JP2012041349A5 - - Google Patents
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- JP2012041349A5 JP2012041349A5 JP2011202172A JP2011202172A JP2012041349A5 JP 2012041349 A5 JP2012041349 A5 JP 2012041349A5 JP 2011202172 A JP2011202172 A JP 2011202172A JP 2011202172 A JP2011202172 A JP 2011202172A JP 2012041349 A5 JP2012041349 A5 JP 2012041349A5
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- JP
- Japan
- Prior art keywords
- group
- alkyl
- hydrogen
- covalent bond
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000004967 formylalkyl group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- -1 nitro, 5-tetrazolyl Chemical group 0.000 claims 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55994300A | 2000-04-27 | 2000-04-27 | |
| US09/559,943 | 2000-04-27 | ||
| US09/833,914 US6809105B2 (en) | 2000-04-27 | 2001-04-12 | Diazabicyclic central nervous system active agents |
| US09/833,914 | 2001-04-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001578437A Division JP4981232B2 (ja) | 2000-04-27 | 2001-04-27 | ジアザビシクロ系中枢神経系活性薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012041349A JP2012041349A (ja) | 2012-03-01 |
| JP2012041349A5 true JP2012041349A5 (cg-RX-API-DMAC10.html) | 2012-12-13 |
Family
ID=27072208
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001578437A Expired - Fee Related JP4981232B2 (ja) | 2000-04-27 | 2001-04-27 | ジアザビシクロ系中枢神経系活性薬剤 |
| JP2011202172A Withdrawn JP2012041349A (ja) | 2000-04-27 | 2011-09-15 | ジアザビシクロ系中枢神経系活性薬剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001578437A Expired - Fee Related JP4981232B2 (ja) | 2000-04-27 | 2001-04-27 | ジアザビシクロ系中枢神経系活性薬剤 |
Country Status (22)
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE380031T1 (de) | 1999-12-10 | 2007-12-15 | Pfizer Prod Inc | Pyrrolo 2,3-d pyrimidinderivate enthaltende zusammensetzungen |
| SE0100326D0 (sv) * | 2001-02-02 | 2001-02-02 | Astrazeneca Ab | New compounds |
| PL377791A1 (pl) * | 2002-11-21 | 2006-02-20 | Pfizer Products Inc. | Pochodne 3-aminopiperydyny i sposoby ich wytwarzania |
| US7354937B2 (en) | 2004-05-21 | 2008-04-08 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane |
| US20040242641A1 (en) * | 2003-05-27 | 2004-12-02 | Buckley Michael J. | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
| US20050261348A1 (en) * | 2004-05-21 | 2005-11-24 | Buckley Michael J | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US20050171079A1 (en) | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
| CA2565211A1 (en) | 2004-04-29 | 2005-11-24 | Abbott Laboratories | Amino-tetrazoles analogues and methods of use |
| US7351833B2 (en) | 2004-07-23 | 2008-04-01 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate |
| ES2391472T3 (es) * | 2005-12-20 | 2012-11-27 | Astrazeneca Ab | Derivados de cinnolina sustituidos como moduladores del receptor de GABAA y método para su síntesis |
| US20070184490A1 (en) * | 2006-01-17 | 2007-08-09 | Marleen Verlinden | Neuronal nicotinic receptor ligands and their use |
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| US20100234349A1 (en) | 2006-09-04 | 2010-09-16 | Olsen Gunnar M | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| US8076350B2 (en) | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| US8163916B2 (en) | 2007-03-23 | 2012-04-24 | Abbott Laboratories | Azaadamantane ester and carbamate derivatives and methods of use thereof |
| WO2009036132A1 (en) | 2007-09-11 | 2009-03-19 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole n-oxides |
| PA8802501A1 (es) | 2007-10-31 | 2009-06-23 | Janssen Pharmaceutica Nv | Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno, hidrolasa |
| EP2231672B1 (en) * | 2007-11-21 | 2014-12-17 | AbbVie Inc. | BIARYL SUBSTITUTED DIAZABICYCLOHEPTANE DERIVATIVES AS nAChR MODULATORS |
| MX2010006202A (es) | 2007-12-07 | 2011-03-04 | Abbott Gmbh & Co Kg | Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
| WO2009071690A2 (de) | 2007-12-07 | 2009-06-11 | Abbott Gmbh & Co. Kg | 5,6-disubstituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| CA2707669C (en) | 2007-12-07 | 2016-07-05 | Wilfried Braje | 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases |
| ES2380398T3 (es) | 2007-12-18 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados 5-aminociclilmetil-oxazolidin-2-ona |
| BRPI0911336A2 (pt) | 2008-04-11 | 2021-06-29 | Janssen Pharmaceutica N.V. | tiazolopiridin-2-iloxifenil e tiazolopirazin-2-iloxifenil aminas como moduladores de leucotrieno a4 hidrolase |
| US8148408B2 (en) | 2008-05-09 | 2012-04-03 | Abbott Laboratories | Selective substituted pyridine ligands for neuronal nicotinic receptors |
| EP2411012A4 (en) * | 2009-03-24 | 2012-08-22 | Msd Kk | NEW AMINO-PYRIDINE DERIVATIVES WITH SELECTIVE AURORA A INHIBITION |
| NZ596137A (en) | 2009-05-14 | 2013-08-30 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase |
| WO2010138600A2 (en) | 2009-05-29 | 2010-12-02 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| PL2473049T3 (pl) | 2009-09-04 | 2019-07-31 | Biogen Ma Inc. | Inhibitory kinazy tyrozynowej brutona |
| RS54945B1 (sr) | 2009-10-23 | 2016-11-30 | Janssen Pharmaceutica Nv | Disupstituisani oktahidropirolo[3,4-c]piroli kao oreksin receptor modulatori |
| US9062044B2 (en) * | 2009-10-23 | 2015-06-23 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| WO2011050200A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
| WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
| AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
| KR101655787B1 (ko) | 2014-05-08 | 2016-09-22 | 대우조선해양 주식회사 | 선박의 하이브리드 공기조화시스템 및 그 방법, 그리고 이를 포함하는 선박 또는 해양구조물 |
| KR20160021679A (ko) | 2014-08-18 | 2016-02-26 | 대우조선해양 주식회사 | 극저온 환경의 장비용 히팅장치 및 방법 그리고 이를 구비하는 선박 |
| KR20170090422A (ko) | 2014-10-31 | 2017-08-07 | 인디비어 유케이 리미티드 | 도파민 d3 수용체 길항제 화합물 |
| DK3426251T3 (da) | 2016-03-10 | 2022-06-20 | Janssen Pharmaceutica Nv | Fremgangsmåder til behandling af depression under anvendelse af orexin-2-receptorantagonister |
| WO2018017153A1 (en) | 2016-07-21 | 2018-01-25 | Biogen Ma Inc. | Succinate forms and compositions of bruton's tyrosine kinase inhibitors |
| CN109843872B (zh) * | 2017-09-20 | 2022-08-30 | 杭州英创医药科技有限公司 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
| GB201809295D0 (en) | 2018-06-06 | 2018-07-25 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
| CR20210240A (es) | 2018-11-14 | 2021-06-08 | Janssen Pharmaceutica Nv | Métodos sintéticos mejorados para elaborar compuestos heterocíclicos fusionados como moduladores del receptor de orexina |
| EP3978497A4 (en) * | 2019-05-30 | 2022-07-13 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences | FUSED CYCLIC COMPOUND, METHOD FOR PREPARING IT AND ITS USE |
| CN112047878B (zh) * | 2020-10-15 | 2022-04-19 | 郑州猫眼农业科技有限公司 | 4-溴-6-氯吡啶-2-羧酸的制备方法 |
| WO2024189472A1 (en) | 2023-03-14 | 2024-09-19 | Janssen Pharmaceutica Nv | Improved synthetic methods of making substituted pyrimidine intermediates for synthesis of orexin receptor modulators |
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| DK0393424T3 (da) | 1989-04-17 | 1996-02-05 | Bayer Ag | Fremgangsmåde til fremstilling af 2,7-diazabicyclo(3.3.0)octaner |
| NL9201810A (nl) | 1992-10-19 | 1994-05-16 | Dsm Nv | Werkwijze voor de omzetting van een olefine of een olefinemengsel. |
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| JP4176147B2 (ja) * | 1995-07-28 | 2008-11-05 | アボツト・ラボラトリーズ | 化学的シナプス伝達の制御に有用なフロピリジン、チエノピリジン、ピロロピリジンおよび関連するピリミジン、ピリダジンおよびトリアジン化合物 |
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| PT1027336E (pt) * | 1997-10-27 | 2005-01-31 | Neurosearch As | Heteroarildiazacicloalcanos como ligandos colinergicos de receptores nocotinicos de acetilcolina |
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| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| JP2000026408A (ja) | 1998-07-02 | 2000-01-25 | Dai Ichi Seiyaku Co Ltd | 対掌体的に純粋なピロリジン誘導体、その塩、それらの製造方法 |
| US6804251B1 (en) | 1998-11-12 | 2004-10-12 | Broadcom Corporation | System and method for multiplexing data from multiple sources |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
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2001
- 2001-04-26 MY MYPI20011984A patent/MY137020A/en unknown
- 2001-04-26 MY MYPI20055633A patent/MY145722A/en unknown
- 2001-04-27 SK SK10-2010A patent/SK287658B6/sk not_active IP Right Cessation
- 2001-04-27 EP EP10177450A patent/EP2298775A1/en not_active Withdrawn
- 2001-04-27 KR KR1020087031655A patent/KR100961406B1/ko not_active Expired - Fee Related
- 2001-04-27 CN CN2012103509141A patent/CN102863441A/zh active Pending
- 2001-04-27 CZ CZ20100538A patent/CZ302795B6/cs not_active IP Right Cessation
- 2001-04-27 CZ CZ20080677A patent/CZ302072B6/cs not_active IP Right Cessation
- 2001-04-27 KR KR1020097010331A patent/KR100947187B1/ko not_active Expired - Fee Related
- 2001-04-27 AR ARP010101990A patent/AR030421A1/es active IP Right Grant
- 2001-04-27 PE PE2001000385A patent/PE20011305A1/es not_active Application Discontinuation
- 2001-04-27 MX MXPA02010594A patent/MXPA02010594A/es active IP Right Grant
- 2001-04-27 CA CA002683045A patent/CA2683045A1/en not_active Abandoned
- 2001-04-27 CA CA002407094A patent/CA2407094C/en not_active Expired - Fee Related
- 2001-04-27 EP EP01944118A patent/EP1284976A2/en not_active Withdrawn
- 2001-04-27 PL PL398491A patent/PL398491A1/pl unknown
- 2001-04-27 CZ CZ20023765A patent/CZ301324B6/cs not_active IP Right Cessation
- 2001-04-27 HK HK03104885.7A patent/HK1054375A1/zh unknown
- 2001-04-27 IL IL15223101A patent/IL152231A0/xx not_active IP Right Cessation
- 2001-04-27 EP EP10177411A patent/EP2295437A1/en not_active Withdrawn
- 2001-04-27 KR KR1020097021390A patent/KR100947188B1/ko not_active Expired - Fee Related
- 2001-04-27 WO PCT/US2001/013798 patent/WO2001081347A2/en not_active Ceased
- 2001-04-27 CN CNB018117112A patent/CN100430398C/zh not_active Expired - Fee Related
- 2001-04-27 BR BR0107246-3A patent/BR0107246A/pt not_active IP Right Cessation
- 2001-04-27 HU HU0300602A patent/HUP0300602A3/hu unknown
- 2001-04-27 AU AU2001266559A patent/AU2001266559C1/en not_active Ceased
- 2001-04-27 PL PL01358340A patent/PL358340A1/xx unknown
- 2001-04-27 NZ NZ521734A patent/NZ521734A/en not_active IP Right Cessation
- 2001-04-27 CZ CZ20090553A patent/CZ302038B6/cs not_active IP Right Cessation
- 2001-04-27 AU AU6655901A patent/AU6655901A/xx active Pending
- 2001-04-27 JP JP2001578437A patent/JP4981232B2/ja not_active Expired - Fee Related
- 2001-04-27 CN CN2010102450796A patent/CN101935322A/zh active Pending
- 2001-04-27 KR KR1020027014385A patent/KR100899950B1/ko not_active Expired - Fee Related
- 2001-04-27 SK SK1681-2002A patent/SK287273B6/sk not_active IP Right Cessation
- 2001-05-22 TW TW090110172A patent/TWI311137B/zh not_active IP Right Cessation
- 2001-05-22 TW TW097145362A patent/TWI357903B/zh not_active IP Right Cessation
- 2001-05-22 TW TW095100404A patent/TWI323733B/zh not_active IP Right Cessation
- 2001-05-22 TW TW100130949A patent/TW201141871A/zh unknown
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2002
- 2002-10-24 NO NO20025107A patent/NO324250B1/no not_active IP Right Cessation
- 2002-11-21 BG BG107303A patent/BG66151B1/bg unknown
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2005
- 2005-03-07 MY MYPI20094589A patent/MY168244A/en unknown
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2006
- 2006-08-06 IL IL177316A patent/IL177316A/en not_active IP Right Cessation
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2009
- 2009-12-29 IL IL203035A patent/IL203035A/en not_active IP Right Cessation
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2010
- 2010-03-17 BG BG110620A patent/BG110620A/bg unknown
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2011
- 2011-09-15 JP JP2011202172A patent/JP2012041349A/ja not_active Withdrawn