JP2012070739A5 - - Google Patents
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- JP2012070739A5 JP2012070739A5 JP2011235756A JP2011235756A JP2012070739A5 JP 2012070739 A5 JP2012070739 A5 JP 2012070739A5 JP 2011235756 A JP2011235756 A JP 2011235756A JP 2011235756 A JP2011235756 A JP 2011235756A JP 2012070739 A5 JP2012070739 A5 JP 2012070739A5
- Authority
- JP
- Japan
- Prior art keywords
- actriib polypeptide
- disease
- amino acid
- domain
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 45
- 229920001184 polypeptide Polymers 0.000 claims 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims 40
- 102000004196 processed proteins & peptides Human genes 0.000 claims 40
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 15
- 101000886562 Homo sapiens Growth/differentiation factor 8 Proteins 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- 108060003951 Immunoglobulin Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 102000018358 immunoglobulin Human genes 0.000 claims 7
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 201000006938 muscular dystrophy Diseases 0.000 claims 5
- 230000035772 mutation Effects 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 4
- 206010028289 Muscle atrophy Diseases 0.000 claims 4
- 201000000585 muscular atrophy Diseases 0.000 claims 4
- 108010059616 Activins Proteins 0.000 claims 3
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 3
- 239000000488 activin Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 201000006935 Becker muscular dystrophy Diseases 0.000 claims 2
- 206010006895 Cachexia Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 101150004989 A43R gene Proteins 0.000 claims 1
- 101150099971 A46R gene Proteins 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 102220479043 BEN domain-containing protein 3_K56A_mutation Human genes 0.000 claims 1
- 208000037663 Best vitelliform macular dystrophy Diseases 0.000 claims 1
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 102100034239 Emerin Human genes 0.000 claims 1
- 201000009344 Emery-Dreifuss muscular dystrophy Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000036119 Frailty Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims 1
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 102100022745 Laminin subunit alpha-2 Human genes 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 201000009342 Limb-girdle muscular dystrophy Diseases 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000026062 Tissue disease Diseases 0.000 claims 1
- 101100161330 Vaccinia virus (strain Western Reserve) VACWR172 gene Proteins 0.000 claims 1
- 206010047626 Vitamin D Deficiency Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 206010003549 asthenia Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000006815 congenital muscular dystrophy Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 201000009338 distal myopathy Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000020694 gallbladder disease Diseases 0.000 claims 1
- 230000006589 gland dysfunction Effects 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 201000003617 glucocorticoid-induced osteoporosis Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 150000002632 lipids Chemical group 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 208000018360 neuromuscular disease Diseases 0.000 claims 1
- 208000013315 neuromuscular junction disease Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 235000018343 nutrient deficiency Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 208000020938 vitelliform macular dystrophy 2 Diseases 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59076504P | 2004-07-23 | 2004-07-23 | |
| US60/590,765 | 2004-07-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522846A Division JP2008507288A (ja) | 2004-07-23 | 2005-07-25 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046188A Division JP2014138607A (ja) | 2004-07-23 | 2014-03-10 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012070739A JP2012070739A (ja) | 2012-04-12 |
| JP2012070739A5 true JP2012070739A5 (cg-RX-API-DMAC7.html) | 2013-01-17 |
Family
ID=34981761
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522846A Withdrawn JP2008507288A (ja) | 2004-07-23 | 2005-07-25 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2011235756A Withdrawn JP2012070739A (ja) | 2004-07-23 | 2011-10-27 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2014046188A Withdrawn JP2014138607A (ja) | 2004-07-23 | 2014-03-10 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2015243744A Withdrawn JP2016094449A (ja) | 2004-07-23 | 2015-12-15 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2018006070A Withdrawn JP2018100275A (ja) | 2004-07-23 | 2018-01-18 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2019193970A Pending JP2020015763A (ja) | 2004-07-23 | 2019-10-25 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2020023608A Pending JP2020073604A (ja) | 2004-07-23 | 2020-02-14 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522846A Withdrawn JP2008507288A (ja) | 2004-07-23 | 2005-07-25 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046188A Withdrawn JP2014138607A (ja) | 2004-07-23 | 2014-03-10 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2015243744A Withdrawn JP2016094449A (ja) | 2004-07-23 | 2015-12-15 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2018006070A Withdrawn JP2018100275A (ja) | 2004-07-23 | 2018-01-18 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2019193970A Pending JP2020015763A (ja) | 2004-07-23 | 2019-10-25 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2020023608A Pending JP2020073604A (ja) | 2004-07-23 | 2020-02-14 | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7709605B2 (cg-RX-API-DMAC7.html) |
| EP (5) | EP1771470B1 (cg-RX-API-DMAC7.html) |
| JP (7) | JP2008507288A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005266875B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2891010C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2332977T3 (cg-RX-API-DMAC7.html) |
| ES (4) | ES2710048T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1771470E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006012627A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1771470B1 (en) | 2004-07-23 | 2013-06-26 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| EP1802326A2 (en) * | 2004-09-09 | 2007-07-04 | Stryker Corporation | Methods for treating bone tumors using bone morphogenic proteins |
| US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| AU2015201033B2 (en) * | 2005-11-23 | 2017-03-16 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for promoting bone growth |
| US7612041B2 (en) | 2005-11-23 | 2009-11-03 | Acceleron Pharma Inc. | Isolated activin-binding ActRIIa polypeptide comprising the SEQ ID NO: 7 and uses for promoting bone growth |
| KR101581961B1 (ko) * | 2006-11-02 | 2016-01-04 | 악셀레론 파마 인코포레이티드 | Ａｌｋ１ 수용체 및 리간드 길항제 및 그의 용도 |
| AU2013221910B2 (en) * | 2006-12-18 | 2016-11-17 | Acceleron Pharma Inc. | Activin-ActRII antagonists and uses for increasing red blood cell levels |
| EP2468290B1 (en) * | 2006-12-18 | 2015-04-01 | Acceleron Pharma, Inc. | Activin-ActRII Antagonists for use in treating anemia |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| AU2016250354B2 (en) * | 2006-12-18 | 2019-01-17 | Acceleron Pharma Inc. | Activin-ActRII antagonists and uses for increasing red blood cell levels |
| CN101835485B (zh) * | 2007-02-01 | 2016-10-26 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂及在治疗或预防乳腺癌中的用途 |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| KR101672156B1 (ko) * | 2007-02-09 | 2016-11-02 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| US8501678B2 (en) | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
| WO2013106175A1 (en) | 2011-12-19 | 2013-07-18 | Amgen Inc. | Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof |
| US7947646B2 (en) | 2007-03-06 | 2011-05-24 | Amgen Inc. | Variant activin receptor polypeptides |
| JP2010529041A (ja) * | 2007-06-01 | 2010-08-26 | ワイス・エルエルシー | Ｂｍｐ−１０活性を調整する方法および組成物 |
| SI2170396T1 (sl) | 2007-08-03 | 2017-04-26 | Summit (Oxford) Limited | Kombinacije zdravil za zdravljenje duchennove mišične distrofije |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| WO2009038745A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| WO2009137075A1 (en) * | 2008-05-06 | 2009-11-12 | Acceleron Pharma Inc. | Anti-activin antibodies and uses for promoting bone growth |
| US20100015144A1 (en) | 2008-06-26 | 2010-01-21 | Acceleron Pharma Inc. | Methods for dosing an activin-actriia antagonist and monitoring of treated patients |
| JP5773868B2 (ja) | 2008-06-26 | 2015-09-02 | アクセルロン ファーマ， インコーポレイテッド | アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| US8058229B2 (en) | 2008-08-14 | 2011-11-15 | Acceleron Pharma Inc. | Method of increasing red blood cell levels or treating anemia in a patient |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| MY159483A (en) | 2008-11-26 | 2017-01-13 | Amgen Inc | Variants of activin iib receptor polypeptides and uses thereof |
| AU2010204985A1 (en) * | 2009-01-13 | 2011-08-04 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| DK3178835T3 (da) | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| US8957021B2 (en) | 2009-02-03 | 2015-02-17 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| HUE035240T2 (hu) * | 2009-04-27 | 2018-05-02 | Novartis Ag | Készítmények és eljárások az izomerõ növelésére |
| CN102482339B (zh) * | 2009-06-08 | 2015-06-17 | 阿塞勒隆制药公司 | 用于增加产热脂肪细胞的方法 |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| CN107267520A (zh) * | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
| CN113171442B (zh) | 2009-08-13 | 2024-11-15 | 阿塞勒隆制药公司 | Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 |
| MX340451B (es) * | 2009-09-09 | 2016-07-08 | Acceleron Pharma Inc | Antagonistas de actriib y dosificacion y usos de los mismos. |
| WO2011056497A1 (en) * | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
| JP5836961B2 (ja) * | 2009-11-03 | 2015-12-24 | アクセルロン ファーマ， インコーポレイテッド | 脂肪肝疾患を処置するための方法 |
| US8710016B2 (en) | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| US8557961B2 (en) | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| EP2638065A4 (en) | 2010-11-08 | 2014-04-09 | Acceleron Pharma Inc | ACTRIIA-BINDING SUBSTANCES AND ITS USES |
| DK3520805T3 (da) | 2011-10-17 | 2021-04-19 | Acceleron Pharma Inc | Sammensætninger til behandling af myelofibrose |
| GR1007832B (el) * | 2011-11-21 | 2013-02-14 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, | Αδρανοποιητες της ακτιβινης και χρηση τους για την θεραπεια ασθενειων που σχετιζονται με παρεκκλινουσα ενεργοποιηση της "αμυντικης αποκρισης του ξενιστη" |
| MX366864B (es) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Composiciones de conjugados de xten y métodos para realizarlas. |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| BR112014031028A2 (pt) * | 2012-06-11 | 2017-08-15 | Amgen Inc | Proteína de ligação ao antígeno isolado, ácido nucléico isolado, vetor de expressão, célula hospedeira, método para produzir uma proteína de ligação ao antígeno, composição, método para reduzir ou bloquear a atividade de miostatina, activin a ou gdf-11, método para aumentar a firmeza da massa muscular ou aumentar a proporção da firmeza da massa muscular para massa adiposo em um indivíduo necessitado do referido tratamento, método para tratar ou prevenir uma doença prejudicial do músculo em um indivíduo sofrendo do referido distúrbio e anticorpo receptor duplo antagonista |
| AU2013313282B2 (en) | 2012-08-01 | 2018-02-01 | Ikaika Therapeutics, Llc | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (LTBP4) |
| WO2014026162A1 (en) | 2012-08-10 | 2014-02-13 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| WO2014066486A2 (en) | 2012-10-24 | 2014-05-01 | Celgene Corporation | Biomarker for use in treating anemia |
| US20150266950A1 (en) | 2012-10-24 | 2015-09-24 | Celgene Corporation | Methods for treating anemia |
| AU2013337677B2 (en) | 2012-11-02 | 2018-06-28 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
| SG11201505960VA (en) | 2013-02-01 | 2015-08-28 | Santa Maria Biotherapeutics Inc | Administration of an anti-activin-a compound to a subject |
| EP2983694B1 (en) | 2013-04-08 | 2022-06-22 | President and Fellows of Harvard College | Compositions for rejuvenating skeletal muscle stem cells |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| EP3656853B1 (en) * | 2013-08-23 | 2023-02-15 | Sumitomo Chemical Company, Limited | Method for producing retinal tissue and retina-related cells |
| EP3094751A4 (en) * | 2014-01-14 | 2017-06-07 | Santa Maria Biotherapeutics, Inc. | Activin inhibitor response prediction and uses for treatment |
| EP3100056A2 (en) | 2014-01-27 | 2016-12-07 | Novartis AG | Biomarkers predictive of muscle atrophy, method and use |
| WO2015152183A1 (ja) * | 2014-03-31 | 2015-10-08 | 大日本住友製薬株式会社 | 進行性骨化性線維異形成症の予防剤及び治療剤 |
| EP3131931B1 (en) | 2014-04-18 | 2020-10-21 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels and treating sickle-cell disease |
| JP6568110B2 (ja) * | 2014-06-04 | 2019-08-28 | アクセルロン ファーマ， インコーポレイテッド | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| BR122023023170A2 (pt) | 2014-06-13 | 2024-02-20 | Acceleron Pharma Inc. | Uso de um antagonista de actrii no tratamento ou prevenção de úlcera cutânea associada com beta-talassemia |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| CN107533040B (zh) | 2014-12-03 | 2022-03-29 | 细胞基因公司 | 激活素-actrii拮抗剂及用于治疗贫血症的用途 |
| MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
| US20180031579A1 (en) | 2015-02-12 | 2018-02-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| JP2018510637A (ja) | 2015-03-26 | 2018-04-19 | アクセルロン ファーマ， インコーポレイテッド | フォリスタチン関連融合タンパク質およびその使用 |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| JP7055636B2 (ja) | 2015-04-06 | 2022-04-18 | アクセルロン ファーマ インコーポレイテッド | ＡＬＫ７：ＡｃｔＲＩＩＢヘテロ多量体およびその使用 |
| JP6810702B2 (ja) | 2015-04-06 | 2021-01-06 | アクセルロン ファーマ インコーポレイテッド | シングルアームｉ型およびｉｉ型受容体融合タンパク質およびその使用 |
| SMT202100294T1 (it) | 2015-04-22 | 2021-07-12 | Biogen Ma Inc | Proteine trappola del liganto acriib ibride innovative per il trattamento di patologie da deperimento muscolare |
| JP2018522579A (ja) | 2015-05-20 | 2018-08-16 | セルジーン コーポレイション | アクチビンＩＩ型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| EP3370754A4 (en) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | METHOD FOR INCREASING ERYTHROCYTE CONCENTRATION AND TREATMENT OF INEFFICIENT ERYTHROPOIESE |
| WO2017091706A1 (en) | 2015-11-23 | 2017-06-01 | Acceleron Pharma Inc. | Methods for treating eye disorders |
| IL293766B2 (en) | 2016-01-06 | 2023-08-01 | Harvard College | Treatment with gdf11 prevents weight gain, improves glucose loading and reduces hepatosteatosis |
| KR102866147B1 (ko) | 2016-03-10 | 2025-09-30 | 악셀레론 파마 인코포레이티드 | 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 |
| EP3439741A4 (en) | 2016-04-06 | 2020-05-06 | Acceleron Pharma Inc. | ALK7 ANTAGONISTS AND USES THEREOF |
| US10722558B2 (en) | 2016-07-15 | 2020-07-28 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| EA201990226A1 (ru) | 2016-07-27 | 2019-08-30 | Акселерон Фарма Инк. | Способы и композиции для лечения миелофиброза |
| KR102761094B1 (ko) | 2016-10-05 | 2025-02-03 | 악셀레론 파마 인코포레이티드 | 변이체 actriib 단백질 및 이의 용도 |
| CN116650622A (zh) | 2016-10-05 | 2023-08-29 | 艾科赛扬制药股份有限公司 | 用于治疗肾脏疾病的组合物和方法 |
| JP7219705B2 (ja) | 2016-10-05 | 2023-02-08 | アクセルロン ファーマ インコーポレイテッド | ＡＬＫ４：ＡｃｔＲＩＩＢヘテロ多量体およびその使用 |
| JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| US11013785B2 (en) * | 2016-11-10 | 2021-05-25 | Keros Therapeutics, Inc. | Activin receptor type IIA variants and methods of use thereof |
| JP2020506702A (ja) | 2017-02-02 | 2020-03-05 | カーギル インコーポレイテッド | Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞 |
| EP3600415B1 (en) * | 2017-03-24 | 2025-09-17 | Novartis AG | Antibody against activin receptor type ii receptor for use in treating heart failure |
| DK3638243T3 (da) | 2017-06-14 | 2024-10-28 | Celgene Corp | Fremgangsmåder til behandling af myeloproliferativ neoplasma-forbundet myelofibrose og anæmi |
| CN107267637B (zh) * | 2017-07-25 | 2021-08-24 | 华南农业大学 | 一种鸡肌间脂肪宽度相关的分子标记及其应用 |
| KR20200085832A (ko) * | 2017-11-09 | 2020-07-15 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| CN120535607A (zh) | 2018-01-12 | 2025-08-26 | 科乐斯疗法公司 | 激活素受体iib型变体及其使用方法 |
| AU2019266314B2 (en) * | 2018-05-09 | 2025-05-15 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| KR20210117271A (ko) | 2018-12-21 | 2021-09-28 | 노쓰웨스턴유니버시티 | 근막 손상 예방 및 치료를 위한 아넥신의 사용근각 손상 예방 및 치료를 위한 아넥신의 사용 |
| US20220062299A1 (en) | 2018-12-26 | 2022-03-03 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
| BR112022003884A2 (pt) | 2019-09-03 | 2022-05-31 | Novartis Ag | Tratamento de doença ou distúrbio hepático compreendendo antagonistas do receptor de actrii |
| JP2022549506A (ja) | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症および関連状態を処置するための方法 |
| AU2021205929A1 (en) | 2020-01-08 | 2022-09-01 | Regeneron Pharmaceuticals, Inc. | Treatment of fibrodysplasia ossificans progressiva |
| EP4121088A4 (en) * | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| EP4121090A4 (en) * | 2020-03-20 | 2024-09-04 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
| EP4149548A4 (en) | 2020-05-13 | 2024-05-08 | Disc Medicine, Inc. | ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS |
| EP4649961A2 (en) | 2020-05-15 | 2025-11-19 | Celgene Corporation | Methods and compositions for treating anemia using actriib ligand traps and mtor inhibitors |
| WO2022072882A1 (en) * | 2020-10-02 | 2022-04-07 | Keros Therapeutics, Inc. | Methods of using activin receptor type ii variants |
| US12186370B1 (en) | 2020-11-05 | 2025-01-07 | Celgene Corporation | ACTRIIB ligand trap compositions and uses thereof |
| KR102680764B1 (ko) * | 2021-08-03 | 2024-07-04 | 주식회사 와이뮨 | Acvr2b를 표적으로 하는 퇴행성 관절염 치료 또는 진단용 조성물 |
| EP4444747A1 (en) | 2021-12-10 | 2024-10-16 | Biogen MA Inc. | Modified actriib proteins and methods of use thereof |
| CA3243129A1 (en) | 2022-01-28 | 2023-08-03 | 35Pharma Inc. | Type IIB Activin Receptor Variants and Their Uses |
| CN121127500A (zh) | 2023-04-07 | 2025-12-12 | 达科纳治疗有限公司 | 针对激活素a受体样1型(alk1)的双特异性激动性抗体 |
| EP4653010A1 (en) | 2024-05-14 | 2025-11-26 | 35Pharma Inc. | Activin receptor type iib traps for use in improving body composition |
Family Cites Families (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0105014B1 (en) | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Repair of tissue in animals |
| NZ210699A (en) | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| ATE128715T1 (de) | 1984-07-16 | 1995-10-15 | Celtrix Pharma | Polypeptide induzierende faktoren in knochen und knorpel. |
| JPH0637520B2 (ja) | 1985-07-03 | 1994-05-18 | 味の素株式会社 | ポリペプチド |
| EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
| US4973577A (en) | 1986-04-04 | 1990-11-27 | The Salk Institute For Biological Studies | FSH-releasing peptides |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| WO1992004913A1 (en) | 1990-09-13 | 1992-04-02 | Children's Hospital Medical Center Of Northern California | Method for increasing red blood cell production by treatment with activin or activin-related peptides |
| US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
| US5885794A (en) | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
| US20050186593A1 (en) | 1991-05-10 | 2005-08-25 | The Salk Institute For Biological Studies | Cloning and recombinant production of CRF receptor(s) |
| US6162896A (en) | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
| CA2086327A1 (en) * | 1991-05-10 | 1992-11-11 | Lawrence S. Mathews | Cloning and recombinant production of receptor(s) of the activin/tgf- .beta. superfamily |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| WO1993000432A1 (en) | 1991-06-25 | 1993-01-07 | Genetics Institute, Inc. | Bmp-9 compositions |
| US6692925B1 (en) | 1992-11-17 | 2004-02-17 | Ludwig Institute For Cancer Research | Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use |
| US5808007A (en) | 1993-01-12 | 1998-09-15 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-3 |
| US5637480A (en) | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
| AU677849B2 (en) | 1993-05-12 | 1997-05-08 | Genetics Institute, Llc | BMP-10 compositions |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US5831050A (en) | 1993-06-07 | 1998-11-03 | Creative Biomolecules, Inc. | Morphogen cell surface receptor |
| JPH09503673A (ja) | 1993-10-14 | 1997-04-15 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | ニューロン細胞の誘導および維持法 |
| US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
| US5658876A (en) | 1994-04-28 | 1997-08-19 | The General Hospital Corporation | Activin antagonists as novel contraceptives |
| US5760010A (en) | 1995-01-01 | 1998-06-02 | Klein; Ira | Method of treating liver disorders with a macrolide antibiotic |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| DE69636866D1 (en) | 1995-04-11 | 2007-03-15 | Gen Hospital Corp | Reverse "two-hybrid"-systeme |
| US6132988A (en) | 1995-10-27 | 2000-10-17 | Takeda Chemical Industries, Ltd. | DNA encoding a neuronal cell-specific receptor protein |
| JPH1072497A (ja) * | 1995-10-27 | 1998-03-17 | Takeda Chem Ind Ltd | 神経系細胞特異的レセプター蛋白質 |
| GB9526131D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
| US20050244867A1 (en) | 1996-03-26 | 2005-11-03 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
| US6004780A (en) | 1996-03-26 | 1999-12-21 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
| US6605699B1 (en) | 1997-01-21 | 2003-08-12 | Human Genome Sciences, Inc. | Galectin-11 polypeptides |
| IL132922A0 (en) * | 1997-05-16 | 2001-03-19 | Procter & Gamble | The use of a bone morphogenetic protein (bmp) receptor complex for screening |
| US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| CA2297489A1 (en) | 1997-07-30 | 1999-02-11 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| WO1999006559A1 (en) | 1997-08-01 | 1999-02-11 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (gdf) receptors |
| US6696260B1 (en) | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6953662B2 (en) | 1997-08-29 | 2005-10-11 | Human Genome Sciences, Inc. | Follistatin-3 |
| AU8921698A (en) | 1997-08-29 | 1999-03-16 | Human Genome Sciences, Inc. | Follistatin-3 |
| WO1999015192A1 (en) * | 1997-09-19 | 1999-04-01 | Auckland Uniservices Limited | Neuronal rescue agent |
| US6696411B1 (en) | 1998-04-22 | 2004-02-24 | Cornell Research Foundation, Inc. | Canine erythropoietin gene and recombinant protein |
| CA2343268A1 (en) | 1998-09-17 | 2000-03-23 | Eli Lilly And Company | Protein formulations |
| CA2343715C (en) | 1998-09-22 | 2004-05-18 | Long Yu | New human growth differentiation factor encoding sequence and polypeptide encoded by such dna sequence and producing method thereof |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US6548634B1 (en) | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
| US6777205B1 (en) | 1998-11-06 | 2004-08-17 | Sterrenbeld Biotechnologie North America, Inc. | Host cells expressing recombinant human erythropoietin |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| DE60027135T2 (de) | 1999-01-21 | 2007-01-11 | Metamorphix, Inc. | Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen |
| EP1174149A1 (en) | 1999-04-19 | 2002-01-23 | Kyowa Hakko Kogyo Co., Ltd. | Proliferation inhibitor for androgen-independent tumor |
| US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| US7358056B1 (en) * | 1999-08-30 | 2008-04-15 | Signal Pharmaceuticals | Methods for modulating signal transduction mediated by TGF-β and related proteins |
| JP2003513681A (ja) | 1999-11-12 | 2003-04-15 | マキシゲン・ホールディングス・リミテッド | インターフェロンガンマ・コンジュゲート |
| CA2394576A1 (en) | 1999-12-15 | 2001-06-21 | Research Development Foundation | Betaglycan as an inhibin receptor and uses thereof |
| JP4487376B2 (ja) | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
| US6627424B1 (en) * | 2000-05-26 | 2003-09-30 | Mj Bioworks, Inc. | Nucleic acid modifying enzymes |
| US6632180B1 (en) | 2000-09-07 | 2003-10-14 | John H. Laragh | Method for evaluating and treating hypertension |
| DE10045591A1 (de) * | 2000-09-15 | 2002-04-04 | Klaus Pfizenmaier | Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine) |
| US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
| AU2002225670B2 (en) * | 2000-11-20 | 2006-05-11 | The Board Of Trustees Of The University Of Illinois | Membrane scaffold proteins |
| WO2002043759A2 (en) | 2000-12-01 | 2002-06-06 | Wyeth | Method and composition for modulating bone growth |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US20040132675A1 (en) | 2002-02-08 | 2004-07-08 | Calvin Kuo | Method for treating cancer and increasing hematocrit levels |
| US20040121008A1 (en) | 2001-03-16 | 2004-06-24 | Keiko Shiraishi | Process for producing sustained release preparation |
| MEP21708A (en) | 2001-05-24 | 2010-06-10 | Zymogenetics Inc | Taci-immunoglobulin fusion proteins |
| IL159015A0 (en) | 2001-05-25 | 2004-05-12 | Genset Sa | Polypeptides, their preparation and use |
| AUPR638101A0 (en) | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| US6855344B2 (en) | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
| CN100419425C (zh) | 2001-07-17 | 2008-09-17 | 帝人株式会社 | 通过测定PPARδ激活作用筛选物质的方法和药剂 |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| US6784154B2 (en) | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
| US20030144203A1 (en) | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
| US6998118B2 (en) | 2001-12-21 | 2006-02-14 | The Salk Institute For Biological Studies | Targeted retrograde gene delivery for neuronal protection |
| JP4429729B2 (ja) | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
| US20030219846A1 (en) | 2002-02-28 | 2003-11-27 | Pfizer Inc. | Assay for activity of the ActRIIB kinase |
| WO2003087162A2 (en) | 2002-04-18 | 2003-10-23 | Mtm Laboratories Ag | Neopeptides and methods useful for detection and treatment of cancer |
| RU2005107330A (ru) | 2002-08-16 | 2005-10-10 | Уайт (Us) | Эстроген-чувствительный элемент вмр-2 и способы его применения |
| AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| AU2002953327A0 (en) | 2002-12-12 | 2003-01-09 | Monash University | Methods of diagnosing prognosing and treating activin associated diseases and conditions |
| WO2004069237A1 (en) | 2003-02-07 | 2004-08-19 | Prometic Biosciences Inc. | Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis |
| WO2004086953A2 (en) | 2003-03-26 | 2004-10-14 | The Board Of Trustees Of The University Of Arkansas | Method for diagnosis and treatment of bone turnover |
| WO2005028517A2 (en) | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
| JP5110877B2 (ja) | 2003-06-02 | 2012-12-26 | ワイス・エルエルシー | 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用 |
| RS20050934A (sr) | 2003-06-16 | 2008-04-04 | Celltech R. & D. Inc., | Antitela specifična za sklerostin i metode za povećanje mineralizacije kostiju |
| WO2005009460A2 (en) | 2003-07-25 | 2005-02-03 | Medexis, S.A. | Pharmaceutical composition comprising activin a, alk-4 or derivatives thereof for the treatment of ophthalmic disorders or cancer |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| ES2330860T3 (es) | 2004-01-22 | 2009-12-16 | Merck Patent Gmbh | Anticuerpos anticancerosos con fijacion del complemento reducida. |
| US20050197292A1 (en) | 2004-01-30 | 2005-09-08 | Glennda Smithson | Compositions and methods for treating T-cell mediated pathological conditions |
| EP1732589A2 (en) | 2004-03-26 | 2006-12-20 | Acceleron Pharma Inc. | Bmp-3 propeptides and related methods |
| AU2005230854A1 (en) | 2004-03-31 | 2005-10-20 | Xencor, Inc | BMP-7 variants with improved properties |
| WO2005113590A2 (en) | 2004-05-12 | 2005-12-01 | Acceleron Pharma Inc. | Bmp10 propeptides and related methods |
| US7465706B2 (en) | 2004-06-24 | 2008-12-16 | Acceleron Pharma Inc. | GDF3 propeptides and related methods |
| EP1771470B1 (en) | 2004-07-23 | 2013-06-26 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| EP1778275A2 (en) | 2004-08-12 | 2007-05-02 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors |
| CA2581896C (en) | 2004-09-29 | 2015-11-10 | Mount Sinai School Of Medicine Of New York University | Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis |
| NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| WO2006088972A2 (en) | 2005-02-16 | 2006-08-24 | The General Hospital Corporation | Use of modulatirs of compounds of tgf-beta superfamily to regulate hepcidin-mediated iron metabolism |
| CN101198321A (zh) | 2005-04-26 | 2008-06-11 | 味之素株式会社 | 骨髓祖红细胞分化诱导剂 |
| JP2007099764A (ja) | 2005-09-09 | 2007-04-19 | Ajinomoto Co Inc | 血糖低下剤 |
| DK1931697T3 (da) | 2005-09-28 | 2010-11-08 | Zymogenetics Inc | IL-17A og IL-17F-antagonister og fremgangsmåder til anvendelse af disse |
| US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US7612041B2 (en) | 2005-11-23 | 2009-11-03 | Acceleron Pharma Inc. | Isolated activin-binding ActRIIa polypeptide comprising the SEQ ID NO: 7 and uses for promoting bone growth |
| MX2008007324A (es) | 2005-12-06 | 2009-03-04 | Amgen Inc | Usos de antagonistas de miostatina. |
| WO2007071023A1 (en) | 2005-12-20 | 2007-06-28 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US20070161578A1 (en) | 2005-12-21 | 2007-07-12 | Hwa Joyce J | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist |
| WO2007076127A2 (en) | 2005-12-22 | 2007-07-05 | Biogen Idec Ma Inc | Condensed imidazoles or pyrazoles and their use as transforming growth factor modulators |
| WO2007084976A2 (en) | 2006-01-20 | 2007-07-26 | Beckman Coulter, Inc. | Methods of detection of iron deficiency |
| JP2009531280A (ja) | 2006-01-25 | 2009-09-03 | ウェルスタット セラピューティクス コーポレイション | 代謝障害を処置するための化合物 |
| AU2007220868B2 (en) | 2006-02-28 | 2011-06-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| CA2650131A1 (en) | 2006-04-14 | 2007-10-25 | Amgen Inc. | Agonist erythropoietin receptor antibodies |
| US20080075692A1 (en) | 2006-05-09 | 2008-03-27 | Perrine Susan P | Methods for treating blood disorders |
| EP2048948B1 (en) | 2006-07-21 | 2012-02-29 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
| GB0615129D0 (en) | 2006-07-29 | 2006-09-06 | Univ Cardiff | Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies |
| CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
| US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| WO2008060139A1 (en) | 2006-11-17 | 2008-05-22 | Erasmus University Medical Center Rotterdam | Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein |
| WO2008073292A2 (en) | 2006-12-08 | 2008-06-19 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Method for protecting renal tubular epithelial cells from radiocontrast nephro parhy (rcn) |
| JP5632582B2 (ja) | 2006-12-14 | 2014-11-26 | 中外製薬株式会社 | 抗Ｃｌａｕｄｉｎ３モノクローナル抗体およびそれを用いる癌の治療および診断 |
| US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| EP2468290B1 (en) | 2006-12-18 | 2015-04-01 | Acceleron Pharma, Inc. | Activin-ActRII Antagonists for use in treating anemia |
| CN101835485B (zh) | 2007-02-01 | 2016-10-26 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂及在治疗或预防乳腺癌中的用途 |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| KR101672156B1 (ko) | 2007-02-09 | 2016-11-02 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| US7947646B2 (en) | 2007-03-06 | 2011-05-24 | Amgen Inc. | Variant activin receptor polypeptides |
| JP2010529041A (ja) | 2007-06-01 | 2010-08-26 | ワイス・エルエルシー | Ｂｍｐ−１０活性を調整する方法および組成物 |
| WO2009009059A1 (en) | 2007-07-09 | 2009-01-15 | Biogen Idec Ma Inc. | Spiro compounds as antagonists of tgf-beta |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| SI2170396T1 (sl) | 2007-08-03 | 2017-04-26 | Summit (Oxford) Limited | Kombinacije zdravil za zdravljenje duchennove mišične distrofije |
| GB0715938D0 (en) | 2007-08-15 | 2007-09-26 | Vastox Plc | Method of treatment of duchenne muscular dystrophy |
| WO2009025651A1 (en) | 2007-08-17 | 2009-02-26 | University Of Maine System Board Of Trustees | Biologically active peptide and method of using the same |
| WO2009038745A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| US8043620B2 (en) | 2007-11-21 | 2011-10-25 | Amgen Inc. | Wise binding agents and epitopes |
| EP2283119B1 (en) | 2008-05-06 | 2015-01-07 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
| WO2009137075A1 (en) | 2008-05-06 | 2009-11-12 | Acceleron Pharma Inc. | Anti-activin antibodies and uses for promoting bone growth |
| JP5773868B2 (ja) | 2008-06-26 | 2015-09-02 | アクセルロン ファーマ， インコーポレイテッド | アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| US20100015144A1 (en) | 2008-06-26 | 2010-01-21 | Acceleron Pharma Inc. | Methods for dosing an activin-actriia antagonist and monitoring of treated patients |
| US8058229B2 (en) | 2008-08-14 | 2011-11-15 | Acceleron Pharma Inc. | Method of increasing red blood cell levels or treating anemia in a patient |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| AU2010204985A1 (en) | 2009-01-13 | 2011-08-04 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| HUE035240T2 (hu) | 2009-04-27 | 2018-05-02 | Novartis Ag | Készítmények és eljárások az izomerõ növelésére |
| CN102482339B (zh) | 2009-06-08 | 2015-06-17 | 阿塞勒隆制药公司 | 用于增加产热脂肪细胞的方法 |
| CN107267520A (zh) | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
| CN113171442B (zh) | 2009-08-13 | 2024-11-15 | 阿塞勒隆制药公司 | Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 |
| MX340451B (es) | 2009-09-09 | 2016-07-08 | Acceleron Pharma Inc | Antagonistas de actriib y dosificacion y usos de los mismos. |
| JP5836961B2 (ja) | 2009-11-03 | 2015-12-24 | アクセルロン ファーマ， インコーポレイテッド | 脂肪肝疾患を処置するための方法 |
| US8710016B2 (en) | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| DK3520805T3 (da) | 2011-10-17 | 2021-04-19 | Acceleron Pharma Inc | Sammensætninger til behandling af myelofibrose |
| CA2874117C (en) | 2012-07-02 | 2021-10-12 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical agent comprising anti-bmp9 antibody as active ingredient for treatment of anemia such as renal anemia and cancer anemia |
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