JP2011520847A - 遅効型ｙ２及び／又はｙ４レセプターアゴニスト - Google Patents

遅効型ｙ２及び／又はｙ４レセプターアゴニスト Download PDF

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Publication number
JP2011520847A
JP2011520847A JP2011508945A JP2011508945A JP2011520847A JP 2011520847 A JP2011520847 A JP 2011520847A JP 2011508945 A JP2011508945 A JP 2011508945A JP 2011508945 A JP2011508945 A JP 2011508945A JP 2011520847 A JP2011520847 A JP 2011520847A
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Japan
Prior art keywords
ethoxy
xaa
seq
acetyl
acid
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JP2011508945A
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Japanese (ja)
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JP2011520847A5 (cg-RX-API-DMAC7.html
Inventor
ソーレン オステルガール，
サンネ モラー クヌドセン，
ジェーン スペツラー，
ラスムス ヨルゲンセン，
ヤコブ コフォエド，
Original Assignee
ノボ・ノルデイスク・エー／エス
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Publication of JP2011520847A publication Critical patent/JP2011520847A/ja
Publication of JP2011520847A5 publication Critical patent/JP2011520847A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011508945A 2008-05-16 2009-05-18 遅効型ｙ２及び／又はｙ４レセプターアゴニスト Withdrawn JP2011520847A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08156360.3 2008-05-16
EP08156360 2008-05-16
EP09154461.9 2009-03-05
EP09154461 2009-03-05
PCT/EP2009/055989 WO2009138511A1 (en) 2008-05-16 2009-05-18 Long-acting y2 and/or y4 receptor agonists

Publications (2)

Publication Number Publication Date
JP2011520847A true JP2011520847A (ja) 2011-07-21
JP2011520847A5 JP2011520847A5 (cg-RX-API-DMAC7.html) 2012-07-05

Family

ID=40934036

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011508945A Withdrawn JP2011520847A (ja) 2008-05-16 2009-05-18 遅効型ｙ２及び／又はｙ４レセプターアゴニスト

Country Status (12)

Country Link
US (1) US20110275559A1 (cg-RX-API-DMAC7.html)
EP (1) EP2279204A1 (cg-RX-API-DMAC7.html)
JP (1) JP2011520847A (cg-RX-API-DMAC7.html)
KR (1) KR20110017874A (cg-RX-API-DMAC7.html)
CN (1) CN102027007A (cg-RX-API-DMAC7.html)
AU (1) AU2009248041B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0912615A2 (cg-RX-API-DMAC7.html)
CA (1) CA2723855A1 (cg-RX-API-DMAC7.html)
IL (1) IL208836A0 (cg-RX-API-DMAC7.html)
MX (1) MX2010011845A (cg-RX-API-DMAC7.html)
RU (1) RU2504550C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009138511A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022506070A (ja) * 2018-11-01 2022-01-17 イーライ リリー アンド カンパニー タンパク質チロシン－チロシン類縁体およびそれを使用する方法
JP2023522081A (ja) * 2020-04-17 2023-05-26 アイツーオー・セラピューティクス・インコーポレイテッド 長時間作用型ペプチドチロシンチロシン（ｐｙｙ）類似体及び使用方法

Families Citing this family (20)

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JP5767582B2 (ja) 2009-07-02 2015-08-19 武田薬品工業株式会社 ペプチド及びその用途
US20130040877A1 (en) * 2009-09-18 2013-02-14 Novo Nordisk A/S Long-acting y2 receptor agonists
CN102905722A (zh) * 2009-11-13 2013-01-30 诺沃—诺迪斯克有限公司 长效y2受体激动剂
GB201001333D0 (en) * 2010-01-27 2010-03-17 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
WO2012006566A2 (en) 2010-07-09 2012-01-12 Amylin Pharmaceuticals, Inc. Microcrystalline y receptor agonists
HUE036066T2 (hu) 2010-12-16 2018-06-28 Novo Nordisk As GLP-1 agonistát és N-(8-(2-hidroxibenzoil)amino)kaprilsav sóját tartalmazó szilárd készítmények
HRP20181447T1 (hr) 2012-03-22 2018-11-02 Novo Nordisk A/S Pripravci glp-1 peptida i njihova priprava
MY172578A (en) 2013-05-02 2019-12-03 Novo Nordisk As Oral dosing of glp-1 compounds
EP2842965A1 (en) 2013-09-03 2015-03-04 Gubra ApS Neuromedin U analogs comprising serum albumin binding amino acid residue
WO2015073878A1 (en) * 2013-11-15 2015-05-21 Ur Diet, Llc Real-time satiety biofeedback
PT3068421T (pt) * 2013-11-15 2019-07-11 Novo Nordisk As Compostos de pyy eletivo e usos dos mesmos
EP3068795B1 (en) 2013-11-15 2019-03-06 Novo Nordisk A/S Hpyy(1-36) having a beta-homoarginine substitution at position 35
RS59026B1 (sr) 2013-11-15 2019-08-30 Novo Nordisk As Selektivna pyy jedinjenja i njihova upotreba
US20240100450A9 (en) * 2014-01-17 2024-03-28 Repligen Corporation Sterilizing chromatography columns
KR102393642B1 (ko) 2014-01-17 2022-05-03 리플리겐 코포레이션 크로마토그래피 컬럼 살균
EP3145523A4 (en) * 2014-05-21 2018-02-21 President and Fellows of Harvard College Ras inhibitory peptides and uses thereof
CA2988500A1 (en) * 2015-06-12 2016-12-15 Novo Nordisk A/S Selective pyy compounds and uses thereof
RS64643B1 (sr) 2018-02-02 2023-10-31 Novo Nordisk As Čvrste kompozicije koje sadrže glp-1 agonist i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline i lubrikant
GB201908426D0 (en) * 2019-06-12 2019-07-24 Imp College Innovations Ltd Appetite suppressing compounds
EP4329812A1 (en) 2021-04-27 2024-03-06 Aardvark Therapeutics Inc. Combination of bitter receptor agonist and gut-signaling compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505840A (ja) * 2003-09-19 2007-03-15 ノボ　ノルディスク　アクティーゼルスカブ 新規ｇｌｐ−１誘導体
JP2007529463A (ja) * 2004-03-17 2007-10-25 ７ティーエム ファーマ エイ／エス 治療的介入のためのｙ４選択性レセプターアゴニスト
JP2007531711A (ja) * 2004-02-11 2007-11-08 アミリン・ファーマシューティカルズ，インコーポレイテッド 膵臓ポリペプチドファミリーモチーフおよびそのモチーフを含むポリペプチド
JP2008507477A (ja) * 2004-07-08 2008-03-13 ノボ　ノルディスク　アクティーゼルスカブ ポリペプチド延長タグ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2275207C2 (ru) * 2000-12-14 2006-04-27 Амилин Фармасьютикалз, Инк. Способ снижения доступности питательного вещества, способ подавления аппетита
CN101222942A (zh) * 2005-07-18 2008-07-16 诺沃-诺迪斯克有限公司 用于治疗肥胖的肽

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505840A (ja) * 2003-09-19 2007-03-15 ノボ　ノルディスク　アクティーゼルスカブ 新規ｇｌｐ−１誘導体
JP2007531711A (ja) * 2004-02-11 2007-11-08 アミリン・ファーマシューティカルズ，インコーポレイテッド 膵臓ポリペプチドファミリーモチーフおよびそのモチーフを含むポリペプチド
JP2007529463A (ja) * 2004-03-17 2007-10-25 ７ティーエム ファーマ エイ／エス 治療的介入のためのｙ４選択性レセプターアゴニスト
JP2008507477A (ja) * 2004-07-08 2008-03-13 ノボ　ノルディスク　アクティーゼルスカブ ポリペプチド延長タグ

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022506070A (ja) * 2018-11-01 2022-01-17 イーライ リリー アンド カンパニー タンパク質チロシン－チロシン類縁体およびそれを使用する方法
JP7280949B2 (ja) 2018-11-01 2023-05-24 イーライ リリー アンド カンパニー タンパク質チロシン－チロシン類縁体およびそれを使用する方法
JP2023082013A (ja) * 2018-11-01 2023-06-13 イーライ リリー アンド カンパニー タンパク質チロシン－チロシン類縁体およびそれを使用する方法
JP2023522081A (ja) * 2020-04-17 2023-05-26 アイツーオー・セラピューティクス・インコーポレイテッド 長時間作用型ペプチドチロシンチロシン（ｐｙｙ）類似体及び使用方法

Also Published As

Publication number Publication date
WO2009138511A1 (en) 2009-11-19
CN102027007A (zh) 2011-04-20
EP2279204A1 (en) 2011-02-02
RU2010149474A (ru) 2012-06-27
AU2009248041A1 (en) 2009-11-19
MX2010011845A (es) 2010-11-22
BRPI0912615A2 (pt) 2016-01-26
KR20110017874A (ko) 2011-02-22
CA2723855A1 (en) 2009-11-19
RU2504550C2 (ru) 2014-01-20
AU2009248041B2 (en) 2013-10-03
US20110275559A1 (en) 2011-11-10
IL208836A0 (en) 2011-01-31

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