JP2011522817A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011522817A5 JP2011522817A5 JP2011512418A JP2011512418A JP2011522817A5 JP 2011522817 A5 JP2011522817 A5 JP 2011522817A5 JP 2011512418 A JP2011512418 A JP 2011512418A JP 2011512418 A JP2011512418 A JP 2011512418A JP 2011522817 A5 JP2011522817 A5 JP 2011522817A5
- Authority
- JP
- Japan
- Prior art keywords
- hrp
- concentration
- solution
- solutions
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims description 86
- 239000000017 hydrogel Substances 0.000 claims description 44
- 229920000642 polymer Polymers 0.000 claims description 43
- DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 claims description 22
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 18
- 238000001879 gelation Methods 0.000 claims description 15
- 238000005259 measurement Methods 0.000 claims description 13
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 11
- 229960003732 tyramine Drugs 0.000 claims description 11
- 229920002674 hyaluronan Polymers 0.000 claims description 8
- 229960003160 hyaluronic acid Drugs 0.000 claims description 8
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 87
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drugs Drugs 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SG2008/000204 WO2009148405A1 (en) | 2008-06-05 | 2008-06-05 | Formation of hydrogel in the presence of peroxidase and low concentration of hydrogen peroxide |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011522817A JP2011522817A (ja) | 2011-08-04 |
JP2011522817A5 true JP2011522817A5 (de) | 2012-07-12 |
JP5563563B2 JP5563563B2 (ja) | 2014-07-30 |
Family
ID=41398337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011512418A Expired - Fee Related JP5563563B2 (ja) | 2008-06-05 | 2008-06-05 | ペルオキシダーゼおよび低濃度の過酸化水素の存在下でのヒドロゲルの形成方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5563563B2 (de) |
WO (1) | WO2009148405A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010138082A1 (en) | 2009-05-29 | 2010-12-02 | Agency For Science, Technology And Research | Flavonoid hydrogel |
KR101091028B1 (ko) * | 2009-07-02 | 2011-12-09 | 아주대학교산학협력단 | 체내 주입형 하이드로젤 및 이의 생의학적 용도 |
KR101103423B1 (ko) * | 2009-09-04 | 2012-01-06 | 아주대학교산학협력단 | 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도 |
CZ2009836A3 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace |
CZ2009835A3 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
CN101864178A (zh) * | 2010-06-17 | 2010-10-20 | 复旦大学 | 一种可注射的化学交联蛋白质/多肽水凝胶及其制备方法 |
CZ2012136A3 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
CZ304512B6 (cs) | 2012-08-08 | 2014-06-11 | Contipro Biotech S.R.O. | Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití |
CZ304654B6 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
SG11201506366SA (en) * | 2013-02-13 | 2015-09-29 | Agency Science Tech & Res | A Polymeric System for Release of an Active Agent |
JP6552487B2 (ja) * | 2013-06-18 | 2019-07-31 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | 癌幹細胞を培養する方法 |
GB2518405A (en) * | 2013-09-20 | 2015-03-25 | Zeiss Carl Meditec Ag | Composition comprising at least one viscoelastic polymer |
CZ2014150A3 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
CN104004231A (zh) * | 2014-06-12 | 2014-08-27 | 东南大学 | 一种生物大分子互穿网络水凝胶及其制备方法 |
CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
AU2016353345B2 (en) | 2015-11-12 | 2021-12-23 | University Of Virginia Patent Foundation | Compositions and methods for vas-occlusive contraception and reversal thereof |
EP3454839A4 (de) | 2016-05-12 | 2020-02-12 | Insitu Biologics, Inc. | Hydrogelbasiertes vehikel zur freisetzung eines biologikums |
CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
JP6834545B2 (ja) * | 2017-02-01 | 2021-02-24 | Jsr株式会社 | 変性多糖およびその用途 |
JP6939607B2 (ja) * | 2017-03-27 | 2021-09-22 | Jsr株式会社 | 組成物およびその用途 |
CN107312193A (zh) * | 2017-06-27 | 2017-11-03 | 吉林大学 | 一种仿生的可注射黏附性水凝胶、制备方法及其在生物方面的应用 |
CN108478852A (zh) * | 2018-04-08 | 2018-09-04 | 湖北工程学院 | 一种药学制品、用于负载医药制品的载体、水凝胶及其方法 |
AU2019380413A1 (en) | 2018-11-13 | 2021-05-20 | Contraline, Inc. | Systems and methods for delivering biomaterials |
CZ2019360A3 (cs) * | 2019-06-10 | 2020-12-23 | Contipro A.S. | Sada pro přípravu hydrogelu na bázi hydroxyfenylového derivátu hyaluronanu, způsob přípravy hydrogelu a jeho použití |
WO2021035217A1 (en) * | 2019-08-22 | 2021-02-25 | Contraline, Inc. | Compositions and methods for sustained drug release from an injectable hydrogel |
US20240082459A1 (en) * | 2019-10-18 | 2024-03-14 | Trustees of Tuffs College | Chemical modification of silk fibroin for fabrication of enzymatically crosslinked hydrogels with tunable gelation kinetics and bioactivity |
CZ2020263A3 (cs) * | 2020-05-12 | 2021-10-27 | Contipro A.S. | Sada gelotvorných roztoků určená pro přípravu hydrogelu na bázi kovalentně zesítěného hydroxyfenylového derivátu hyaluronanu k prevenci pooperačních komplikací souvisejících s vytvořením kolorektální anastomózy a její použití |
CA3183275A1 (en) * | 2020-05-14 | 2021-11-18 | Contraline, Inc. | Biomaterial compositions and methods of delivery |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7465766B2 (en) * | 2004-01-08 | 2008-12-16 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
AU2006248166B2 (en) * | 2005-05-20 | 2012-11-01 | Agency For Science, Technology And Research | Aldehyde conjugated flavonoid preparations |
US20090186077A1 (en) * | 2006-02-15 | 2009-07-23 | Ying Jackie Y | Thermo-responsive materials |
WO2007097710A1 (en) * | 2006-02-27 | 2007-08-30 | Agency For Science, Technology And Research | Curable bone cement |
-
2008
- 2008-06-05 JP JP2011512418A patent/JP5563563B2/ja not_active Expired - Fee Related
- 2008-06-05 WO PCT/SG2008/000204 patent/WO2009148405A1/en active Application Filing
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2011522817A5 (de) | ||
Yin et al. | Superporous hydrogels containing poly (acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks | |
JP2004204058A (ja) | オレフィン系ブロック共重合体 | |
ATE234872T1 (de) | Lineare, isotaktische polymere, verfahren zu ihrer herstellung und ihre verwendung | |
JPH10120906A (ja) | 光学的に透明なシリコーンゴム | |
CN103201340B (zh) | 异丁烯系嵌段共聚物组合物 | |
Luo et al. | Novel amphoteric pH-sensitive hydrogels derived from ethylenediaminetetraacetic dianhydride, butanediamine and amino-terminated poly (ethylene glycol): Design, synthesis and swelling behavior | |
SE0001309D0 (sv) | Hydrogels and methods for their production | |
JP2008280528A (ja) | 液封入防振ゴム用ゴム組成物 | |
Chatterjee et al. | Thermal and mechanical properties of poly (N‐isopropylacrylamide)‐based hydrogels as a function of porosity and medium change | |
JP2018100395A (ja) | 芳香族ポリアミドフィルム | |
JP2000231228A5 (de) | ||
Hofer et al. | Glass-liquid transition and calorimetric relaxation of glassy aqueous solutions imbibed in poly (2-hydroxyethyl methacrylate); a comparison with bulk behavior | |
KR20160131149A (ko) | 디싸이클로펜타디엔 변성 페놀수지, 및 이를 포함하는 타이어 트레드용 고무 조성물 | |
JP6135971B2 (ja) | 架橋密度の試験方法 | |
US10513150B2 (en) | Diene rubber/polypropylene thermoplastic elastomer copolymer, compositions containing same, and preparation method | |
Vouyiouka et al. | Solid state post-polymerization of PA 6, 6: The effect of sodium 5-sulfoisophthalic acid | |
Ibarra et al. | A comparative study of the effect of some paraffinic oils on rheological and dynamic properties and behavior at low temperature in EPDM rubber compounds | |
CN112707826A (zh) | 一种交联剂及其制备方法与在制备粘缸剂中的应用 | |
US20130261264A1 (en) | Branched saturated hydrocarbon polymers as extensional rheology modifiers without impacting shear properties | |
Inoue et al. | Viscoelasticity and birefringence of low birefringent polyesters | |
Malone et al. | Validity of the swelling method for the determination of the interaction parameter | |
JP2014218554A (ja) | ゴム組成物ならびにそれを用いた靴底および靴 | |
KR20170038507A (ko) | 고분자 필름 | |
Krzyminski et al. | Reversible sol–gel transitions in aqueous solutions of N‐isopropylacrylamide ionic copolymers |