725233T3 (enExample) |
| ES (3) | ES2566973T3 (enExample) |
| HU (1) | HUE027266T2 (enExample) |
| IL (2) | IL177946A (enExample) |
| MX (2) | MX349188B (enExample) |
| NO (3) | NO338058B1 (enExample) |
| NZ (2) | NZ549557A (enExample) |
| PL (3) | PL2295056T3 (enExample) |
| PT (2) | PT1729770E (enExample) |
| SI (2) | SI1729770T1 (enExample) |
| WO (2) | WO2005089756A1 (enExample) |
| ZA (1) | ZA200607248B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1725233T3 (da) | 2004-03-15 | 2011-03-14 | Sunesis Pharmaceuticals Inc | Farmaceutisk sammensætning omfattende SNS-595 og anvendelse deraf |
| US7652134B2 (en) | 2004-09-17 | 2010-01-26 | Cylene Pharmaceuticals, Inc. | Methods for converting quinolone esters into quinolone amides |
| BRPI0515319A (pt) | 2004-09-17 | 2008-07-22 | Cylene Pharmaceuticals Inc | análogos de quinolona |
| CA2619663A1 (en) * | 2005-08-19 | 2007-02-22 | Cylene Pharmaceuticals, Inc. | Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof |
| KR20080041298A (ko) * | 2005-09-02 | 2008-05-09 | 선에시스 파마슈티컬스 인코포레이티드 | 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법 |
| US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| CA2620915C (en) * | 2005-09-02 | 2014-03-25 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| US8124773B2 (en) * | 2006-06-12 | 2012-02-28 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
| US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| PL2049109T3 (pl) * | 2006-08-02 | 2016-05-31 | Sunesis Pharmaceuticals Inc | Skojarzone zastosowanie kwasu (+)-1,4-dihydro-7-[(3s,4s)-3-metoksy-4-(metyloamino)-1-pirolidynylo]-4-okso-1-(2-tiazolilo)-1,8-naftyrydyno-3-karboksylowego i cytarabiny (Ara-C) do leczenia białaczki |
| US20090093513A1 (en) * | 2007-10-09 | 2009-04-09 | Hamann Mark T | Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter |
| AU2014277779B2 (en) * | 2007-10-22 | 2016-05-19 | Sunesis Pharmaceuticals, Inc. | METHODS OF USING (+)-1,4-DIHYDRO-7-[(3s,4s)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY |
| WO2009054935A1 (en) * | 2007-10-22 | 2009-04-30 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
| AU2008335772B2 (en) * | 2007-12-10 | 2014-11-27 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| JP6129471B2 (ja) | 2008-12-31 | 2017-05-17 | サネシス ファーマシューティカルズ， インコーポレイテッド | （＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の製造方法 |
| CN102405045A (zh) | 2009-02-27 | 2012-04-04 | 逊尼希思制药公司 | 利用sns-595 治疗具有降低的brca2 活性的癌症对象的方法 |
| UA110465C2 (en) * | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| US8470817B2 (en) * | 2009-10-26 | 2013-06-25 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
| CN108551828B (zh) | 2012-02-27 | 2021-04-30 | 阿吉齐科技公司 | 土壤条件的监测与控制 |
| SI3459942T1 (sl) | 2012-04-24 | 2021-05-31 | Vertex Pharmaceuticals Incorporated | Inhibitorji DNA-PK |
| HRP20211855T1 (hr) | 2013-03-12 | 2022-03-04 | Vertex Pharmaceuticals Incorporated | Inhibitori dnk-pk |
| WO2014169067A1 (en) * | 2013-04-09 | 2014-10-16 | Merrimack Pharmaceuticals, Inc. | Compositions for improving outcomes of liposomal chemotherapy |
| US20160136173A1 (en) * | 2013-07-02 | 2016-05-19 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Method for Preventing and/or Treating Chronic Traumatic Encephalopathy - III |
| SI3424920T1 (sl) | 2013-10-17 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Kokristali (s)-n-metil-8-(1-((2'-metil-(4,5'-bipirimidin)-6-il)amino)propan-2-il) kinolin-4-karboksamida in devterirani derivati le-teh kot inhibitorji dna-pk |
| KR101775356B1 (ko) * | 2015-07-06 | 2017-09-06 | 재단법인 아산사회복지재단 | Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법 |
| MX394860B (es) | 2016-09-27 | 2025-03-24 | Vertex Pharma | Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk). |
| WO2025033367A1 (ja) * | 2023-08-04 | 2025-02-13 | 湧永製薬株式会社 | 抗腫瘍剤併用療法 |
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| US216316A (en) * | 1879-06-10 | Improvement in latches | ||
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| US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| DK0787726T3 (da) * | 1994-06-14 | 2002-02-11 | Dainippon Pharmaceutical Co | Ny forbindelse, fremgangsmåde til fremstilling deraf og antitumor-middel |
| JP4323574B2 (ja) | 1995-12-13 | 2009-09-02 | 大日本住友製薬株式会社 | 抗腫瘍剤 |
| JP2001508868A (ja) * | 1997-01-13 | 2001-07-03 | クードス ファーマシューティカルズ リミティド | 細胞ｄｎａ 修復活性の調節に関するアッセイ、剤、治療及び診断 |
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| EP1003856A1 (en) | 1997-06-05 | 2000-05-31 | Board of Regents, The University of Texas System | Apaf-1, the ced-4 human homolog, an activator of caspase-3 |
| US6171857B1 (en) * | 1997-10-17 | 2001-01-09 | Brown University Research Foundatiion | Leucine zipper protein, KARP-1 and methods of regulating DNA dependent protein kinase activity |
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| JP4294121B2 (ja) | 1998-06-05 | 2009-07-08 | 大日本住友製薬株式会社 | ピリドンカルボン酸誘導体の製造方法およびその中間体 |
| AU5206899A (en) * | 1998-06-30 | 2000-01-17 | Sloan-Kettering Institute For Cancer Research | Uses of dna-pk |
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| WO2000050453A1 (en) * | 1999-02-26 | 2000-08-31 | The Johns Hopkins University | A novel inhibitor of programmed cell death |
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| AU2001288432A1 (en) * | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
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| JP2006523681A (ja) * | 2003-03-24 | 2006-10-19 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | Ｄｎａ−ｐｋ阻害剤としてのキサントン、チオキサントンおよびアクリジノン |
| DK1725233T3 (da) * | 2004-03-15 | 2011-03-14 | Sunesis Pharmaceuticals Inc | Farmaceutisk sammensætning omfattende SNS-595 og anvendelse deraf |
| KR20080041298A (ko) | 2005-09-02 | 2008-05-09 | 선에시스 파마슈티컬스 인코포레이티드 | 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법 |
| US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| US8124773B2 (en) | 2006-06-12 | 2012-02-28 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
| US20100048609A1 (en) | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| PL2049109T3 (pl) * | 2006-08-02 | 2016-05-31 | Sunesis Pharmaceuticals Inc | Skojarzone zastosowanie kwasu (+)-1,4-dihydro-7-[(3s,4s)-3-metoksy-4-(metyloamino)-1-pirolidynylo]-4-okso-1-(2-tiazolilo)-1,8-naftyrydyno-3-karboksylowego i cytarabiny (Ara-C) do leczenia białaczki |
| WO2009054935A1 (en) | 2007-10-22 | 2009-04-30 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
| AU2008335772B2 (en) | 2007-12-10 | 2014-11-27 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| JP6129471B2 (ja) | 2008-12-31 | 2017-05-17 | サネシス ファーマシューティカルズ， インコーポレイテッド | （＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の製造方法 |
| CN102405045A (zh) | 2009-02-27 | 2012-04-04 | 逊尼希思制药公司 | 利用sns-595 治疗具有降低的brca2 活性的癌症对象的方法 |
| CN101631081B (zh) | 2009-08-12 | 2011-06-08 | 华为技术有限公司 | 一种多级交换网 |
| UA110465C2 (en) | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| US8470817B2 (en) | 2009-10-26 | 2013-06-25 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
-
2005
- 2005-03-14 DK DK05731600.2T patent/DK1725233T3/da active
- 2005-03-14 KR KR1020067021270A patent/KR101169825B1/ko not_active Expired - Fee Related
- 2005-03-14 AU AU2005222607A patent/AU2005222607B2/en not_active Ceased
- 2005-03-14 US US11/080,283 patent/US7989468B2/en not_active Expired - Fee Related
- 2005-03-14 JP JP2007503972A patent/JP5096913B2/ja not_active Expired - Fee Related
- 2005-03-14 WO PCT/US2005/008036 patent/WO2005089756A1/en not_active Ceased
- 2005-03-14 PT PT05732554T patent/PT1729770E/pt unknown
- 2005-03-14 PL PL10177951T patent/PL2295056T3/pl unknown
- 2005-03-14 AT AT05732554T patent/ATE451924T1/de active
- 2005-03-14 CA CA2559652A patent/CA2559652C/en not_active Expired - Fee Related
- 2005-03-14 BR BRPI0508700-7A patent/BRPI0508700A/pt not_active IP Right Cessation
- 2005-03-14 DK DK10177951.0T patent/DK2295056T5/en active
- 2005-03-14 CA CA2559650A patent/CA2559650C/en not_active Expired - Fee Related
- 2005-03-14 EP EP05731600A patent/EP1725233B1/en not_active Expired - Lifetime
- 2005-03-14 DE DE602005025738T patent/DE602005025738D1/de not_active Expired - Lifetime
- 2005-03-14 CN CN201410477839.4A patent/CN104324029A/zh active Pending
- 2005-03-14 DK DK05732554.0T patent/DK1729770T3/da active
- 2005-03-14 AU AU2005222622A patent/AU2005222622B2/en not_active Ceased
- 2005-03-14 ES ES10177951.0T patent/ES2566973T3/es not_active Expired - Lifetime
- 2005-03-14 CN CN201210307920.9A patent/CN103083316B/zh not_active Expired - Fee Related
- 2005-03-14 DE DE602005018333T patent/DE602005018333D1/de not_active Expired - Lifetime
- 2005-03-14 SI SI200530890T patent/SI1729770T1/sl unknown
- 2005-03-14 CA CA2954578A patent/CA2954578A1/en not_active Abandoned
- 2005-03-14 SI SI200531244T patent/SI1725233T1/sl unknown
- 2005-03-14 PT PT05731600T patent/PT1725233E/pt unknown
- 2005-03-14 ES ES05731600T patent/ES2358267T3/es not_active Expired - Lifetime
- 2005-03-14 WO PCT/US2005/008346 patent/WO2005089757A1/en not_active Ceased
- 2005-03-14 NZ NZ549557A patent/NZ549557A/en not_active IP Right Cessation
- 2005-03-14 AT AT05731600T patent/ATE493982T1/de active
- 2005-03-14 MX MX2011011851A patent/MX349188B/es unknown
- 2005-03-14 EP EP15202939.3A patent/EP3053579A1/en not_active Withdrawn
- 2005-03-14 CN CN200910221540A patent/CN101703508A/zh active Pending
- 2005-03-14 ZA ZA200607248A patent/ZA200607248B/xx unknown
- 2005-03-14 JP JP2007503987A patent/JP5317472B2/ja not_active Expired - Fee Related
- 2005-03-14 ES ES05732554T patent/ES2334802T3/es not_active Expired - Lifetime
- 2005-03-14 US US11/080,102 patent/US7968565B2/en not_active Expired - Fee Related
- 2005-03-14 MX MXPA06010382A patent/MXPA06010382A/es active IP Right Grant
- 2005-03-14 EP EP05732554A patent/EP1729770B1/en not_active Expired - Lifetime
- 2005-03-14 EP EP10177951.0A patent/EP2295056B9/en not_active Expired - Lifetime
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- 2005-03-14 CN CN200580015456.4A patent/CN1997368B/zh not_active Expired - Fee Related
- 2005-03-14 PL PL05732554T patent/PL1729770T3/pl unknown
- 2005-04-14 NZ NZ588060A patent/NZ588060A/en not_active IP Right Cessation
- 2005-09-02 US US11/218,653 patent/US20060063795A1/en active Pending
- 2005-09-02 US US11/218,387 patent/US20060025437A1/en active Pending
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2006
- 2006-06-29 US US11/478,765 patent/US7829577B2/en not_active Expired - Fee Related
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2010
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2011
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- 2011-03-22 AU AU2011201277A patent/AU2011201277B2/en not_active Ceased
- 2011-04-27 US US13/095,111 patent/US20110263524A1/en not_active Abandoned
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- 2011-06-17 JP JP2011135675A patent/JP2011225590A/ja active Pending
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2012
- 2012-02-23 JP JP2012036919A patent/JP2012140442A/ja active Pending
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2013
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2014
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2015
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2016
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2018
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- 2018-04-27 US US15/965,741 patent/US20180316309A1/en not_active Abandoned
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