CN102036558A - 作为硬脂酰-CoA去饱和酶抑制剂的新颖哌啶衍生物 - Google Patents
作为硬脂酰-CoA去饱和酶抑制剂的新颖哌啶衍生物 Download PDFInfo
- Publication number
- CN102036558A CN102036558A CN2009801176982A CN200980117698A CN102036558A CN 102036558 A CN102036558 A CN 102036558A CN 2009801176982 A CN2009801176982 A CN 2009801176982A CN 200980117698 A CN200980117698 A CN 200980117698A CN 102036558 A CN102036558 A CN 102036558A
- Authority
- CN
- China
- Prior art keywords
- oxo
- ethyl
- phenyl
- carboxylic acid
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 O=C(CNC(c1n[n]c(-c2ccccc2)c1)=O)N(CC1)CCC1S(c1c2cccc1)=*C2(F)F Chemical compound O=C(CNC(c1n[n]c(-c2ccccc2)c1)=O)N(CC1)CCC1S(c1c2cccc1)=*C2(F)F 0.000 description 2
- YZIACKPSPAJNNP-UHFFFAOYSA-N CCN(CC[U])[n]1nnc(C(NCC(N(CC2)CCC2Oc(cc(cc2)F)c2Cl)=O)=O)c1 Chemical compound CCN(CC[U])[n]1nnc(C(NCC(N(CC2)CCC2Oc(cc(cc2)F)c2Cl)=O)=O)c1 YZIACKPSPAJNNP-UHFFFAOYSA-N 0.000 description 1
- KQCGLRGHMCWMQB-UHFFFAOYSA-N C[n](c(-c1ccccc1O)c1)nc1C(NCC(N(CC1)CCC1Nc(cccc1)c1Cl)=[O]=C)=O Chemical compound C[n](c(-c1ccccc1O)c1)nc1C(NCC(N(CC1)CCC1Nc(cccc1)c1Cl)=[O]=C)=O KQCGLRGHMCWMQB-UHFFFAOYSA-N 0.000 description 1
- UXNPMDKLHYMKBZ-UHFFFAOYSA-N Cc(ccc(C#N)c1)c1O Chemical compound Cc(ccc(C#N)c1)c1O UXNPMDKLHYMKBZ-UHFFFAOYSA-N 0.000 description 1
- JJFZRIFPWLWUTK-UHFFFAOYSA-N Cc1cc(NC(CC2)=CCN2C(CC(Nc(cc2)ccc2-c2ccccc2)=O)=O)c(C)cc1 Chemical compound Cc1cc(NC(CC2)=CCN2C(CC(Nc(cc2)ccc2-c2ccccc2)=O)=O)c(C)cc1 JJFZRIFPWLWUTK-UHFFFAOYSA-N 0.000 description 1
- FLIQYTXJLWGVBG-UHFFFAOYSA-N Nc(cc1)cnc1-c1ccccc1 Chemical compound Nc(cc1)cnc1-c1ccccc1 FLIQYTXJLWGVBG-UHFFFAOYSA-N 0.000 description 1
- GFIFKGLZEGKMTK-UHFFFAOYSA-N O=C(CC(N(CC1)CCC1Oc1cc(F)ccc1Cl)=O)Nc(cc1)ccc1-c1ccccc1 Chemical compound O=C(CC(N(CC1)CCC1Oc1cc(F)ccc1Cl)=O)Nc(cc1)ccc1-c1ccccc1 GFIFKGLZEGKMTK-UHFFFAOYSA-N 0.000 description 1
- LKNIYPRCTXLXQH-UHFFFAOYSA-N O=C(CNC(c(nc1)c[n]1-c1ccccc1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)ccc1 Chemical compound O=C(CNC(c(nc1)c[n]1-c1ccccc1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)ccc1 LKNIYPRCTXLXQH-UHFFFAOYSA-N 0.000 description 1
- AUWAPZKUUGAMSO-UHFFFAOYSA-N O=C(CNC(c1c[n](-c2cccnc2)nn1)=O)N(C1)CC1Oc1cc(F)cc(C(F)(F)F)c1 Chemical compound O=C(CNC(c1c[n](-c2cccnc2)nn1)=O)N(C1)CC1Oc1cc(F)cc(C(F)(F)F)c1 AUWAPZKUUGAMSO-UHFFFAOYSA-N 0.000 description 1
- FCWRLRQZBFXHQF-UHFFFAOYSA-N O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CC1Oc1cc(F)ccc1F Chemical compound O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CC1Oc1cc(F)ccc1F FCWRLRQZBFXHQF-UHFFFAOYSA-N 0.000 description 1
- QCJACBAPSVJZGI-UHFFFAOYSA-N O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)cnc1 Chemical compound O=C(CNC(c1n[nH]c(-c2ccccc2)c1)=O)N(CC1)CCC1Oc1cc(C(F)(F)F)cnc1 QCJACBAPSVJZGI-UHFFFAOYSA-N 0.000 description 1
- UZDOEXMWGAVVBA-UHFFFAOYSA-N O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc(cccn1)c1Cl Chemical compound O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc(cccn1)c1Cl UZDOEXMWGAVVBA-UHFFFAOYSA-N 0.000 description 1
- UIDKAUBYKQKRML-UHFFFAOYSA-N O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc1cncc(Cl)c1 Chemical compound O=C(CNC(c1n[o]c(-c(cc2)ccc2F)c1)=O)N(CC1)CCC1Oc1cncc(Cl)c1 UIDKAUBYKQKRML-UHFFFAOYSA-N 0.000 description 1
- OMGPNSFUSJHLFT-UHFFFAOYSA-N OC(c1ccc(Nc2ccccc2)nc1)=O Chemical compound OC(c1ccc(Nc2ccccc2)nc1)=O OMGPNSFUSJHLFT-UHFFFAOYSA-N 0.000 description 1
- DAWLJPOZGTYCCA-UHFFFAOYSA-N [O-][N+](c(cccc1)c1OC(CC1)CCN1C(CC(Nc(cc1)ccc1-c1ccccc1)=O)=O)=O Chemical compound [O-][N+](c(cccc1)c1OC(CC1)CCN1C(CC(Nc(cc1)ccc1-c1ccccc1)=O)=O)=O DAWLJPOZGTYCCA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN575/KOL/2008 | 2008-03-20 | ||
| IN575KO2008 | 2008-03-20 | ||
| US4948008P | 2008-05-01 | 2008-05-01 | |
| US61/049,480 | 2008-05-01 | ||
| PCT/US2009/037835 WO2009117676A2 (en) | 2008-03-20 | 2009-03-20 | Novel piperidine derivatives as inhibitors of stearoyl-coa desaturase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102036558A true CN102036558A (zh) | 2011-04-27 |
Family
ID=41089526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801176982A Pending CN102036558A (zh) | 2008-03-20 | 2009-03-20 | 作为硬脂酰-CoA去饱和酶抑制剂的新颖哌啶衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8129376B2 (https=) |
| EP (1) | EP2268143A4 (https=) |
| JP (1) | JP2011518774A (https=) |
| KR (1) | KR20100134680A (https=) |
| CN (1) | CN102036558A (https=) |
| AU (1) | AU2009225441B2 (https=) |
| BR (1) | BRPI0909183A2 (https=) |
| CA (1) | CA2719000A1 (https=) |
| IL (1) | IL208232A0 (https=) |
| MX (1) | MX2010010241A (https=) |
| NZ (1) | NZ588633A (https=) |
| RU (1) | RU2010142937A (https=) |
| WO (1) | WO2009117676A2 (https=) |
| ZA (1) | ZA201007252B (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103772267A (zh) * | 2012-10-24 | 2014-05-07 | 常州化学研究所 | 一种二苯胺制备咔唑的方法 |
| CN105370411A (zh) * | 2014-08-15 | 2016-03-02 | 通用电气公司 | 具有低损耗润滑剂轴承和低密度材料的动力系体系 |
| CN106432232A (zh) * | 2016-09-18 | 2017-02-22 | 苏州汉德创宏生化科技有限公司 | 1‑哌啶‑4‑基‑1,3‑二氢‑咪唑[4,5‑b]吡啶‑2‑酮的合成方法 |
| CN107663184A (zh) * | 2017-11-15 | 2018-02-06 | 上海皓伯化工科技有限公司 | 一种N‑Boc‑4‑羟基哌啶的合成方法 |
| CN110845396A (zh) * | 2019-11-07 | 2020-02-28 | 宿迁联盛科技股份有限公司 | 一种2,2,6,6-四甲基-4-哌啶胺类化合物的制备方法 |
| CN117247347A (zh) * | 2023-09-15 | 2023-12-19 | 安徽昊帆生物有限公司 | N-Boc-4-氨基哌啶的制备方法 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009051244A1 (ja) | 2007-10-18 | 2009-04-23 | Takeda Pharmaceutical Company Limited | 複素環化合物 |
| US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| KR20120117905A (ko) | 2010-01-28 | 2012-10-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 프로테아좀 활성을 향상시키는 조성물 및 방법 |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
| HUE044867T2 (hu) | 2011-05-12 | 2019-11-28 | Proteostasis Therapeutics Inc | Proteosztázis szabályzók |
| NO2686520T3 (https=) | 2011-06-06 | 2018-03-17 | ||
| FR3000491B1 (fr) | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | Composes utilisables dans le traitement des infections mycobacteriennes |
| US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| CU24442B1 (es) | 2014-04-04 | 2019-09-04 | X Rx Inc | Derivados de n-(1-(espirocíclico)oxo) amida sustituidos como inhibidores de autotaxina |
| BR112016024473A2 (pt) * | 2014-04-23 | 2018-01-23 | X Rx Inc | composto, composição farmacêutica, e, método para tratamento de uma doença e/ou condição |
| WO2016054560A1 (en) | 2014-10-02 | 2016-04-07 | Flatley Discovery Lab | Isoxazole compounds and methods for the treatment of cystic fibrosis |
| ES2973850T3 (es) | 2016-09-20 | 2024-06-24 | Centre Leon Berard | Derivados del benzoimidazol como agentes anticancerígenos |
| JP2019533022A (ja) | 2016-10-24 | 2019-11-14 | ユマニティ セラピューティクス，インコーポレーテッド | 化合物及びその使用 |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| EP3566055B1 (en) | 2017-01-06 | 2025-03-12 | Janssen Pharmaceutica NV | Scd inhibitor for the treatment of neurological disorders |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2019183587A1 (en) | 2018-03-23 | 2019-09-26 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| JP2021522253A (ja) | 2018-04-25 | 2021-08-30 | ユマニティ セラピューティクス，インコーポレーテッド | 化合物及びその使用 |
| US11713298B2 (en) | 2018-05-09 | 2023-08-01 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| WO2020154571A1 (en) * | 2019-01-24 | 2020-07-30 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| AU2020346814A1 (en) * | 2019-09-13 | 2022-02-17 | Dana-Farber Cancer Institute, Inc. | KDM inhibitors and uses thereof |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| WO2021117767A1 (ja) | 2019-12-10 | 2021-06-17 | 田辺三菱製薬株式会社 | 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6659090A (en) | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| US5459151A (en) * | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
| ES2293638T3 (es) * | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) * | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| WO2001062954A2 (en) | 2000-02-24 | 2001-08-30 | Xenon Genetics, Inc. | Stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents |
| ATE402262T1 (de) | 2000-09-26 | 2008-08-15 | Xenon Pharmaceuticals Inc | Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden |
| MXPA05008878A (es) * | 2003-02-21 | 2005-10-05 | Pfizer | Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso. |
| KR20050045927A (ko) | 2003-11-12 | 2005-05-17 | 주식회사 엘지생명과학 | 멜라노코틴 수용체의 항진제 |
| JP4787529B2 (ja) * | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
| BRPI0515500A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| EP1827438B2 (en) * | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
| AU2005286728A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| WO2008157844A1 (en) * | 2007-06-21 | 2008-12-24 | Forest Laboratories Holdings Limited | Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase |
| US20110053933A1 (en) * | 2008-03-26 | 2011-03-03 | Daiichi Sankyo Company, Limited | Hydroxyquinoxalinecarboxamide derivative |
-
2009
- 2009-03-20 RU RU2010142937/04A patent/RU2010142937A/ru unknown
- 2009-03-20 NZ NZ588633A patent/NZ588633A/en not_active IP Right Cessation
- 2009-03-20 MX MX2010010241A patent/MX2010010241A/es active IP Right Grant
- 2009-03-20 KR KR1020107023415A patent/KR20100134680A/ko not_active Ceased
- 2009-03-20 WO PCT/US2009/037835 patent/WO2009117676A2/en not_active Ceased
- 2009-03-20 EP EP09721822A patent/EP2268143A4/en not_active Withdrawn
- 2009-03-20 US US12/408,486 patent/US8129376B2/en not_active Expired - Fee Related
- 2009-03-20 JP JP2011500989A patent/JP2011518774A/ja active Pending
- 2009-03-20 CN CN2009801176982A patent/CN102036558A/zh active Pending
- 2009-03-20 BR BRPI0909183-1A patent/BRPI0909183A2/pt not_active IP Right Cessation
- 2009-03-20 AU AU2009225441A patent/AU2009225441B2/en not_active Expired - Fee Related
- 2009-03-20 CA CA2719000A patent/CA2719000A1/en not_active Abandoned
-
2010
- 2010-09-19 IL IL208232A patent/IL208232A0/en unknown
- 2010-10-11 ZA ZA2010/07252A patent/ZA201007252B/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103772267A (zh) * | 2012-10-24 | 2014-05-07 | 常州化学研究所 | 一种二苯胺制备咔唑的方法 |
| CN105370411A (zh) * | 2014-08-15 | 2016-03-02 | 通用电气公司 | 具有低损耗润滑剂轴承和低密度材料的动力系体系 |
| CN106432232A (zh) * | 2016-09-18 | 2017-02-22 | 苏州汉德创宏生化科技有限公司 | 1‑哌啶‑4‑基‑1,3‑二氢‑咪唑[4,5‑b]吡啶‑2‑酮的合成方法 |
| CN107663184A (zh) * | 2017-11-15 | 2018-02-06 | 上海皓伯化工科技有限公司 | 一种N‑Boc‑4‑羟基哌啶的合成方法 |
| CN110845396A (zh) * | 2019-11-07 | 2020-02-28 | 宿迁联盛科技股份有限公司 | 一种2,2,6,6-四甲基-4-哌啶胺类化合物的制备方法 |
| CN117247347A (zh) * | 2023-09-15 | 2023-12-19 | 安徽昊帆生物有限公司 | N-Boc-4-氨基哌啶的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009117676A3 (en) | 2010-01-07 |
| CA2719000A1 (en) | 2009-09-24 |
| RU2010142937A (ru) | 2012-04-27 |
| AU2009225441A1 (en) | 2009-09-24 |
| MX2010010241A (es) | 2010-12-06 |
| IL208232A0 (en) | 2010-12-30 |
| JP2011518774A (ja) | 2011-06-30 |
| BRPI0909183A2 (pt) | 2015-08-25 |
| ZA201007252B (en) | 2011-12-28 |
| EP2268143A2 (en) | 2011-01-05 |
| US8129376B2 (en) | 2012-03-06 |
| EP2268143A4 (en) | 2012-06-27 |
| KR20100134680A (ko) | 2010-12-23 |
| WO2009117676A2 (en) | 2009-09-24 |
| AU2009225441B2 (en) | 2012-12-13 |
| US20090239810A1 (en) | 2009-09-24 |
| NZ588633A (en) | 2012-03-30 |
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