JP2011526930A5 - - Google Patents
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- Publication number
- JP2011526930A5 JP2011526930A5 JP2011516892A JP2011516892A JP2011526930A5 JP 2011526930 A5 JP2011526930 A5 JP 2011526930A5 JP 2011516892 A JP2011516892 A JP 2011516892A JP 2011516892 A JP2011516892 A JP 2011516892A JP 2011526930 A5 JP2011526930 A5 JP 2011526930A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- phenyl
- phenoxy
- acetic acid
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7831108P | 2008-07-03 | 2008-07-03 | |
| US61/078,311 | 2008-07-03 | ||
| PCT/US2009/049621 WO2010003120A2 (en) | 2008-07-03 | 2009-07-02 | Antagonists of prostaglandin d2 receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526930A JP2011526930A (ja) | 2011-10-20 |
| JP2011526930A5 true JP2011526930A5 (enExample) | 2012-08-16 |
| JP5531370B2 JP5531370B2 (ja) | 2014-06-25 |
Family
ID=41008689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516892A Expired - Fee Related JP5531370B2 (ja) | 2008-07-03 | 2009-07-02 | プロスタグランジンd2受容体のアンタゴニスト |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20110190227A1 (enExample) |
| EP (1) | EP2307362A4 (enExample) |
| JP (1) | JP5531370B2 (enExample) |
| KR (1) | KR101325367B1 (enExample) |
| CN (1) | CN102076661B (enExample) |
| AR (1) | AR074165A1 (enExample) |
| AU (1) | AU2009266793B2 (enExample) |
| BR (1) | BRPI0913930A2 (enExample) |
| CA (1) | CA2729292C (enExample) |
| EA (1) | EA019351B1 (enExample) |
| GB (1) | GB2461629B (enExample) |
| IL (1) | IL210000A (enExample) |
| MX (1) | MX2010014172A (enExample) |
| PE (1) | PE20100094A1 (enExample) |
| TW (1) | TWI403319B (enExample) |
| UY (1) | UY31956A (enExample) |
| WO (2) | WO2010003127A2 (enExample) |
| ZA (1) | ZA201009090B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2502628B1 (en) | 2006-06-23 | 2016-12-14 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
| ES2566739T3 (es) | 2008-02-01 | 2016-04-15 | Brickell Biotech, Inc. | Aminoalquilbifenilo N,N-disustituidos antagonistas de receptores de prostaglandina D2 |
| EP2245002A4 (en) * | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
| JP2011512359A (ja) * | 2008-02-14 | 2011-04-21 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアンタゴニストとしての環式ジアリールエーテル化合物 |
| WO2009108720A2 (en) * | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| JP2011518130A (ja) * | 2008-04-02 | 2011-06-23 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト |
| PE20100094A1 (es) | 2008-07-03 | 2010-02-18 | Amira Pharmaceuticals Inc | Antagonistas heteroalquilo de receptores de prostaglandina d2 |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| US20100173313A1 (en) * | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
| WO2011014587A2 (en) | 2009-07-31 | 2011-02-03 | Amira Pharmaceuticals, Inc. | Ophthalmic pharmaceutical compositions of dp2 receptor antagonists |
| CA2768587A1 (en) * | 2009-08-05 | 2011-02-10 | Panmira Pharmaceuticals, Llc | Dp2 antagonist and uses thereof |
| PH12012501349A1 (en) * | 2010-01-06 | 2013-01-14 | Panmira Pharmaceuticals Llc | Dp2 antagonist and uses thereof |
| WO2011100840A1 (en) | 2010-02-17 | 2011-08-25 | UNIVERSITé LAVAL | Substituted 2-imidazolidones and analogs |
| EP2590944B1 (en) | 2010-07-05 | 2015-09-30 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| US9820951B2 (en) | 2011-01-14 | 2017-11-21 | National Jewish Health, A Non-Profit Organization | Pulmonary disease treatment and diagnosis based on Arhgef1 |
| TWI527809B (zh) * | 2011-01-24 | 2016-04-01 | 百靈佳殷格翰國際股份有限公司 | 作為crth2拮抗劑之吡唑化合物 |
| DK3173427T3 (da) | 2011-03-31 | 2019-08-05 | Adc Therapeutics Sa | Antistoffer mod nyre-associeret antigen 1 og antigen-bindende fragmenter deraf |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| US9255090B2 (en) | 2011-12-21 | 2016-02-09 | Actelion Pharmaceuticals Ltd. | Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| HRP20190946T1 (hr) | 2012-01-09 | 2019-07-26 | Adc Therapeutics Sa | Sredstva za liječenje trostruko negativnog raka dojke |
| US9169270B2 (en) | 2012-07-05 | 2015-10-27 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| AU2013318206B2 (en) | 2012-09-20 | 2018-07-26 | Temple University - Of The Commonwealth System Of Higher Education | Substituted alkyl diaryl derivatives, methods of preparation and uses |
| EP2912458B1 (en) | 2012-10-24 | 2018-07-18 | NYU Winthrop Hospital | Non-invasive biomarker to identify subjects at risk of preterm delivery |
| KR20220102662A (ko) * | 2014-05-06 | 2022-07-20 | 노쓰웨스턴유니버시티 | Nmdar 조절 화합물의 조합물 |
| CN104016878B (zh) * | 2014-06-24 | 2015-06-10 | 中国药科大学 | 芳基乙酸类衍生物、其制备方法及其医药用途 |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| CN110325518A (zh) * | 2017-02-26 | 2019-10-11 | 日本欧爱特农业科技株式会社 | 噻唑化合物及除草剂 |
| US20200264188A1 (en) | 2017-09-13 | 2020-08-20 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
| EP3936192B1 (en) | 2019-03-06 | 2025-04-09 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5239084A (en) * | 1990-06-29 | 1993-08-24 | Hoffmann-La Roche Inc. | Substituted aminoalkyl biphenyl compounds |
| US5827868A (en) * | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
| US5565485A (en) * | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| US5334598A (en) * | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| US5391566A (en) | 1993-07-20 | 1995-02-21 | Merck & Co., Inc. | Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives |
| CO4960662A1 (es) * | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| WO1999065867A1 (en) * | 1998-06-17 | 1999-12-23 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| US6617351B1 (en) * | 1998-07-31 | 2003-09-09 | Eli Lilly And Company | Amide, carbamate, and urea derivatives |
| EE200100558A (et) * | 1999-04-28 | 2002-12-16 | Aventis Pharma Deutschland Gmbh | Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine |
| DE19937537A1 (de) * | 1999-08-09 | 2001-03-08 | Gruenenthal Gmbh | Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate |
| US6884593B1 (en) * | 1999-08-23 | 2005-04-26 | Bml, Inc. | Method of identifying properties of substance with respect to human prostaglandin D2 receptors |
| US20010047027A1 (en) * | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| AU2002302248B2 (en) * | 2001-05-23 | 2008-03-06 | Merck Frosst Canada Ltd. | Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists |
| WO2002098840A1 (en) * | 2001-06-04 | 2002-12-12 | Eisai Co., Ltd. | Carboxylic acid derivative and medicine comprising salt or ester of the same |
| BR0315681A (pt) * | 2002-10-30 | 2005-09-06 | Merck Frosst Canada Inc | Composto e seus sais e hidratos farmaceuticamente aceitáveis, composição farmacêutica, métodos para o tratamento de doenças mediadas pela prostaglandina d2, para o tratamento de congestão nasal, para o tratamento de asma alérgica, e para o tratamento de rinite alérgica, composto ou um seu sal ou solvato farmaceuticamente aceitável, sal ou hidrato do composto, e, uso de um composto ou de um seu sal ou solvato farmaceuticamente aceitável |
| JP2004182657A (ja) | 2002-12-04 | 2004-07-02 | Eisai Co Ltd | Hdlレベル上昇促進剤 |
| MXPA05006701A (es) | 2002-12-20 | 2006-03-30 | Amgen Inc | Moduladores de asma y de inflacion alergica. |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
| AU2004283139A1 (en) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| CA2547430A1 (en) * | 2003-11-26 | 2005-06-09 | Takeda Pharmaceutical Company Limited | Receptor function regulating agent |
| US7019022B2 (en) * | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
| JP2007186422A (ja) * | 2004-01-28 | 2007-07-26 | Astellas Pharma Inc | アリールスルフィド誘導体 |
| GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| DE602005010876D1 (de) | 2004-08-17 | 2008-12-18 | Galderma Res & Dev | Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen |
| US7405215B2 (en) * | 2004-09-21 | 2008-07-29 | Wyeth | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof |
| BRPI0515522A (pt) * | 2004-09-21 | 2008-07-29 | Athersys Inc | composto, composição farmacêutica. métodos de inibir a ligação de ligandos endógenos ao receptor crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor crth-2 em um animal e de preparar um composto, e, kit |
| WO2006052798A2 (en) | 2004-11-08 | 2006-05-18 | Merck & Co., Inc. | Method of treating pathological blushing |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0518783D0 (en) * | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
| US8993763B2 (en) | 2005-09-27 | 2015-03-31 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
| EP1937632A1 (en) | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
| ATE545637T1 (de) * | 2005-12-15 | 2012-03-15 | Astrazeneca Ab | Substituierte diphenylether, -amine, -sulfide und methane zur behandlung von atemwegserkrankungen |
| US7737145B2 (en) * | 2005-12-29 | 2010-06-15 | Estrellita Pharmaceuticals, Llc | Diamine derivatives as inhibitors of leukotriene A4 hydrolase |
| TWI409247B (zh) | 2006-08-21 | 2013-09-21 | Array Biopharma Inc | 4-取代之苯氧基苯基乙酸衍生物 |
| US7960567B2 (en) | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
| WO2008154642A2 (en) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Antibacterial agents |
| CN101687844B (zh) | 2007-07-02 | 2013-11-13 | 弗·哈夫曼-拉罗切有限公司 | 用作ccr2受体拮抗剂的咪唑衍生物 |
| CN101801952A (zh) * | 2007-10-01 | 2010-08-11 | 弗·哈夫曼-拉罗切有限公司 | 用作ccr受体拮抗剂的n-杂环联芳基甲酰胺类化合物 |
| GB0719521D0 (en) | 2007-10-05 | 2007-11-14 | Argenta Discovery Ltd | Compounds |
| GB0722216D0 (en) | 2007-11-13 | 2007-12-27 | Oxagen Ltd | Use of crth2 antagonist compounds |
| GB0722203D0 (en) | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
| HRP20140045T1 (hr) * | 2008-01-18 | 2014-02-14 | Atopix Therapeutics Limited | Spojevi koji imaju antagonistiäśku aktivnost na crth2 |
| ES2566739T3 (es) * | 2008-02-01 | 2016-04-15 | Brickell Biotech, Inc. | Aminoalquilbifenilo N,N-disustituidos antagonistas de receptores de prostaglandina D2 |
| EP2245002A4 (en) * | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
| JP2011512359A (ja) | 2008-02-14 | 2011-04-21 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアンタゴニストとしての環式ジアリールエーテル化合物 |
| JP2011518130A (ja) | 2008-04-02 | 2011-06-23 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト |
| PE20100094A1 (es) * | 2008-07-03 | 2010-02-18 | Amira Pharmaceuticals Inc | Antagonistas heteroalquilo de receptores de prostaglandina d2 |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| US20100173313A1 (en) * | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
| WO2011014587A2 (en) | 2009-07-31 | 2011-02-03 | Amira Pharmaceuticals, Inc. | Ophthalmic pharmaceutical compositions of dp2 receptor antagonists |
| KR20120046762A (ko) | 2009-07-31 | 2012-05-10 | 판미라 파마슈티칼스, 엘엘씨 | Dp2 수용체 길항제의 피부 제형 |
| PH12012501349A1 (en) * | 2010-01-06 | 2013-01-14 | Panmira Pharmaceuticals Llc | Dp2 antagonist and uses thereof |
-
2009
- 2009-07-02 PE PE2009000917A patent/PE20100094A1/es not_active Application Discontinuation
- 2009-07-02 CA CA2729292A patent/CA2729292C/en not_active Expired - Fee Related
- 2009-07-02 US US12/999,621 patent/US20110190227A1/en not_active Abandoned
- 2009-07-02 WO PCT/US2009/049631 patent/WO2010003127A2/en not_active Ceased
- 2009-07-02 KR KR1020117001585A patent/KR101325367B1/ko not_active Expired - Fee Related
- 2009-07-02 US US12/999,617 patent/US20110144160A1/en not_active Abandoned
- 2009-07-02 AU AU2009266793A patent/AU2009266793B2/en not_active Ceased
- 2009-07-02 UY UY0001031956A patent/UY31956A/es not_active Application Discontinuation
- 2009-07-02 MX MX2010014172A patent/MX2010014172A/es active IP Right Grant
- 2009-07-02 BR BRPI0913930A patent/BRPI0913930A2/pt not_active IP Right Cessation
- 2009-07-02 EP EP09774569A patent/EP2307362A4/en not_active Withdrawn
- 2009-07-02 JP JP2011516892A patent/JP5531370B2/ja not_active Expired - Fee Related
- 2009-07-02 EA EA201100133A patent/EA019351B1/ru not_active IP Right Cessation
- 2009-07-02 CN CN200980125478.4A patent/CN102076661B/zh not_active Expired - Fee Related
- 2009-07-02 WO PCT/US2009/049621 patent/WO2010003120A2/en not_active Ceased
- 2009-07-02 TW TW098122461A patent/TWI403319B/zh not_active IP Right Cessation
- 2009-07-02 US US12/497,343 patent/US8071807B2/en not_active Expired - Fee Related
- 2009-07-03 GB GB0911563A patent/GB2461629B/en not_active Expired - Fee Related
- 2009-07-03 AR ARP090102505A patent/AR074165A1/es not_active Application Discontinuation
-
2010
- 2010-12-15 IL IL210000A patent/IL210000A/en not_active IP Right Cessation
- 2010-12-17 ZA ZA2010/09090A patent/ZA201009090B/en unknown
-
2011
- 2011-09-27 US US13/246,688 patent/US8247602B2/en not_active Expired - Fee Related
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