JP2011521915A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011521915A5 JP2011521915A5 JP2011510511A JP2011510511A JP2011521915A5 JP 2011521915 A5 JP2011521915 A5 JP 2011521915A5 JP 2011510511 A JP2011510511 A JP 2011510511A JP 2011510511 A JP2011510511 A JP 2011510511A JP 2011521915 A5 JP2011521915 A5 JP 2011521915A5
- Authority
- JP
- Japan
- Prior art keywords
- aspirin
- hours
- niacin
- release
- daily dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 130
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 130
- 239000000203 mixture Substances 0.000 claims description 75
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 59
- 229960003512 nicotinic acid Drugs 0.000 claims description 41
- 235000001968 nicotinic acid Nutrition 0.000 claims description 41
- 239000011664 nicotinic acid Substances 0.000 claims description 41
- 239000008194 pharmaceutical composition Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 3
- 230000003111 delayed effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims 11
- 238000009472 formulation Methods 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 7
- 238000011010 flushing procedure Methods 0.000 claims 6
- 238000013268 sustained release Methods 0.000 claims 5
- 239000012730 sustained-release form Substances 0.000 claims 5
- 239000003524 antilipemic agent Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000036470 plasma concentration Effects 0.000 claims 4
- 230000029142 excretion Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 2
- 239000003094 microcapsule Substances 0.000 claims 2
- 208000004611 Abdominal Obesity Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- 102100032752 C-reactive protein Human genes 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010065941 Central obesity Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010072268 Drug-induced liver injury Diseases 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 1
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 206010028851 Necrosis Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 208000018914 glucose metabolism disease Diseases 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000006132 lipodystrophy Diseases 0.000 claims 1
- 230000008604 lipoprotein metabolism Effects 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 238000012261 overproduction Methods 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 4
- 238000013270 controlled release Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000000541 pulsatile effect Effects 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- -1 multilayer coatings Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5479508P | 2008-05-20 | 2008-05-20 | |
| US61/054,795 | 2008-05-20 | ||
| US10233508P | 2008-10-02 | 2008-10-02 | |
| US61/102,335 | 2008-10-02 | ||
| PCT/US2009/003119 WO2009142731A2 (en) | 2008-05-20 | 2009-05-20 | Niacin and nsaid combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521915A JP2011521915A (ja) | 2011-07-28 |
| JP2011521915A5 true JP2011521915A5 (enExample) | 2012-07-05 |
Family
ID=41258481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510511A Pending JP2011521915A (ja) | 2008-05-20 | 2009-05-20 | ナイアシン及びｎｓａｉｄ併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100015220A1 (enExample) |
| EP (1) | EP2303327A2 (enExample) |
| JP (1) | JP2011521915A (enExample) |
| KR (1) | KR20110036540A (enExample) |
| CN (1) | CN102083466A (enExample) |
| AU (1) | AU2009249600A1 (enExample) |
| BR (1) | BRPI0912842A8 (enExample) |
| CA (1) | CA2724594A1 (enExample) |
| IL (1) | IL209436A0 (enExample) |
| MX (1) | MX2010012514A (enExample) |
| NZ (1) | NZ589469A (enExample) |
| RU (1) | RU2010151944A (enExample) |
| WO (1) | WO2009142731A2 (enExample) |
| ZA (1) | ZA201008278B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404275B2 (en) | 2007-07-01 | 2013-03-26 | Vitalis Llc | Combination tablet with chewable outer layer |
| US9074122B2 (en) * | 2008-12-31 | 2015-07-07 | Intevep, S.A. | Mitigation of H2S in steam injection technology using amines of natural origin |
| EA021588B1 (ru) | 2009-06-25 | 2015-07-30 | Тетра Сиа | Бетаиновые соли ацетилсалициловой кислоты |
| EP2585072A4 (en) * | 2010-06-24 | 2013-12-25 | Tufts College | MIMETICS OF NIACIN AND METHODS OF USE |
| WO2013063078A1 (en) | 2011-10-28 | 2013-05-02 | Vitalis Llc | Anti-flush compositions |
| JP6189333B2 (ja) * | 2012-02-07 | 2017-08-30 | バイオジェン エムエー インコーポレーテッド | フマル酸ジメチルを含有する医薬組成物 |
| CA2876540C (en) * | 2012-06-15 | 2022-11-29 | Conaris Research Institute Ag | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
| WO2015061442A1 (en) * | 2013-10-22 | 2015-04-30 | Cadila Healthcare Limited | Delayed release pharmaceutical compositions of salsalate |
| KR20150050406A (ko) * | 2013-10-29 | 2015-05-08 | 한림대학교 산학협력단 | 니코틴아마이드 라이보사이드를 유효성분으로 포함하는 패혈증 치료 또는 예방용 약제학적 조성물 |
| ES2915907T3 (es) | 2014-03-24 | 2022-06-27 | Univ Colorado Regents | Procedimientos para el tratamiento de la disfunción endotelial vascular utilizando mononucleótido de nicotinamida |
| SG11201702496XA (en) | 2014-11-14 | 2017-04-27 | Gemphire Therapeutics Inc | PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS |
| US9863094B2 (en) | 2015-02-11 | 2018-01-09 | Westrock Mwv, Llc | Printable compostable paperboard |
| JP2018536710A (ja) * | 2015-11-06 | 2018-12-13 | ジェンファイア・セラピューティクス・インコーポレイテッドＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 混合型脂質異常症の治療 |
| US20170165283A1 (en) * | 2015-12-11 | 2017-06-15 | Bontac Bio-Engineering (Shenzhen) Co., Ltd | Use of beta-nicotinamide mononucleotide in preparation of health-care products for preventing and treating arteriosclerosis and cardio-cerebrovascular diseases, and health-care product containing the same |
| US20170165282A1 (en) * | 2015-12-11 | 2017-06-15 | Bontac Bio-Engineering (Shenzhen) Co., Ltd. | Use of beta-nicotinamide mononucleotide in preparation of drugs for preventing and treating arteriosclerosis and cardio-cerebrovascular diseases, and drugs containing the same |
| JP2020516622A (ja) | 2017-04-18 | 2020-06-11 | ジェムフィアー セラピューティクス インコーポレイテッド | ゲムカベン、薬学的に許容されるその塩、その組成物、およびその使用方法 |
| CN110893179A (zh) * | 2019-12-13 | 2020-03-20 | 沈阳东星医药科技有限公司 | 一种阿司匹林缓释胶囊及其制备方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) * | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4410545A (en) * | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4328245A (en) * | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4409239A (en) * | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| KR890002631B1 (ko) * | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물 |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| US5612059A (en) * | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
| US4970081A (en) * | 1989-01-03 | 1990-11-13 | Sterling Drug Inc. | Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith |
| IT1229203B (it) * | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5120548A (en) * | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) * | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| TW333456B (en) * | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| US5591767A (en) * | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| FR2704146B1 (fr) * | 1993-04-19 | 1995-07-13 | Cripdom | Microcapsules d'acide acétylsalicylique à libération contrôlée. |
| US6087324A (en) * | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| IT1270594B (it) * | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| FR2725623A1 (fr) * | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
| EP0821587A4 (en) * | 1995-04-19 | 1999-05-19 | Lipoprotein Technologies Inc | COMPOSITIONS, KITS AND METHODS FOR ADMINISTERING ANTILIPEMICS AND MEDICINES AGAINST PLATELET AGGREGATION |
| WO1997001331A2 (en) * | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
| US5855915A (en) * | 1995-06-30 | 1999-01-05 | Baylor University | Tablets or biologically acceptable implants for long-term antiinflammatory drug release |
| TW448055B (en) * | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
| JP2909418B2 (ja) * | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
| US5980945A (en) * | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| US6264970B1 (en) * | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US6419961B1 (en) * | 1996-08-29 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
| CA2217134A1 (en) * | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
| ES2221019T3 (es) * | 1996-10-31 | 2004-12-16 | Takeda Chemical Industries, Ltd. | Preparacion de liberacion mantenida. |
| DE69719367T2 (de) * | 1996-12-20 | 2003-10-16 | Takeda Chemical Industries, Ltd. | Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| EP1792616B1 (en) * | 1997-07-31 | 2009-12-16 | Abbott Respiratory LLC | Composition comprising an HMG-CoA inhibitor and a nicotinic acid compound for treating hyperlipidemia |
| US6469035B1 (en) * | 1997-07-31 | 2002-10-22 | Eugenio A. Cefali | Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid |
| US6350458B1 (en) * | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| US6613358B2 (en) * | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
| KR19990085365A (ko) * | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| AR041089A1 (es) * | 2003-05-15 | 2005-05-04 | Merck & Co Inc | Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas |
| US20080058292A1 (en) * | 2003-10-29 | 2008-03-06 | Raif Tawakol | Method for increasing HDL and HDL-2b levels |
| WO2005041878A2 (en) * | 2003-10-29 | 2005-05-12 | Tawakol Raif M D | Compositions and methods for increasing hdl and hdl-2b levels |
| US7019022B2 (en) * | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
| FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
| CA2569776A1 (en) * | 2006-02-17 | 2007-08-17 | Kos Life Sciences, Inc. | Low flush niacin formulation |
-
2009
- 2009-05-20 JP JP2011510511A patent/JP2011521915A/ja active Pending
- 2009-05-20 BR BRPI0912842A patent/BRPI0912842A8/pt not_active IP Right Cessation
- 2009-05-20 NZ NZ589469A patent/NZ589469A/xx not_active IP Right Cessation
- 2009-05-20 RU RU2010151944/15A patent/RU2010151944A/ru not_active Application Discontinuation
- 2009-05-20 EP EP09750962A patent/EP2303327A2/en not_active Withdrawn
- 2009-05-20 CN CN200980124201XA patent/CN102083466A/zh active Pending
- 2009-05-20 KR KR1020107028450A patent/KR20110036540A/ko not_active Withdrawn
- 2009-05-20 AU AU2009249600A patent/AU2009249600A1/en not_active Abandoned
- 2009-05-20 US US12/469,653 patent/US20100015220A1/en not_active Abandoned
- 2009-05-20 CA CA2724594A patent/CA2724594A1/en not_active Abandoned
- 2009-05-20 MX MX2010012514A patent/MX2010012514A/es not_active Application Discontinuation
- 2009-05-20 WO PCT/US2009/003119 patent/WO2009142731A2/en not_active Ceased
-
2010
- 2010-11-18 ZA ZA2010/08278A patent/ZA201008278B/en unknown
- 2010-11-18 IL IL209436A patent/IL209436A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011521915A5 (enExample) | ||
| CN101505737B (zh) | 包含二氢吡啶类钙通道阻断剂和HMG-CoA还原酶抑制剂的控释组合药物制剂 | |
| US10610488B2 (en) | Sustained-release formulations of colchicine and methods of using same | |
| JP5377317B2 (ja) | 放出性が制御されたアンジオテンシン−ＩＩ−受容体遮断剤とＨＭＧ−ＣｏＡ還元酵素阻害剤の複合組成物 | |
| RU2570752C2 (ru) | Способы лечения сердечно-сосудистых нарушений | |
| RU2010151944A (ru) | Ниацин и нспвс для комбинированной терапии | |
| US20110117194A1 (en) | Pharmaceutical formulation containing angiotensin-ii receptor blocker | |
| EP2517697B1 (en) | Combination composition useful for treating cardiovascular diseases | |
| KR20090114328A (ko) | 약제학적 제제 | |
| WO2009127974A2 (ko) | 심혈관계 질환 치료용 약제학적 제제 | |
| JP6068765B2 (ja) | 薬学的複合製剤 | |
| US10363235B2 (en) | Compositions comprising 15-HEPE and methods of treating or preventing fibrosis using same | |
| WO2008069546A1 (en) | Oral administrative preparation for treating cardiovascular system disease | |
| KR20140101391A (ko) | 심혈관 질환의 치료 방법 | |
| EP2241310A2 (en) | Modified release formulations of emoxypine | |
| JP2020100627A (ja) | １５−ｈｅｐｅを含む組成物及びそれを使用する方法 | |
| WO2003005967A2 (en) | Dual release levodopa ethyl ester and decarboxylase in controlled release core | |
| WO2018195163A1 (en) | Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor | |
| CN101642444B (zh) | 单硝酸异山梨酯双速渗透泵型控释制剂及其制备方法 | |
| CN102149376B (zh) | 症状性心力衰竭的长期治疗 | |
| KR100646576B1 (ko) | 고지혈증 환자의 동맥경화증 예방을 위한 에이치엠지이-씨오에이 환원효소 저해제 및 장용코팅된 아스피린을 함유하는 복합 펠렛 | |
| EP4297733A1 (en) | Fixed-dose pharmaceutical compositions | |
| KR20110129405A (ko) | 약제학적 제제 | |
| US20130158084A1 (en) | Pharmaceutical Composition Comprising Losartin For Treating or Preventing Statin BasedGrug-Induced Muscle Toxicity | |
| KR20190001340A (ko) | 이바브라딘을 포함하는 서방성 약제학적 조성물 및 이의 제조방법 |