CN102036558A - 作为硬脂酰-CoA去饱和酶抑制剂的新颖哌啶衍生物 - Google Patents
作为硬脂酰-CoA去饱和酶抑制剂的新颖哌啶衍生物 Download PDFInfo
- Publication number
- CN102036558A CN102036558A CN2009801176982A CN200980117698A CN102036558A CN 102036558 A CN102036558 A CN 102036558A CN 2009801176982 A CN2009801176982 A CN 2009801176982A CN 200980117698 A CN200980117698 A CN 200980117698A CN 102036558 A CN102036558 A CN 102036558A
- Authority
- CN
- China
- Prior art keywords
- oxo
- ethyl
- phenyl
- carboxylic acid
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 O=C(CNC(c1n[n]c(-c2ccccc2)c1)=O)N(CC1)CCC1S(c1c2cccc1)=*C2(F)F Chemical compound O=C(CNC(c1n[n]c(-c2ccccc2)c1)=O)N(CC1)CCC1S(c1c2cccc1)=*C2(F)F 0.000 description 2
- YZIACKPSPAJNNP-UHFFFAOYSA-N CCN(CC[U])[n]1nnc(C(NCC(N(CC2)CCC2Oc(cc(cc2)F)c2Cl)=O)=O)c1 Chemical compound CCN(CC[U])[n]1nnc(C(NCC(N(CC2)CCC2Oc(cc(cc2)F)c2Cl)=O)=O)c1 YZIACKPSPAJNNP-UHFFFAOYSA-N 0.000 description 1
- KQCGLRGHMCWMQB-UHFFFAOYSA-N C[n](c(-c1ccccc1O)c1)nc1C(NCC(N(CC1)CCC1Nc(cccc1)c1Cl)=[O]=C)=O Chemical compound C[n](c(-c1ccccc1O)c1)nc1C(NCC(N(CC1)CCC1Nc(cccc1)c1Cl)=[O]=C)=O KQCGLRGHMCWMQB-UHFFFAOYSA-N 0.000 description 1
- UXNPMDKLHYMKBZ-UHFFFAOYSA-N Cc(ccc(C#N)c1)c1O Chemical compound Cc(ccc(C#N)c1)c1O UXNPMDKLHYMKBZ-UHFFFAOYSA-N 0.000 description 1
- JJFZRIFPWLWUTK-UHFFFAOYSA-N Cc1cc(NC(CC2)=CCN2C(CC(Nc(cc2)ccc2-c2ccccc2)=O)=O)c(C)cc1 Chemical compound Cc1cc(NC(CC2)=CCN2C(CC(Nc(cc2)ccc2-c2ccccc2)=O)=O)c(C)cc1 JJFZRIFPWLWUTK-UHFFFAOYSA-N 0.000 description 1
- FLIQYTXJLWGVBG-UHFFFAOYSA-N Nc(cc1)cnc1-c1ccccc1 Chemical compound Nc(cc1)cnc1-c1ccccc1 FLIQYTXJLWGVBG-UHFFFAOYSA-N 0.000 description 1
- GFIFKGLZEGKMTK-UHFFFAOYSA-N O=C(CC(N(CC1)CCC1Oc1cc(F)ccc1Cl)=O)Nc(cc1)ccc1-c1ccccc1 Chemical compound O=C(CC(N(CC1)CCC1Oc1cc(F)ccc1Cl)=O)Nc(cc1)ccc1-c1ccccc1 GFIFKGLZEGKMTK-UHFFFAOYSA-N 0.000 description 1
- LKNIYPRCTXLXQH-UHFFFAOYSA-N O=C(CNC(c(nc1)c[n]1-c1ccccc1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)ccc1 Chemical compound O=C(CNC(c(nc1)c[n]1-c1ccccc1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)ccc1 LKNIYPRCTXLXQH-UHFFFAOYSA-N 0.000 description 1
- AUWAPZKUUGAMSO-UHFFFAOYSA-N O=C(CNC(c1c[n](-c2cccnc2)nn1)=O)N(C1)CC1Oc1cc(F)cc(C(F)(F)F)c1 Chemical compound O=C(CNC(c1c[n](-c2cccnc2)nn1)=O)N(C1)CC1Oc1cc(F)cc(C(F)(F)F)c1 AUWAPZKUUGAMSO-UHFFFAOYSA-N 0.000 description 1
- FCWRLRQZBFXHQF-UHFFFAOYSA-N O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CC1Oc1cc(F)ccc1F Chemical compound O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CC1Oc1cc(F)ccc1F FCWRLRQZBFXHQF-UHFFFAOYSA-N 0.000 description 1
- QCJACBAPSVJZGI-UHFFFAOYSA-N O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)cnc1 Chemical compound O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)cnc1 QCJACBAPSVJZGI-UHFFFAOYSA-N 0.000 description 1
- UZDOEXMWGAVVBA-UHFFFAOYSA-N O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc(cccn1)c1Cl Chemical compound O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc(cccn1)c1Cl UZDOEXMWGAVVBA-UHFFFAOYSA-N 0.000 description 1
- UIDKAUBYKQKRML-UHFFFAOYSA-N O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc1cncc(Cl)c1 Chemical compound O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc1cncc(Cl)c1 UIDKAUBYKQKRML-UHFFFAOYSA-N 0.000 description 1
- OMGPNSFUSJHLFT-UHFFFAOYSA-N OC(c1ccc(Nc2ccccc2)nc1)=O Chemical compound OC(c1ccc(Nc2ccccc2)nc1)=O OMGPNSFUSJHLFT-UHFFFAOYSA-N 0.000 description 1
- DAWLJPOZGTYCCA-UHFFFAOYSA-N [O-][N+](c(cccc1)c1OC(CC1)CCN1C(CC(Nc(cc1)ccc1-c1ccccc1)=O)=O)=O Chemical compound [O-][N+](c(cccc1)c1OC(CC1)CCN1C(CC(Nc(cc1)ccc1-c1ccccc1)=O)=O)=O DAWLJPOZGTYCCA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN575KO2008 | 2008-03-20 | ||
| IN575/KOL/2008 | 2008-03-20 | ||
| US4948008P | 2008-05-01 | 2008-05-01 | |
| US61/049,480 | 2008-05-01 | ||
| PCT/US2009/037835 WO2009117676A2 (en) | 2008-03-20 | 2009-03-20 | Novel piperidine derivatives as inhibitors of stearoyl-coa desaturase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102036558A true CN102036558A (zh) | 2011-04-27 |
Family
ID=41089526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801176982A Pending CN102036558A (zh) | 2008-03-20 | 2009-03-20 | 作为硬脂酰-CoA去饱和酶抑制剂的新颖哌啶衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8129376B2 (https=) |
| EP (1) | EP2268143A4 (https=) |
| JP (1) | JP2011518774A (https=) |
| KR (1) | KR20100134680A (https=) |
| CN (1) | CN102036558A (https=) |
| AU (1) | AU2009225441B2 (https=) |
| BR (1) | BRPI0909183A2 (https=) |
| CA (1) | CA2719000A1 (https=) |
| IL (1) | IL208232A0 (https=) |
| MX (1) | MX2010010241A (https=) |
| NZ (1) | NZ588633A (https=) |
| RU (1) | RU2010142937A (https=) |
| WO (1) | WO2009117676A2 (https=) |
| ZA (1) | ZA201007252B (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103772267A (zh) * | 2012-10-24 | 2014-05-07 | 常州化学研究所 | 一种二苯胺制备咔唑的方法 |
| CN105370411A (zh) * | 2014-08-15 | 2016-03-02 | 通用电气公司 | 具有低损耗润滑剂轴承和低密度材料的动力系体系 |
| CN106432232A (zh) * | 2016-09-18 | 2017-02-22 | 苏州汉德创宏生化科技有限公司 | 1‑哌啶‑4‑基‑1,3‑二氢‑咪唑[4,5‑b]吡啶‑2‑酮的合成方法 |
| CN107663184A (zh) * | 2017-11-15 | 2018-02-06 | 上海皓伯化工科技有限公司 | 一种N‑Boc‑4‑羟基哌啶的合成方法 |
| CN110845396A (zh) * | 2019-11-07 | 2020-02-28 | 宿迁联盛科技股份有限公司 | 一种2,2,6,6-四甲基-4-哌啶胺类化合物的制备方法 |
| CN117247347A (zh) * | 2023-09-15 | 2023-12-19 | 安徽昊帆生物有限公司 | N-Boc-4-氨基哌啶的制备方法 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8586571B2 (en) | 2007-10-18 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US8642583B2 (en) * | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| MX336731B (es) | 2010-01-28 | 2016-01-28 | Harvard College | Composiciones y metodos para potenciar la actividad de proteasoma. |
| WO2012007500A2 (de) | 2010-07-15 | 2012-01-19 | Bayer Cropscience Ag | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| DK2707101T3 (da) | 2011-05-12 | 2019-05-13 | Proteostasis Therapeutics Inc | Proteostaseregulatorer |
| NO2686520T3 (https=) | 2011-06-06 | 2018-03-17 | ||
| FR3000491B1 (fr) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | Composes utilisables dans le traitement des infections mycobacteriennes |
| US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| MX2016013049A (es) | 2014-04-04 | 2017-04-27 | X-Rx Inc | Inhibidores de autotaxina espirociclicos sustituidos. |
| CN107205972A (zh) * | 2014-04-23 | 2017-09-26 | X-Rx股份有限公司 | 自分泌运动因子的取代的n‑(2‑(氨基)‑2‑氧代乙基)苯甲酰胺抑制剂及它们的制备和在治疗lpa‑依赖的或lpa‑介导的疾病中的用途 |
| WO2016054560A1 (en) | 2014-10-02 | 2016-04-07 | Flatley Discovery Lab | Isoxazole compounds and methods for the treatment of cystic fibrosis |
| ES2973850T3 (es) | 2016-09-20 | 2024-06-24 | Centre Leon Berard | Derivados del benzoimidazol como agentes anticancerígenos |
| US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| EA201991650A1 (ru) | 2017-01-06 | 2020-01-20 | Юманити Терапьютикс, Инк. | Способы лечения неврологических расстройств |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| BR112020019191A2 (pt) | 2018-03-23 | 2021-01-05 | Yumanity Therapeutics, Inc. | Compostos e seus usos |
| WO2019209962A1 (en) | 2018-04-25 | 2019-10-31 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| EP3790863A1 (en) | 2018-05-09 | 2021-03-17 | Akebia Therapeutics Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| MX2021008903A (es) * | 2019-01-24 | 2021-11-04 | Yumanity Therapeutics Inc | Compuestos y usos de los mismos. |
| EP4027994A4 (en) * | 2019-09-13 | 2024-03-27 | Dana-Farber Cancer Institute, Inc. | KDM INHIBITORS AND THEIR USES |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6659090A (en) | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| US5459151A (en) * | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| EP1315831B8 (en) | 2000-02-24 | 2010-09-01 | Xenon Pharmaceuticals Inc. | Stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents |
| US7232662B2 (en) | 2000-09-26 | 2007-06-19 | Xenon Pharmaceuticals Inc. | Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5 |
| JP2006518368A (ja) * | 2003-02-21 | 2006-08-10 | ファイザー・インク | プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体 |
| WO2005047253A1 (en) * | 2003-11-12 | 2005-05-26 | Lg Life Sciences Ltd. | Melanocortin receptor agonists |
| JP4787529B2 (ja) * | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
| EP1827438B2 (en) * | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
| AR051091A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| US7829712B2 (en) * | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| US7842696B2 (en) * | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
| US20110053933A1 (en) * | 2008-03-26 | 2011-03-03 | Daiichi Sankyo Company, Limited | Hydroxyquinoxalinecarboxamide derivative |
-
2009
- 2009-03-20 BR BRPI0909183-1A patent/BRPI0909183A2/pt not_active IP Right Cessation
- 2009-03-20 RU RU2010142937/04A patent/RU2010142937A/ru unknown
- 2009-03-20 JP JP2011500989A patent/JP2011518774A/ja active Pending
- 2009-03-20 CA CA2719000A patent/CA2719000A1/en not_active Abandoned
- 2009-03-20 CN CN2009801176982A patent/CN102036558A/zh active Pending
- 2009-03-20 US US12/408,486 patent/US8129376B2/en not_active Expired - Fee Related
- 2009-03-20 WO PCT/US2009/037835 patent/WO2009117676A2/en not_active Ceased
- 2009-03-20 AU AU2009225441A patent/AU2009225441B2/en not_active Expired - Fee Related
- 2009-03-20 MX MX2010010241A patent/MX2010010241A/es active IP Right Grant
- 2009-03-20 KR KR1020107023415A patent/KR20100134680A/ko not_active Ceased
- 2009-03-20 EP EP09721822A patent/EP2268143A4/en not_active Withdrawn
- 2009-03-20 NZ NZ588633A patent/NZ588633A/en not_active IP Right Cessation
-
2010
- 2010-09-19 IL IL208232A patent/IL208232A0/en unknown
- 2010-10-11 ZA ZA2010/07252A patent/ZA201007252B/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103772267A (zh) * | 2012-10-24 | 2014-05-07 | 常州化学研究所 | 一种二苯胺制备咔唑的方法 |
| CN105370411A (zh) * | 2014-08-15 | 2016-03-02 | 通用电气公司 | 具有低损耗润滑剂轴承和低密度材料的动力系体系 |
| CN106432232A (zh) * | 2016-09-18 | 2017-02-22 | 苏州汉德创宏生化科技有限公司 | 1‑哌啶‑4‑基‑1,3‑二氢‑咪唑[4,5‑b]吡啶‑2‑酮的合成方法 |
| CN107663184A (zh) * | 2017-11-15 | 2018-02-06 | 上海皓伯化工科技有限公司 | 一种N‑Boc‑4‑羟基哌啶的合成方法 |
| CN110845396A (zh) * | 2019-11-07 | 2020-02-28 | 宿迁联盛科技股份有限公司 | 一种2,2,6,6-四甲基-4-哌啶胺类化合物的制备方法 |
| CN117247347A (zh) * | 2023-09-15 | 2023-12-19 | 安徽昊帆生物有限公司 | N-Boc-4-氨基哌啶的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011518774A (ja) | 2011-06-30 |
| IL208232A0 (en) | 2010-12-30 |
| US8129376B2 (en) | 2012-03-06 |
| NZ588633A (en) | 2012-03-30 |
| CA2719000A1 (en) | 2009-09-24 |
| WO2009117676A2 (en) | 2009-09-24 |
| US20090239810A1 (en) | 2009-09-24 |
| WO2009117676A3 (en) | 2010-01-07 |
| KR20100134680A (ko) | 2010-12-23 |
| BRPI0909183A2 (pt) | 2015-08-25 |
| ZA201007252B (en) | 2011-12-28 |
| AU2009225441A1 (en) | 2009-09-24 |
| EP2268143A2 (en) | 2011-01-05 |
| RU2010142937A (ru) | 2012-04-27 |
| MX2010010241A (es) | 2010-12-06 |
| EP2268143A4 (en) | 2012-06-27 |
| AU2009225441B2 (en) | 2012-12-13 |
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