BR0007296A - Novas formulações poliméricas contendo compostos perfluorados para a engenharia de células e tecidos para transplantes que melhoram o metabolismo e a sobrevivência celular, e métodos para a sua produção - Google Patents

Novas formulações poliméricas contendo compostos perfluorados para a engenharia de células e tecidos para transplantes que melhoram o metabolismo e a sobrevivência celular, e métodos para a sua produção

Info

Publication number
BR0007296A
BR0007296A BR0007296-6A BR0007296A BR0007296A BR 0007296 A BR0007296 A BR 0007296A BR 0007296 A BR0007296 A BR 0007296A BR 0007296 A BR0007296 A BR 0007296A
Authority
BR
Brazil
Prior art keywords
alginate
glycosaminoglycan
cross
methods
polymerized
Prior art date
Application number
BR0007296-6A
Other languages
English (en)
Inventor
Christopher Fraker
Luca Inverardi
Marcos Mares-Guia
Camillo Ricordi
Original Assignee
Biomm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomm Inc filed Critical Biomm Inc
Publication of BR0007296A publication Critical patent/BR0007296A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/02—Halogenated hydrocarbons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"NOVAS FORMULAçõES POLIMéRICAS CONTENDO COMPOSTOS PERFLUORADOS PARA A ENGENHARIA DE CéLULAS E TECIDOS PARA TRANSPLANTES QUE MELHORAM O METABOLISMO E A SOBREVIVêNCIA CELULAR, E MéTODOS PARA A SUA PRODUçãO". São revelados e reivindicados: uma composição incluindo pelo menos um glicosaminoglican, por ex., CIS, pelo menos uma substância perfluorada e pelo menos um alginato, por ex., alginato de sódio, onde: o pelo menos um glicosaminoglican e/ou a substância perfluorada e/ou o alginato são reticulados ou polimerizados, por ex., o alginato é reticulado ou polimerizado, por exemplo, pela adição de um sal inorgânico, tal como um sal de cálcio; ou o pelo menos um glicosaminoglican, a substância perfluorada e o alginato estão covalentemente ligados, por ex., por meio de uma reação de acoplamento envolvendo uma molécula ligante tal como DVS; ou o pelo menos um glicosaminoglican e/ou a substância perfluorada e/ou o alginato são reticulados ou polimerizados, por ex., o alginato é reticulado ou polimerizado, por ex., por meio da adição de um sal inorgânico, tal como um sal de cálcio, e o pelo menos um glicosaminoglican e o alginato são covalentemente ligados, por ex., por meio de uma reação de acoplamento envolvendo uma molécula ligante tal como DVS, e a ligação covalente pode ser realizada antes da reticulação ou polimerização ou vice-versa; e, géis contendo a composição; misturas de tais géis ou de pelo menos um tal gel e pelo menos uma tal composição; e, métodos para a produção e utilização de tais composições e géis, incluindo produtos deles derivados tais como "pinturas", borrifadores, matrizes, pérolas, microcápsulas.
BR0007296-6A 1999-01-04 2000-01-04 Novas formulações poliméricas contendo compostos perfluorados para a engenharia de células e tecidos para transplantes que melhoram o metabolismo e a sobrevivência celular, e métodos para a sua produção BR0007296A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11470899P 1999-01-04 1999-01-04
PCT/US2000/000106 WO2000040252A1 (en) 1999-01-04 2000-01-04 Novel polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same

Publications (1)

Publication Number Publication Date
BR0007296A true BR0007296A (pt) 2002-02-05

Family

ID=22356944

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007296-6A BR0007296A (pt) 1999-01-04 2000-01-04 Novas formulações poliméricas contendo compostos perfluorados para a engenharia de células e tecidos para transplantes que melhoram o metabolismo e a sobrevivência celular, e métodos para a sua produção

Country Status (6)

Country Link
US (1) US6630154B1 (pt)
EP (1) EP1146884B1 (pt)
AT (1) ATE321562T1 (pt)
BR (1) BR0007296A (pt)
DE (1) DE60026974T2 (pt)
WO (1) WO2000040252A1 (pt)

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US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
AU2003224917A1 (en) 2002-04-11 2003-10-27 Carbomer Diabetes imaging probes
WO2003086474A2 (en) 2002-04-11 2003-10-23 Carbomer, Inc Fluorinated or paramagnetic alginate polymer, annexin paramagnetic conjugate, and their use as contrasting agent in mri
NZ597965A (en) * 2003-10-08 2013-09-27 Vet Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
US7109280B2 (en) * 2003-10-29 2006-09-19 Council Of Scientific And Industrial Research Block copolymers and preparation thereof
DK1759536T3 (da) 2004-06-01 2011-09-05 Kwalata Trading Ltd In vitro-teknikker til anvendelse med stamceller
EP2532356A1 (en) 2004-07-14 2012-12-12 Glusense Ltd. Implantable power sources and sensors
US7910359B2 (en) * 2004-07-29 2011-03-22 University Of Miami Hybrid device for cell therapies
US20060204482A1 (en) * 2005-03-14 2006-09-14 Deolden James Methods of islet isolation and transplantation
TW200734462A (en) * 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
WO2008063465A2 (en) * 2006-11-13 2008-05-29 Massachusetts Institute Of Technology Encapsulated pancreatic islet cell products and methods of use thereof
WO2008062417A2 (en) * 2006-11-22 2008-05-29 Beta O2 Technologies Ltd. Protecting algae from body fluids
ES2659988T3 (es) * 2006-11-28 2018-03-20 Beta O2 Technologies Ltd. Suministro de oxígeno para el transplante celular y la vascularización
CA2677082A1 (en) * 2007-02-02 2008-08-14 University Of Miami Therapeutic hybrid implantable devices
US20090017092A1 (en) * 2007-07-12 2009-01-15 Aroop Kumar Dutta Novel Class of Cell-Interactive Material and Process of Preparation of Artificial Tissues of Human and Animal Origin
WO2009031154A2 (en) 2007-09-07 2009-03-12 Beta O2 Technologies Ltd. Air gap for supporting cells
AU2009240512B2 (en) 2008-04-24 2014-07-10 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
AU2009240514B2 (en) * 2008-04-24 2014-12-18 Medtronic, Inc. Cold ionizing radiation sterilization
US9198997B2 (en) 2008-04-24 2015-12-01 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
US20100159567A1 (en) * 2008-11-07 2010-06-24 Kuehnle Adelheid R Preservation and composition of bioprocess algae for production of lipids, seedstock, and feed
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
US20100160749A1 (en) * 2008-12-24 2010-06-24 Glusense Ltd. Implantable optical glucose sensing
US9037205B2 (en) 2011-06-30 2015-05-19 Glusense, Ltd Implantable optical glucose sensing
KR101401798B1 (ko) 2011-09-21 2014-05-29 가톨릭대학교 산학협력단 퍼플루오데칼린 교질 입자를 함유하는 알긴산 미세 캡슐 조성물 및 이의 제조 방법
WO2013188626A2 (en) 2012-06-15 2013-12-19 Dow Global Technologies Llc Probiotic-containing particles having improved probiotic stability when in aqueous formulations
US10575765B2 (en) 2014-10-13 2020-03-03 Glusense Ltd. Analyte-sensing device
US10871487B2 (en) 2016-04-20 2020-12-22 Glusense Ltd. FRET-based glucose-detection molecules
CN107496953A (zh) * 2017-07-31 2017-12-22 滨州医学院 一种硫酸软骨素的灭菌方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021116A1 (en) * 1993-03-16 1994-09-29 Alliance Pharmaceutical Corp. Preservation solution and method for warm organ preservation
US6281341B1 (en) * 1997-04-30 2001-08-28 Biomm, Inc. & University Of Miami Hetero-polysaccharide conjugate and methods of making and using the same

Also Published As

Publication number Publication date
WO2000040252A1 (en) 2000-07-13
EP1146884B1 (en) 2006-03-29
US6630154B1 (en) 2003-10-07
EP1146884A4 (en) 2003-05-28
DE60026974D1 (de) 2006-05-18
ATE321562T1 (de) 2006-04-15
DE60026974T2 (de) 2007-04-19
EP1146884A1 (en) 2001-10-24

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.