JP2011518774A5 - - Google Patents
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- JP2011518774A5 JP2011518774A5 JP2011500989A JP2011500989A JP2011518774A5 JP 2011518774 A5 JP2011518774 A5 JP 2011518774A5 JP 2011500989 A JP2011500989 A JP 2011500989A JP 2011500989 A JP2011500989 A JP 2011500989A JP 2011518774 A5 JP2011518774 A5 JP 2011518774A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- oxo
- ethyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 89
- 150000003839 salts Chemical class 0.000 claims 58
- -1 cyano, nitro, amino Chemical group 0.000 claims 9
- 150000001408 amides Chemical class 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- CFLQPPVBAQNLTQ-UHFFFAOYSA-N 1-pyridin-3-yltriazole-4-carboxylic acid Chemical compound N1=NC(C(=O)O)=CN1C1=CC=CN=C1 CFLQPPVBAQNLTQ-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010087894 Fatty acid desaturases Proteins 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 102000016553 Stearoyl-CoA Desaturase Human genes 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- FDNYHBASQZFVBL-UHFFFAOYSA-N 3-(4-fluorophenyl)-1h-pyrazole-5-carboxylic acid Chemical compound N1C(C(=O)O)=CC(C=2C=CC(F)=CC=2)=N1 FDNYHBASQZFVBL-UHFFFAOYSA-N 0.000 claims 2
- 229940123980 Desaturase inhibitor Drugs 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- VPJQNNTZMCTRKE-UHFFFAOYSA-N 1-(3,5-difluorophenyl)triazole-4-carboxylic acid Chemical compound N1=NC(C(=O)O)=CN1C1=CC(F)=CC(F)=C1 VPJQNNTZMCTRKE-UHFFFAOYSA-N 0.000 claims 1
- SLGDDWABRNAGHM-UHFFFAOYSA-N 1-(3-methylphenyl)triazole-4-carboxylic acid Chemical compound CC1=CC=CC(N2N=NC(=C2)C(O)=O)=C1 SLGDDWABRNAGHM-UHFFFAOYSA-N 0.000 claims 1
- FUQVEOXNFSKAFB-UHFFFAOYSA-N 2-[1-[2-[(3-phenyl-1h-pyrazole-5-carbonyl)amino]acetyl]piperidin-4-yl]oxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1OC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 FUQVEOXNFSKAFB-UHFFFAOYSA-N 0.000 claims 1
- BBFVYPZHDREFSP-UHFFFAOYSA-N 3-[2-(trifluoromethyl)phenyl]-1h-pyrazole-5-carboxylic acid Chemical compound N1C(C(=O)O)=CC(C=2C(=CC=CC=2)C(F)(F)F)=N1 BBFVYPZHDREFSP-UHFFFAOYSA-N 0.000 claims 1
- GFQYKYPGSBTSII-HHHXNRCGSA-N 4-[[(2r)-2-methyl-6-nitro-3h-imidazo[2,1-b][1,3]oxazol-2-yl]methoxy]-n-[2-oxo-2-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]ethyl]benzamide Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1C(=O)NCC(=O)N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 GFQYKYPGSBTSII-HHHXNRCGSA-N 0.000 claims 1
- VZTKTOKASVGDFZ-UHFFFAOYSA-N 4-amino-n-[2-[4-[[4-amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino]piperidin-1-yl]-2-oxoethyl]benzamide Chemical compound S1C(C(=O)C=2C(=CC=CC=2F)F)=C(N)N=C1NC(CC1)CCN1C(=O)CNC(=O)C1=CC=C(N)C=C1 VZTKTOKASVGDFZ-UHFFFAOYSA-N 0.000 claims 1
- KQJNEJZQJRLPPB-UHFFFAOYSA-N 4-anilino-n-[2-[4-(2-chloroanilino)piperidin-1-yl]-2-oxoethyl]benzamide Chemical compound ClC1=CC=CC=C1NC1CCN(C(=O)CNC(=O)C=2C=CC(NC=3C=CC=CC=3)=CC=2)CC1 KQJNEJZQJRLPPB-UHFFFAOYSA-N 0.000 claims 1
- BPKQAZUPMXCHJJ-UHFFFAOYSA-N 5-(3-hydroxyphenyl)-n-[2-oxo-2-[4-[3-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl]-1,2-oxazole-3-carboxamide Chemical compound OC1=CC=CC(C=2ON=C(C=2)C(=O)NCC(=O)N2CCC(CC2)OC=2C=C(C=CC=2)C(F)(F)F)=C1 BPKQAZUPMXCHJJ-UHFFFAOYSA-N 0.000 claims 1
- AMBDRXRCOGOEHY-UHFFFAOYSA-N 6-anilino-n-[2-[4-(2-chloroanilino)piperidin-1-yl]-2-oxoethyl]pyridine-3-carboxamide Chemical compound ClC1=CC=CC=C1NC1CCN(C(=O)CNC(=O)C=2C=NC(NC=3C=CC=CC=3)=CC=2)CC1 AMBDRXRCOGOEHY-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- RWKMMQRQJJXJNX-UHFFFAOYSA-N N-[2-[4-(2-chloroanilino)piperidin-1-yl]-2-oxoethyl]-5-(2-hydroxyphenyl)-1,2-oxazole-3-carboxamide Chemical compound OC1=CC=CC=C1C1=CC(C(=O)NCC(=O)N2CCC(CC2)NC=2C(=CC=CC=2)Cl)=NO1 RWKMMQRQJJXJNX-UHFFFAOYSA-N 0.000 claims 1
- BVXVSCNTHVGDRU-UHFFFAOYSA-N N-[2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]-5-(2-hydroxyphenyl)-1,2-oxazole-3-carboxamide Chemical compound OC1=CC=CC=C1C1=CC(C(=O)NCC(=O)N2CCC(CC2)OC=2C(=CC=CC=2)Cl)=NO1 BVXVSCNTHVGDRU-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- BZDPLIAACVTKNV-UHFFFAOYSA-N n-[2-[3-[3-fluoro-5-(trifluoromethyl)phenoxy]azetidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound FC(F)(F)C1=CC(F)=CC(OC2CN(C2)C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)=C1 BZDPLIAACVTKNV-UHFFFAOYSA-N 0.000 claims 1
- YBZAZJVFYNOKDB-UHFFFAOYSA-N n-[2-[4-(2,5-difluorophenoxy)piperidin-1-yl]-2-oxoethyl]-1-phenylimidazole-4-carboxamide Chemical compound FC1=CC=C(F)C(OC2CCN(CC2)C(=O)CNC(=O)C=2N=CN(C=2)C=2C=CC=CC=2)=C1 YBZAZJVFYNOKDB-UHFFFAOYSA-N 0.000 claims 1
- DBGFNCYANRRSIL-UHFFFAOYSA-N n-[2-[4-(2,5-dimethylanilino)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound CC1=CC=C(C)C(NC2CCN(CC2)C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)=C1 DBGFNCYANRRSIL-UHFFFAOYSA-N 0.000 claims 1
- OGWBHUYCALEIPO-UHFFFAOYSA-N n-[2-[4-(2-acetylphenoxy)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound CC(=O)C1=CC=CC=C1OC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 OGWBHUYCALEIPO-UHFFFAOYSA-N 0.000 claims 1
- IMNSGCAUWONPEE-UHFFFAOYSA-N n-[2-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-2-oxoethyl]-2-phenyl-4h-thieno[3,2-b]pyrrole-5-carboxamide Chemical compound FC1=CC=C(Cl)C(OC2CCN(CC2)C(=O)CNC(=O)C=2NC=3C=C(SC=3C=2)C=2C=CC=CC=2)=C1 IMNSGCAUWONPEE-UHFFFAOYSA-N 0.000 claims 1
- WFAALKOUHKWGCA-UHFFFAOYSA-N n-[2-[4-(2-chloroanilino)piperidin-1-yl]-2-oxoethyl]-3-(3-hydroxyphenyl)-1h-pyrazole-5-carboxamide Chemical compound OC1=CC=CC(C=2NN=C(C=2)C(=O)NCC(=O)N2CCC(CC2)NC=2C(=CC=CC=2)Cl)=C1 WFAALKOUHKWGCA-UHFFFAOYSA-N 0.000 claims 1
- YXWTVUAGHOZUIC-UHFFFAOYSA-N n-[2-[4-(2-chloroanilino)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound ClC1=CC=CC=C1NC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 YXWTVUAGHOZUIC-UHFFFAOYSA-N 0.000 claims 1
- BWFZXKALYDFNKM-UHFFFAOYSA-N n-[2-[4-(2-chloroanilino)piperidin-1-yl]-2-oxoethyl]-5-phenyl-1,2-oxazole-3-carboxamide Chemical compound ClC1=CC=CC=C1NC1CCN(C(=O)CNC(=O)C2=NOC(=C2)C=2C=CC=CC=2)CC1 BWFZXKALYDFNKM-UHFFFAOYSA-N 0.000 claims 1
- GNSCZTQFUZQSLY-UHFFFAOYSA-N n-[2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]-1-phenylpyrazole-4-carboxamide Chemical compound ClC1=CC=CC=C1OC1CCN(C(=O)CNC(=O)C2=CN(N=C2)C=2C=CC=CC=2)CC1 GNSCZTQFUZQSLY-UHFFFAOYSA-N 0.000 claims 1
- RJUZKNPHBBGMEE-UHFFFAOYSA-N n-[2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]-3-(2-fluorophenyl)-1h-pyrazole-5-carboxamide Chemical compound FC1=CC=CC=C1C1=CC(C(=O)NCC(=O)N2CCC(CC2)OC=2C(=CC=CC=2)Cl)=NN1 RJUZKNPHBBGMEE-UHFFFAOYSA-N 0.000 claims 1
- LVVXQQDLOJHCDK-UHFFFAOYSA-N n-[2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]-4-phenylpyrazole-1-carboxamide Chemical compound ClC1=CC=CC=C1OC1CCN(C(=O)CNC(=O)N2N=CC(=C2)C=2C=CC=CC=2)CC1 LVVXQQDLOJHCDK-UHFFFAOYSA-N 0.000 claims 1
- TUULZIHYKXUNBK-UHFFFAOYSA-N n-[2-[4-(2-chlorophenyl)sulfanylpiperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound ClC1=CC=CC=C1SC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 TUULZIHYKXUNBK-UHFFFAOYSA-N 0.000 claims 1
- UZDOEXMWGAVVBA-UHFFFAOYSA-N n-[2-[4-(2-chloropyridin-3-yl)oxypiperidin-1-yl]-2-oxoethyl]-5-(4-fluorophenyl)-1,2-oxazole-3-carboxamide Chemical compound C1=CC(F)=CC=C1C1=CC(C(=O)NCC(=O)N2CCC(CC2)OC=2C(=NC=CC=2)Cl)=NO1 UZDOEXMWGAVVBA-UHFFFAOYSA-N 0.000 claims 1
- PQLJHGORBYLEKR-UHFFFAOYSA-N n-[2-[4-(2-cyanophenoxy)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound C1CC(OC=2C(=CC=CC=2)C#N)CCN1C(=O)CNC(=O)C(=NN1)C=C1C1=CC=CC=C1 PQLJHGORBYLEKR-UHFFFAOYSA-N 0.000 claims 1
- MCTHOEYUMWNULO-UHFFFAOYSA-N n-[2-[4-(2-hydroxyphenoxy)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound OC1=CC=CC=C1OC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 MCTHOEYUMWNULO-UHFFFAOYSA-N 0.000 claims 1
- USXJGPACGOUYCA-UHFFFAOYSA-N n-[2-[4-(2-methylpyridin-3-yl)oxypiperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound CC1=NC=CC=C1OC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 USXJGPACGOUYCA-UHFFFAOYSA-N 0.000 claims 1
- VWOSFUOLZVTQLH-UHFFFAOYSA-N n-[2-[4-(2-methylsulfonylphenoxy)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound CS(=O)(=O)C1=CC=CC=C1OC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 VWOSFUOLZVTQLH-UHFFFAOYSA-N 0.000 claims 1
- OBYSXHARNGLINB-UHFFFAOYSA-N n-[2-[4-(3-cyanoanilino)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound C1CC(NC=2C=C(C=CC=2)C#N)CCN1C(=O)CNC(=O)C(=NN1)C=C1C1=CC=CC=C1 OBYSXHARNGLINB-UHFFFAOYSA-N 0.000 claims 1
- TYBVKIPMLUSAOJ-UHFFFAOYSA-N n-[2-[4-(3-cyanophenoxy)piperidin-1-yl]-2-oxoethyl]-1-phenyltriazole-4-carboxamide Chemical compound C1CC(OC=2C=C(C=CC=2)C#N)CCN1C(=O)CNC(=O)C(N=N1)=CN1C1=CC=CC=C1 TYBVKIPMLUSAOJ-UHFFFAOYSA-N 0.000 claims 1
- IXIZADTUIXLHKO-UHFFFAOYSA-N n-[2-[4-(3-cyanophenoxy)piperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound C1CC(OC=2C=C(C=CC=2)C#N)CCN1C(=O)CNC(=O)C(=NN1)C=C1C1=CC=CC=C1 IXIZADTUIXLHKO-UHFFFAOYSA-N 0.000 claims 1
- RTNRLPYMJXGTBZ-UHFFFAOYSA-N n-[2-[4-(4-methylpyridin-3-yl)oxypiperidin-1-yl]-2-oxoethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound CC1=CC=NC=C1OC1CCN(C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)CC1 RTNRLPYMJXGTBZ-UHFFFAOYSA-N 0.000 claims 1
- SHFMSQWRLSJMEJ-UHFFFAOYSA-N n-[2-[4-[4-fluoro-3-(trifluoromethyl)phenoxy]piperidin-1-yl]-2-oxoethyl]-1-phenylimidazole-4-carboxamide Chemical compound C1=C(C(F)(F)F)C(F)=CC=C1OC1CCN(C(=O)CNC(=O)C=2N=CN(C=2)C=2C=CC=CC=2)CC1 SHFMSQWRLSJMEJ-UHFFFAOYSA-N 0.000 claims 1
- KERBTFURRLPANO-UHFFFAOYSA-N n-[2-[4-[[4-amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino]piperidin-1-yl]-2-oxoethyl]-3-methylbenzamide Chemical compound CC1=CC=CC(C(=O)NCC(=O)N2CCC(CC2)NC=2SC(=C(N)N=2)C(=O)C=2C(=CC=CC=2F)F)=C1 KERBTFURRLPANO-UHFFFAOYSA-N 0.000 claims 1
- KEKOLPIGAGGFCH-UHFFFAOYSA-N n-[2-[4-[n-methyl-2-(trifluoromethyl)anilino]piperidin-1-yl]-2-oxoethyl]-4-phenylbenzamide Chemical compound C=1C=CC=C(C(F)(F)F)C=1N(C)C(CC1)CCN1C(=O)CNC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 KEKOLPIGAGGFCH-UHFFFAOYSA-N 0.000 claims 1
- NCKQFZBBVWTDSR-UHFFFAOYSA-N n-[2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl]-4-phenylbenzamide Chemical compound FC(F)(F)C1=CC=CC=C1OC1CCN(C(=O)CNC(=O)C=2C=CC(=CC=2)C=2C=CC=CC=2)CC1 NCKQFZBBVWTDSR-UHFFFAOYSA-N 0.000 claims 1
- DSLPYHOJHSHWOO-UHFFFAOYSA-N n-[2-oxo-2-[4-[3-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl]-3-phenyl-1h-pyrazole-5-carboxamide Chemical compound FC(F)(F)C1=CC=CC(OC2CCN(CC2)C(=O)CNC(=O)C2=NNC(=C2)C=2C=CC=CC=2)=C1 DSLPYHOJHSHWOO-UHFFFAOYSA-N 0.000 claims 1
- LKWPGLCZVNYLPL-UHFFFAOYSA-N n-[2-oxo-2-[4-[3-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl]-4-(pyrrolidine-1-carbonyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(OC2CCN(CC2)C(=O)CNC(=O)C=2C=CC(=CC=2)C(=O)N2CCCC2)=C1 LKWPGLCZVNYLPL-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN575KO2008 | 2008-03-20 | ||
| IN575/KOL/2008 | 2008-03-20 | ||
| US4948008P | 2008-05-01 | 2008-05-01 | |
| US61/049,480 | 2008-05-01 | ||
| PCT/US2009/037835 WO2009117676A2 (en) | 2008-03-20 | 2009-03-20 | Novel piperidine derivatives as inhibitors of stearoyl-coa desaturase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011518774A JP2011518774A (ja) | 2011-06-30 |
| JP2011518774A5 true JP2011518774A5 (https=) | 2012-03-29 |
Family
ID=41089526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011500989A Pending JP2011518774A (ja) | 2008-03-20 | 2009-03-20 | ステアロイル−ＣｏＡデサチュラーゼの阻害剤としての新規ピペリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8129376B2 (https=) |
| EP (1) | EP2268143A4 (https=) |
| JP (1) | JP2011518774A (https=) |
| KR (1) | KR20100134680A (https=) |
| CN (1) | CN102036558A (https=) |
| AU (1) | AU2009225441B2 (https=) |
| BR (1) | BRPI0909183A2 (https=) |
| CA (1) | CA2719000A1 (https=) |
| IL (1) | IL208232A0 (https=) |
| MX (1) | MX2010010241A (https=) |
| NZ (1) | NZ588633A (https=) |
| RU (1) | RU2010142937A (https=) |
| WO (1) | WO2009117676A2 (https=) |
| ZA (1) | ZA201007252B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8586571B2 (en) | 2007-10-18 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US8642583B2 (en) * | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| MX336731B (es) | 2010-01-28 | 2016-01-28 | Harvard College | Composiciones y metodos para potenciar la actividad de proteasoma. |
| WO2012007500A2 (de) | 2010-07-15 | 2012-01-19 | Bayer Cropscience Ag | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| DK2707101T3 (da) | 2011-05-12 | 2019-05-13 | Proteostasis Therapeutics Inc | Proteostaseregulatorer |
| NO2686520T3 (https=) | 2011-06-06 | 2018-03-17 | ||
| FR3000491B1 (fr) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | Composes utilisables dans le traitement des infections mycobacteriennes |
| CN103772267A (zh) * | 2012-10-24 | 2014-05-07 | 常州化学研究所 | 一种二苯胺制备咔唑的方法 |
| US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| MX2016013049A (es) | 2014-04-04 | 2017-04-27 | X-Rx Inc | Inhibidores de autotaxina espirociclicos sustituidos. |
| CN107205972A (zh) * | 2014-04-23 | 2017-09-26 | X-Rx股份有限公司 | 自分泌运动因子的取代的n‑(2‑(氨基)‑2‑氧代乙基)苯甲酰胺抑制剂及它们的制备和在治疗lpa‑依赖的或lpa‑介导的疾病中的用途 |
| US20160047307A1 (en) * | 2014-08-15 | 2016-02-18 | General Electric Company | Power train architectures with low-loss lubricant bearings and low-density materials |
| WO2016054560A1 (en) | 2014-10-02 | 2016-04-07 | Flatley Discovery Lab | Isoxazole compounds and methods for the treatment of cystic fibrosis |
| CN106432232A (zh) * | 2016-09-18 | 2017-02-22 | 苏州汉德创宏生化科技有限公司 | 1‑哌啶‑4‑基‑1,3‑二氢‑咪唑[4,5‑b]吡啶‑2‑酮的合成方法 |
| ES2973850T3 (es) | 2016-09-20 | 2024-06-24 | Centre Leon Berard | Derivados del benzoimidazol como agentes anticancerígenos |
| US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
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| CN107663184A (zh) * | 2017-11-15 | 2018-02-06 | 上海皓伯化工科技有限公司 | 一种N‑Boc‑4‑羟基哌啶的合成方法 |
| BR112020019191A2 (pt) | 2018-03-23 | 2021-01-05 | Yumanity Therapeutics, Inc. | Compostos e seus usos |
| WO2019209962A1 (en) | 2018-04-25 | 2019-10-31 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| EP3790863A1 (en) | 2018-05-09 | 2021-03-17 | Akebia Therapeutics Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| MX2021008903A (es) * | 2019-01-24 | 2021-11-04 | Yumanity Therapeutics Inc | Compuestos y usos de los mismos. |
| EP4027994A4 (en) * | 2019-09-13 | 2024-03-27 | Dana-Farber Cancer Institute, Inc. | KDM INHIBITORS AND THEIR USES |
| CN110845396B (zh) * | 2019-11-07 | 2023-01-20 | 宿迁联盛科技股份有限公司 | 一种2,2,6,6-四甲基-4-哌啶胺类化合物的制备方法 |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
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| AU6659090A (en) | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| US5459151A (en) * | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| EP1315831B8 (en) | 2000-02-24 | 2010-09-01 | Xenon Pharmaceuticals Inc. | Stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents |
| US7232662B2 (en) | 2000-09-26 | 2007-06-19 | Xenon Pharmaceuticals Inc. | Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5 |
| JP2006518368A (ja) * | 2003-02-21 | 2006-08-10 | ファイザー・インク | プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体 |
| WO2005047253A1 (en) * | 2003-11-12 | 2005-05-26 | Lg Life Sciences Ltd. | Melanocortin receptor agonists |
| JP4787529B2 (ja) * | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
| EP1827438B2 (en) * | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
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| US7829712B2 (en) * | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| US7842696B2 (en) * | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
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- 2009-03-20 RU RU2010142937/04A patent/RU2010142937A/ru unknown
- 2009-03-20 JP JP2011500989A patent/JP2011518774A/ja active Pending
- 2009-03-20 CA CA2719000A patent/CA2719000A1/en not_active Abandoned
- 2009-03-20 CN CN2009801176982A patent/CN102036558A/zh active Pending
- 2009-03-20 US US12/408,486 patent/US8129376B2/en not_active Expired - Fee Related
- 2009-03-20 WO PCT/US2009/037835 patent/WO2009117676A2/en not_active Ceased
- 2009-03-20 AU AU2009225441A patent/AU2009225441B2/en not_active Expired - Fee Related
- 2009-03-20 MX MX2010010241A patent/MX2010010241A/es active IP Right Grant
- 2009-03-20 KR KR1020107023415A patent/KR20100134680A/ko not_active Ceased
- 2009-03-20 EP EP09721822A patent/EP2268143A4/en not_active Withdrawn
- 2009-03-20 NZ NZ588633A patent/NZ588633A/en not_active IP Right Cessation
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