JP2011517457A5 - - Google Patents

Download PDF

Info

Publication number
JP2011517457A5
JP2011517457A5 JP2011503076A JP2011503076A JP2011517457A5 JP 2011517457 A5 JP2011517457 A5 JP 2011517457A5 JP 2011503076 A JP2011503076 A JP 2011503076A JP 2011503076 A JP2011503076 A JP 2011503076A JP 2011517457 A5 JP2011517457 A5 JP 2011517457A5
Authority
JP
Japan
Prior art keywords
oxepin
thieno
dihydrobenzo
methyl
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011503076A
Other languages
English (en)
Japanese (ja)
Other versions
JP5511786B2 (ja
JP2011517457A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/038795 external-priority patent/WO2009123971A1/en
Publication of JP2011517457A publication Critical patent/JP2011517457A/ja
Publication of JP2011517457A5 publication Critical patent/JP2011517457A5/ja
Application granted granted Critical
Publication of JP5511786B2 publication Critical patent/JP5511786B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011503076A 2008-03-31 2009-03-30 ベンゾピランおよびベンゾキセピンｐｉ３ｋ阻害剤化合物および使用方法 Active JP5511786B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4082708P 2008-03-31 2008-03-31
US61/040,827 2008-03-31
US10222008P 2008-10-02 2008-10-02
US61/102,220 2008-10-02
PCT/US2009/038795 WO2009123971A1 (en) 2008-03-31 2009-03-30 Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2011517457A JP2011517457A (ja) 2011-06-09
JP2011517457A5 true JP2011517457A5 (enExample) 2012-05-24
JP5511786B2 JP5511786B2 (ja) 2014-06-04

Family

ID=40790991

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011503076A Active JP5511786B2 (ja) 2008-03-31 2009-03-30 ベンゾピランおよびベンゾキセピンｐｉ３ｋ阻害剤化合物および使用方法

Country Status (21)

Country Link
US (4) US7928248B2 (enExample)
EP (1) EP2276767B1 (enExample)
JP (1) JP5511786B2 (enExample)
KR (1) KR101626996B1 (enExample)
CN (1) CN102333779B (enExample)
AR (1) AR071112A1 (enExample)
AU (1) AU2009231885B2 (enExample)
BR (1) BRPI0910346A2 (enExample)
CA (1) CA2719032C (enExample)
CL (1) CL2009000780A1 (enExample)
DK (1) DK2276767T3 (enExample)
ES (1) ES2480994T3 (enExample)
IL (1) IL208359A (enExample)
MX (1) MX2010010659A (enExample)
PE (1) PE20091720A1 (enExample)
PL (1) PL2276767T3 (enExample)
RU (1) RU2506267C2 (enExample)
SI (1) SI2276767T1 (enExample)
TW (1) TWI443102B (enExample)
WO (1) WO2009123971A1 (enExample)
ZA (1) ZA201007218B (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029411B2 (en) 2008-01-25 2015-05-12 Millennium Pharmaceuticals, Inc. Thiophenes and uses thereof
TWI443102B (zh) 2008-03-31 2014-07-01 Genentech Inc 苯并哌喃及苯并氧呯ｐｉ３ｋ抑制劑化合物及其使用方法
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
CN102395585A (zh) 2009-01-30 2012-03-28 米伦纽姆医药公司 杂芳基化合物和其作为pi3k抑制剂的用途
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
CA2766853A1 (en) * 2009-07-02 2011-01-06 Novartis Ag 2-carboxamide cycloamino ureas useful as pi3k inhibitors
PE20121025A1 (es) 2009-09-28 2012-08-06 Hoffmann La Roche Compuestos de benzoxazepina como inhibidores de la p13k
NZ599090A (en) * 2009-09-28 2014-02-28 Hoffmann La Roche Benzoxepin pi3k inhibitor compounds and methods of use
WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
EP2592071B1 (en) * 2009-10-29 2019-09-18 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
EP3444242A3 (en) 2009-11-05 2019-03-20 Rhizen Pharmaceuticals S.A. Novel benzopyran kinase modulators
ES2607952T3 (es) * 2009-11-13 2017-04-04 Merck Serono S.A. Derivados tricíclicos de Pirazol Amina
WO2011063126A1 (en) * 2009-11-18 2011-05-26 Satoshi Ohtake Highly dispersible powders, compositions and methods for preparation
US8859768B2 (en) 2010-08-11 2014-10-14 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
PH12013500274A1 (en) 2010-08-11 2013-03-04 Millennium Pharm Inc Heteroaryls and uses thereof
WO2012021611A1 (en) 2010-08-11 2012-02-16 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EP2627181A4 (en) * 2010-10-13 2014-03-19 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
CA2825966A1 (en) * 2011-03-21 2012-09-27 F. Hoffmann-La Roche Ag Benzoxazepin compounds selective for pi3k p110 delta and methods of use
PT2705029T (pt) 2011-05-04 2019-02-01 Rhizen Pharmaceuticals S A Novos compostos como moduladores de proteína quinases
HUE043221T2 (hu) 2011-05-27 2019-08-28 Lexicon Pharmaceuticals Inc Notum pektinacetilészteráz 4H-tieno[3,2-C]kromén-alapú inhibitorai és alkalmazási eljárásaik
HK1206024A1 (en) * 2012-02-17 2015-12-31 F. Hoffmann-La Roche Ag Tricyclic compounds and methods of use therefor
US8940742B2 (en) * 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6301316B2 (ja) 2012-05-23 2018-03-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 内胚葉細胞および肝実質細胞の組成物ならびにそれらの細胞を入手および使用する方法
HRP20171610T1 (hr) 2012-07-04 2018-03-23 Rhizen Pharmaceuticals S.A. Selektivni inhibitori pi3k delta
WO2014068070A1 (en) 2012-10-31 2014-05-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
EP3404032B1 (en) 2013-03-13 2025-07-02 F. Hoffmann-La Roche AG Process for making benzoxazepin compounds
RU2015143437A (ru) 2013-03-15 2017-04-27 Дженентек, Инк. Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака
AU2014251038A1 (en) 2013-04-08 2015-11-26 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
PL3052485T3 (pl) 2013-10-04 2022-02-28 Infinity Pharmaceuticals, Inc. Związki heterocykliczne i ich zastosowania
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2943075C (en) 2014-03-19 2023-02-28 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
RS59409B1 (sr) 2014-12-11 2019-11-29 Natco Pharma Ltd 7-(morfolinil)-2-(n-piperazinil) metil tieno [2, 3-c]piridinski derivati kao antikancerski lekovi
DK3277683T3 (en) 2015-03-30 2022-05-02 Jubilant Biosys Ltd Tricyklisk sammensmeltet afledt af 1-(cyklo)alkyl pyridin-2-one nyttig til behandling af kræft
NZ740616A (en) 2015-09-14 2023-05-26 Infinity Pharmaceuticals Inc Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
ES3014630T3 (en) 2016-07-29 2025-04-23 Janssen Pharmaceutica Nv Niraparib for use in a method of treating prostate cancer
JP7029445B2 (ja) 2016-09-02 2022-03-03 ブリストル－マイヤーズ スクイブ カンパニー 置換された三環式ヘテロ環化合物
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
SG11202000418XA (en) 2017-07-18 2020-02-27 Nuvation Bio Inc Heterocyclic compounds as adenosine antagonists
AU2018302178A1 (en) 2017-07-18 2020-02-13 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
WO2019032632A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company ALKYLPHENYL COMPOUNDS
WO2019032631A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company Oxime ether compounds
CN107805255B (zh) * 2017-09-22 2020-06-16 中国药科大学 呋喃[3，2-b]吡啶-2(1H)-酮类化合物、制备方法和医药用途
EP3762379A1 (en) 2018-03-07 2021-01-13 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
CN110467629B (zh) * 2018-05-09 2022-04-08 上海迪诺医药科技有限公司 苯醌衍生物、其药物组合物及应用
AU2020207951A1 (en) 2019-01-18 2021-08-26 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
EP3911323A4 (en) 2019-01-18 2022-11-16 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
CN114156414B (zh) * 2021-11-30 2024-05-31 合肥工业大学 一种高效稳定CsPbI3无机钙钛矿电池的制备方法
CN117209457B (zh) * 2022-06-09 2025-08-15 四川师范大学 一种α-手性脒化合物的合成
CN115403591A (zh) * 2022-10-08 2022-11-29 河南师范大学 一种合成萘并噻吩并奥塞平并异喹啉酮类化合物的方法
WO2025082467A1 (zh) * 2023-10-19 2025-04-24 成都先导药物开发股份有限公司 一种免疫调节剂

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8504702D0 (en) * 1985-02-23 1985-03-27 Zyma Sa Tricyclic compounds
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
FI943948A7 (fi) * 1992-12-28 1994-08-26 Eisai Co Ltd Heterosykliset hiilihappojohdannaiset
WO1997019087A1 (en) * 1995-11-17 1997-05-29 E.I. Du Pont De Nemours And Company Tricyclic herbicidal heterocycles
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908537A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE19908535A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen Thiazol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
DE19908533A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
US7273880B2 (en) * 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
AU2001246494A1 (en) 2000-03-03 2001-09-12 Novartis Ag Condensed thiazolamines and their use as neuropeptide y5 antagonists
US20040198791A1 (en) * 2001-06-05 2004-10-07 Yoshinari Sato Fused imidazole derivative
AU2003256650A1 (en) * 2002-07-19 2004-02-09 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
CA2514241A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Oxazolidinone derivates n-substituted by a tricyclic ring, for use as antibacterial agents
RU2403258C2 (ru) * 2004-10-07 2010-11-10 Бёрингер Ингельхайм Интернациональ Гмбх Тиазолилдигидроиндазолы
CN101039667A (zh) * 2004-10-15 2007-09-19 辉瑞大药厂 双相性精神障碍和相关症状的治疗
RU2281947C1 (ru) * 2005-07-05 2006-08-20 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Аннелированные карбамоилазагетероциклы, фокусированная библиотека, фармацевтическая композиция и способ получения
US8877791B2 (en) * 2006-08-04 2014-11-04 Beth Israel Deaconess Medical Center, Inc. Inhibitors of pyruvate kinase and methods of treating disease
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
TWI443102B (zh) 2008-03-31 2014-07-01 Genentech Inc 苯并哌喃及苯并氧呯ｐｉ３ｋ抑制劑化合物及其使用方法

Similar Documents

Publication Publication Date Title
RU2506267C2 (ru) Бензопирановые и бензоксепиновые ингибиторы рi3k и их применение
JP2011517457A5 (enExample)
US11524938B2 (en) Aromatic sulfonamide derivatives
RU2015104301A (ru) Бензоксепиновые ингибиторы р13 и способы применения
JP2004525965A5 (enExample)
JP2007523182A5 (enExample)
JP2008526723A5 (enExample)
RU2006130683A (ru) Производные 3-замещенного 1, 5-дифенилпиразола, полезные в качестве св1 модуляторов
KR20130004316A (ko) 비스아릴-결합된 아릴트리아졸론 및 그의 용도
RU2016141646A (ru) Ингибиторы trka киназы, основанные на них композиции и способы
EA010132B1 (ru) Производные триазола в качестве антагонистов вазопрессина
RU2002110104A (ru) Производные бензодиазепина
EA029718B1 (ru) Бифтордиоксалан-аминобензимидазольные ингибиторы киназы для лечения рака, аутоиммунного воспаления и нарушений цнс
RU2006135482A (ru) Терапевтические агенты
US9650377B2 (en) Diazepinone derivatives
TWI902864B (zh) 新穎二唑系選擇性ｈｄａｃ６抑制劑及其用途
EA040608B1 (ru) Ароматические сульфонамидные производные