JP2011516570A5 - - Google Patents
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- Publication number
- JP2011516570A5 JP2011516570A5 JP2011504170A JP2011504170A JP2011516570A5 JP 2011516570 A5 JP2011516570 A5 JP 2011516570A5 JP 2011504170 A JP2011504170 A JP 2011504170A JP 2011504170 A JP2011504170 A JP 2011504170A JP 2011516570 A5 JP2011516570 A5 JP 2011516570A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- item
- quencher
- red blood
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 136
- 238000000034 method Methods 0.000 claims description 131
- 210000003743 erythrocyte Anatomy 0.000 claims description 94
- 244000052769 pathogen Species 0.000 claims description 31
- 230000001717 pathogenic effect Effects 0.000 claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 27
- 230000000415 inactivating effect Effects 0.000 claims description 23
- 238000004062 sedimentation Methods 0.000 claims description 13
- 230000018044 dehydration Effects 0.000 claims description 11
- 238000006297 dehydration reaction Methods 0.000 claims description 11
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 9
- 230000000996 additive effect Effects 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 8
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 7
- 229930024421 Adenine Natural products 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- 229960000643 adenine Drugs 0.000 claims description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
- 239000003446 ligand Substances 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 239000000138 intercalating agent Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 108010024636 Glutathione Proteins 0.000 claims description 5
- 206010018910 Haemolysis Diseases 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 125000000524 functional group Chemical group 0.000 claims description 5
- 229960003180 glutathione Drugs 0.000 claims description 5
- 230000008588 hemolysis Effects 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- 150000001944 cysteine derivatives Chemical class 0.000 claims description 4
- -1 2- [bis (2-chloroethyl) amino] ethyl Chemical group 0.000 claims description 3
- 125000004559 acridin-9-yl group Chemical group C1=CC=CC2=NC3=CC=CC=C3C(=C12)* 0.000 claims description 3
- 125000000641 acridinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 claims description 3
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims description 3
- 210000000601 blood cell Anatomy 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 3
- 230000007717 exclusion Effects 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 9
- 239000003085 diluting agent Substances 0.000 claims 6
- 239000008121 dextrose Substances 0.000 claims 4
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 2
- KJQNSWHBRKOGHW-GEMLJDPKSA-N (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;sodium Chemical group [Na].OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O KJQNSWHBRKOGHW-GEMLJDPKSA-N 0.000 claims 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 1
- 229940029575 guanosine Drugs 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 241000219198 Brassica Species 0.000 description 6
- 235000003351 Brassica cretica Nutrition 0.000 description 6
- 235000003343 Brassica rupestris Nutrition 0.000 description 6
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 6
- 235000010460 mustard Nutrition 0.000 description 6
- NOWKCMXCCJGMRR-UHFFFAOYSA-O aziridinium Chemical compound C1C[NH2+]1 NOWKCMXCCJGMRR-UHFFFAOYSA-O 0.000 description 4
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229940000635 beta-alanine Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- GKLGRDVQLWPZTE-GEMLJDPKSA-N (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;potassium Chemical group [K].OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O GKLGRDVQLWPZTE-GEMLJDPKSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- QWXDICNEPRTOLR-GEMLJDPKSA-M sodium 2-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-sulfanylpropanoyl]amino]acetate Chemical compound [Na+].N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC([O-])=O)C(O)=O QWXDICNEPRTOLR-GEMLJDPKSA-M 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4366608P | 2008-04-09 | 2008-04-09 | |
| US61/043,666 | 2008-04-09 | ||
| US8703408P | 2008-08-07 | 2008-08-07 | |
| US61/087,034 | 2008-08-07 | ||
| PCT/US2009/040032 WO2009126786A2 (en) | 2008-04-09 | 2009-04-09 | Improved quenching methods for red blood cell pathogen inactivation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014187495A Division JP2014231528A (ja) | 2008-04-09 | 2014-09-16 | 赤血球病原体の不活化のための改善されたクエンチング方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516570A JP2011516570A (ja) | 2011-05-26 |
| JP2011516570A5 true JP2011516570A5 (cg-RX-API-DMAC7.html) | 2013-04-25 |
| JP5916383B2 JP5916383B2 (ja) | 2016-05-11 |
Family
ID=41162599
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504170A Active JP5916383B2 (ja) | 2008-04-09 | 2009-04-09 | 赤血球病原体の不活化のための改善されたクエンチング方法 |
| JP2014187495A Pending JP2014231528A (ja) | 2008-04-09 | 2014-09-16 | 赤血球病原体の不活化のための改善されたクエンチング方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014187495A Pending JP2014231528A (ja) | 2008-04-09 | 2014-09-16 | 赤血球病原体の不活化のための改善されたクエンチング方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8900805B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3257375A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5916383B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101896430B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102046006B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009233807B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0911176B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2720824C (cg-RX-API-DMAC7.html) |
| EA (1) | EA023596B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2636563T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL208431A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2010011018A (cg-RX-API-DMAC7.html) |
| SG (2) | SG189745A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009126786A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201006936B (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101896430B1 (ko) | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| EA201790265A1 (ru) | 2014-07-23 | 2017-07-31 | Сирус Корпорейшн | Способы получения тромбоцит-содержащих продуктов |
| KR20250033333A (ko) | 2015-03-10 | 2025-03-07 | 헤마넥스트 인코포레이티드 | 산소 감소 1회용 키트, 장치 및 이의 사용 방법 |
| BR122022005103B1 (pt) | 2015-04-23 | 2023-03-14 | Hemanext Inc | Dispositivo de armazenamento de sangue para armazenar sangue depletado de oxigênio e método para armazenar sangue depletado de oxigênio |
| PT3297641T (pt) | 2015-05-18 | 2025-10-09 | Hemanext Inc | Métodos de armazenamento de sangue total e respetivas composições |
| CN122182613A (zh) | 2015-06-26 | 2026-06-12 | 塞鲁斯公司 | 冷沉淀物组合物及其制备方法 |
| US10799533B2 (en) | 2015-10-23 | 2020-10-13 | Cerus Corporation | Plasma compositions and methods of use thereof |
| CN109195632A (zh) * | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | 厌氧血液储存和病原体失活方法 |
| IT201600079328A1 (it) * | 2016-07-28 | 2018-01-28 | Altergon Sa | Metodo migliorato per la decontaminazione di materiale biologico mediante partizione e inattivazione |
| AU2017382449B2 (en) * | 2016-12-23 | 2024-10-24 | Cerus Corporation | Systems and methods for testing and screening using compound bound substrates |
| US20190321407A1 (en) * | 2016-12-31 | 2019-10-24 | Cerus Corporation | Compositions and methods for preparation of red blood cells |
| EP4606379A3 (en) | 2017-03-03 | 2025-11-19 | Cerus Corporation | Kits and methods for preparing pathogen-inactivated platelet compositions |
| JP7311518B2 (ja) | 2017-12-29 | 2023-07-19 | シーラス コーポレイション | 生物学的流体を処理するためのシステムおよび方法 |
| US20210227827A1 (en) * | 2018-07-27 | 2021-07-29 | Zata Pharmaceuticals, Inc. | Method for pathogens, microorganisms, and parasites inactivation |
| CA3113655A1 (en) * | 2018-09-20 | 2020-03-26 | Cerus Corporation | Methods and kits for preparing pathogen-inactivated whole blood |
| US12103222B2 (en) | 2018-12-21 | 2024-10-01 | The Curators Of The University Of Missouri | Methods and systems for drawn fused filament fabrication printing |
| WO2020263745A1 (en) | 2019-06-22 | 2020-12-30 | Cerus Corporation | Systems and methods for implementing treatment of biological fluids |
| CN114173842B (zh) | 2019-06-22 | 2026-07-14 | 塞鲁斯公司 | 生物流体处理系统 |
| JP7645203B2 (ja) | 2019-06-28 | 2025-03-13 | シーラス コーポレイション | 生物学的流体処理デバイスを実装するためのシステム及び方法 |
| WO2025264876A1 (en) | 2024-06-20 | 2025-12-26 | Cerus Corporation | Systems and methods for pathogen inactivation of blood products |
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| KR101896430B1 (ko) | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
-
2009
- 2009-04-09 KR KR1020177008174A patent/KR101896430B1/ko active Active
- 2009-04-09 MX MX2010011018A patent/MX2010011018A/es active IP Right Grant
- 2009-04-09 MX MX2015006091A patent/MX373157B/es unknown
- 2009-04-09 ES ES09730332.5T patent/ES2636563T3/es active Active
- 2009-04-09 KR KR1020107024925A patent/KR101742533B1/ko not_active Expired - Fee Related
- 2009-04-09 EP EP17162270.7A patent/EP3257375A1/en not_active Ceased
- 2009-04-09 BR BRPI0911176A patent/BRPI0911176B8/pt active IP Right Grant
- 2009-04-09 WO PCT/US2009/040032 patent/WO2009126786A2/en not_active Ceased
- 2009-04-09 JP JP2011504170A patent/JP5916383B2/ja active Active
- 2009-04-09 CA CA2720824A patent/CA2720824C/en active Active
- 2009-04-09 SG SG2013025275A patent/SG189745A1/en unknown
- 2009-04-09 CN CN200980119812.5A patent/CN102046006B/zh active Active
- 2009-04-09 US US12/936,763 patent/US8900805B2/en active Active
- 2009-04-09 SG SG10201605663UA patent/SG10201605663UA/en unknown
- 2009-04-09 EA EA201071178A patent/EA023596B1/ru not_active IP Right Cessation
- 2009-04-09 AU AU2009233807A patent/AU2009233807B2/en not_active Ceased
- 2009-04-09 EP EP09730332.5A patent/EP2285210B1/en active Active
-
2010
- 2010-09-29 ZA ZA2010/06936A patent/ZA201006936B/en unknown
- 2010-10-03 IL IL208431A patent/IL208431A/en active IP Right Grant
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2014
- 2014-09-16 JP JP2014187495A patent/JP2014231528A/ja active Pending
- 2014-10-31 US US14/530,415 patent/US9713627B2/en active Active
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2017
- 2017-06-20 US US15/628,510 patent/US10357516B2/en active Active
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