JP2009535362A5 - - Google Patents
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- Publication number
- JP2009535362A5 JP2009535362A5 JP2009507978A JP2009507978A JP2009535362A5 JP 2009535362 A5 JP2009535362 A5 JP 2009535362A5 JP 2009507978 A JP2009507978 A JP 2009507978A JP 2009507978 A JP2009507978 A JP 2009507978A JP 2009535362 A5 JP2009535362 A5 JP 2009535362A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pyrrolidin
- ylmethyl
- dichloro
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HZZCSLKKNXVQSN-UHFFFAOYSA-N CC(N(CC1)CCC1(F)F)=O Chemical compound CC(N(CC1)CCC1(F)F)=O HZZCSLKKNXVQSN-UHFFFAOYSA-N 0.000 description 1
- 0 CC(N1CC(O*)OC(*)C1)=O Chemical compound CC(N1CC(O*)OC(*)C1)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79611206P | 2006-04-28 | 2006-04-28 | |
| US60/796,112 | 2006-04-28 | ||
| PCT/US2007/067597 WO2007127901A1 (en) | 2006-04-28 | 2007-04-27 | Pieridinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009535362A JP2009535362A (ja) | 2009-10-01 |
| JP2009535362A5 true JP2009535362A5 (https=) | 2010-05-13 |
| JP5225980B2 JP5225980B2 (ja) | 2013-07-03 |
Family
ID=38421166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507978A Expired - Fee Related JP5225980B2 (ja) | 2006-04-28 | 2007-04-27 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのピエリジニル置換ピロリジノン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7829582B2 (https=) |
| EP (1) | EP2049513B1 (https=) |
| JP (1) | JP5225980B2 (https=) |
| KR (1) | KR101060016B1 (https=) |
| CN (1) | CN101448816B (https=) |
| AT (1) | ATE542811T1 (https=) |
| AU (1) | AU2007244742B2 (https=) |
| BR (1) | BRPI0710469A2 (https=) |
| CA (1) | CA2650627C (https=) |
| CY (1) | CY1112466T1 (https=) |
| DK (1) | DK2049513T3 (https=) |
| EA (1) | EA014719B1 (https=) |
| EC (1) | ECSP088849A (https=) |
| IL (1) | IL194879A0 (https=) |
| MA (1) | MA30421B1 (https=) |
| MX (1) | MX2008013844A (https=) |
| NO (1) | NO20084874L (https=) |
| PL (1) | PL2049513T3 (https=) |
| PT (1) | PT2049513E (https=) |
| SI (1) | SI2049513T1 (https=) |
| TN (1) | TNSN08432A1 (https=) |
| WO (1) | WO2007127901A1 (https=) |
| ZA (1) | ZA200808816B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA014718B1 (ru) | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
| JP5161869B2 (ja) | 2006-04-21 | 2013-03-13 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体 |
| EA016415B1 (ru) | 2006-04-24 | 2012-04-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1 |
| JP5269765B2 (ja) | 2006-04-24 | 2013-08-21 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| CN101432263B (zh) | 2006-04-24 | 2012-03-07 | 伊莱利利公司 | 作为11-β-羟类固醇脱氢酶1抑制剂的取代的吡咯烷酮类 |
| DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| JP5101602B2 (ja) | 2006-04-25 | 2012-12-19 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| CN101432265B (zh) | 2006-04-25 | 2011-12-14 | 伊莱利利公司 | 11-β-羟类固醇脱氢酶1的抑制剂 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| KR101593493B1 (ko) | 2014-10-28 | 2016-02-18 | 주식회사 아이에스티이 | 대면적 유리기판 열처리 장치 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004033427A1 (en) * | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| AU2005240785B2 (en) | 2004-05-07 | 2011-02-03 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| AU2005240784C1 (en) * | 2004-05-07 | 2011-12-22 | Janssen Pharmaceutica N.V. | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| EP1802623A1 (en) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| US7713979B2 (en) | 2004-10-29 | 2010-05-11 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ES2547724T3 (es) | 2004-11-10 | 2015-10-08 | Incyte Corporation | Compuestos de lactama y su uso como productos farmacéuticos |
| WO2006068992A1 (en) | 2004-12-20 | 2006-06-29 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| DE602005008282D1 (de) | 2004-12-21 | 2008-08-28 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5161869B2 (ja) | 2006-04-21 | 2013-03-13 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体 |
| EA014718B1 (ru) | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
| CN101432263B (zh) | 2006-04-24 | 2012-03-07 | 伊莱利利公司 | 作为11-β-羟类固醇脱氢酶1抑制剂的取代的吡咯烷酮类 |
| JP5269765B2 (ja) | 2006-04-24 | 2013-08-21 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| EA016415B1 (ru) | 2006-04-24 | 2012-04-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1 |
| DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| CN101432265B (zh) | 2006-04-25 | 2011-12-14 | 伊莱利利公司 | 11-β-羟类固醇脱氢酶1的抑制剂 |
| JP5101602B2 (ja) | 2006-04-25 | 2012-12-19 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-27 DK DK07761424.6T patent/DK2049513T3/da active
- 2007-04-27 CA CA2650627A patent/CA2650627C/en not_active Expired - Fee Related
- 2007-04-27 BR BRPI0710469-3A patent/BRPI0710469A2/pt not_active IP Right Cessation
- 2007-04-27 CN CN2007800154205A patent/CN101448816B/zh not_active Expired - Fee Related
- 2007-04-27 AU AU2007244742A patent/AU2007244742B2/en not_active Ceased
- 2007-04-27 JP JP2009507978A patent/JP5225980B2/ja not_active Expired - Fee Related
- 2007-04-27 MX MX2008013844A patent/MX2008013844A/es active IP Right Grant
- 2007-04-27 PL PL07761424T patent/PL2049513T3/pl unknown
- 2007-04-27 SI SI200730872T patent/SI2049513T1/sl unknown
- 2007-04-27 AT AT07761424T patent/ATE542811T1/de active
- 2007-04-27 KR KR1020087026195A patent/KR101060016B1/ko not_active Expired - Fee Related
- 2007-04-27 WO PCT/US2007/067597 patent/WO2007127901A1/en not_active Ceased
- 2007-04-27 PT PT07761424T patent/PT2049513E/pt unknown
- 2007-04-27 US US12/297,951 patent/US7829582B2/en not_active Expired - Fee Related
- 2007-04-27 EP EP07761424A patent/EP2049513B1/en active Active
- 2007-04-27 EA EA200870489A patent/EA014719B1/ru not_active IP Right Cessation
-
2008
- 2008-10-15 ZA ZA200808816A patent/ZA200808816B/xx unknown
- 2008-10-23 IL IL194879A patent/IL194879A0/en unknown
- 2008-10-24 TN TNP2008000432A patent/TNSN08432A1/en unknown
- 2008-10-27 EC EC2008008849A patent/ECSP088849A/es unknown
- 2008-11-19 NO NO20084874A patent/NO20084874L/no not_active Application Discontinuation
- 2008-11-20 MA MA31397A patent/MA30421B1/fr unknown
-
2012
- 2012-03-08 CY CY20121100235T patent/CY1112466T1/el unknown
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