JP2011518922A5 - - Google Patents

Info

Publication number

JP2011518922A5

JP2011518922A5 JP2011506463A JP2011506463A JP2011518922A5 JP 2011518922 A5 JP2011518922 A5 JP 2011518922A5 JP 2011506463 A JP2011506463 A JP 2011506463A JP 2011506463 A JP2011506463 A JP 2011506463A JP 2011518922 A5 JP2011518922 A5 JP 2011518922A5

Authority

JP

Japan

Prior art keywords

polysaccharide

chitosan

carboxymethylcellulose

mixture

particles

Prior art date

2009-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000004676 glycans Chemical class 0.000 claims 36
• 229920001282 polysaccharide Polymers 0.000 claims 36
• 239000005017 polysaccharide Substances 0.000 claims 36
• 238000000034 method Methods 0.000 claims 24
• 239000000203 mixture Substances 0.000 claims 22
• 229920001661 Chitosan Polymers 0.000 claims 20
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 15
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 15
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 15
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 15
• 239000002245 particle Substances 0.000 claims 11
• 239000000017 hydrogel Substances 0.000 claims 6
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 5
• OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims 5
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 5
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 5
• 229920001817 Agar Polymers 0.000 claims 5
• 229920002101 Chitin Polymers 0.000 claims 5
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 5
• 229920002307 Dextran Polymers 0.000 claims 5
• 229920000926 Galactomannan Polymers 0.000 claims 5
• 229920002527 Glycogen Polymers 0.000 claims 5
• 229920002472 Starch Polymers 0.000 claims 5
• 239000008272 agar Substances 0.000 claims 5
• 229940023476 agar Drugs 0.000 claims 5
• 235000010419 agar Nutrition 0.000 claims 5
• 229940072056 alginate Drugs 0.000 claims 5
• 235000010443 alginic acid Nutrition 0.000 claims 5
• 229920000615 alginic acid Polymers 0.000 claims 5
• 239000000679 carrageenan Substances 0.000 claims 5
• 229920001525 carrageenan Polymers 0.000 claims 5
• 235000010418 carrageenan Nutrition 0.000 claims 5
• 229940113118 carrageenan Drugs 0.000 claims 5
• 229920002678 cellulose Polymers 0.000 claims 5
• 239000001913 cellulose Substances 0.000 claims 5
• 229940045110 chitosan Drugs 0.000 claims 5
• 229940059329 chondroitin sulfate Drugs 0.000 claims 5
• 229940096919 glycogen Drugs 0.000 claims 5
• 229920002674 hyaluronan Polymers 0.000 claims 5
• 229960003160 hyaluronic acid Drugs 0.000 claims 5
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 239000008107 starch Substances 0.000 claims 5
• 229940032147 starch Drugs 0.000 claims 5
• 235000019698 starch Nutrition 0.000 claims 5
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 5
• 239000000853 adhesive Substances 0.000 claims 4
• 230000001070 adhesive effect Effects 0.000 claims 4
• 238000004132 cross linking Methods 0.000 claims 3
• 239000002270 dispersing agent Substances 0.000 claims 3
• 238000005507 spraying Methods 0.000 claims 3
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
• 239000003125 aqueous solvent Substances 0.000 claims 2
• 239000000499 gel Substances 0.000 claims 2
• 238000004806 packaging method and process Methods 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 230000002378 acidificating effect Effects 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 239000003431 cross linking reagent Substances 0.000 claims 1
• 239000006185 dispersion Substances 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 238000004108 freeze drying Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000004400 mucous membrane Anatomy 0.000 claims 1