AU2009266793B2 - Antagonists of prostaglandin D2 receptors - Google Patents

Antagonists of prostaglandin D2 receptors Download PDF

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Publication number
AU2009266793B2
AU2009266793B2 AU2009266793A AU2009266793A AU2009266793B2 AU 2009266793 B2 AU2009266793 B2 AU 2009266793B2 AU 2009266793 A AU2009266793 A AU 2009266793A AU 2009266793 A AU2009266793 A AU 2009266793A AU 2009266793 B2 AU2009266793 B2 AU 2009266793B2
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Australia
Prior art keywords
compound
phenyl
acetic acid
phenoxy
methoxy
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AU2009266793A
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AU2009266793A1 (en
Inventor
Jeannie M. Arruda
John Howard Hutchinson
Thomas Jon Seiders
Brian Andrew Stearns
Bowei Wang
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Fresh Tracks Therapeutics Inc
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Brickell Biotech Inc
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AU2009266793A 2008-07-03 2009-07-02 Antagonists of prostaglandin D2 receptors Ceased AU2009266793B2 (en)

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US7831108P 2008-07-03 2008-07-03
US61/078,311 2008-07-03
PCT/US2009/049621 WO2010003120A2 (en) 2008-07-03 2009-07-02 Antagonists of prostaglandin d2 receptors

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AU2009266793A1 AU2009266793A1 (en) 2010-01-07
AU2009266793B2 true AU2009266793B2 (en) 2012-12-20

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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2032701T3 (da) 2006-06-23 2014-02-10 Alethia Biotherapeutics Inc Polynukleotider og polypeptider, der er inddraget i cancer
EP2257524B1 (en) * 2008-02-01 2016-01-06 Brickell Biotech, Inc. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
UA98839C2 (en) * 2008-02-01 2012-06-25 Панмира Фармасьютикалз, Ллк. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
JP2011512359A (ja) 2008-02-14 2011-04-21 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体のアンタゴニストとしての環式ジアリールエーテル化合物
US8497381B2 (en) * 2008-02-25 2013-07-30 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
JP2011518130A (ja) 2008-04-02 2011-06-23 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト
WO2010003120A2 (en) * 2008-07-03 2010-01-07 Amira Pharmaceuticals, Inc. Antagonists of prostaglandin d2 receptors
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
JP5781932B2 (ja) 2008-11-03 2015-09-24 アレシア・バイオセラピューティクス・インコーポレーテッド 腫瘍抗原の生物活性を特異的にブロックする抗体
US8383654B2 (en) 2008-11-17 2013-02-26 Panmira Pharmaceuticals, Llc Heterocyclic antagonists of prostaglandin D2 receptors
US20100173313A1 (en) * 2009-01-08 2010-07-08 Amira Pharmaceuticals, Inc. Biomarkers of inflammation
EP2461809A4 (en) 2009-07-31 2013-06-19 Panmira Pharmaceuticals Llc OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONSITES
CA2768587A1 (en) 2009-08-05 2011-02-10 Panmira Pharmaceuticals, Llc Dp2 antagonist and uses thereof
CA2782085A1 (en) * 2010-01-06 2011-07-14 Panmira Pharmaceuticals, Llc Dp2 antagonist and uses thereof
CA2787860C (en) 2010-02-17 2019-04-02 Universite Laval Substituted 2-imidazolidones and analogs and their use against cancer
EP2590944B1 (en) 2010-07-05 2015-09-30 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
US9820951B2 (en) 2011-01-14 2017-11-21 National Jewish Health, A Non-Profit Organization Pulmonary disease treatment and diagnosis based on Arhgef1
TWI527809B (zh) * 2011-01-24 2016-04-01 百靈佳殷格翰國際股份有限公司 作為crth2拮抗劑之吡唑化合物
EP2691421B1 (en) 2011-03-31 2016-11-09 Alethia Biotherapeutics Inc. Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
ES2624379T3 (es) 2011-12-21 2017-07-14 Idorsia Pharmaceuticals Ltd Derivados de heterociclilo y su uso como moduladores del receptor de prostaglandina D2
EA201992513A1 (ru) 2012-01-09 2020-05-31 Адс Терапьютикс Са Способ лечения рака груди
US9169270B2 (en) 2012-07-05 2015-10-27 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
CN110776447A (zh) * 2012-09-20 2020-02-11 坦普尔大学 取代的烷基二芳基衍生物、制备方法和用途
EP2912458B1 (en) 2012-10-24 2018-07-18 NYU Winthrop Hospital Non-invasive biomarker to identify subjects at risk of preterm delivery
MX2016014581A (es) * 2014-05-06 2018-02-16 Univ Northwestern Composiciones de compuestos que modulan nmdar.
CN104016878B (zh) * 2014-06-24 2015-06-10 中国药科大学 芳基乙酸类衍生物、其制备方法及其医药用途
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
EP3587405A1 (en) * 2017-02-26 2020-01-01 OAT Agrio Co., Ltd. Thiazole compounds and herbicide
JP2020533595A (ja) 2017-09-13 2020-11-19 プロジェニティ, インコーポレイテッド 子癇前症バイオマーカならびに関連するシステムおよび方法
WO2020179859A1 (ja) 2019-03-06 2020-09-10 第一三共株式会社 ピロロピラゾール誘導体
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006005909A1 (en) * 2004-07-08 2006-01-19 Astrazeneca Ab Substituted acids for the treatment of respiratory diseases

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239084A (en) * 1990-06-29 1993-08-24 Hoffmann-La Roche Inc. Substituted aminoalkyl biphenyl compounds
US5827868A (en) * 1991-10-07 1998-10-27 E. R. Squibb & Sons, Inc. Prostaglandin analogs
US5565485A (en) * 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5391566A (en) 1993-07-20 1995-02-21 Merck & Co., Inc. Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
EP1087937A1 (en) * 1998-06-17 2001-04-04 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
US6617351B1 (en) * 1998-07-31 2003-09-09 Eli Lilly And Company Amide, carbamate, and urea derivatives
NZ515087A (en) * 1999-04-28 2003-11-28 Aventis Pharma Gmbh Tri-aryl acid derivatives as PPAR receptor ligands
DE19937537A1 (de) * 1999-08-09 2001-03-08 Gruenenthal Gmbh Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate
CA2383135C (en) * 1999-08-23 2010-11-30 Hiroyuki Hirai Method of identifying properties of substance with respect to human prostaglandin d2 receptors
US20010047027A1 (en) * 2000-04-12 2001-11-29 Marc Labelle Prostaglandin D2 receptor antagonists
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
JP4279561B2 (ja) * 2001-05-23 2009-06-17 メルク フロスト カナダ リミテツド プロスタグランジンD2受容体拮抗薬としてのジヒドロピロロ[1,2−a]インドールおよびテトラヒドロピリド[1,2−a]−インドール誘導体
WO2002098840A1 (en) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
JP4332151B2 (ja) * 2002-10-30 2009-09-16 メルク フロスト カナダ リミテツド ピリドピロリジンおよびピリドインドリジン誘導体
JP2004182657A (ja) 2002-12-04 2004-07-02 Eisai Co Ltd Hdlレベル上昇促進剤
ES2401079T3 (es) * 2002-12-20 2013-04-16 Amgen Inc. Moduladores del asma y de la inflamación alérgica
ATE316077T1 (de) 2003-04-25 2006-02-15 Actimis Pharmaceuticals Inc Pyrimidin-essigsäure derivate geeignet zur behandlung von crth2-bedingten krankheiten
EP1675826A1 (en) 2003-10-14 2006-07-05 Oxagen Limited Compounds having crth2 antagonist activity
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
WO2005051373A1 (ja) 2003-11-26 2005-06-09 Takeda Pharmaceutical Company Limited 受容体機能調節剤
US7019022B2 (en) * 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
JP2007186422A (ja) * 2004-01-28 2007-07-26 Astellas Pharma Inc アリールスルフィド誘導体
GB0409921D0 (en) 2004-05-04 2004-06-09 Novartis Ag Organic compounds
WO2006018325A1 (en) 2004-08-17 2006-02-23 Galderma Research & Development, S.N.C. Novel biaromatic compounds which activate receptors of ppar type and their use in cosmetic or pharmaceutical compositions
WO2006034419A2 (en) * 2004-09-21 2006-03-30 Athersys, Inc. Indole acetic acids exhibiting crth2 receptor antagonism and uses thereof
EP1814865A4 (en) * 2004-09-21 2009-09-02 Wyeth Corp BENZIMIDAZOL ACETIC ACIDS WITH CRTH2 RECEPTOR ANTAGONISM AND ITS APPLICATIONS
US20070299122A1 (en) 2004-11-08 2007-12-27 Tobert Jonathan A Method of Treating Pathological Blushing
GB0510584D0 (en) 2005-05-24 2005-06-29 Novartis Ag Organic compounds
GB0518783D0 (en) 2005-09-14 2005-10-26 Argenta Discovery Ltd Indolizine compounds
EP1939175B1 (en) 2005-09-27 2017-03-01 Shionogi&Co., Ltd. Sulfonamide derivative having pgd2 receptor antagonistic activity
US8148572B2 (en) 2005-10-06 2012-04-03 Astrazeneca Ab Compounds
ES2380683T3 (es) * 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
HUE031972T2 (en) * 2005-12-29 2017-08-28 Celtaxsys Inc Diamine derivatives as inhibitors of leukotriene a4 hydrolase
MX2009001876A (es) 2006-08-21 2009-03-06 Array Biopharma Inc Derivados de acido fenoxifenilacetico 4-sustituidos.
US7960567B2 (en) 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
CN101765585B (zh) 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
AU2008270438B2 (en) 2007-07-02 2013-10-10 F. Hoffmann-La Roche Ag Imidazole derivatives as CCR2 receptor antagonists
CN101801952A (zh) 2007-10-01 2010-08-11 弗·哈夫曼-拉罗切有限公司 用作ccr受体拮抗剂的n-杂环联芳基甲酰胺类化合物
GB0719521D0 (en) 2007-10-05 2007-11-14 Argenta Discovery Ltd Compounds
GB0722203D0 (en) 2007-11-13 2007-12-19 Oxagen Ltd Use of CRTH2 antagonist compounds
GB0722216D0 (en) 2007-11-13 2007-12-27 Oxagen Ltd Use of crth2 antagonist compounds
NZ587251A (en) * 2008-01-18 2011-12-22 Oxagen Ltd Indole derivatives having CRTH2 antagonist activity
EP2257524B1 (en) 2008-02-01 2016-01-06 Brickell Biotech, Inc. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
UA98839C2 (en) * 2008-02-01 2012-06-25 Панмира Фармасьютикалз, Ллк. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
JP2011512359A (ja) 2008-02-14 2011-04-21 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体のアンタゴニストとしての環式ジアリールエーテル化合物
JP2011518130A (ja) 2008-04-02 2011-06-23 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト
WO2010003120A2 (en) * 2008-07-03 2010-01-07 Amira Pharmaceuticals, Inc. Antagonists of prostaglandin d2 receptors
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
US8383654B2 (en) 2008-11-17 2013-02-26 Panmira Pharmaceuticals, Llc Heterocyclic antagonists of prostaglandin D2 receptors
US20100173313A1 (en) 2009-01-08 2010-07-08 Amira Pharmaceuticals, Inc. Biomarkers of inflammation
KR20120046762A (ko) 2009-07-31 2012-05-10 판미라 파마슈티칼스, 엘엘씨 Dp2 수용체 길항제의 피부 제형
EP2461809A4 (en) 2009-07-31 2013-06-19 Panmira Pharmaceuticals Llc OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONSITES
CA2782085A1 (en) * 2010-01-06 2011-07-14 Panmira Pharmaceuticals, Llc Dp2 antagonist and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006005909A1 (en) * 2004-07-08 2006-01-19 Astrazeneca Ab Substituted acids for the treatment of respiratory diseases

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